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4KZF
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BU of 4kzf by Molmil
The mechanism of the amidases: The effect of the mutation E142L in the amidase from Geobacillus pallidus
Descriptor: Aliphatic amidase, CHLORIDE ION
Authors:Weber, B.W, Sewell, B.T, Kimani, S.W, Varsani, A, Cowan, D.A, Hunter, R.
Deposit date:2013-05-29
Release date:2013-08-21
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The mechanism of the amidases: mutating the glutamate adjacent to the catalytic triad inactivates the enzyme due to substrate mispositioning.
J.Biol.Chem., 288, 2013
4LF0
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BU of 4lf0 by Molmil
The E142D mutant of the amidase from Geobacillus pallidus
Descriptor: Aliphatic amidase
Authors:Sewell, B.T, Weber, B.W, Kimani, S.W, Cowan, D.A, Hunter, R, Venter, G.A, Gumbart, J.C, Thuku, R.N, Varsani, A.
Deposit date:2013-06-26
Release date:2013-08-21
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:The mechanism of the amidases: mutating the glutamate adjacent to the catalytic triad inactivates the enzyme due to substrate mispositioning.
J.Biol.Chem., 288, 2013
4GYN
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BU of 4gyn by Molmil
The E142L mutant of the amidase from Geobacillus pallidus
Descriptor: Aliphatic amidase, CHLORIDE ION
Authors:Weber, B.W, Sewell, B.T, Kimani, S.W, Varsani, A, Cowan, D.A, Hunter, R.
Deposit date:2012-09-05
Release date:2013-08-21
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The mechanism of the amidases: mutating the glutamate adjacent to the catalytic triad inactivates the enzyme due to substrate mispositioning.
J.Biol.Chem., 288, 2013
4GYL
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BU of 4gyl by Molmil
The E142L mutant of the amidase from Geobacillus pallidus showing the result of Michael addition of acrylamide at the active site cysteine
Descriptor: Aliphatic amidase, CHLORIDE ION, PROPIONAMIDE
Authors:Weber, B.W, Sewell, B.T, Kimani, S.W, Varsani, A, Cowan, D.A, Hunter, R.
Deposit date:2012-09-05
Release date:2013-08-21
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The mechanism of the amidases: mutating the glutamate adjacent to the catalytic triad inactivates the enzyme due to substrate mispositioning.
J.Biol.Chem., 288, 2013
5JQN
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BU of 5jqn by Molmil
NitN Amidase from Neterenkonia sp. AN1 after thrombin His-tag removal.
Descriptor: Aliphatic amidase
Authors:Sewell, B.T, Kimani, S.W, Weber, B.W.
Deposit date:2016-05-05
Release date:2016-05-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.19 Å)
Cite:QM/MM Modelling of Substrate Binding in the Amidase Active Site
To Be Published
4FRS
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BU of 4frs by Molmil
Structure of BACE in complex with (S)-4-(3-chloro-5-(5-(prop-1-yn-1-yl)pyridin-3-yl)thiophen-2-yl)-1,4-dimethyl-6-oxotetrahydropyrimidin-2(1H)-iminium
Descriptor: (2Z,6S)-6-{3-chloro-5-[5-(prop-1-yn-1-yl)pyridin-3-yl]thiophen-2-yl}-2-imino-3,6-dimethyltetrahydropyrimidin-4(1H)-one, Beta-secretase 1
Authors:Orth, P.
Deposit date:2012-06-26
Release date:2012-08-08
Last modified:2013-06-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS A(beta) Reduction
ACS Med Chem Lett, 3, 2012
7OVG
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BU of 7ovg by Molmil
The C146A variant of an amidase from Pyrococcus horikoshii with bound acetamide
Descriptor: ACETAMIDE, CHLORIDE ION, CN hydrolase domain-containing protein
Authors:Su, S, Makumire, S, Sewell, B.T.
Deposit date:2021-06-14
Release date:2021-07-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The structures of the C146A variant of the amidase from Pyrococcus horikoshii bound to glutaramide and acetamide suggest the basis of amide recognition.
J.Struct.Biol., 214, 2022
4IZT
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BU of 4izt by Molmil
The E41Q mutant of the amidase from Nesterenkonia sp. AN1 showing covalent addition of the acetamide moiety of fluoroacetamide at the active site cysteine
Descriptor: 2-fluoroacetamide, ACETAMIDE, Amidase
Authors:Kimani, S.W, Sewell, B.T.
Deposit date:2013-01-30
Release date:2014-02-12
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Covalent modifications of the active site cysteine occur as a result of mutating the glutamate of the catalytic triad in the amidase from Nesterenkonia sp.
To be Published
4IZV
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BU of 4izv by Molmil
The E41Q/C145A double mutant of the amidase from Nesterenkonia sp. AN1 in complex with acrylamide
Descriptor: Amidase, PROPIONAMIDE, prop-2-enamide
Authors:Kimani, S.W, Sewell, B.T.
Deposit date:2013-01-30
Release date:2014-02-12
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Covalent modifications of the active site cysteine occur as a result of mutating the glutamate of the catalytic triad in the amidase from Nesterenkonia sp.
To be Published
4IZS
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BU of 4izs by Molmil
The C145A mutant of the amidase from Nesterenkonia sp. AN1 in complex with butyramide
Descriptor: Amidase, BUTYRAMIDE, DI(HYDROXYETHYL)ETHER
Authors:Kimani, S.W, Sewell, B.T.
Deposit date:2013-01-30
Release date:2014-02-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.44 Å)
Cite:Covalent modifications of the active site cysteine occur as a result of mutating the glutamate of the catalytic triad in the amidase from Nesterenkonia sp.
To be Published
4IZU
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BU of 4izu by Molmil
The E41Q mutant of the amidase from Nesterenkonia sp. AN1 showing the result of Michael addition of acrylamide at the active site cysteine
Descriptor: Amidase, PROPIONAMIDE, prop-2-enamide
Authors:Kimani, S.W, Sewell, B.T.
Deposit date:2013-01-30
Release date:2014-02-12
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Covalent modifications of the active site cysteine occur as a result of mutating the glutamate of the catalytic triad in the amidase from Nesterenkonia sp.
To be Published
4IZW
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BU of 4izw by Molmil
The E41L mutant of the amidase from Nesterenkonia sp. AN1 showing covalent addition of the acetamide moiety of fluoroacetamide at the active site cysteine
Descriptor: 2-fluoroacetamide, ACETAMIDE, Amidase
Authors:Kimani, S.W, Sewell, B.T.
Deposit date:2013-01-30
Release date:2014-02-12
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Covalent modifications of the active site cysteine occur as a result of mutating the glutamate of the catalytic triad in the amidase from Nesterenkonia sp.
To be Published
3FRZ
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BU of 3frz by Molmil
Crystal Structure of HCV NS5B RNA polymerase in complex with PF868554
Descriptor: (6R)-6-cyclopentyl-6-[2-(2,6-diethylpyridin-4-yl)ethyl]-3-[(5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl]-4-hydroxy-5,6-dihydro-2H-pyran-2-one, BETA-MERCAPTOETHANOL, N-[(benzyloxy)carbonyl]-L-alpha-glutamyl-N-[(1S)-4-oxo-4-phenyl-1-propylbut-2-en-1-yl]-L-phenylalaninamide, ...
Authors:Parge, H.E.
Deposit date:2009-01-08
Release date:2009-03-10
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor.
J.Med.Chem., 52, 2009

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PDB entries from 2024-03-27

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