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1LR7
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BU of 1lr7 by Molmil
Crystal structure of Fs1, the heparin-binding domain of follistatin, complexed with the heparin analogue sucrose octasulphate (SOS)
Descriptor: SULFATE ION, follistatin
Authors:Innis, C.A, Hyvonen, M.
Deposit date:2002-05-15
Release date:2003-07-29
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structures of the Heparan Sulfate-binding Domain of Follistatin: Insights into ligand binding.
J.Biol.Chem., 278, 2003
1LR8
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BU of 1lr8 by Molmil
Crystal structure of Fs1, the heparin-binding domain of follistatin, complexed with the heparin analogue D-myo-inositol hexasulphate (Ins6S)
Descriptor: D-MYO-INOSITOL-HEXASULPHATE, Follistatin
Authors:Innis, C.A, Hyvonen, M.
Deposit date:2002-05-15
Release date:2003-07-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of the Heparan Sulfate-binding Domain of Follistatin: Insights into ligand binding.
J.Biol.Chem., 278, 2003
1LR9
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BU of 1lr9 by Molmil
STRUCTURE OF Fs1, THE HEPARIN-BINDING DOMAIN OF FOLLISTATIN
Descriptor: Follistatin
Authors:Innis, C.A, Hyvonen, M.
Deposit date:2002-05-15
Release date:2003-07-29
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structures of the Heparan Sulfate-binding Domain of Follistatin: Insights into ligand binding.
J.Biol.Chem., 278, 2003
6TC3
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BU of 6tc3 by Molmil
Cryo-EM structure of an Escherichia coli ribosome-SpeFL complex stalled in response to L-ornithine (Replicate 1)
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
Authors:Innis, C.A, Herrero del Valle, A.
Deposit date:2019-11-05
Release date:2020-01-01
Last modified:2020-04-08
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Ornithine capture by a translating ribosome controls bacterial polyamine synthesis.
Nat Microbiol, 5, 2020
7ZTA
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BU of 7zta by Molmil
Structure of an Escherichia coli 70S ribosome stalled by Tetracenomycin X during translation of an MAAAPQK(C) peptide
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Leroy, E.C, Perry, T.N, Renault, T.T, Innis, C.A.
Deposit date:2022-05-09
Release date:2023-04-12
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Tetracenomycin X sequesters peptidyl-tRNA during translation of QK motifs.
Nat.Chem.Biol., 19, 2023
4V7Y
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BU of 4v7y by Molmil
Structure of the Thermus thermophilus 70S ribosome complexed with azithromycin.
Descriptor: 16S rRNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Bulkley, D.P, Innis, C.A, Blaha, G, Steitz, T.A.
Deposit date:2010-08-18
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Revisiting the structures of several antibiotics bound to the bacterial ribosome.
Proc.Natl.Acad.Sci.USA, 107, 2010
4V7X
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BU of 4v7x by Molmil
Structure of the Thermus thermophilus ribosome complexed with erythromycin.
Descriptor: 16S rRNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Bulkley, D.P, Innis, C.A, Blaha, G, Steitz, T.A.
Deposit date:2010-08-17
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Revisiting the structures of several antibiotics bound to the bacterial ribosome.
Proc.Natl.Acad.Sci.USA, 107, 2010
4V7Z
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BU of 4v7z by Molmil
Structure of the Thermus thermophilus 70S ribosome complexed with telithromycin.
Descriptor: 16S rRNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Bulkley, D.P, Innis, C.A, Blaha, G, Steitz, T.A.
Deposit date:2010-08-18
Release date:2014-07-09
Last modified:2021-01-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Revisiting the structures of several antibiotics bound to the bacterial ribosome.
Proc.Natl.Acad.Sci.USA, 107, 2010
4ZER
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BU of 4zer by Molmil
Crystal structure of the Onc112 antimicrobial peptide bound to the Thermus thermophilus 70S ribosome
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 16s ribosomal RNA, 23s ribosomal RNA, ...
Authors:Seefeldt, A.C, Nguyen, F, Antunes, S, Perebaskine, N, Graf, M, Arenz, S, Inampudi, K.K, Douat, C, Guichard, G, Wilson, D.N, Innis, C.A.
Deposit date:2015-04-20
Release date:2015-05-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The proline-rich antimicrobial peptide Onc112 inhibits translation by blocking and destabilizing the initiation complex.
Nat.Struct.Mol.Biol., 22, 2015
6FKR
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BU of 6fkr by Molmil
Crystal structure of the dolphin proline-rich antimicrobial peptide Tur1A bound to the Thermus thermophilus 70S ribosome
Descriptor: 16 ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Mardirossian, M, Perebaskine, N, Benincasa, M, Gambato, S, Hofmann, S, Huter, P, Muller, C, Hilpert, K, Innis, C.A, Tossi, A, Wilson, D.N.
Deposit date:2018-01-24
Release date:2018-03-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The Dolphin Proline-Rich Antimicrobial Peptide Tur1A Inhibits Protein Synthesis by Targeting the Bacterial Ribosome.
Cell Chem Biol, 25, 2018
4V5H
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BU of 4v5h by Molmil
E.Coli 70s Ribosome Stalled During Translation Of Tnac Leader Peptide.
Descriptor: 16S RIBOSOMAL RNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ...
Authors:Seidelt, B, Innis, C.A, Wilson, D.N, Gartmann, M, Armache, J, Villa, E, Trabuco, L.G, Becker, T, Mielke, T, Schulten, K, Steitz, T.A, Beckmann, R.
Deposit date:2009-10-26
Release date:2014-07-09
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Structural insight into nascent polypeptide chain-mediated translational stalling.
Science, 326, 2009
4V7W
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BU of 4v7w by Molmil
Structure of the Thermus thermophilus ribosome complexed with chloramphenicol.
Descriptor: 16S rRNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Bulkley, D.P, Innis, C.A, Blaha, G, Steitz, T.A.
Deposit date:2010-08-16
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Revisiting the structures of several antibiotics bound to the bacterial ribosome.
Proc.Natl.Acad.Sci.USA, 107, 2010
5JTE
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BU of 5jte by Molmil
Cryo-EM structure of an ErmBL-stalled ribosome in complex with A-, P-, and E-tRNA
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Arenz, S, Bock, L.V, Graf, M, Innis, C.A, Beckmann, R, Grubmueller, H, Vaiana, A.C, Wilson, D.N.
Deposit date:2016-05-09
Release date:2016-07-20
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest.
Nat Commun, 7, 2016
5JU8
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BU of 5ju8 by Molmil
Cryo-EM structure of an ErmBL-stalled ribosome in complex with P-, and E-tRNA
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Arenz, S, Bock, L.V, Graf, M, Innis, C.A, Beckmann, R, Grubmueller, H, Vaiana, A.C, Wilson, D.N.
Deposit date:2016-05-10
Release date:2016-07-20
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest.
Nat Commun, 7, 2016
7O1C
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BU of 7o1c by Molmil
Cryo-EM structure of an Escherichia coli TnaC(R23F)-ribosome-RF2 complex stalled in response to L-tryptophan
Descriptor: 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, ...
Authors:van der Stel, A.X, Gordon, E.R, Sengupta, A, Martinez, A.K, Klepacki, D, Perry, T.N, Herrero del Valle, A, Vazquez-Laslop, N, Sachs, M.S, Cruz-Vera, L.R, Innis, C.A.
Deposit date:2021-03-29
Release date:2021-09-01
Last modified:2021-09-29
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural basis for the tryptophan sensitivity of TnaC-mediated ribosome stalling.
Nat Commun, 12, 2021
7O19
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BU of 7o19 by Molmil
Cryo-EM structure of an Escherichia coli TnaC-ribosome complex stalled in response to L-tryptophan
Descriptor: 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, ...
Authors:van der Stel, A.X, Gordon, E.R, Sengupta, A, Martinez, A.K, Klepacki, D, Perry, T.N, Herrero del Valle, A, Vazquez-Laslop, N, Sachs, M.S, Cruz-Vera, L.R, Innis, C.A.
Deposit date:2021-03-29
Release date:2021-09-01
Last modified:2021-09-29
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural basis for the tryptophan sensitivity of TnaC-mediated ribosome stalling.
Nat Commun, 12, 2021
7O1A
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BU of 7o1a by Molmil
Cryo-EM structure of an Escherichia coli TnaC(R23F)-ribosome complex stalled in response to L-tryptophan
Descriptor: 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, ...
Authors:van der Stel, A.X, Gordon, E.R, Sengupta, A, Martinez, A.K, Klepacki, D, Perry, T.N, Herrero del Valle, A, Vazquez-Laslop, N, Sachs, M.S, Cruz-Vera, L.R, Innis, C.A.
Deposit date:2021-03-29
Release date:2021-09-01
Last modified:2021-10-20
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Structural basis for the tryptophan sensitivity of TnaC-mediated ribosome stalling.
Nat Commun, 12, 2021
6TBV
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BU of 6tbv by Molmil
Cryo-EM structure of an Escherichia coli ribosome-SpeFL complex stalled in response to L-ornithine (Replicate 2)
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
Authors:Herrero del Valle, A, Innis, C.A.
Deposit date:2019-11-04
Release date:2020-01-01
Last modified:2020-04-08
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Ornithine capture by a translating ribosome controls bacterial polyamine synthesis.
Nat Microbiol, 5, 2020
3GNA
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BU of 3gna by Molmil
Crystal structure of the RAG1 nonamer-binding domain with DNA
Descriptor: 5'-D(*AP*CP*TP*TP*AP*AP*CP*AP*AP*AP*AP*AP*CP*C)-3', 5'-D(*TP*GP*GP*TP*TP*TP*TP*TP*GP*TP*TP*AP*AP*G)-3', V(D)J recombination-activating protein 1
Authors:Yin, F.F, Bailey, S, Innis, C.A, Steitz, T.A, Schatz, D.G.
Deposit date:2009-03-16
Release date:2009-04-28
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis.
Nat.Struct.Mol.Biol., 16, 2009
3GNB
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BU of 3gnb by Molmil
Crystal structure of the RAG1 nonamer-binding domain with DNA
Descriptor: 5'-D(*AP*AP*TP*TP*TP*TP*CP*AP*GP*AP*AP*AP*CP*C)-3', 5'-D(*AP*GP*GP*TP*TP*TP*CP*TP*GP*AP*AP*AP*AP*C)-3', V(D)J recombination-activating protein 1
Authors:Yin, F.F, Bailey, S, Innis, C.A, Steitz, T.A, Schatz, D.G.
Deposit date:2009-03-16
Release date:2009-04-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis.
Nat.Struct.Mol.Biol., 16, 2009
3J9W
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BU of 3j9w by Molmil
Cryo-EM structure of the Bacillus subtilis MifM-stalled ribosome complex
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein bS16, ...
Authors:Sohmen, D, Chiba, S, Shimokawa-Chiba, N, Innis, C.A, Berninghausen, O, Beckmann, R, Ito, K, Wilson, D.N.
Deposit date:2015-03-16
Release date:2015-04-29
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structure of the Bacillus subtilis 70S ribosome reveals the basis for species-specific stalling.
Nat Commun, 6, 2015
5F8K
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BU of 5f8k by Molmil
Crystal structure of the Bac7(1-16) antimicrobial peptide bound to the Thermus thermophilus 70S ribosome
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Seefeldt, A.C, Graf, M, Perebaskine, N, Nguyen, F, Arenz, S, Mardirossian, M, Scocchi, M, Wilson, D.N, Innis, C.A.
Deposit date:2015-12-09
Release date:2016-02-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the mammalian antimicrobial peptide Bac7(1-16) bound within the exit tunnel of a bacterial ribosome.
Nucleic Acids Res., 44, 2016
5FDU
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BU of 5fdu by Molmil
Crystal structure of the Metalnikowin I antimicrobial peptide bound to the Thermus thermophilus 70S ribosome
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Seefeldt, A.C, Graf, M, Perebaskine, N, Nguyen, F, Arenz, S, Mardirossian, M, Scocchi, M, Wilson, D.N, Innis, C.A.
Deposit date:2015-12-16
Release date:2016-01-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of the mammalian antimicrobial peptide Bac7(1-16) bound within the exit tunnel of a bacterial ribosome.
Nucleic Acids Res., 44, 2016
5FDV
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BU of 5fdv by Molmil
Crystal structure of the Pyrrhocoricin antimicrobial peptide bound to the Thermus thermophilus 70S ribosome
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Seefeldt, A.C, Graf, M, Perebaskine, N, Nguyen, F, Arenz, S, Mardirossian, M, Scocchi, M, Wilson, D.N, Innis, C.A.
Deposit date:2015-12-16
Release date:2016-01-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the mammalian antimicrobial peptide Bac7(1-16) bound within the exit tunnel of a bacterial ribosome.
Nucleic Acids Res., 44, 2016
1VY6
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BU of 1vy6 by Molmil
Crystal structure of the Thermus thermophilus 70S ribosome in the pre-attack state of peptide bond formation containing short substrate-mimic Cytidine-Puromycin in the A site and acylated tRNA in the P site.
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Polikanov, Y.S, Steitz, T.A, Innis, C.A.
Deposit date:2014-05-13
Release date:2014-08-20
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome.
Nat.Struct.Mol.Biol., 21, 2014

 

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