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2W83
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BU of 2w83 by Molmil
Crystal structure of the ARF6 GTPase in complex with a specific effector, JIP4
Descriptor: 1,4-DIETHYLENE DIOXIDE, ADP-RIBOSYLATION FACTOR 6, C-JUN-AMINO-TERMINAL KINASE-INTERACTING PROTEIN 4, ...
Authors:Isabet, T, Montagnac, G, Regazzoni, K, Raynal, B, El Khadali, F, Franco, M, England, P, Chavrier, P, Houdusse, A, Menetrey, J.
Deposit date:2009-01-08
Release date:2009-07-14
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:The Structural Basis of Arf Effector Specificity: The Crystal Structure of Arf6 in a Complex with Jip4.
Embo J., 28, 2009
5I0I
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BU of 5i0i by Molmil
Crystal structure of myosin X motor domain with 2IQ motifs in pre-powerstroke state
Descriptor: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, Calmodulin, ...
Authors:Isabet, T, Sweeney, H.L, Houdusse, A.
Deposit date:2016-02-04
Release date:2016-09-07
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:The myosin X motor is optimized for movement on actin bundles.
Nat Commun, 7, 2016
5I0H
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BU of 5i0h by Molmil
Crystal structure of myosin X motor domain in pre-powerstroke state
Descriptor: 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, ...
Authors:Isabet, T, Blanc, F, Sweeney, H.L, Houdusse, A.
Deposit date:2016-02-04
Release date:2016-09-07
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The myosin X motor is optimized for movement on actin bundles.
Nat Commun, 7, 2016
5O2L
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BU of 5o2l by Molmil
Myosin VI motor domain in the Pre-Transition State
Descriptor: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, GLYCEROL, ...
Authors:Isabet, T, Benisty, H, Houdusse, A.
Deposit date:2017-05-22
Release date:2018-05-23
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:An intermediate along the recovery stroke of myosin VI revealed by X-ray crystallography and molecular dynamics.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
4E7Z
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BU of 4e7z by Molmil
Myosin VI (MD) pre-powerstroke state, P21 crystal form
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
Authors:Isabet, T, Sweeney, H.L, Houdusse, A.
Deposit date:2012-03-19
Release date:2012-09-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Processive Steps in the Reverse Direction Require Uncoupling of the Lead Head Lever Arm of Myosin VI.
Mol.Cell, 48, 2012
4E7S
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BU of 4e7s by Molmil
Myosin VI D23R I24R R569E (MD) pre-powerstroke state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
Authors:Isabet, T, Sweeney, H.L, Houdusse, A.
Deposit date:2012-03-19
Release date:2012-09-19
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Processive Steps in the Reverse Direction Require Uncoupling of the Lead Head Lever Arm of Myosin VI.
Mol.Cell, 48, 2012
6G3O
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BU of 6g3o by Molmil
Crystal structure of human HDAC2 in complex with (R)-6-[3,4-Dioxo-2-(4-trifluoromethoxy-phenylamino)-cyclobut-1-enylamino]-heptanoic acid hydroxyamide
Descriptor: (6~{R})-6-[[3,4-bis(oxidanylidene)-2-[[4-(trifluoromethyloxy)phenyl]amino]cyclobuten-1-yl]amino]-~{N}-oxidanyl-heptanamide, CALCIUM ION, Histone deacetylase 2, ...
Authors:Isabet, T, Aurelly, M, Chantalat, L, Thoreau, E.
Deposit date:2018-03-26
Release date:2018-06-27
Last modified:2018-08-29
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Squaramides as novel class I and IIB histone deacetylase inhibitors for topical treatment of cutaneous t-cell lymphoma.
Bioorg. Med. Chem. Lett., 28, 2018
6F2A
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BU of 6f2a by Molmil
Crystal structure of the complex Fe(II)/alpha-ketoglutarate dependent dioxygenase KDO1 with Fe(II)/Lysine
Descriptor: ACETIC ACID, CHLORIDE ION, FE (II) ION, ...
Authors:Isabet, T, Stura, E.A, Legrand, P, Zaparucha, A, Bastard, K.
Deposit date:2017-11-24
Release date:2018-11-14
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Studies based on two Lysine Dioxygenases with Distinct Regioselectivity Brings Insights Into Enzyme Specificity within the Clavaminate Synthase-Like Family.
Sci Rep, 8, 2018
6F2B
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BU of 6f2b by Molmil
Crystal structure of the complex Fe(II)/alpha-ketoglutarate dependent dioxygenase KDO1 with Fe(II)/alpha-ketoglutarate
Descriptor: 2-OXOGLUTARIC ACID, FE (II) ION, L-lysine 3-hydroxylase
Authors:Isabet, T, Stura, E.A, Legrand, P, Zaparucha, A, Bastard, K.
Deposit date:2017-11-24
Release date:2018-11-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Studies based on two Lysine Dioxygenases with Distinct Regioselectivity Brings Insights Into Enzyme Specificity within the Clavaminate Synthase-Like Family.
Sci Rep, 8, 2018
6EXF
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BU of 6exf by Molmil
Crystal structure of the complex Fe(II)/alpha-ketoglutarate dependent dioxygenase KDO5 with Fe(II)/Lysine
Descriptor: FE (III) ION, GLYCEROL, L-lysine 4-hydroxylase, ...
Authors:Isabet, T, Stura, E, Legrand, P, Zaparucha, A, Bastard, K.
Deposit date:2017-11-08
Release date:2018-11-14
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Studies based on two Lysine Dioxygenases with Distinct Regioselectivity Brings Insights Into Enzyme Specificity within the Clavaminate Synthase-Like Family.
Sci Rep, 8, 2018
6F9P
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BU of 6f9p by Molmil
Crystal structure of the Fe(II)/alpha-ketoglutarate dependent dioxygenase KDO5 with Re(II)
Descriptor: CHLORIDE ION, GLYCEROL, L-lysine 4-hydroxylase, ...
Authors:Isabet, T, Stura, E, Legrand, P, Zaparucha, A, Bastard, K.
Deposit date:2017-12-15
Release date:2018-11-14
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Studies based on two Lysine Dioxygenases with Distinct Regioselectivity Brings Insights Into Enzyme Specificity within the Clavaminate Synthase-Like Family.
Sci Rep, 8, 2018
6EUO
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BU of 6euo by Molmil
Crystal structure of APO Fe(II)/alpha-ketoglutarate dependent dioxygenase KDO5
Descriptor: D-MALATE, FE (III) ION, GLYCEROL, ...
Authors:Isabet, T, Stura, E, Legrand, P, Zaparucha, A, Bastard, K.
Deposit date:2017-10-30
Release date:2018-11-14
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Studies based on two Lysine Dioxygenases with Distinct Regioselectivity Brings Insights Into Enzyme Specificity within the Clavaminate Synthase-Like Family.
Sci Rep, 8, 2018
6EXH
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BU of 6exh by Molmil
Crystal structure of the complex Fe(II)/alpha-ketoglutarate dependent dioxygenase KDO5 with Fe(II)/succinate/(4R)-4-hydroxy-L-lysine
Descriptor: 4-HYDROXY-LYSINE, FE (III) ION, GLYCEROL, ...
Authors:Isabet, T, Stura, E, Legrand, P, Zaparucha, A, Bastard, K.
Deposit date:2017-11-08
Release date:2018-11-14
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Studies based on two Lysine Dioxygenases with Distinct Regioselectivity Brings Insights Into Enzyme Specificity within the Clavaminate Synthase-Like Family.
Sci Rep, 8, 2018
6F2E
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BU of 6f2e by Molmil
Crystal structure of the APO Fe(II)/alpha-ketoglutarate dependent dioxygenase KDO1
Descriptor: ACETIC ACID, L-lysine 3-hydroxylase
Authors:Isabet, T, Stura, E.A, Legrand, P, Zaparucha, A, Bastard, K.
Deposit date:2017-11-24
Release date:2018-11-14
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Studies based on two Lysine Dioxygenases with Distinct Regioselectivity Brings Insights Into Enzyme Specificity within the Clavaminate Synthase-Like Family.
Sci Rep, 8, 2018
6F6J
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BU of 6f6j by Molmil
Crystal structure of the Fe(II)/alpha-ketoglutarate dependent dioxygenase KDO1 with Fe(II)/succinate/(3S)-3-hydroxy-L-lysine
Descriptor: (2~{S},3~{R})-2,6-bis(azanyl)-3-oxidanyl-hexanoic acid, ACETATE ION, FE (III) ION, ...
Authors:Isabet, T, Stura, E.A, Legrand, P, Zaparucha, A, Bastard, K.
Deposit date:2017-12-05
Release date:2018-11-14
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Studies based on two Lysine Dioxygenases with Distinct Regioselectivity Brings Insights Into Enzyme Specificity within the Clavaminate Synthase-Like Family.
Sci Rep, 8, 2018
6EUR
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BU of 6eur by Molmil
Crystal structure of the complex Fe(II)/alpha-ketoglutarate dependent dioxygenase KDO5 with Fe(II)/alpha-ketoglutarate
Descriptor: 2-OXOGLUTARIC ACID, FE (III) ION, GLYCEROL, ...
Authors:Isabet, T, Stura, E, Legrand, P, Zaparucha, A, Bastard, K.
Deposit date:2017-10-31
Release date:2018-11-14
Last modified:2018-11-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Studies based on two Lysine Dioxygenases with Distinct Regioselectivity Brings Insights Into Enzyme Specificity within the Clavaminate Synthase-Like Family.
Sci Rep, 8, 2018
4PK4
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BU of 4pk4 by Molmil
Myosin VI motor domain in the PPS state - from a Pi release state crystal, space group P212121 after long soaking with PO4
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Isabet, T, Benisty, H, Llinas, P, Sweeney, H.L, Houdusse, A.
Deposit date:2014-05-13
Release date:2015-04-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:How actin initiates the motor activity of Myosin.
Dev.Cell, 33, 2015
4PFO
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BU of 4pfo by Molmil
Myosin VI motor domain in the Pi release state, space group P212121
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
Authors:Isabet, T, Benisty, H, Llinas, P, Sweeney, H.L, Houdusse, A.
Deposit date:2014-04-30
Release date:2015-04-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:How actin initiates the motor activity of Myosin.
Dev.Cell, 33, 2015
4PJK
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BU of 4pjk by Molmil
Dicty myosin II R238E.E459R mutant (with ADP.Pi) in the Pi release state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
Authors:Isabet, T, Benisty, H, Llinas, P, Sweeney, H.L, Houdusse, A.
Deposit date:2014-05-12
Release date:2015-04-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:How actin initiates the motor activity of Myosin.
Dev.Cell, 33, 2015
4PJM
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BU of 4pjm by Molmil
Myosin VI motor domain in the Pi release state, space group P212121 - soaked with PO4 - located in the active site
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ISOPROPYL ALCOHOL, ...
Authors:Isabet, T, Benisty, H, Llinas, P, Sweeney, H.L, Houdusse, A.
Deposit date:2014-05-12
Release date:2015-04-29
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:How actin initiates the motor activity of Myosin.
Dev.Cell, 33, 2015
4PFP
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BU of 4pfp by Molmil
Myosin VI motor domain in the Pi release state (with Pi) space group P21
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Isabet, T, Benisty, H, Llinas, P, Sweeney, H.L, Houdusse, A.
Deposit date:2014-04-30
Release date:2015-04-29
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:How actin initiates the motor activity of Myosin.
Dev.Cell, 33, 2015
4PJJ
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BU of 4pjj by Molmil
MYOSIN VI (MD-INSERT2-CAM, DELTA-INSERT1) post-rigor state - long soaking with PO4
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, Calmodulin, ...
Authors:Isabet, T, Benisty, H, Llinas, P, Sweeney, H.L, Houdusse, A.
Deposit date:2014-05-12
Release date:2015-04-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:How actin initiates the motor activity of Myosin.
Dev.Cell, 33, 2015
4PJN
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BU of 4pjn by Molmil
Myosin VI motor domain in the Pi release state, space group P212121 - shortly soaked with PO4
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
Authors:Isabet, T, Benisty, H, Llinas, P, Sweeney, H.L, Houdusse, A.
Deposit date:2014-05-12
Release date:2015-04-29
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:How actin initiates the motor activity of Myosin.
Dev.Cell, 33, 2015
4PJL
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BU of 4pjl by Molmil
Myosin VI motor domain A458E mutant in the Pi release state, space group P212121 -
Descriptor: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
Authors:Isabet, T, Benisty, H, Llinas, P, Sweeney, H.L, Houdusse, A.
Deposit date:2014-05-12
Release date:2015-04-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:How actin initiates the motor activity of Myosin.
Dev.Cell, 33, 2015
5MTK
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BU of 5mtk by Molmil
Crystal structure of human Caspase-1 with (3S,6S,10aS)-N-((2S,3S)-2-hydroxy-5-oxotetrahydrofuran-3-yl)-6-(isoquinoline-1-carboxamido)-5-oxodecahydropyrrolo[1,2-a]azocine-3-carboxamide (PGE-3935199)
Descriptor: (3~{S})-3-[[(3~{S},6~{S},10~{a}~{S})-6-(isoquinolin-1-ylcarbonylamino)-5-oxidanylidene-2,3,6,7,8,9,10,10~{a}-octahydro-1~{H}-pyrrolo[1,2-a]azocin-3-yl]carbonylamino]-4-oxidanyl-butanoic acid, Caspase-1
Authors:Brethon, A, Chantalat, L, Christin, O, Clary, L, Fournier, J.F, Gastreich, M, Harris, C, Pascau, J, Isabet, T, Rodeschin, V, Thoreau, E, Roche, D.
Deposit date:2017-01-09
Release date:2018-02-28
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Playing against the odds: scaffold hopping from 3D-fragments
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