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Discovery of Oral Polo-Like Kinase (PLK) Inhibitors with Enhanced Selectivity Profile using Residue Targeted Drug Design
Descriptor:	4-[[(4R)-5-cyclopentyl-4-ethyl-3a,4-dihydro-3H-[1,2,4]triazolo[4,3-f]pteridin-7-yl]amino]-N-cyclopropyl-3-methoxy-benzamide, SERINE/THREONINE-PROTEIN KINASE PLK3, SULFATE ION
Authors:	Brown, K, Charrier, J.D, Durrant, S, Griffiths, M, Hudson, C, Kay, D, Knegtel, R, ODonnell, M, Pierard, F, Twin, H, Weber, P, Young, S.
Deposit date:	2012-08-14
Release date:	2013-08-21
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Discovery of Oral Polo-Like Kinase (Plk) Inhibitors with Enhanced Selectivity Profile Using Residue Targeted Drug Design To be Published

Cryo-EM structure of the human GS-GN complex in the inhibited state
Descriptor:	Glycogen [starch] synthase, muscle, Isoform GN-1 of Glycogenin-1
Authors:	Marr, L, Zeqiraj, E.
Deposit date:	2022-03-23
Release date:	2022-06-22
Method:	ELECTRON MICROSCOPY (2.62 Å)
Cite:	Mechanism of glycogen synthase inactivation and interaction with glycogenin. Nat Commun, 13, 2022

Choline Kinase alpha acts through a double-displacement kinetic mechanism involving enzyme isomerisation, as determined through enzyme and inhibitor kinetics and structural biology
Descriptor:	(3R)-1-azabicyclo[2.2.2]oct-3-yl[bis(5-chlorothiophen-2-yl)]methanol, Choline kinase alpha, SULFATE ION
Authors:	Brown, K, Hudson, C, Charlton, P, Pollard, J.
Deposit date:	2012-01-12
Release date:	2013-04-17
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Kinetic and mechanistic characterisation of Choline Kinase-alpha. Biochim.Biophys.Acta, 1834, 2013