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1LP4
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CRYSTAL STRUCTURE OF A BINARY COMPLEX OF THE CATALYTIC SUBUNIT OF PROTEIN KINASE CK2 WITH MG-AMPPNP
Descriptor:Protein kinase CK2, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Niefind, K., Puetter, M., Guerra, B., Issinger, O.-G., Schomburg, D.
Deposit date:2002-05-07
Release date:2002-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate.
J.Mol.Biol., 347, 2005
1LPU
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LOW TEMPERATURE CRYSTAL STRUCTURE OF THE APO-FORM OF THE CATALYTIC SUBUNIT OF PROTEIN KINASE CK2 FROM ZEA MAYS
Descriptor:Protein kinase CK2, BENZAMIDINE
Authors:Niefind, K., Puetter, M., Guerra, B., Issinger, O.-G., Schomburg, D.
Deposit date:2002-05-08
Release date:2002-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate.
J.Mol.Biol., 347, 2005
1LR4
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ROOM TEMPERATURE CRYSTAL STRUCTURE OF THE APO-FORM OF THE CATALYTIC SUBUNIT OF PROTEIN KINASE CK2 FROM ZEA MAYS
Descriptor:Protein kinase CK2, BENZAMIDINE
Authors:Niefind, K., Puetter, M., Guerra, B., Issinger, O.-G., Schomburg, D.
Deposit date:2002-05-14
Release date:2002-05-29
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate.
J.Mol.Biol., 347, 2005
3U87
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STRUCTURE OF A CHIMERIC CONSTRUCT OF HUMAN CK2ALPHA AND HUMAN CK2ALPHA' IN COMPLEX WITH A NON-HYDROLYSABLE ATP-ANALOGUE
Descriptor:Casein kinase II subunit alpha, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
Authors:Niefind, K., Raaf, J., Issinger, O.-G., Olsen, B.
Deposit date:2011-10-16
Release date:2012-05-30
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Low-density crystal packing of human protein kinase CK2 catalytic subunit in complex with resorufin or other ligands: a tool to study the unique hinge-region plasticity of the enzyme without packing bias.
Acta Crystallogr.,Sect.D, 68, 2012
3JUH
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CRYSTAL STRUCTURE OF A MUTANT OF HUMAN PROTEIN KINASE CK2ALPHA WITH ALTERED COSUBSTRATE SPECIFICITY
Descriptor:Casein kinase II subunit alpha, CHLORIDE ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Niefind, K., Issinger, O.-G.
Deposit date:2009-09-15
Release date:2009-10-20
Last modified:2011-10-26
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate
J.Mol.Biol., 347, 2005
3H30
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CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF HUMAN PROTEIN KINASE CK2 WITH 5,6-DICHLORO-1-BETA-D-RIBOFURANOSYLBENZIMIDAZOLE
Descriptor:Casein kinase II subunit alpha, 5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole, CHLORIDE ION
Authors:Niefind, K., Raaf, J., Issinger, O.-G.
Deposit date:2009-04-15
Release date:2009-05-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:The CK2alpha/CK2beta Interface of Human Protein Kinase CK2 Harbors a Binding Pocket for Small Molecules
Chem.Biol., 15, 2008
2PVR
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CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF PROTEIN KINASE CK2 (C-TERMINAL DELETION MUTANT 1-335) IN COMPLEX WITH TWO SULFATE IONS
Descriptor:Casein kinase II subunit alpha, catalytic subunit, SULFATE ION, ...
Authors:Niefind, K., Yde, C.W., Ermakova, I., Issinger, O.-G.
Deposit date:2007-05-10
Release date:2007-06-26
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.605 Å)
Cite:Evolved to Be Active: Sulfate Ions Define Substrate Recognition Sites of CK2alpha and Emphasise its Exceptional Role within the CMGC Family of Eukaryotic Protein Kinases
J.Mol.Biol., 370, 2007
3OFM
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STRUCTURE OF A HUMAN CK2ALPHA PRIME, THE PARALOG ISOFORM OF THE CATALYTIC SUBUNIT OF PROTEIN KINASE CK2 FROM HOMO SAPIENS
Descriptor:Casein kinase II subunit alpha', 3-(4,5,6,7-tetrabromo-1H-benzotriazol-1-yl)propan-1-ol, CHLORIDE ION
Authors:Bischoff, N., Olsen, B., Raaf, J., Bretner, M., Issinger, O.-G., Niefind, K.
Deposit date:2010-08-15
Release date:2011-01-19
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis of the reduced affinity between the protein kinase CK2 subunits CK2alpha prime and CK2beta
J.Mol.Biol., 407, 2011
4NH1
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CRYSTAL STRUCTURE OF A HETEROTETRAMERIC CK2 HOLOENZYME COMPLEX CARRYING THE ANDANTE-MUTATION IN CK2BETA AND CONSISTENT WITH PROPOSED MODELS OF AUTOINHIBITION AND TRANS-AUTOPHOSPHORYLATION
Descriptor:Casein kinase II subunit alpha, Casein kinase II subunit beta, MAGNESIUM ION, ...
Authors:Schnitzler, A., Issinger, O.-G., Niefind, K.
Deposit date:2013-11-04
Release date:2014-03-12
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:The Protein Kinase CK2(Andante) Holoenzyme Structure Supports Proposed Models of Autoregulation and Trans-Autophosphorylation
J.Mol.Biol., 426, 2014
1PJK
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CRYSTAL STRUCTURE OF A C-TERMINAL DELETION MUTANT OF HUMAN PROTEIN KINASE CK2 CATALYTIC SUBUNIT
Descriptor:Casein kinase II, alpha chain, CHLORIDE ION, ...
Authors:Ermakova, I., Boldyreff, B., Issinger, O.-G., Niefind, K.
Deposit date:2003-06-03
Release date:2003-06-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit
J.Mol.Biol., 330, 2003
3EED
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CRYSTAL STRUCTURE OF HUMAN PROTEIN KINASE CK2 REGULATORY SUBUNIT (CK2BETA; MUTANT 1-193)
Descriptor:Casein kinase II subunit beta, ZINC ION, SULFATE ION
Authors:Niefind, K., Raaf, J., Issinger, O.-G.
Deposit date:2008-09-04
Release date:2008-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The interaction of CK2{alpha} and CK2{beta}, the subunits of protein kinase CK2, requires CK2{beta} in a preformed conformation and is enthalpically driven
Protein Sci., 17, 2008
3BQC
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HIGH PH-VALUE CRYSTAL STRUCTURE OF EMODIN IN COMPLEX WITH THE CATALYTIC SUBUNIT OF PROTEIN KINASE CK2
Descriptor:Casein kinase II subunit alpha, CHLORIDE ION, 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE
Authors:Niefind, K., Raaf, J., Issinger, O.-G.
Deposit date:2007-12-20
Release date:2008-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The Catalytic Subunit of Human Protein Kinase CK2 Structurally Deviates from Its Maize Homologue in Complex with the Nucleotide Competitive Inhibitor Emodin
J.Mol.Biol., 377, 2008
3C13
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LOW PH-VALUE CRYSTAL STRUCTURE OF EMODIN IN COMPLEX WITH THE CATALYTIC SUBUNIT OF PROTEIN KINASE CK2
Descriptor:Casein kinase II subunit alpha, CHLORIDE ION, 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE
Authors:Niefind, K., Raaf, J., Issinger, O.-G.
Deposit date:2008-01-22
Release date:2008-02-12
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The Catalytic Subunit of Human Protein Kinase CK2 Structurally Deviates from Its Maize Homologue in Complex with the Nucleotide Competitive Inhibitor Emodin
J.Mol.Biol., 377, 2008
3U9C
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STRUCTURE OF A C-TERMINAL DELETION MUTANT OF HUMAN PROTEIN KINASE CK2 CATALYTIC SUBUNIT WITH THE ATP-COMPETITIVE INHIBITOR RESORUFIN
Descriptor:Casein kinase II subunit alpha, SULFATE ION, 7-hydroxy-3H-phenoxazin-3-one, ...
Authors:Klopffleisch, K., Issinger, O.-G., Niefind, K.
Deposit date:2011-10-18
Release date:2012-05-30
Last modified:2013-01-23
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Low-density crystal packing of human protein kinase CK2 catalytic subunit in complex with resorufin or other ligands: a tool to study the unique hinge-region plasticity of the enzyme without packing bias.
Acta Crystallogr.,Sect.D, 68, 2012
4FBX
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COMPLEX STRUCTURE OF HUMAN PROTEIN KINASE CK2 CATALYTIC SUBUNIT CRYSTALLIZED IN THE PRESENCE OF A BISUBSTRATE INHIBITOR
Descriptor:Casein kinase II subunit alpha, bisubstrate inhibitor, CHLORIDE ION
Authors:Enkvist, E., Viht, K., Bischoff, N., Vahter, J., Saaver, S., Raidaru, G., Issinger, O.-G., Niefind, K., Uri, A.
Deposit date:2012-05-23
Release date:2012-10-17
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:A subnanomolar fluorescent probe for protein kinase CK2 interaction studies.
Org.Biomol.Chem., 10, 2012
3RPS
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STRUCTURE OF HUMAN CK2ALPHA IN COMPLEX WITH THE ATP-COMPETITIVE INHIBITOR 3-(4,5,6,7-TETRABROMO-1H-BENZOTRIAZOL-1-YL)PROPAN-1-OL
Descriptor:Casein kinase II subunit alpha, 3-(4,5,6,7-tetrabromo-1H-benzotriazol-1-yl)propan-1-ol, SULFATE ION, ...
Authors:Bischoff, N., Raaf, J., Olsen, B., Bretner, M., Issinger, O.-G., Niefind, K.
Deposit date:2011-04-27
Release date:2011-06-08
Last modified:2013-08-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Enzymatic activity with an incomplete catalytic spine - insights from a comparative structural analysis of human CK2alpha and its paralogous isoform CK2alpha'
Mol.Cell.Biochem., 356, 2011
4UB7
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HIGH-SALT STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT WITH 4'-CARBOXY-6,8-BROMO-FLAVONOL (FLC26) SHOWING AN EXTREME DISTORTION OF THE ATP-BINDING LOOP COMBINED WITH A PI-HALOGEN BOND
Descriptor:Casein kinase II subunit alpha, 4-(6,8-dibromo-3-hydroxy-4-oxo-4H-chromen-2-yl)benzoic acid, CHLORIDE ION
Authors:Niefind, K., Bischoff, N., Guerra, B., Golub, A., Issinger, O.-G.
Deposit date:2014-08-12
Release date:2015-07-01
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Note of Caution on the Role of Halogen Bonds for Protein Kinase/Inhibitor Recognition Suggested by High- And Low-Salt CK2 alpha Complex Structures.
Acs Chem.Biol., 10, 2015
4UBA
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LOW-SALT STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT WITH 4'-CARBOXY-6,8-BROMO-FLAVONOL (FLC26)
Descriptor:Casein kinase II subunit alpha, 4-(6,8-dibromo-3-hydroxy-4-oxo-4H-chromen-2-yl)benzoic acid
Authors:Niefind, K., Bischoff, N., Guerra, B., Golub, A., Issinger, O.-G.
Deposit date:2014-08-12
Release date:2015-07-01
Method:X-RAY DIFFRACTION (2.995 Å)
Cite:A Note of Caution on the Role of Halogen Bonds for Protein Kinase/Inhibitor Recognition Suggested by High- And Low-Salt CK2 alpha Complex Structures.
Acs Chem.Biol., 10, 2015
4IB5
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STRUCTURE OF HUMAN PROTEIN KINASE CK2 CATALYTIC SUBUNIT IN COMPLEX WITH A CK2BETA-COMPETITIVE CYCLIC PEPTIDE
Descriptor:Casein kinase II subunit alpha, CK2beta-derived cyclic peptide, GLYCEROL, ...
Authors:Raaf, J., Guerra, B., Neundorf, I., Bopp, B., Issinger, O.-G., Jose, J., Pietsch, M., Niefind, K.
Deposit date:2012-12-08
Release date:2013-03-20
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:First structure of protein kinase CK2 catalytic subunit with an effective CK2 beta-competitive ligand
Acs Chem.Biol., 8, 2013
1NA7
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CRYSTAL STRUCTURE OF THE CATALYTIC SUBUNIT OF HUMAN PROTEIN KINASE CK2
Descriptor:Casein kinase II, alpha chain
Authors:Pechkova, E., Zanotti, G., Nicolini, C.
Deposit date:2002-11-27
Release date:2003-08-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2.
Acta Crystallogr.,Sect.D, 59, 2003