6BP2
 
 | | Therapeutic human monoclonal antibody MR191 bound to a marburgvirus glycoprotein | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein, Envelope glycoprotein GP2, ... | | Authors: | King, L.B, Fusco, M.L, Flyak, A.I, Ilinykh, P.A, Huang, K, Gunn, B, Kirchdoerfer, R.N, Hastie, K.M, Sangha, A.K, Meiler, J, Alter, G, Bukreyev, A, Crowe, J.E.J, Saphire, E.O. | | Deposit date: | 2017-11-21 | | Release date: | 2018-01-17 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.172 Å) | | Cite: | The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding.
Cell Host Microbe, 23, 2018
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7SWD
 | | Structure of EBOV GP lacking the mucin-like domain with 1C11 scFv and 1C3 Fab bound | | Descriptor: | 1C11 scFv, 1C3 heavy chain, 1C3 light chain, ... | | Authors: | Milligan, J.C, Yu, X, Saphire, E.O. | | Deposit date: | 2021-11-19 | | Release date: | 2022-04-06 | | Last modified: | 2022-08-10 | | Method: | ELECTRON MICROSCOPY (3.59 Å) | | Cite: | Asymmetric and non-stoichiometric glycoprotein recognition by two distinct antibodies results in broad protection against ebolaviruses.
Cell, 185, 2022
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6UYE
 | | EBOV GPdMuc Makona bound to rEBOV-548 Fab | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody rEBOV-548 Fab, ... | | Authors: | Murin, C.D, Ward, A.B. | | Deposit date: | 2019-11-13 | | Release date: | 2020-03-11 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3.96 Å) | | Cite: | Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization.
Immunity, 52, 2020
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7M8L
 | | EBOV GP bound to rEBOV-442 and rEBOV-515 Fabs | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Virion spike glycoprotein 1, ... | | Authors: | Murin, C.D, Ward, A.B. | | Deposit date: | 2021-03-30 | | Release date: | 2021-11-10 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Pan-ebolavirus protective therapy by two multifunctional human antibodies.
Cell, 184, 2021
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7N6P
 | | Crystal structure of the anti-EBOV and SUDV monoclonal antibody 1C3 Fab | | Descriptor: | 1C3 Fab heavy chain, 1C3 Fab light chain | | Authors: | Milligan, J.C, Yu, X, Buck, T, Saphire, E.O. | | Deposit date: | 2021-06-08 | | Release date: | 2022-04-06 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Asymmetric and non-stoichiometric glycoprotein recognition by two distinct antibodies results in broad protection against ebolaviruses.
Cell, 185, 2022
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6MAM
 | | Cleaved Ebola GP in complex with a broadly neutralizing human antibody, ADI-15946 | | Descriptor: | ADI-15946 Fab Heavy Chain, ADI-15946 Fab Light Chain, Envelope glycoprotein, ... | | Authors: | West, B.R, Moyer, C.L, Fusco, M.L, Saphire, E.O. | | Deposit date: | 2018-08-28 | | Release date: | 2019-03-20 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (4.1 Å) | | Cite: | Structural basis of broad ebolavirus neutralization by a human survivor antibody.
Nat. Struct. Mol. Biol., 26, 2019
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6N7U
 | | apo-BDBV223 Fab | | Descriptor: | BDBV223 antibody heavy chain, BDBV223 antibody light chain | | Authors: | King, L.B, West, B.R, Saphire, E.O. | | Deposit date: | 2018-11-28 | | Release date: | 2019-03-20 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk.
Nat Commun, 10, 2019
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6N7J
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6OZ9
 | | Ebola virus glycoprotein in complex with EBOV-520 Fab | | Descriptor: | EBOV-520 Fab heavy chain, EBOV-520 Fab light chain, Envelope glycoprotein, ... | | Authors: | Milligan, J.C, Altman, P.X, Hui, S, Hastie, K.M, Gilchuk, P, Crowe, J.E, Saphire, E.O. | | Deposit date: | 2019-05-15 | | Release date: | 2020-03-11 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (3.462 Å) | | Cite: | Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization.
Immunity, 52, 2020
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6PCI
 | | EBOV GPdMuc (Makona) in complex with rEBOV-520 and rEBOV-548 Fabs | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Virion spike glycoprotein, Virion spike glycoprotein,Virion spike glycoprotein,Ebola Virus (Makona) GP2, ... | | Authors: | Ward, A.B, Murin, C.D, Alkutkar, T. | | Deposit date: | 2019-06-17 | | Release date: | 2020-03-11 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (4.12 Å) | | Cite: | Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization.
Immunity, 52, 2020
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7KEW
 | | Bundibugyo virus GP (mucin deleted) bound to antibody Fab BDBV-43 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BDBV-43 Fab heavy chain, ... | | Authors: | Murin, C.D, Ward, A.B. | | Deposit date: | 2020-10-13 | | Release date: | 2021-04-28 | | Method: | ELECTRON MICROSCOPY (4.16 Å) | | Cite: | Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies.
Cell Rep, 35, 2021
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7KFG
 | | Antibody Fab BDBV-289 | | Descriptor: | Antibody Fab BDBV-289 heavy chain, Antibody Fab BDBV-289 light chain, DI(HYDROXYETHYL)ETHER | | Authors: | Murin, C.D, Bruhn, J.F, Ward, A.B. | | Deposit date: | 2020-10-13 | | Release date: | 2021-04-28 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (3.002 Å) | | Cite: | Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies.
Cell Rep, 35, 2021
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7KFE
 | | Bundibugyo virus GP (mucin deleted) bound to antibody Fab BDBV-329 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody BDBV-329 heavy chain, ... | | Authors: | Murin, C.D, Ward, A.B. | | Deposit date: | 2020-10-13 | | Release date: | 2021-04-28 | | Method: | ELECTRON MICROSCOPY (6.6 Å) | | Cite: | Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies.
Cell Rep, 35, 2021
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7KFH
 | | Ebola virus GP (mucin deleted, Makona strain) bound to antibody Fab EBOV-437 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab EBOV-437 heavy chain, ... | | Authors: | Murin, C.D, Ward, A.B. | | Deposit date: | 2020-10-13 | | Release date: | 2021-04-28 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies.
Cell Rep, 35, 2021
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7KFB
 | | Ebola virus GP (mucin deleted, Makona strain) bound to antibody Fab EBOV-442 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab EBOV-442 heavy chain, ... | | Authors: | Murin, C.D, Ward, A.B. | | Deposit date: | 2020-10-13 | | Release date: | 2021-04-28 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies.
Cell Rep, 35, 2021
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7KEX
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7KF9
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7KEJ
 | | BDBV-289 bound to EBOV GPdMuc Makona | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab heavy chain (HC) BDBV-289, Antibody Fab light chain (LC) BDBV-289, ... | | Authors: | Murin, C.D, Ward, A.B. | | Deposit date: | 2020-10-11 | | Release date: | 2021-06-23 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies.
Cell Rep, 35, 2021
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