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1EZX
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BU of 1ezx by Molmil
CRYSTAL STRUCTURE OF A SERPIN:PROTEASE COMPLEX
Descriptor: ALPHA-1-ANTITRYPSIN, TRYPSIN
Authors:Huntington, J.A, Carrell, R.W.
Deposit date:2000-05-12
Release date:2000-10-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of a serpin-protease complex shows inhibition by deformation.
Nature, 407, 2000
1QMB
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BU of 1qmb by Molmil
Cleaved alpha-1-antitrypsin polymer
Descriptor: ALPHA-1-ANTITRYPSIN
Authors:Huntington, J.A, Pannu, N.S, Hazes, B, Read, R.J, Lomas, D.A, Carrell, R.W.
Deposit date:1999-09-24
Release date:2000-02-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A 2.6A Structure of a Serpin Polymer and Implications for Conformational Disease
J.Mol.Biol., 293, 1999
1JOU
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BU of 1jou by Molmil
Crystal Structure of Native S195A Thrombin with an Unoccupied Active Site
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETIC ACID, GLYCEROL, ...
Authors:Huntington, J.A, Esmon, C.T.
Deposit date:2001-07-31
Release date:2001-08-10
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The molecular basis of thrombin allostery revealed by a 1.8A structure of the slow form
Structure, 11, 2003
1LQ8
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BU of 1lq8 by Molmil
Crystal structure of cleaved protein C inhibitor
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Huntington, J.A, Kjellberg, M, Stenflo, J.
Deposit date:2002-05-09
Release date:2003-02-11
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of Protein C Inhibitor Provides Insights into Hormone Binding and Heparin Activation
Structure, 11, 2003
6RFK
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BU of 6rfk by Molmil
Crystal structure of EGRCK-inhibited Gla-domainless fIXa (K148Q, R150Q variant)
Descriptor: 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, Coagulation factor IX, ...
Authors:Huntington, J.A, Sendall, T.J.
Deposit date:2019-04-15
Release date:2019-06-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:NMR resonance assignments of apo and EGRCK-inhibited factor IXa
To Be Published
1DZH
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BU of 1dzh by Molmil
P14-FLUORESCEIN-N135Q-S380C-ANTITHROMBIN-III
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANTITHROMBIN-III, ...
Authors:Mccoy, A.J, Huntington, J.A, Carrell, R.W.
Deposit date:2000-02-28
Release date:2000-05-26
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The Conformational Activation of Antithrombin. A 2. 85-A Structure of a Fluorescein Derivative Reveals an Electrostatic Link between the Hinge and Heparin Binding Regions.
J.Biol.Chem., 275, 2000
1DZG
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BU of 1dzg by Molmil
N135Q-S380C-ANTITHROMBIN-III
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANTITHROMBIN-III, ...
Authors:McCoy, A.J, Huntington, J.A, Carrell, R.W.
Deposit date:2000-02-28
Release date:2000-05-26
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The Conformational Activation of Antithrombin. A 2. 85-A Structure of a Fluorescein Derivative Reveals an Electrostatic Link between the Hinge and Heparin Binding Regions.
J.Biol.Chem., 275, 2000
5NBV
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BU of 5nbv by Molmil
Crystal structure of native alpha-1-antitrypsin with seven stabilising mutations
Descriptor: Alpha-1-antitrypsin, GLYCEROL
Authors:Huntington, J.A, Pomowski, A, Johnson, D.J.D.
Deposit date:2017-03-02
Release date:2018-03-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:CRYSTAL STRUCTURE OF THE Z VARIANT OF ALPHA-1-ANTITRYPSIN REVEALS STRUCTURAL AND DYNAMICAL CHANGES AND SUPPORTS A C-TERMINAL DOMAIN SWAP MECHANISM OF POLYMERIZATION
To Be Published
5NBU
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BU of 5nbu by Molmil
Crystal structure of native alpha-1-antitrypsin with seven stabilising mutations
Descriptor: Alpha-1-antitrypsin, GLYCEROL, OXAMIC ACID
Authors:Huntington, J.A, Pomowski, A, Johnson, D.J.D.
Deposit date:2017-03-02
Release date:2018-03-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:CRYSTAL STRUCTURE OF THE Z VARIANT OF ALPHA-1-ANTITRYPSIN REVEALS STRUCTURAL AND DYNAMICAL CHANGES AND SUPPORTS A C-TERMINAL DOMAIN SWAP MECHANISM OF POLYMERIZATION
To Be Published
3T1P
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BU of 3t1p by Molmil
Crystal structure of an alpha-1-antitrypsin trimer
Descriptor: Alpha-1-antitrypsin
Authors:Huntington, J.A, Yamasaki, M.
Deposit date:2011-07-22
Release date:2011-08-17
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Molecular basis of alpha 1-antitrypsin deficiency revealed by the structure of a domain-swapped trimer.
EMBO Rep., 12, 2011
3EVJ
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BU of 3evj by Molmil
Intermediate structure of antithrombin bound to the natural pentasaccharide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranoside, ...
Authors:Huntington, J.A, Belzar, K.J.
Deposit date:2008-10-13
Release date:2008-10-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:The critical role of hinge-region expulsion in the induced-fit heparin binding mechanism of antithrombin.
J. Mol. Biol., 386, 2009
1NQ9
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BU of 1nq9 by Molmil
Crystal Structure of Antithrombin in the Pentasaccharide-Bound Intermediate State
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3,4-di-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-3-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2,3,6-tri-O-sulfo-alpha-D-glucopyranoside, ...
Authors:Huntington, J.A, Johnson, D.J.D.
Deposit date:2003-01-21
Release date:2003-09-30
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of Antithrombin in a Heparin-Bound Intermediate State
Biochemistry, 42, 2003
3KCG
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BU of 3kcg by Molmil
Crystal structure of the antithrombin-factor IXa-pentasaccharide complex
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 3,4-di-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-3-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2,3,6-tri-O-sulfo-alpha-D-glucopyranoside, Antithrombin-III, ...
Authors:Huntington, J.A, Johnson, D.J.D.
Deposit date:2009-10-21
Release date:2010-02-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular basis of factor IXa recognition by heparin-activated antithrombin revealed by a 1.7-A structure of the ternary complex.
Proc.Natl.Acad.Sci.USA, 107, 2010
3NDF
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BU of 3ndf by Molmil
Cleaved antitrypsin with P8-P6 Asp
Descriptor: Alpha-1-antitrypsin
Authors:Huntington, J.A, Sendall, T.J, Yamasaki, M.
Deposit date:2010-06-07
Release date:2010-07-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Loop-sheet mechanism of serpin polymerization tested by reactive center loop mutations
J. Biol. Chem., 285, 2010
4DY0
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BU of 4dy0 by Molmil
Crystal structure of native protease nexin-1 with heparin
Descriptor: 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, GLYCEROL, Glia-derived nexin, ...
Authors:Huntington, J.A, Li, W.
Deposit date:2012-02-28
Release date:2012-08-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism.
Blood, 120, 2012
4DY7
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BU of 4dy7 by Molmil
Crystal structures of protease nexin-1 in complex with S195A thrombin
Descriptor: ACETATE ION, CALCIUM ION, Glia-derived nexin, ...
Authors:Huntington, J.A, Li, W.
Deposit date:2012-02-28
Release date:2012-08-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism.
Blood, 120, 2012
5E8E
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BU of 5e8e by Molmil
Crystal structure of thrombin bound to an exosite 1-specific IgA Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CITRIC ACID, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ...
Authors:Baglin, T.P, Langdown, J, Frasson, R, Huntington, J.A.
Deposit date:2015-10-14
Release date:2015-10-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery and characterization of an antibody directed against exosite I of thrombin.
J.Thromb.Haemost., 14, 2016
2ZNH
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BU of 2znh by Molmil
Crystal Structure of a Domain-Swapped Serpin Dimer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antithrombin-III, ...
Authors:Yamasaki, M, Huntington, J.A.
Deposit date:2008-04-25
Release date:2008-10-21
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of a stable dimer reveals the molecular basis of serpin polymerization
Nature, 455, 2008
2OL2
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BU of 2ol2 by Molmil
High Resolution Structure of Native PCI in Space Group P21
Descriptor: GLYCEROL, Plasma serine protease inhibitor
Authors:Li, W, Huntington, J.A.
Deposit date:2007-01-18
Release date:2007-03-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of native protein C inhibitor provides insight into its multiple functions.
J.Biol.Chem., 282, 2007
7PMU
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BU of 7pmu by Molmil
Crystal structure of native Iripin-8
Descriptor: DI(HYDROXYETHYL)ETHER, HEXAETHYLENE GLYCOL, Serpin-8, ...
Authors:Polderdijk, S, Kotal, J, Chmelar, J, Huntington, J.A.
Deposit date:2021-09-02
Release date:2021-10-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Ixodes ricinus Salivary Serpin Iripin-8 Inhibits the Intrinsic Pathway of Coagulation and Complement.
Int J Mol Sci, 22, 2021
3B9F
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BU of 3b9f by Molmil
1.6 A structure of the PCI-thrombin-heparin complex
Descriptor: 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, GLYCEROL, Plasma serine protease inhibitor, ...
Authors:Li, W, Adams, T.E, Huntington, J.A.
Deposit date:2007-11-05
Release date:2008-04-22
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-A structure of the heparin-bridged complex.
Proc.Natl.Acad.Sci.Usa, 105, 2008
1JB2
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BU of 1jb2 by Molmil
CRYSTAL STRUCTURE OF NTF2 M84E MUTANT
Descriptor: NUCLEAR TRANSPORT FACTOR 2
Authors:Chaillan-Huntington, C, Butler, P.J, Huntington, J.A, Akin, D, Feldherr, C, Stewart, M.
Deposit date:2001-06-01
Release date:2002-03-13
Last modified:2021-11-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:NTF2 monomer-dimer equilibrium.
J.Mol.Biol., 314, 2001
1BR8
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BU of 1br8 by Molmil
IMPLICATIONS FOR FUNCTION AND THERAPY OF A 2.9A STRUCTURE OF BINARY-COMPLEXED ANTITHROMBIN
Descriptor: PROTEIN (ANTITHROMBIN-III), PROTEIN (PEPTIDE)
Authors:Skinner, R, Chang, W.S.W, Jin, L, Pei, X.Y, Huntington, J.A, Abrahams, J.P, Carrell, R.W, Lomas, D.A.
Deposit date:1998-08-26
Release date:1998-09-02
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Implications for function and therapy of a 2.9 A structure of binary-complexed antithrombin.
J.Mol.Biol., 283, 1998
1JB4
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BU of 1jb4 by Molmil
CRYSTAL STRUCTURE OF NTF2 M102E MUTANT
Descriptor: NUCLEAR TRANSPORT FACTOR 2
Authors:Chaillan-Huntington, C, Butler, P.J, Huntington, J.A, Akin, D, Feldherr, C, Stewart, M.
Deposit date:2001-06-01
Release date:2002-03-13
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:NTF2 monomer-dimer equilibrium.
J.Mol.Biol., 314, 2001
2B5T
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BU of 2b5t by Molmil
2.1 Angstrom structure of a nonproductive complex between antithrombin, synthetic heparin mimetic SR123781 and two S195A thrombin molecules
Descriptor: 2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-sulfonato-beta-D-glucopyranose-(1-4)-2,3-di-O-methyl-6-O-sulfonato-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3-di-O-methyl-6-O-sulfonato-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-alpha-L-idopyranuronic acid-(1-4)-methyl 3-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Johnson, D.J, Li, W, Luis, S.A, Carrell, R.W, Huntington, J.A.
Deposit date:2005-09-29
Release date:2006-09-19
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of monomeric native antithrombin reveals a novel reactive center loop conformation.
J.Biol.Chem., 281, 2006

 

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