Author results

1HYV
  • Download 1hyv
  • View 1hyv
Molmil generated image of 1hyv
HIV INTEGRASE CORE DOMAIN COMPLEXED WITH TETRAPHENYL ARSONIUM
Descriptor:INTEGRASE, SULFATE ION, CHLORIDE ION, ...
Authors:Molteni, V., Greenwald, J., Rhodes, D., Hwang, Y., Kwiatkowski, W., Bushman, F.D., Siegel, J.S., Choe, S.
Deposit date:2001-01-22
Release date:2001-04-04
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain.
Acta Crystallogr.,Sect.D, 57, 2001
1HYZ
  • Download 1hyz
  • View 1hyz
Molmil generated image of 1hyz
HIV INTEGRASE CORE DOMAIN COMPLEXED WITH A DERIVATIVE OF TETRAPHENYL ARSONIUM.
Descriptor:INTEGRASE, SULFATE ION, CHLORIDE ION, ...
Authors:Molteni, V., Greenwald, J., Rhodes, D., Hwang, Y., Kwiatkowski, W., Bushman, F.D., Siegel, J.S., Choe, S.
Deposit date:2001-01-22
Release date:2001-04-04
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Identification of a small-molecule binding site at the dimer interface of the HIV integrase catalytic domain.
Acta Crystallogr.,Sect.D, 57, 2001
2H7F
  • Download 2h7f
  • View 2h7f
Molmil generated image of 2h7f
STRUCTURE OF VARIOLA TOPOISOMERASE COVALENTLY BOUND TO DNA
Descriptor:5'-D(*TP*TP*GP*TP*CP*GP*CP*CP*CP*TP*T)-3', 5'-D(*TP*AP*AP*TP*AP*AP*GP*GP*GP*CP*GP*AP*CP*A)-3', DNA topoisomerase 1
Authors:Perry, K., Hwang, Y., Bushman, F.D., Van Duyne, G.D.
Deposit date:2006-06-02
Release date:2006-08-15
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for specificity in the poxvirus topoisomerase.
Mol.Cell, 23, 2006
2H7G
  • Download 2h7g
  • View 2h7g
Molmil generated image of 2h7g
STRUCTURE OF VARIOLA TOPOISOMERASE NON-COVALENTLY BOUND TO DNA
Descriptor:5'-D(*TP*TP*GP*TP*CP*GP*CP*CP*CP*TP*TP*A)-3', 5'-D(*TP*AP*AP*TP*AP*AP*GP*GP*GP*CP*GP*AP*CP*A)-3', DNA topoisomerase 1
Authors:Perry, K., Hwang, Y., Bushman, F.D., Van Duyne, G.D.
Deposit date:2006-06-02
Release date:2006-08-15
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for specificity in the poxvirus topoisomerase.
Mol.Cell, 23, 2006
3BIY
  • Download 3biy
  • View 3biy
Molmil generated image of 3biy
CRYSTAL STRUCTURE OF P300 HISTONE ACETYLTRANSFERASE DOMAIN IN COMPLEX WITH A BISUBSTRATE INHIBITOR, LYS-COA
Descriptor:Histone acetyltransferase p300, BROMIDE ION, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate
Authors:Liu, X., Wang, L., Zhao, K., Thompson, P.R., Hwang, Y., Marmorstein, R., Cole, P.A.
Deposit date:2007-12-02
Release date:2008-02-12
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The structural basis of protein acetylation by the p300/CBP transcriptional coactivator
Nature, 451, 2008
3IGC
  • Download 3igc
  • View 3igc
Molmil generated image of 3igc
SMALLPOX VIRUS TOPOISOMERASE-DNA TRANSITION STATE
Descriptor:DNA topoisomerase 1, 5'-D(*GP*TP*GP*TP*CP*GP*CP*CP*CP*TP*T)-3', 5'-D(*AP*TP*TP*CP*C)-3', ...
Authors:Perry, K., Hwang, Y., Bushman, F.D., Van Duyne, G.D.
Deposit date:2009-07-27
Release date:2010-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Insights from the Structure of a Smallpox Virus Topoisomerase-DNA Transition State Mimic.
Structure, 18, 2010
4OJR
  • Download 4ojr
  • View 4ojr
Molmil generated image of 4ojr
CRYSTAL STRUCTURE OF THE HIV-1 INTEGRASE CATALYTIC DOMAIN WITH GSK1264
Descriptor:HIV-1 Integrase, (2S)-tert-butoxy[4-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl]ethanoic acid, CACODYLATE ION, ...
Authors:Gupta, K., Brady, T., Dyer, B., Hwang, Y., Male, F., Nolte, R.T., Wang, L., Velthuisen, E., Jeffrey, J., Van Duyne, G., Bushman, F.D.
Deposit date:2014-01-21
Release date:2014-06-11
Last modified:2014-08-13
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Allosteric Inhibition of Human Immunodeficiency Virus Integrase: LATE BLOCK DURING VIRAL REPLICATION AND ABNORMAL MULTIMERIZATION INVOLVING SPECIFIC PROTEIN DOMAINS.
J.Biol.Chem., 289, 2014
5E6F
  • Download 5e6f
  • View 5e6f
Molmil generated image of 5e6f
CANARYPOX VIRUS RESOLVASE
Descriptor:CNPV261 Holliday junction resolvase protein, MAGNESIUM ION, D(-)-TARTARIC ACID
Authors:Li, H., Hwang, Y., Perry, K., Bushman, F.D., Van Duyne, G.D.
Deposit date:2015-10-09
Release date:2016-03-30
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure and Metal Binding Properties of a Poxvirus Resolvase.
J.Biol.Chem., 291, 2016
5HOT
  • Download 5hot
  • View 5hot
Molmil generated image of 5hot
STRUCTURAL BASIS FOR INHIBITOR-INDUCED AGGREGATION OF HIV-1 INTEGRASE
Descriptor:Integrase, (2S)-tert-butoxy[4-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl]ethanoic acid
Authors:Gupta, K., Turkki, V., Sherrill-Mix, S., Hwang, Y., Eilers, G., Taylor, L., McDanal, C., Wang, P., Temelkoff, D., Nolte, R., Velthuisen, E., Jeffrey, J., Van Duyne, G.D., Bushman, F.D.
Deposit date:2016-01-19
Release date:2016-12-14
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (4.4 Å)
Cite:Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase.
PLoS Biol., 14, 2016
5HRN
  • Download 5hrn
  • View 5hrn
Molmil generated image of 5hrn
HIV INTEGRASE CATALYTIC DOMAIN CONTAINING F185K MUTATION COMPLEXED WITH GSK0002
Descriptor:Integrase, CACODYLATE ION, SULFATE ION, ...
Authors:Nolte, R.T.
Deposit date:2016-01-23
Release date:2016-12-14
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase.
PLoS Biol., 14, 2016
5HRP
  • Download 5hrp
  • View 5hrp
Molmil generated image of 5hrp
HIV INTEGRASE CATALYTIC DOMAIN CONTAINING F185K + A124T MUTATIONS COMPLEXED WITH GSK0002
Descriptor:Integrase, CACODYLATE ION, SULFATE ION, ...
Authors:Nolte, R.T.
Deposit date:2016-01-24
Release date:2016-12-14
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase.
PLoS Biol., 14, 2016
5HRR
  • Download 5hrr
  • View 5hrr
Molmil generated image of 5hrr
HIV INTEGRASE CATALYTIC DOMAIN CONTAINING F185K + A124N + T125S MUTATIONS COMPLEXED WITH GSK0002
Descriptor:Integrase, CACODYLATE ION, SULFATE ION, ...
Authors:Nolte, R.T.
Deposit date:2016-01-24
Release date:2016-12-14
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase.
PLoS Biol., 14, 2016
5HRS
  • Download 5hrs
  • View 5hrs
Molmil generated image of 5hrs
HIV INTEGRASE CATALYTIC DOMAIN CONTAINING F185K + A124N + T125A MUTATIONS COMPLEXED WITH GSK0002
Descriptor:Integrase, CACODYLATE ION, SULFATE ION, ...
Authors:Nolte, R.T.
Deposit date:2016-01-24
Release date:2016-12-14
Last modified:2016-12-21
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase.
PLoS Biol., 14, 2016