Author results

5XGT
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF STAPHYLOCOCCUS AUREUS SINGLE-STRANDED DNA-BINDING PROTEIN SSBA AT 1.82 ANGSTROM RESOLUTION
Descriptor:Single-stranded DNA-binding protein, GLYCEROL
Authors:Huang, Y.H., Chen, C.J., Huang, C.Y.
Deposit date:2017-04-17
Release date:2017-08-09
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Staphylococcus aureus single-stranded DNA-binding protein SsbA can bind but cannot stimulate PriA helicase.
PLoS ONE, 12, 2017
5YUO
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CRYSTAL STRUCTURE OF SSB PROTEIN FROM PSEUDOMONAS AERUGINOSA PAO1
Descriptor:Single-stranded DNA-binding protein, GLYCEROL
Authors:Huang, Y.H., Huang, C.Y.
Deposit date:2017-11-22
Release date:2018-10-31
Method:X-RAY DIFFRACTION (2.037 Å)
Cite:The glycine-rich flexible region in SSB is crucial for PriA stimulation.
RSC Adv., 8, 2018
4F5D
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ERIS/STING IN COMPLEX WITH LIGAND
Descriptor:Transmembrane protein 173, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), MAGNESIUM ION
Authors:Huang, Y.H., Liu, X.Y., Su, X.D.
Deposit date:2012-05-13
Release date:2012-06-27
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structural basis for the sensing and binding of cyclic di-GMP by STING
Nat.Struct.Mol.Biol., 19, 2012
4F5E
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CRYSTAL STRUCTURE OF ERIS/STING
Descriptor:Transmembrane protein 173, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Huang, Y.H., Liu, X.Y., Su, X.D.
Deposit date:2012-05-13
Release date:2012-06-27
Last modified:2012-11-14
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:The structural basis for the sensing and binding of cyclic di-GMP by STING
Nat.Struct.Mol.Biol., 19, 2012
4QXW
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CRYSTAL STRUCTURE OF THE HUMAN CEACAM1 MEMBRANE DISTAL AMINO TERMINAL (N)-DOMAIN
Descriptor:Carcinoembryonic antigen-related cell adhesion molecule 1, MALONIC ACID, B-OCTYLGLUCOSIDE
Authors:Huang, Y.H., Gandhi, A.K., Russell, A., Kondo, Y., Chen, Q., Petsko, G.A., Blumberg, R.S.
Deposit date:2014-07-22
Release date:2014-11-12
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.
Nature, 517, 2015
5DZL
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CRYSTAL STRUCTURE OF THE PROTEIN HUMAN CEACAM1
Descriptor:Carcinoembryonic antigen-related cell adhesion molecule 1
Authors:Huang, Y.H., Russell, A., Gandhi, A.K., Kondo, Y., Chen, Q., Petsko, G.A., Blumberg, R.S.
Deposit date:2015-09-25
Release date:2015-10-07
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.4006 Å)
Cite:CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.
Nature, 517, 2015
5YKD
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CRYSTAL STRUCTURE OF DIHYDROPYRIMIDINASE FROM PSEUDOMONAS AERUGINOSA PAO1 AT 2.17 ANGSTROM RESOLUTION
Descriptor:D-hydantoinase/dihydropyrimidinase, ZINC ION
Authors:Huang, Y.H., Huang, C.Y.
Deposit date:2017-10-14
Release date:2018-02-21
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Structural Basis for pH-Dependent Oligomerization of Dihydropyrimidinase fromPseudomonas aeruginosaPAO1.
Bioinorg Chem Appl, 2018, 2018
5YNZ
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CRYSTAL STRUCTURE OF THE DIHYDROOROTASE DOMAIN (K1556A) OF HUMAN CAD
Descriptor:CAD protein, ZINC ION
Authors:Huang, Y.H., Chen, K.L., Cheng, J.H., Huang, C.Y.
Deposit date:2017-10-26
Release date:2018-10-24
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (2.774 Å)
Cite:Crystal structures of monometallic dihydropyrimidinase and the human dihydroorotase domain K1556A mutant reveal no lysine carbamylation within the active site
Biochem. Biophys. Res. Commun., 505, 2018
5YYU
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS SINGLE-STRANDED DNA-BINDING PROTEIN SSBB
Descriptor:Single-stranded DNA-binding protein
Authors:Huang, Y.H., Huang, C.Y.
Deposit date:2017-12-11
Release date:2018-08-15
Method:X-RAY DIFFRACTION (2.984 Å)
Cite:Characterization of single-stranded DNA-binding protein SsbB from Staphylococcus aureus: SsbB cannot stimulate PriA helicase.
Rsc Adv, 8, 2018
6AEQ
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CRYSTAL STRUCTURE OF THE SSDNA-BINDING DOMAIN OF DNAT FROM SALMONELLA ENTERICA SEROVAR TYPHIMURIUM LT2
Descriptor:Primosomal protein 1
Authors:Huang, Y.H., Huang, C.Y.
Deposit date:2018-08-06
Release date:2019-03-20
Method:X-RAY DIFFRACTION (2.251808 Å)
Cite:Crystal structure of the C-terminal domain of the primosomal DnaT protein: Insights into a new oligomerization mechanism.
Biochem. Biophys. Res. Commun., 511, 2019
6AJD
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CRYSTAL STRUCTURE OF A MONOMETALLIC DIHYDROPYRIMIDINASE FROM PSEUDOMONAS AERUGINOSA PAO1 REVEALS NO LYSINE CARBAMYLATION WITHIN THE ACTIVE SITE
Descriptor:D-hydantoinase/dihydropyrimidinase, ZINC ION
Authors:Huang, Y.H., Huang, C.Y.
Deposit date:2018-08-27
Release date:2018-10-24
Last modified:2018-10-31
Method:X-RAY DIFFRACTION (2.223 Å)
Cite:Crystal structures of monometallic dihydropyrimidinase and the human dihydroorotase domain K1556A mutant reveal no lysine carbamylation within the active site
Biochem. Biophys. Res. Commun., 505, 2018
5E5C
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CRYSTAL STRUCTURE OF DIHYDROPYRIMIDINASE FROM PSEUDOMONAS AERUGINOSA PAO1
Descriptor:D-hydantoinase/dihydropyrimidinase, ZINC ION
Authors:Huang, C.C., Huang, Y.H., Hsieh, Y.C., Tzeng, C.T., Chen, C.J., Huang, C.Y.
Deposit date:2015-10-08
Release date:2016-09-21
Last modified:2016-09-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of dihydropyrimidinase from Pseudomonas aeruginosa PAO1: Insights into the molecular basis of formation of a dimer
Biochem.Biophys.Res.Commun., 478, 2016
2MN1
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SOLUTION STRUCTURE OF KALATA B1[W23WW]
Descriptor:kalata B1[W23WW]
Authors:Henriques, S.T., Huang, Y.H., Chaousis, S., Wang, C.K., Craik, D.J.
Deposit date:2014-03-26
Release date:2015-05-27
Method:SOLUTION NMR
Cite:Anticancer and toxic properties of cyclotides are dependent on phosphatidylethanolamine phospholipid targeting.
Chembiochem, 15, 2014
3L9C
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THE CRYSTAL STRUCTURE OF SMU.777 FROM STREPTOCOCCUS MUTANS UA159
Descriptor:3-dehydroquinate dehydratase
Authors:Su, X.-D., Huang, Y.H., Liu, X.
Deposit date:2010-01-05
Release date:2011-01-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The Crystal Structure of smu.777 from Streptococcus mutans UA159
TO BE PUBLISHED
3L9D
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THE CRYSTAL STRUCTURE OF SMU.1046C FROM STREPTOCOCCUS MUTANS UA159
Descriptor:Putative GTP pyrophosphokinase
Authors:Su, X.-D., Huang, Y.H., Liu, X.
Deposit date:2010-01-05
Release date:2011-01-12
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.484 Å)
Cite:The Crystal Structure of smu.1046c from Streptococcus mutans UA159
TO BE PUBLISHED
6AVP
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STAPHYLOCOCCUS AUREUS TYPE II PANTOTHENATE KINASE IN COMPLEX WITH ADP AND PANTOTHENATE ANALOG PHOSPHATE-MEO-N5PAN
Descriptor:Type II pantothenate kinase, ADENOSINE-5'-DIPHOSPHATE, N~3~-[(2R)-2-hydroxy-3,3-dimethyl-4-(phosphonooxy)butanoyl]-N-(5-methoxypentyl)-beta-alaninamide, ...
Authors:Chen, Y., Antoshchenko, T., Strauss, E., Barnard, L., Huang, Y.H.
Deposit date:2017-09-04
Release date:2018-09-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-based identification of uncompetitive inhibitors for Staphylococcus aureus pantothenate kinase.
To Be Published
6AWG
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STAPHYLOCOCCUS AUREUS TYPE II PANTOTHENATE KINASE IN COMPLEX WITH NUCLEOTIDES AND PANTOTHENATE ANALOG DEOXY-N190PAN
Descriptor:Type II pantothenate kinase, ADENOSINE-5'-TRIPHOSPHATE, (2R)-N-(3-{[(2H-1,3-benzodioxol-5-yl)methyl]amino}-3-oxopropyl)-2-hydroxy-3,3-dimethylbutanamide, ...
Authors:Chen, Y., Antoshchenko, T., Strauss, E., Barnard, L., Huang, Y.H.
Deposit date:2017-09-05
Release date:2018-09-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure-based identification of uncompetitive inhibitors for Staphylococcus aureus pantothenate kinase.
To Be Published
6AWH
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STAPHYLOCOCCUS AUREUS TYPE II PANTOTHENATE KINASE IN COMPLEX WITH ATP AND PANTOTHENATE ANALOG DEOXY-MEO-N5PAN
Descriptor:Type II pantothenate kinase, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Chen, Y., Antoshchenko, T., Strauss, E., Barnard, L., Huang, Y.H.
Deposit date:2017-09-05
Release date:2018-09-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure-based identification of uncompetitive inhibitors for Staphylococcus aureus pantothenate kinase.
To Be Published
6AWI
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STAPHYLOCOCCUS AUREUS TYPE II PANTOTHENATE KINASE IN COMPLEX WITH ADP AND PANTOTHENATE ANALOG DEOXY-N5PAN
Descriptor:Type II pantothenate kinase, ADENOSINE-5'-DIPHOSPHATE, (2R)-2-hydroxy-3,3-dimethyl-N-[3-oxo-3-(pentylamino)propyl]butanamide
Authors:Chen, Y., Antoshchenko, T., Strauss, E., Barnard, L., Huang, Y.H.
Deposit date:2017-09-05
Release date:2018-09-12
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure-based identification of uncompetitive inhibitors for Staphylococcus aureus pantothenate kinase.
To Be Published
6AWJ
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STAPHYLOCOCCUS AUREUS TYPE II PANTOTHENATE KINASE IN COMPLEX WITH ADP AND PANTOTHENATE ANALOG DEOXY-MEO-N5PAN WITH PANTOTHENATE PRESENT IN REACTION
Descriptor:Type II pantothenate kinase, ADENOSINE-5'-DIPHOSPHATE, (2R)-2-hydroxy-N-{3-[(5-methoxypentyl)amino]-3-oxopropyl}-3,3-dimethylbutanamide
Authors:Chen, Y., Antoshchenko, T., Strauss, E., Barnard, L., Huang, Y.H.
Deposit date:2017-09-05
Release date:2018-09-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-based identification of uncompetitive inhibitors for Staphylococcus aureus pantothenate kinase.
To Be Published
6DHB
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CRYSTAL STRUCTURE OF THE HUMAN TIM-3 WITH BOUND CALCIUM
Descriptor:Hepatitis A virus cellular receptor 2, CALCIUM ION, BENZOIC ACID, ...
Authors:Gandhi, A.K., Kim, W.M., Huang, Y.H., Bonsor, D., Sundberg, E., Sun, Z.-Y., Petsko, G.A., Kuchroo, V., Blumberg, R.S.
Deposit date:2018-05-19
Release date:2018-12-12
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:High resolution X-ray and NMR structural study of human T-cell immunoglobulin and mucin domain containing protein-3.
Sci Rep, 8, 2018
5YUN
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CRYSTAL STRUCTURE OF SSB COMPLEXED WITH MYC
Descriptor:Single-stranded DNA-binding protein, 3,5,7-TRIHYDROXY-2-(3,4,5-TRIHYDROXYPHENYL)-4H-CHROMEN-4-ONE
Authors:Huang, Y.H., Huang, C.Y.
Deposit date:2017-11-22
Release date:2018-10-10
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Crystal structure of SSB complexed with inhibitor myricetin.
Biochem. Biophys. Res. Commun., 504, 2018
2MT8
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SOLUTION STRUCTURE MTABL13, A GRAFTED MCOTI-II
Descriptor:MTAbl13 of grafted MCoTI-II
Authors:Huang, Y., Wang, C., Craik, D.
Deposit date:2014-08-15
Release date:2015-10-14
Method:SOLUTION NMR
Cite:Design of substrate-based BCR-ABL kinase inhibitors using the cyclotide scaffold.
Sci Rep, 5, 2015
4N74
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CRYSTAL STRUCTURE OF OUTER MEMBRANE PROTEIN TAMA BETA-BARREL DOMAIN IN E.COLI
Descriptor:Predicted outer membrane protein and surface antigen
Authors:Wang, Y.
Deposit date:2013-10-14
Release date:2014-10-15
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis of BamA-mediate Outer Membrane Protein Biogenesis
To be Published
4APV
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THE KLEBSIELLA PNEUMONIAE PRIMOSOMAL PRIB PROTEIN: IDENTIFICATION, CRYSTAL STRUCTURE, AND SSDNA BINDING MODE
Descriptor:PRIMOSOMAL REPLICATION PROTEIN N
Authors:Lo, Y.H., Huang, Y.H., Hsiao, C.D., Huang, C.Y.
Deposit date:2012-04-06
Release date:2012-04-25
Last modified:2013-01-23
Method:X-RAY DIFFRACTION (2.095 Å)
Cite:Crystal Structure and DNA-Binding Mode of Klebsiella Pneumoniae Primosomal Prib Protein.
Genes Cells, 17, 2012
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