Author results

1NQ0
  • Download 1nq0
  • View 1nq0
Molmil generated image of 1nq0
TR RECEPTOR MUTATIONS CONFERRING HORMONE RESISTANCE AND REDUCED COREPRESSOR RELEASE EXHIBIT DECREASED STABILITY IN THE NTERMINAL LBD
Descriptor:Thyroid hormone receptor beta-1, [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID, ARSENIC
Authors:Huber, B.R., Desclozeaux, M., West, B.L., Cunha-Lima, S.T., Nguyen, H.T., Baxter, J.D., Ingraham, H.A., Fletterick, R.J.
Deposit date:2003-01-20
Release date:2003-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain
Mol.Endocrinol., 17, 2003
1NQ1
  • Download 1nq1
  • View 1nq1
Molmil generated image of 1nq1
TR RECEPTOR MUTATIONS CONFERRING HORMONE RESISTANCE AND REDUCED COREPRESSOR RELEASE EXHIBIT DECREASED STABILITY IN THE NTERMINAL LBD
Descriptor:Thyroid hormone receptor beta-1, [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID, ARSENIC
Authors:Huber, B.R., Desclozeaux, M., West, B.L., Cunha-Lima, S.T., Nguyen, H.T., Baxter, J.D., Ingraham, H.A., Fletterick, R.J.
Deposit date:2003-01-20
Release date:2003-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Thyroid hormone receptor-beta mutations conferring hormone resistance and reduced corepressor release exhibit decreased stability in the N-terminal ligand-binding domain
Mol.Endocrinol., 17, 2003
1PK5
  • Download 1pk5
  • View 1pk5
Molmil generated image of 1pk5
CRYSTAL STRUCTURE OF THE ORPHAN NUCLEAR RECEPTOR LRH-1
Descriptor:Orphan nuclear receptor NR5A2
Authors:Sablin, E.P., Krylova, I.N., Fletterick, R.J., Ingraham, H.A.
Deposit date:2003-06-04
Release date:2003-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1
Mol.Cell, 11, 2003
1YMT
  • Download 1ymt
  • View 1ymt
Molmil generated image of 1ymt
MOUSE SF-1 LBD
Descriptor:Steroidogenic factor 1, Nuclear receptor 0B2, 1-CIS-9-OCTADECANOYL-2-CIS-9-HEXADECANOYL PHOSPHATIDYL GLYCEROL
Authors:Krylova, I.N., Sablin, E.P., Moore, J., Xu, R.X., Waitt, G.M., Juzumiene, D., Bynum, J.M., Fletterick, R.J., Willson, T.M., Ingraham, H.A.
Deposit date:2005-01-21
Release date:2005-03-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1
Cell(Cambridge,Mass.), 120, 2005
1YOK
  • Download 1yok
  • View 1yok
Molmil generated image of 1yok
CRYSTAL STRUCTURE OF HUMAN LRH-1 BOUND WITH TIF-2 PEPTIDE AND PHOSPHATIDYLGLYCEROL
Descriptor:Orphan nuclear receptor NR5A2, Nuclear receptor coactivator 2, (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE
Authors:Krylova, I.N., Sablin, E.P., Moore, J., Xu, R.X., Waitt, G.M., MacKay, J.A., Juzumiene, D., Bynum, J.M., Madauss, K., Montana, V., Lebedeva, L., Suzawa, M., Williams, J.D., Williams, S.P., Guy, R.K., Thornton, J.W., Fletterick, R.J., Willson, T.M., Ingraham, H.A.
Deposit date:2005-01-27
Release date:2005-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.
Cell(Cambridge,Mass.), 120, 2005
1YOW
  • Download 1yow
  • View 1yow
Molmil generated image of 1yow
HUMAN STEROIDOGENIC FACTOR 1 LBD WITH BOUND CO-FACTOR PEPTIDE
Descriptor:Steroidogenic factor 1, TIF2 peptide, PHOSPHATIDYL ETHANOL
Authors:Krylova, I.N., Sablin, E.P., Xu, R.X., Waitt, G.M., Juzumiene, D., Williams, J.D., Ingraham, H.A., Willson, T.M., Williams, S.P., Montana, V., Madauss, K.P., Moore, J., Bynum, J.M., Lebedeva, L., MacKay, J.A., Suzawa, M., Guy, R.K., Thornton, J.W.
Deposit date:2005-01-28
Release date:2005-05-10
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1
Cell(Cambridge,Mass.), 120, 2005
3F7D
  • Download 3f7d
  • View 3f7d
Molmil generated image of 3f7d
SF-1 LBD BOUND BY PHOSPHATIDYLCHOLINE
Descriptor:nuclear receptor SF-1, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate
Authors:Sablin, E.P., Fletterick, R.J.
Deposit date:2008-11-07
Release date:2008-12-09
Last modified:2014-04-02
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands.
Mol.Endocrinol., 23, 2009
3F5C
  • Download 3f5c
  • View 3f5c
Molmil generated image of 3f5c
STRUCTURE OF DAX-1:LRH-1 COMPLEX
Descriptor:Nuclear receptor subfamily 5 group A member 2, Nuclear receptor subfamily 0 group B member 1
Authors:Fletterick, R.J., Sablin, E.P.
Deposit date:2008-11-03
Release date:2008-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure of corepressor Dax-1 bound to its target nuclear receptor LRH-1.
Proc.Natl.Acad.Sci.USA, 105, 2008
3PLZ
  • Download 3plz
  • View 3plz
Molmil generated image of 3plz
HUMAN LRH1 LBD BOUND TO GR470
Descriptor:FTZ-F1 related protein, Nuclear receptor coactivator 2, (3aS,6aR)-5-[(4E)-oct-4-en-4-yl]-N,4-diphenyl-2,3,6,6a-tetrahydropentalen-3a(1H)-amine, ...
Authors:Williams, S.P., Xu, R., Zuercher, W.J.
Deposit date:2010-11-15
Release date:2011-03-30
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Small Molecule Agonists of the Orphan Nuclear Receptors Steroidogenic Factor-1 (SF-1, NR5A1) and Liver Receptor Homologue-1 (LRH-1, NR5A2).
J.Med.Chem., 54, 2011
4QJR
  • Download 4qjr
  • View 4qjr
Molmil generated image of 4qjr
CRYSTAL STRUCTURE OF HUMAN NUCLEAR RECEPTOR SF-1 (NR5A1) BOUND TO ITS HORMONE PIP3 AT 2.4 A RESOLUTION
Descriptor:Steroidogenic factor 1, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, (2S)-3-{[(R)-{[(1S,2S,3R,4S,5S,6S)-2,6-dihydroxy-3,4,5-tris(phosphonooxy)cyclohexyl]oxy}(hydroxy)phosphoryl]oxy}propane-1,2-diyl dihexadecanoate, ...
Authors:Joint Center for Structural Genomics (JCSG), Partnership for Stem Cell Biology (STEMCELL)
Deposit date:2014-06-04
Release date:2014-07-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1.
Proc.Natl.Acad.Sci.USA, 111, 2014
4QK4
  • Download 4qk4
  • View 4qk4
Molmil generated image of 4qk4
CRYSTAL STRUCTURE OF HUMAN NUCLEAR RECEPTOR SF-1 (NR5A1) BOUND TO PIP2 AT 2.8 A RESOLUTION
Descriptor:Steroidogenic factor 1, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, (2S)-3-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dihexadecanoate, ...
Authors:Joint Center for Structural Genomics (JCSG), Partnership for Stem Cell Biology (STEMCELL)
Deposit date:2014-06-05
Release date:2014-07-30
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1.
Proc.Natl.Acad.Sci.USA, 111, 2014