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5V12
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BU of 5v12 by Molmil
Crystal structure of Carbon Sulfoxide lyase, Egt2 Y134F with sulfenic acid intermediate
Descriptor: (2~{S})-3-(2-oxidanylsulfanyl-1~{H}-imidazol-4-yl)-2-(trimethyl-$l^{4}-azanyl)propanoic acid, FORMIC ACID, Hercynylcysteine sulfoxide lyase
Authors:Irani, S, Zhang, Y.
Deposit date:2017-03-01
Release date:2018-03-07
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.451 Å)
Cite:Snapshots of C-S Cleavage in Egt2 Reveals Substrate Specificity and Reaction Mechanism.
Cell Chem Biol, 25, 2018
5V1X
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BU of 5v1x by Molmil
Carbon Sulfoxide lyase, Egt2 Y134F in complex with its substrate
Descriptor: (2~{S})-3-[2-[(2~{R})-2-azanyl-3-oxidanyl-3-oxidanylidene-propyl]sulfinyl-1~{H}-imidazol-4-yl]-2-(trimethyl-$l^{4}-azanyl)propanoic acid, FORMIC ACID, Hercynylcysteine sulfoxide lyase
Authors:Irani, S, Zhang, Y.
Deposit date:2017-03-02
Release date:2018-03-07
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.558 Å)
Cite:Snapshots of C-S Cleavage in Egt2 Reveals Substrate Specificity and Reaction Mechanism.
Cell Chem Biol, 25, 2018
5UTS
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BU of 5uts by Molmil
Carbon Sulfoxide lyase, Egt2 in the Ergothioneine biosynthesis pathway
Descriptor: C-S Lyase Egt2, FORMIC ACID
Authors:Irani, S, Zhang, Y.
Deposit date:2017-02-15
Release date:2018-02-21
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.303 Å)
Cite:Snapshots of C-S Cleavage in Egt2 Reveals Substrate Specificity and Reaction Mechanism.
Cell Chem Biol, 25, 2018
6NPW
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BU of 6npw by Molmil
SSu72/Sympk in complex with Ser2/Ser5 phosphorylated peptide
Descriptor: PHOSPHATE ION, Ser2/Ser5 phosphorylated peptide, Ssu72 ortholog, ...
Authors:Irani, S, Zhang, Y.
Deposit date:2019-01-18
Release date:2019-04-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.486 Å)
Cite:Structural determinants for accurate dephosphorylation of RNA polymerase II by its cognate C-terminal domain (CTD) phosphatase during eukaryotic transcription.
J.Biol.Chem., 294, 2019
5C2Y
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BU of 5c2y by Molmil
Crystal structure of the Saccharomyces cerevisiae Rtr1 (regulator of transcription)
Descriptor: GLYCEROL, RNA polymerase II subunit B1 CTD phosphatase RTR1, SULFATE ION, ...
Authors:Yogesha, S.D, Irani, S, Zhang, Y.J.
Deposit date:2015-06-16
Release date:2016-05-04
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of Saccharomyces cerevisiae Rtr1 reveals an active site for an atypical phosphatase.
Sci.Signal., 9, 2016
6O6L
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BU of 6o6l by Molmil
The Structure of EgtB(Cabther) in complex with Hercynine
Descriptor: EgtB (Cabther), FE (III) ION, N,N,N-trimethyl-histidine
Authors:Irani, S, Zhang, Y.
Deposit date:2019-03-07
Release date:2019-07-31
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal Structure of the Ergothioneine Sulfoxide Synthase fromCandidatus Chloracidobacterium thermophilumand Structure-Guided Engineering To Modulate Its Substrate Selectivity.
Acs Catalysis, 9, 2019
6O6M
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BU of 6o6m by Molmil
The Structure of EgtB (Cabther)
Descriptor: EgtB (Cabther), FE (III) ION, GLYCEROL
Authors:Irani, S, Zhang, Y.
Deposit date:2019-03-07
Release date:2019-07-31
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.506 Å)
Cite:Crystal Structure of the Ergothioneine Sulfoxide Synthase fromCandidatus Chloracidobacterium thermophilumand Structure-Guided Engineering To Modulate Its Substrate Selectivity.
Acs Catalysis, 9, 2019
6OVG
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BU of 6ovg by Molmil
L-Methionine Depletion with an Engineered Human Enzyme Disrupts Prostate Cancer Metabolism
Descriptor: Cystathionine gamma-lyase, SULFATE ION
Authors:Yan, W, Irani, S, Zhang, J.
Deposit date:2019-05-07
Release date:2020-04-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.719 Å)
Cite:Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity.
Proc.Natl.Acad.Sci.USA, 117, 2020
6DU3
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BU of 6du3 by Molmil
Structure of Scp1 D96N bound to REST-pS861/4 peptide
Descriptor: Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1, MAGNESIUM ION, REST-pS861
Authors:Burkholder, N.T, Mayfield, J.E, Yu, X, Irani, S, Arce, D.K, Jiang, F, Matthews, W, Xue, Y, Zhang, Y.J.
Deposit date:2018-06-19
Release date:2018-09-26
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Phosphatase activity of small C-terminal domain phosphatase 1 (SCP1) controls the stability of the key neuronal regulator RE1-silencing transcription factor (REST).
J. Biol. Chem., 293, 2018
6DU2
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BU of 6du2 by Molmil
Structure of Scp1 D96N bound to REST-pS861/4 peptide
Descriptor: MAGNESIUM ION, REST-pS861/4, carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform X2
Authors:Burkholder, N.T, Mayfield, J.E, Yu, X, Irani, S, Arce, D.K, Jiang, F, Matthews, W, Xue, Y, Zhang, Y.J.
Deposit date:2018-06-19
Release date:2018-09-26
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Phosphatase activity of small C-terminal domain phosphatase 1 (SCP1) controls the stability of the key neuronal regulator RE1-silencing transcription factor (REST).
J. Biol. Chem., 293, 2018
6NKO
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BU of 6nko by Molmil
Crystal structure of ForH
Descriptor: ForH
Authors:Zheng, J, Irani, S, Zhang, Y.
Deposit date:2019-01-07
Release date:2019-04-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.403 Å)
Cite:Identification of the Formycin A Biosynthetic Gene Cluster from Streptomyces kaniharaensis Illustrates the Interplay between Biological Pyrazolopyrimidine Formation and de Novo Purine Biosynthesis.
J. Am. Chem. Soc., 141, 2019
4ZM9
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BU of 4zm9 by Molmil
Crystal structure of circularly permuted human asparaginase-like protein 1
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, BETA-MERCAPTOETHANOL, CITRATE ANION, ...
Authors:Li, W.Z, Zhang, Y.
Deposit date:2015-05-02
Release date:2016-02-17
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Intramolecular Cleavage of the hASRGL1 Homodimer Occurs in Two Stages.
Biochemistry, 55, 2016

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