Author results

5UBQ
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CRYO-EM STRUCTURE OF CILIARY MICROTUBULE DOUBLET
Descriptor:Tubulin alpha chain, Tubulin beta chain, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Ichikawa, M., Liu, D., Kastritis, P.L., Basu, K., Bui, K.H.
Deposit date:2016-12-21
Release date:2017-05-10
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (5.7 Å)
Cite:Subnanometre-resolution structure of the doublet microtubule reveals new classes of microtubule-associated proteins.
Nat Commun, 8, 2017
5UCY
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CRYO-EM MAP OF PROTOFILAMENT OF MICROTUBULE DOUBLET
Descriptor:Tubulin alpha chain, Tubulin beta chain, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Ichikawa, M., Liu, D., Kastritis, P.L., Basu, K., Bui, K.H.
Deposit date:2016-12-22
Release date:2017-05-10
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Subnanometre-resolution structure of the doublet microtubule reveals new classes of microtubule-associated proteins.
Nat Commun, 8, 2017
3V66
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HUMAN SQUALENE SYNTHASE IN COMPLEX WITH 2-(1-{2-[(4R,6S)-8-CHLORO-6-(2,3-DIMETHOXYPHENYL)-4H,6H-PYRROLO[1,2-A][4,1]BENZOXAZEPIN-4-YL]ACETYL}-4-PIPERIDINYL)ACETIC ACID
Descriptor:Squalene synthase, PHOSPHATE ION, (1-{[(4R,6S)-8-chloro-6-(2,3-dimethoxyphenyl)-4H,6H-pyrrolo[1,2-a][4,1]benzoxazepin-4-yl]acetyl}piperidin-4-yl)acetic acid
Authors:Suzuki, M., Ohtsuka, M., Ohki, H., Haginoya, N., Itoh, M., Sugita, K., Usui, H., Ichikawa, M., Higashihashi, N.
Deposit date:2011-12-18
Release date:2012-12-19
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of novel tricyclic compounds as squalene synthase inhibitors
Bioorg.Med.Chem., 20, 2012
3ASX
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HUMAN SQUALENE SYNTHASE IN COMPLEX WITH 1-{4-[{4-CHLORO-2-[(2-CHLOROPHENYL)(HYDROXY)METHYL]PHENYL}(2,2-DIMETHYLPROPYL)AMINO]-4-OXOBUTANOYL}PIPERIDINE-3-CARBOXYLIC ACID
Descriptor:Squalene synthase, PHOSPHATE ION, (3R)-1-{4-[{4-chloro-2-[(S)-(2-chlorophenyl)(hydroxy)methyl]phenyl}(2,2-dimethylpropyl)amino]-4-oxobutanoyl}piperidine-3-carboxylic acid
Authors:Shimizu, H., Suzuki, M., Katakura, S., Yamazaki, K., Higashihashi, N., Ichikawa, M., Yokomizo, A., Itoh, M., Sugita, K., Usui, H.
Deposit date:2010-12-22
Release date:2011-12-21
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors
Bioorg.Med.Chem., 19, 2011
3Q2Z
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HUMAN SQUALENE SYNTHASE IN COMPLEX WITH N-[(3R,5S)-7-CHLORO-5-(2,3-DIMETHOXYPHENYL)-1-NEOPENTYL-2-OXO-1,2,3,5-TETRAHYDRO-4,1-BENZOXAZEPINE-3-ACETYL]-L-ASPARTIC ACID
Descriptor:Squalene synthase, PHOSPHATE ION, N-{[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl}-L-aspartic acid
Authors:Suzuki, M., Shimizu, H., Katakura, S., Yamazaki, K., Higashihashi, N., Ichikawa, M., Yokomizo, A., Itoh, M., Sugita, K., Usui, H.
Deposit date:2010-12-21
Release date:2011-12-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors
Bioorg.Med.Chem., 19, 2011
3Q30
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HUMAN SQUALENE SYNTHASE IN COMPLEX WITH (2R,3R)-2-CARBOXYMETHOXY-3-[5-(2-NAPHTHALENYL)PENTYL]AMINOCARBONYL-3-[5-(2-NAPHTHALENYL)PENTYLOXY]PROPIONIC ACID
Descriptor:Squalene synthase, MAGNESIUM ION, (2R,3R)-2-(carboxymethoxy)-4-{[5-(naphthalen-2-yl)pentyl]amino}-3-{[5-(naphthalen-2-yl)pentyl]oxy}-4-oxobutanoic acid, ...
Authors:Suzuki, M., Shimizu, H., Katakura, S., Yamazaki, K., Higashihashi, N., Ichikawa, M., Yokomizo, A., Itoh, M., Sugita, K., Usui, H.
Deposit date:2010-12-21
Release date:2011-12-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors
Bioorg.Med.Chem., 19, 2011
2Z4T
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CRYSTAL STRUCTURE OF VIBRIONACEAE PHOTOBACTERIUM SP. JT-ISH-224 2,6-SIALYLTRANSFERASE IN A TERNARY COMPLEX WITH DONOR PRODUCT CMP AND ACCEPTER SUBSTRATE LACTOSE
Descriptor:Beta-galactoside alpha-2,6-sialyltransferase, ALPHA-LACTOSE, PHOSPHATE ION, ...
Authors:Kakuta, Y., Okino, N., Kajiwara, H., Ichikawa, M., Takakura, Y., Ito, M., Yamamoto, T.
Deposit date:2007-06-25
Release date:2008-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of Vibrionaceae Photobacterium sp. JT-ISH-224 alpha2,6-sialyltransferase in a ternary complex with donor product CMP and acceptor substrate lactose: catalytic mechanism and substrate recognition
Glycobiology, 18, 2008
3W7W
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CRYSTAL STRUCTURE OF E. COLI YGJK E727A COMPLEXED WITH 2-O-ALPHA-D-GLUCOPYRANOSYL-ALPHA-D-GALACTOPYRANOSE
Descriptor:Uncharacterized protein YgjK, CALCIUM ION, MAGNESIUM ION, ...
Authors:Miyazaki, T., Ichikawa, M., Yokoi, G., Kitaoka, M., Mori, H., Kitano, Y., Nishikawa, A., Tonozuka, T.
Deposit date:2013-03-08
Release date:2013-07-17
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of a bacterial glycoside hydrolase family 63 enzyme in complex with its glycosynthase product, and insights into the substrate specificity.
Febs J., 280, 2013
3W7X
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CRYSTAL STRUCTURE OF E. COLI YGJK D324N COMPLEXED WITH MELIBIOSE
Descriptor:Uncharacterized protein YgjK, CALCIUM ION, 6-O-alpha-D-galactopyranosyl-alpha-D-glucopyranose
Authors:Miyazaki, T., Ichikawa, M., Yokoi, G., Kitaoka, M., Mori, H., Kitano, Y., Nishikawa, A., Tonozuka, T.
Deposit date:2013-03-08
Release date:2013-07-17
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of a bacterial glycoside hydrolase family 63 enzyme in complex with its glycosynthase product, and insights into the substrate specificity.
Febs J., 280, 2013
3VSR
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MICROBACTERIUM SACCHAROPHILUM K-1 BETA-FRUCTOFURANOSIDASE CATALYTIC DOMAIN
Descriptor:Beta-fructofuranosidase
Authors:Tonozuka, T., Tamaki, A., Yokoi, G., Miyazaki, T., Ichikawa, M., Nishikawa, A., Ohta, Y., Hidaka, Y., Katayama, K., Hatada, Y., Ito, T., Fujita, K.
Deposit date:2012-05-08
Release date:2012-08-22
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of a lactosucrose-producing enzyme, Arthrobacter sp. K-1 beta-fructofuranosidase
Enzyme.Microb.Technol., 51, 2012
3VSS
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MICROBACTERIUM SACCHAROPHILUM K-1 BETA-FRUCTOFURANOSIDASE CATALYTIC DOMAIN COMPLEXED WITH FRUCTOSE
Descriptor:Beta-fructofuranosidase, FRUCTOSE
Authors:Tonozuka, T., Tamaki, A., Yokoi, G., Miyazaki, T., Ichikawa, M., Nishikawa, A., Ohta, Y., Hidaka, Y., Katayama, K., Hatada, Y., Ito, T., Fujita, K.
Deposit date:2012-05-08
Release date:2012-08-22
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Crystal structure of a lactosucrose-producing enzyme, Arthrobacter sp. K-1 beta-fructofuranosidase
Enzyme.Microb.Technol., 51, 2012
4WVA
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CRYSTAL STRUCTURE OF GH63 MANNOSYLGLYCERATE HYDROLASE FROM THERMUS THERMOPHILUS HB8 IN COMPLEX WITH TRIS
Descriptor:Uncharacterized protein, CHLORIDE ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Miyazaki, T., Ichikawa, M., Nishikawa, A., Tonozuka, T.
Deposit date:2014-11-05
Release date:2015-03-11
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Crystal structure and substrate-binding mode of GH63 mannosylglycerate hydrolase from Thermus thermophilus HB8.
J.Struct.Biol., 190, 2015
4WVB
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CRYSTAL STRUCTURE OF GH63 MANNOSYLGLYCERATE HYDROLASE FROM THERMUS THERMOPHILUS HB8 IN COMPLEX WITH GLUCOSE
Descriptor:Uncharacterized protein, CHLORIDE ION, (4S)-2-METHYL-2,4-PENTANEDIOL, ...
Authors:Miyazaki, T., Ichikawa, M., Nishikawa, A., Tonozuka, T.
Deposit date:2014-11-05
Release date:2015-03-11
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Crystal structure and substrate-binding mode of GH63 mannosylglycerate hydrolase from Thermus thermophilus HB8.
J.Struct.Biol., 190, 2015
4WVC
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CRYSTAL STRUCTURE OF GH63 MANNOSYLGLYCERATE HYDROLASE FROM THERMUS THERMOPHILUS HB8 IN COMPLEX WITH TRIS AND D-GLYCERATE
Descriptor:Uncharacterized protein, CHLORIDE ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Miyazaki, T., Ichikawa, M., Nishikawa, A., Tonozuka, T.
Deposit date:2014-11-05
Release date:2015-03-11
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure and substrate-binding mode of GH63 mannosylglycerate hydrolase from Thermus thermophilus HB8.
J.Struct.Biol., 190, 2015
4XPO
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CRYSTAL STRUCTURE OF A NOVEL ALPHA-GALACTOSIDASE FROM PEDOBACTER SALTANS
Descriptor:Alpha-glucosidase, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 1,2-ETHANEDIOL
Authors:Miyazaki, T., Ishizaki, Y., Ichikawa, M., Nishikawa, A., Tonozuka, T.
Deposit date:2015-01-17
Release date:2015-05-20
Last modified:2015-09-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and biochemical characterization of novel bacterial alpha-galactosidases belonging to glycoside hydrolase family 31
Biochem.J., 469, 2015
4XPP
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CRYSTAL STRUCTURE OF PEDOBACTER SALTANS GH31 ALPHA-GALACTOSIDASE COMPLEXED WITH D-GALACTOSE
Descriptor:Alpha-glucosidase, BETA-D-GALACTOSE, 1,2-ETHANEDIOL
Authors:Miyazaki, T., Ishizaki, Y., Ichikawa, M., Nishikawa, A., Tonozuka, T.
Deposit date:2015-01-17
Release date:2015-05-20
Last modified:2015-09-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural and biochemical characterization of novel bacterial alpha-galactosidases belonging to glycoside hydrolase family 31
Biochem.J., 469, 2015
4XPQ
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CRYSTAL STRUCTURE OF PEDOBACTER SALTANS GH31 ALPHA-GALACTOSIDASE COMPLEXED WITH L-FUCOSE
Descriptor:Alpha-glucosidase, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BETA-L-FUCOSE, ...
Authors:Miyazaki, T., Ishizaki, Y., Ichikawa, M., Nishikawa, A., Tonozuka, T.
Deposit date:2015-01-17
Release date:2015-05-20
Last modified:2015-09-09
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural and biochemical characterization of novel bacterial alpha-galactosidases belonging to glycoside hydrolase family 31
Biochem.J., 469, 2015
4XPR
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CRYSTAL STRUCTURE OF THE MUTANT D365A OF PEDOBACTER SALTANS GH31 ALPHA-GALACTOSIDASE
Descriptor:Alpha-glucosidase, 1,2-ETHANEDIOL
Authors:Miyazaki, T., Ishizaki, Y., Ichikawa, M., Nishikawa, A., Tonozuka, T.
Deposit date:2015-01-17
Release date:2015-05-20
Last modified:2015-09-09
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Structural and biochemical characterization of novel bacterial alpha-galactosidases belonging to glycoside hydrolase family 31
Biochem.J., 469, 2015
4XPS
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CRYSTAL STRUCTURE OF THE MUTANT D365A OF PEDOBACTER SALTANS GH31 ALPHA-GALACTOSIDASE COMPLEXED WITH P-NITROPHENYL-ALPHA-GALACTOPYRANOSIDE
Descriptor:Alpha-glucosidase, ALPHA D-GALACTOSE, P-NITROPHENOL, ...
Authors:Miyazaki, T., Ishizaki, Y., Ichikawa, M., Nishikawa, A., Tonozuka, T.
Deposit date:2015-01-17
Release date:2015-05-20
Last modified:2015-09-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and biochemical characterization of novel bacterial alpha-galactosidases belonging to glycoside hydrolase family 31
Biochem.J., 469, 2015
2ZWI
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CRYSTAL STRUCTURE OF ALPHA/BETA-GALACTOSIDE ALPHA-2,3-SIALYLTRANSFERASE FROM A LUMINOUS MARINE BACTERIUM, PHOTOBACTERIUM PHOSPHOREUM
Descriptor:Alpha-/beta-galactoside alpha-2,3-sialyltransferase, CYTIDINE-5'-MONOPHOSPHATE, ZINC ION, ...
Authors:Iwatani, T., Okino, N., Sakakura, M., Kajiwara, H., Ichikawa, M., Takakura, Y., Kimura, M., Ito, M., Yamamoto, T., Kakuta, Y.
Deposit date:2008-12-05
Release date:2009-06-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Crystal structure of alpha/beta-galactoside alpha2,3-sialyltransferase from a luminous marine bacterium, Photobacterium phosphoreum
Febs Lett., 583, 2009
6PIH
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HEXAMERIC ARNA CRYO-EM STRUCTURE
Descriptor:Bifunctional polymyxin resistance protein ArnA, UDP-4-amino-4-deoxy-L-arabinose formyltransferase
Authors:Yang, M., Gehring, K.
Deposit date:2019-06-26
Release date:2019-07-31
Last modified:2019-08-07
Method:ELECTRON MICROSCOPY (6.6 Å)
Cite:Cryo-electron microscopy structures of ArnA, a key enzyme for polymyxin resistance, revealed unexpected oligomerizations and domain movements.
J.Struct.Biol., 2019
6PIK
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TETRAMERIC CRYO-EM ARNA
Descriptor:Bifunctional polymyxin resistance protein ArnA, UDP-4-amino-4-deoxy-L-arabinose formyltransferase
Authors:Yang, M., Gehring, K.
Deposit date:2019-06-26
Release date:2019-07-31
Last modified:2019-08-07
Method:ELECTRON MICROSCOPY (7.8 Å)
Cite:Cryo-electron microscopy structures of ArnA, a key enzyme for polymyxin resistance, revealed unexpected oligomerizations and domain movements.
J.Struct.Biol., 2019