Author results

2JH0
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HUMAN THROMBIN HIRUGEN INHIBITOR COMPLEX
分子名称:THROMBIN LIGHT CHAIN, THROMBIN HEAVY CHAIN, HIRUDIN IIIA, ...
著者Senger, S., Chan, C., Convery, M.A., Hubbard, J.A., Young, R.J., Shah, G.P., Watson, N.S.
登録日2007-02-19
公開日2007-05-08
最終更新日2013-08-07
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Sulfonamide-Related Conformational Effects and Their Importance in Structure-Based Design.
Bioorg.Med.Chem.Lett., 17, 2007
2JH5
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HUMAN THROMBIN HIRUGEN INHIBITOR COMPLEX
分子名称:THROMBIN LIGHT CHAIN, THROMBIN HEAVY CHAIN, HIRUDIN IIIA, ...
著者Senger, S., Chan, C., Convery, M.A., Hubbard, J.A., Young, R.J., Shah, G.P., Watson, N.S.
登録日2007-02-20
公開日2007-05-08
最終更新日2017-06-28
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Sulfonamide-Related Conformational Effects and Their Importance in Structure-Based Design.
Bioorg.Med.Chem.Lett., 17, 2007
2JH6
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HUMAN THROMBIN HIRUGEN INHIBITOR COMPLEX
分子名称:THROMBIN LIGHT CHAIN, THROMBIN HEAVY CHAIN, HIRUDIN IIIA, ...
著者Senger, S., Chan, C., Convery, M.A., Hubbard, J.A., Young, R.J., Shah, G.P., Watson, N.S.
登録日2007-02-20
公開日2007-05-08
最終更新日2013-08-07
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Sulfonamide-Related Conformational Effects and Their Importance in Structure-Based Design.
Bioorg.Med.Chem.Lett., 17, 2007
2UU8
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X-RAY STRUCTURE OF NI, CA CONCANAVALIN A AT ULTRA-HIGH RESOLUTION (0. 94A)
分子名称:CONCANAVALIN, NICKEL (II) ION, CALCIUM ION
著者Ahmed, H.U., Blakeley, M.P., Cianci, M., Cruickshank, D.W.J., Hubbard, J.A., Helliwell, J.R.
登録日2007-03-01
公開日2007-07-31
最終更新日2019-05-22
実験手法X-RAY DIFFRACTION (0.94 Å)
主引用文献The Determination of Protonation States in Proteins.
Acta Crystallogr.,Sect.D, 63, 2007
2UUF
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THROMBIN-HIRUGEN BINARY COMPLEX AT 1.26A RESOLUTION
分子名称:HUMAN ALPHA THROMBIN, THROMBIN, HIRUDIN I, ...
著者Ahmed, H.U., Blakeley, M.P., Cianci, M., Cruickshank, D.W.J., Hubbard, J.A., Helliwell, J.R.
登録日2007-03-02
公開日2007-09-04
最終更新日2019-05-22
実験手法X-RAY DIFFRACTION (1.26 Å)
主引用文献The Determination of Protonation States in Proteins.
Acta Crystallogr.,Sect.D, 63, 2007
2UUJ
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THROMBIN-HIRUGEN-GW473178 TERNARY COMPLEX AT 1.32A RESOLUTION
分子名称:HUMAN ALPHA THROMBIN, PROTHROMBIN, HIRUDIN I, ...
著者Ahmed, H.U., Blakeley, M.P., Cianci, M., Cruickshank, D.W.J., Hubbard, J.A., Helliwell, J.R.
登録日2007-03-03
公開日2007-09-04
最終更新日2019-05-22
実験手法X-RAY DIFFRACTION (1.32 Å)
主引用文献The Determination of Protonation States in Proteins.
Acta Crystallogr.,Sect.D, 63, 2007
2UUK
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THROMBIN-HIRUGEN-GW420128 TERNARY COMPLEX AT 1.39A RESOLUTION
分子名称:HUMAN ALPHA THROMBIN, THROMBIN, HIRUDIN I, ...
著者Ahmed, H.U., Blakeley, M.P., Cianci, M., Cruickshank, D.W.J., Hubbard, J.A., Helliwell, J.R.
登録日2007-03-03
公開日2007-09-04
最終更新日2019-05-22
実験手法X-RAY DIFFRACTION (1.39 Å)
主引用文献The Determination of Protonation States in Proteins.
Acta Crystallogr.,Sect.D, 63, 2007
2UWL
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SELECTIVE AND DUAL ACTION ORALLY ACTIVE INHIBITORS OF THROMBIN AND FACTOR XA
分子名称:COAGULATION FACTOR X, 2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHENESULFONAMIDE
著者Young, R.J., Brown, D., Burns-Kurtis, C.L., Chan, C., Convery, M.A., Hubbard, J.A., Kelly, H.A., Pateman, A.J., Patikis, A., Senger, S., Shah, G.P., Toomey, J.R., Watson, N.S., Zhou, P.
登録日2007-03-22
公開日2007-04-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Selective and Dual Action Orally Active Inhibitors of Thrombin and Factor Xa.
Bioorg.Med.Chem.Lett., 17, 2007
2UWO
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SELECTIVE AND DUAL ACTION ORALLY ACTIVE INHIBITORS OF THROMBIN AND FACTOR XA
分子名称:COAGULATION FACTOR X, (2R)-2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}PROPENE-1-SULFONAMIDE
著者Young, R.J., Brown, D., Burns-Kurtis, C.L., Chan, C., Convery, M.A., Hubbard, J.A., Kelly, H.A., Pateman, A.J., Patikis, A., Senger, S., Shah, G.P., Toomey, J.R., Watson, N.S., Zhou, P.
登録日2007-03-22
公開日2007-05-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Selective and Dual Action Orally Active Inhibitors of Thrombin and Factor Xa.
Bioorg.Med.Chem.Lett., 17, 2007
2UWP
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FACTOR XA INHIBITOR COMPLEX
分子名称:COAGULATION FACTOR X, 2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHANESULFONAMIDE, CALCIUM ION, ...
著者Young, R.J., Brown, D., Burns-Kurtis, C.L., Chan, C., Convery, M.A., Hubbard, J.A., Kelly, H.A., Pateman, A.J., Patikis, A., Senger, S., Shah, G.P., Toomey, J.R., Watson, N.S., Zhou, P., Thorpe, J.H.
登録日2007-03-22
公開日2007-05-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Selective and Dual Action Orally Active Inhibitors of Thrombin and Factor Xa.
Bioorg.Med.Chem.Lett., 17, 2007
2XCF
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CRYSTAL STRUCTURE OF HCV NS3 PROTEASE WITH A BORONATE INHIBITOR
分子名称:NS3 PROTEASE, NS4A, ZINC ION, ...
著者Li, X., Zhang, Y.-K., Liu, Y., Ding, C.Z., Li, Q., Zhou, Y., Plattner, J.J., Baker, S.J., Qian, X., Fan, D., Liao, L., Ni, Z.-J., White, G.V., Mordaunt, J.E., Lazarides, L.X., Slater, M.J., Jarvest, R.L., Thommes, P., Ellis, M., Edge, C.M., Hubbard, J.A., Nassau, P., McDowell, B., Skarzynski, T.J., Rowland, P., Somers, D.O., Kazmierski, W.M., Grimes, R.M., Wright, L.L., Smith, G.K., Zou, W., Wright, J., Pennicott, L.E.
登録日2010-04-22
公開日2010-06-02
最終更新日2019-02-06
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Synthesis and Evaluation of Novel Alpha-Amino Cyclic Boronates as Inhibitors of Hcv Ns3 Protease.
Bioorg.Med.Chem.Lett., 20, 2010
2XCN
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CRYSTAL STRUCTURE OF HCV NS3 PROTEASE WITH A BORONATE INHIBITOR
分子名称:NS3 PROTEASE, NS4A, N-[(CYCLOPENTYLOXY)CARBONYL]-3-METHYL-L-VALYL-(4R)-N-{(1R)-3-HYDROXY-1-[HYDROXY(OXIDO)BORANYL]PROPYL}-4-(ISOQUINOLIN-1-YLOXY)-L-PROLINAMIDE, ...
著者Li, X., Zhang, Y.-K., Liu, Y., Ding, C.Z., Li, Q., Zhou, Y., Plattner, J.J., Baker, S.J., Qian, X., Fan, D., Liao, L., Ni, Z.-J., White, G.V., Mordaunt, J.E., Lazarides, L.X., Slater, M.J., Jarvest, R.L., Thommes, P., Ellis, M., Edge, C.M., Hubbard, J.A., Nassau, P., McDowell, B., Skarzynski, T.J., Rowland, P., Somers, D.O., Kazmierski, W.M., Grimes, R.M., Wright, L.L., Smith, G.K., Zou, W., Wright, J., Pennicott, L.E.
登録日2010-04-23
公開日2010-06-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.02 Å)
主引用文献Synthesis and Evaluation of Novel Alpha-Amino Cyclic Boronates as Inhibitors of Hcv Ns3 Protease.
Bioorg.Med.Chem.Lett., 20, 2010
2XNI
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PROTEIN-LIGAND COMPLEX OF A NOVEL MACROCYCLIC HCV NS3 PROTEASE INHIBITOR DERIVED FROM AMINO CYCLIC BORONATES
分子名称:NS3 PROTEASE, NS4A COFACTOR, (1-{[(10-tert-butyl-15,15-dimethyl-3,9,12-trioxo-6,7,9,10,11,12,14,15,16,17,18,19,23,23a-tetradecahydro-1H,5H-2,23:5,8-dimethano-4,13,2,8,11-benzodioxatriazacyclohenicosin-7(3H)-yl)carbonyl]amino}-3-hydroxypropyl)(trihydroxy)borate(1-), ...
著者Li, X., Zhang, Y.-K., Liu, Y., Ding, C.Z., Zhou, Y., Li, Q., Plattner, J.J., Baker, S.J., Zhang, S., Kazmierski, W.M., Wright, L.L., Smith, G.K., Grimes, R.M., Crosby, R.M., Creech, K.L., Carballo, L.H., Slater, M.J., Jarvest, R.L., Thommes, P., Hubbard, J.A., Convery, M.A., Nassau, P.M., McDowell, W., Skarzynski, T.J., Qian, X., Fan, D., Liao, L., Ni, Z.-J., Pennicott, L.E., Zou, W., Wright, J.
登録日2010-08-02
公開日2011-08-17
最終更新日2012-09-26
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Novel Macrocyclic Hcv Ns3 Protease Inhibitors Derived from Alpha-Amino Cyclic Boronates.
Bioorg.Med.Chem.Lett., 20, 2010
2YZ4
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THE NEUTRON STRUCTURE OF CONCANAVALIN A AT 2.2 ANGSTROMS
分子名称:Concanavalin A, MANGANESE (II) ION, CALCIUM ION
著者Ahmed, H.U., Blakeley, M.P., Cianci, M., Hubbard, J.A., Helliwell, J.R.
登録日2007-05-02
公開日2008-02-05
最終更新日2017-10-11
実験手法NEUTRON DIFFRACTION (2.2 Å)
主引用文献The determination of protonation states in proteins.
Acta Crystallogr.,Sect.D, 63, 2007
5ISO
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STRUCTURE OF FULL LENGTH HUMAN AMPK (NON-PHOSPHORYLATED AT T-LOOP) IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR, A BENZIMIDAZOLE DERIVATIVE (991)
分子名称:5'-AMP-activated protein kinase catalytic subunit alpha-2, 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1, ...
著者XIAO, B., HUBBARD, J.A., GAMBLIN, S.J.
登録日2016-03-15
公開日2017-03-29
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献STRUCTURE OF FULL LENGTH HUMAN AMPK (NON-PHOSPHORYLATED AT T-LOOP) IN COMPLEX WITH A SMALL MOLECULE ACTIVATOR, A BENZIMIDAZOLE DERIVATIVE (991)
To Be Published