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5ZZ4
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CRYSTAL STRUCTURE OF BRUTON'S TYROSINE KINASE IN COMPLEX WITH INHIBITOR 2E
分子名称:Tyrosine-protein kinase BTK, N-[3-(4-amino-6-{[4-(morpholine-4-carbonyl)phenyl]amino}-1,3,5-triazin-2-yl)-2-methylphenyl]-4-tert-butylbenzamide
著者Kawahata, W., Asami, T., Irie, T., Kiyoi, T., Taniguchi, H., Asamitsu, Y., Inoue, T., Miyake, T., Sawa, M.
登録日2018-05-30
公開日2018-09-26
最終更新日2018-11-28
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Design and Synthesis of Novel Amino-triazine Analogues as Selective Bruton's Tyrosine Kinase Inhibitors for Treatment of Rheumatoid Arthritis.
J. Med. Chem., 61, 2018
4Y2B
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CO-CRYSTAL STRUCTURE OF 3-ETHYL-2-(ISOPROPYLAMINO)-7-(PYRIDIN-3-YL)THIENO[3,2-D]PYRIMIDIN-4(3H)-ONE BOUND TO PDE7A
分子名称:High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A, ZINC ION, MAGNESIUM ION, ...
著者Endo, Y., Kawai, K., Asano, T., Amano, S., Asanuma, Y., Sawada, K., Onodera, Y., Ueo, N., Takahashi, N., Sonoda, Y., Kamei, N., Irie, T.
登録日2015-02-09
公開日2015-04-08
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献2-(Isopropylamino)thieno[3,2-d]pyrimidin-4(3H)-one derivatives as selective phosphodiesterase 7 inhibitors with potent in vivo efficacy
Bioorg.Med.Chem.Lett., 25, 2015
3WWT
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CRYSTAL STRUCTURE OF THE Y3:STAT1ND COMPLEX
分子名称:Signal transducer and activator of transcription 1-alpha/beta, Protein C', CALCIUM ION
著者Sakaguchi, T., Oda, K., Matoba, Y.
登録日2014-06-27
公開日2015-07-01
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Basis of the Inhibition of STAT1 Activity by Sendai Virus C protein
To be Published