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2R5W
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BU of 2r5w by Molmil
Crystal structure of a bifunctional NMN adenylyltransferase/ADP ribose pyrophosphatase from Francisella tularensis
Descriptor: CHLORIDE ION, MAGNESIUM ION, Nicotinamide-nucleotide adenylyltransferase
Authors:Huang, N, Sorci, L, Zhang, X, Brautigan, C, Li, X, Raffaelli, N, Grishin, N, Osterman, A, Zhang, H.
Deposit date:2007-09-04
Release date:2008-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Bifunctional NMN Adenylyltransferase/ADP-Ribose Pyrophosphatase: Structure and Function in Bacterial NAD Metabolism.
Structure, 16, 2008
2QJO
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BU of 2qjo by Molmil
crystal structure of a bifunctional NMN adenylyltransferase/ADP ribose pyrophosphatase (NadM) complexed with ADPRP and NAD from Synechocystis sp.
Descriptor: ADENOSINE-5-DIPHOSPHORIBOSE, Bifunctional NMN adenylyltransferase/Nudix hydrolase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Huang, N, Sorci, L, Zhang, X, Brautigan, C, Raffaelli, N, Magni, G, Grishin, N.V, Osterman, A, Zhang, H.
Deposit date:2007-07-08
Release date:2008-03-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Bifunctional NMN Adenylyltransferase/ADP-Ribose Pyrophosphatase: Structure and Function in Bacterial NAD Metabolism.
Structure, 16, 2008
2QJT
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BU of 2qjt by Molmil
Crystal structure of a bifunctional NMN adenylyltransferase/ADP ribose pyrophosphatase complexed with AMP and MN ion from Francisella tularensis
Descriptor: ADENOSINE MONOPHOSPHATE, MANGANESE (II) ION, Nicotinamide-nucleotide adenylyltransferase
Authors:Huang, N, Sorci, L, Zhang, X, Brautigan, C, Raffaelli, N, Magni, G, Grishin, N.V, Osterman, A, Zhang, H.
Deposit date:2007-07-09
Release date:2008-03-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Bifunctional NMN Adenylyltransferase/ADP-Ribose Pyrophosphatase: Structure and Function in Bacterial NAD Metabolism.
Structure, 16, 2008
3GZ8
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BU of 3gz8 by Molmil
Cocrystal structure of NUDIX domain of Shewanella oneidensis NrtR complexed with ADP ribose
Descriptor: ADENOSINE-5-DIPHOSPHORIBOSE, MutT/nudix family protein
Authors:Huang, N, Zhang, H.
Deposit date:2009-04-06
Release date:2009-06-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Structure and function of an ADP-ribose-dependent transcriptional regulator of NAD metabolism
Structure, 17, 2009
3GZ5
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BU of 3gz5 by Molmil
Crystal structure of Shewanella oneidensis NrtR
Descriptor: MutT/nudix family protein, SODIUM ION
Authors:Huang, N, Zhang, H.
Deposit date:2009-04-06
Release date:2009-06-09
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and function of an ADP-ribose-dependent transcriptional regulator of NAD metabolism
Structure, 17, 2009
3GZ6
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BU of 3gz6 by Molmil
Crystal structure of Shewanella oneidensis NrtR complexed with a 27mer DNA
Descriptor: DNA (27-MER), MutT/nudix family protein, SODIUM ION
Authors:Huang, N, Zhang, H.
Deposit date:2009-04-06
Release date:2009-06-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.901 Å)
Cite:Structure and function of an ADP-ribose-dependent transcriptional regulator of NAD metabolism
Structure, 17, 2009
3MLA
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BU of 3mla by Molmil
BaNadD in complex with inhibitor 1_02
Descriptor: 4-[2-(anthracen-9-ylmethylidene)hydrazino]-N-(3-chlorophenyl)-4-oxobutanamide, DIMETHYL SULFOXIDE, FORMIC ACID, ...
Authors:Huang, N, Eyobo, Y, Zhang, H.
Deposit date:2010-04-16
Release date:2010-07-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Complexes of bacterial nicotinate mononucleotide adenylyltransferase with inhibitors: implication for structure-based drug design and improvement.
J.Med.Chem., 53, 2010
3MMX
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BU of 3mmx by Molmil
Bacillus anthracis NadD (baNadD) in complex with compound 1_02_3
Descriptor: CITRIC ACID, DIMETHYL SULFOXIDE, POTASSIUM ION, ...
Authors:Huang, N, Zhang, H.
Deposit date:2010-04-20
Release date:2010-07-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.552 Å)
Cite:Complexes of bacterial nicotinate mononucleotide adenylyltransferase with inhibitors: implication for structure-based drug design and improvement.
J.Med.Chem., 53, 2010
3MLB
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BU of 3mlb by Molmil
BaNadD in complex with inhibitor 1_02_1
Descriptor: 4,4'-{cyclohexa-2,5-diene-1,4-diylidenebis[(E)methylylidene(E)diazene-2,1-diyl]}bis[N-(2-chlorophenyl)-4-oxobutanamide], FORMIC ACID, POTASSIUM ION, ...
Authors:Huang, N, Zhang, H, Eyobo, Y.
Deposit date:2010-04-16
Release date:2010-07-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Complexes of bacterial nicotinate mononucleotide adenylyltransferase with inhibitors: implication for structure-based drug design and improvement.
J.Med.Chem., 53, 2010
4F3L
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BU of 4f3l by Molmil
Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex
Descriptor: BMAL1b, Circadian locomoter output cycles protein kaput
Authors:Huang, N, Chelliah, Y, Shan, Y, Taylor, C, Yoo, S, Partch, C, Green, C.B, Zhang, H, Takahashi, J.
Deposit date:2012-05-09
Release date:2012-06-06
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.268 Å)
Cite:Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex.
Science, 337, 2012
3PJA
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BU of 3pja by Molmil
Crystal structure of human C3PO complex
Descriptor: Translin, Translin-associated protein X
Authors:Huang, N, Zhang, H.
Deposit date:2010-11-09
Release date:2011-05-11
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of C3PO and mechanism of human RISC activation.
Nat.Struct.Mol.Biol., 18, 2011
8H3E
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BU of 8h3e by Molmil
Complex structure of a small molecule (SPC-14) bound SARS-CoV-2 spike protein, closed state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 7-(6-nitro-2,3-dihydroindol-1-yl)-7-oxidanylidene-heptanoic acid, Spike glycoprotein,Fibritin
Authors:Meng, F, Wang, Q, Xie, Y, Ni, X, Huang, N.
Deposit date:2022-10-08
Release date:2023-03-22
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:In Silico Discovery of Small Molecule Modulators Targeting the Achilles' Heel of SARS-CoV-2 Spike Protein.
Acs Cent.Sci., 9, 2023
8H3D
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BU of 8h3d by Molmil
Structure of apo SARS-CoV-2 spike protein with one RBD up
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein,Fibritin
Authors:Meng, F, Wang, Q, Xie, Y, Ni, X, Huang, N.
Deposit date:2022-10-08
Release date:2023-03-22
Method:ELECTRON MICROSCOPY (3.27 Å)
Cite:In Silico Discovery of Small Molecule Modulators Targeting the Achilles' Heel of SARS-CoV-2 Spike Protein.
Acs Cent.Sci., 9, 2023
1SKM
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BU of 1skm by Molmil
HhaI methyltransferase in complex with DNA containing an abasic south carbocyclic sugar at its target site
Descriptor: 5'-D(*T*GP*TP*CP*AP*GP*(HCX)P*GP*CP*AP*TP*GP*G)-3', 5'-D(*TP*CP*CP*AP*TP*GP*CP*GP*CP*TP*GP*AP*C)-3', Modification methylase HhaI, ...
Authors:Horton, J.R, Ratner, G, Banavali, N, Huang, N, Marquez, V.E, MacKerell, A.D, Cheng, X.
Deposit date:2004-03-05
Release date:2004-08-24
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Caught in the act: visualization of an intermediate in the DNA base-flipping pathway induced by HhaI methyltransferase
Nucleic Acids Res., 32, 2004
5KPP
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BU of 5kpp by Molmil
Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor
Descriptor: 1-[[4-fluoranyl-3-[(3R)-3-methyl-4-[2,2,2-tris(fluoranyl)ethyl]piperazin-1-yl]carbonyl-phenyl]methyl]quinazoline-2,4-dione, Poly [ADP-ribose] polymerase 1
Authors:Cao, R, Wang, Y.L, Zhou, J, Huang, N, Xu, B.L.
Deposit date:2016-07-05
Release date:2016-11-30
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor
To Be Published
5KPO
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BU of 5kpo by Molmil
Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor
Descriptor: 1-[[3-(4-ethyl-3-oxidanylidene-piperazin-1-yl)carbonyl-4-fluoranyl-phenyl]methyl]quinazoline-2,4-dione, Poly [ADP-ribose] polymerase 1
Authors:Cao, R, Wang, Y.L, Zhou, J, Yao, H.P, Huang, N, Xu, B.L.
Deposit date:2016-07-05
Release date:2016-12-21
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor
To Be Published
5KPQ
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BU of 5kpq by Molmil
Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor
Descriptor: 1-[[4-fluoranyl-3-[(3R)-3-methyl-4-propyl-piperazin-1-yl]carbonyl-phenyl]methyl]quinazoline-2,4-dione, Poly [ADP-ribose] polymerase 1
Authors:Cao, R, Wang, Y.L, Zhou, J, Huang, N, Xu, B.L.
Deposit date:2016-07-05
Release date:2016-12-14
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor
To Be Published
5KPN
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BU of 5kpn by Molmil
Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor
Descriptor: 1-[[4-fluoranyl-3-(3-oxidanylidene-4-propyl-piperazin-1-yl)carbonyl-phenyl]methyl]quinazoline-2,4-dione, Poly [ADP-ribose] polymerase 1
Authors:Cao, R, Wang, Y.L, Zhou, J, Yao, H.P, Huang, N, Xu, B.L.
Deposit date:2016-07-05
Release date:2016-12-21
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of human PARP1 catalytic domain bound to a quinazoline-2,4(1H,3H)-dione inhibitor
To Be Published
6AEJ
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BU of 6aej by Molmil
Crystal structure of human FTO in complex with small-molecule inhibitors
Descriptor: (E)-3-[3-nitro-4,5-bis(oxidanyl)phenyl]-2-(1,3-oxazinan-3-ylcarbonyl)prop-2-enenitrile, Alpha-ketoglutarate-dependent dioxygenase FTO,Alpha-ketoglutarate-dependent dioxygenase FTO, ZINC ION
Authors:Wang, Y, Cao, R, Peng, S, Zhang, W, Huang, N.
Deposit date:2018-08-05
Release date:2019-06-19
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1.
Sci Transl Med, 11, 2019
6AK4
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BU of 6ak4 by Molmil
Crystal structure of human FTO in complex with small-molecule inhibitors
Descriptor: (~{E})-2-cyano-~{N},~{N}-diethyl-3-[3-nitro-4,5-bis(oxidanyl)phenyl]prop-2-enamide, Alpha-ketoglutarate-dependent dioxygenase FTO,Alpha-ketoglutarate-dependent dioxygenase FTO, ZINC ION
Authors:Wang, Y, Cao, R, Peng, S, Zhang, W, Huang, N.
Deposit date:2018-08-30
Release date:2019-07-10
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1.
Sci Transl Med, 11, 2019
2Z8O
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BU of 2z8o by Molmil
Structural basis for the catalytic mechanism of phosphothreonine lyase
Descriptor: 27.5 kDa virulence protein, L(+)-TARTARIC ACID
Authors:Chen, L, Wang, H, Gu, L, Huang, N, Zhou, J.M, Chai, J.
Deposit date:2007-09-07
Release date:2007-12-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for the catalytic mechanism of phosphothreonine lyase.
Nat.Struct.Mol.Biol., 15, 2008
2Z8N
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BU of 2z8n by Molmil
Structural basis for the catalytic mechanism of phosphothreonine lyase
Descriptor: 27.5 kDa virulence protein, SULFATE ION
Authors:Chen, L, Wang, H, Gu, L, Huang, N, Zhou, J.M, Chai, J.
Deposit date:2007-09-07
Release date:2007-12-18
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for the catalytic mechanism of phosphothreonine lyase.
Nat.Struct.Mol.Biol., 15, 2008
2Z8M
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BU of 2z8m by Molmil
Structural basis for the catalytic mechanism of phosphothreonine lyase
Descriptor: 27.5 kDa virulence protein
Authors:Chen, L, Wang, H, Gu, L, Huang, N, Zhou, J.M, Chai, J.
Deposit date:2007-09-07
Release date:2007-12-18
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for the catalytic mechanism of phosphothreonine lyase.
Nat.Struct.Mol.Biol., 15, 2008
2Z8P
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BU of 2z8p by Molmil
Structural basis for the catalytic mechanism of phosphothreonine lyase
Descriptor: (GLY)(GLU)(ALA)(TPO)(VAL)(PTR)(ALA), 27.5 kDa virulence protein
Authors:Chen, L, Wang, H, Gu, L, Huang, N, Zhou, J.M, Chai, J.
Deposit date:2007-09-07
Release date:2007-12-18
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for the catalytic mechanism of phosphothreonine lyase.
Nat.Struct.Mol.Biol., 15, 2008
4RC4
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BU of 4rc4 by Molmil
Crystal structure of Ser/Thr kinase Pim1 in complex with Mitoxantrone derivatives
Descriptor: 1,4-bis[(2-aminoethyl)amino]-5,8-dihydroxyanthracene-9,10-dione, Serine/threonine-protein kinase pim-1
Authors:Zhang, W, Wan, X, Huang, N.
Deposit date:2014-09-14
Release date:2015-03-18
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.651 Å)
Cite:Crystal structure of Ser/Thr kinase Pim1 in complex with Mitoxantrone derivatives
To be Published

 

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