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3G7N
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CRYSTAL STRUCTURE OF A TRIACYLGLYCEROL LIPASE FROM PENICILLIUM EXPANSUM AT 1.3
Descriptor:Lipase, SULFATE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Bian, C.B., Yuan, C., Chen, L.Q., Edward, J.M., Lin, L., Jiang, L.G., Huang, Z.X., Huang, M.D.
Deposit date:2009-02-10
Release date:2010-02-23
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structure of a triacylglycerol lipase from Penicillium expansum at 1.3 A determined by sulfur SAD
Proteins, 78, 2010
3MWI
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THE COMPLEX CRYSTAL STRUCTURE OF UROKIANSE AND 5-NITRO-1H-INDOLE-2-AMIDINE
Descriptor:Urokinase-type plasminogen activator, 5-nitro-1H-indole-2-carboximidamide, SULFATE ION
Authors:Jiang, L.G., Yu, H.Y., Yuan, C., Huang, Z.X., Huang, M.D.
Deposit date:2010-05-06
Release date:2011-06-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:The complex crystal Structure of Urokianse and 5-nitro-1H-indole-2-amidine
To be Published
1MWA
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2C/H-2KBM3/DEV8 ALLOGENEIC COMPLEX
Descriptor:2C T CELL RECEPTOR ALPHA CHAIN, 2C T CELL RECEPTOR BETA CHAIN, H-2KBM3 MHC CLASS I MOLECULE HEAVY CHAIN, ...
Authors:Luz, J.G., Huang, M.D., Garcia, K.C., Rudolph, M.G., Teyton, L., Wilson, I.A.
Deposit date:2002-09-27
Release date:2002-11-27
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) Interactions.
J.EXP.MED., 195, 2002
3D69
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CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF AN ANTI-FACTOR IX ANTIBODY 10C12
Descriptor:anti-factor IX antibody, 10C12
Authors:Shi, X.L., Huang, M.D., Zeng, T.
Deposit date:2008-05-19
Release date:2009-03-31
Last modified:2013-10-02
Method:X-RAY DIFFRACTION (3.77 Å)
Cite:Crystal structure of Fab Fragment of an anti-Factor IX antibody 10C12
CHIN.J.STRUCT.CHEM., 27, 2008
3OX7
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THE CRYSTAL STRUCTURE OF UPA COMPLEX WITH PEPTIDE INHIBITOR MH027 AT PH4.6
Descriptor:Urokinase-type plasminogen activator, MH027, SULFATE ION, ...
Authors:Jiang, L.G., Andreasen, P.A., Huang, M.D.
Deposit date:2010-09-21
Release date:2011-08-10
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:The binding mechanism of a peptidic cyclic serine protease inhibitor
J.Mol.Biol., 412, 2011
3OY5
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THE CRYSTAL STRUCTURE OF UPA COMPLEX WITH PEPTIDE INHIBITOR MH027 AT PH7.4
Descriptor:Urokinase-type plasminogen activator, MH027, SULFATE ION
Authors:Jiang, L.G., Andreasen, P.A., Huang, M.D.
Deposit date:2010-09-22
Release date:2011-08-10
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:The binding mechanism of a peptidic cyclic serine protease inhibitor
J.Mol.Biol., 412, 2011
3OY6
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THE CRYSTAL STRUCTURE OF UPA COMPLEX WITH PEPTIDE INHIBITOR MH036 AT PH4.6
Descriptor:Urokinase-type plasminogen activator, MH036
Authors:Jiang, L.G., Andreasen, P.A., Huang, M.D.
Deposit date:2010-09-22
Release date:2011-08-10
Last modified:2013-06-26
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:The binding mechanism of a peptidic cyclic serine protease inhibitor
J.Mol.Biol., 412, 2011
3UT3
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A NOVEL PAI-I INHIBITOR AND ITS STRUCTURAL MECHANISM
Descriptor:Plasminogen activator inhibitor 1, 2,5-dihydroxy-3-undecylcyclohexa-2,5-diene-1,4-dione
Authors:Lin, Z.H., Hong, Z.B., Shi, X.L., Hu, L.H., Andreasen, P.A., Huang, M.D.
Deposit date:2011-11-25
Release date:2013-02-06
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:A novel PAI-I inhibitor and its structural mechanism
To be Published
4E99
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HUMAN SERUM ALBUMIN COMPLEX WITH PERFLUOROOCTANE SULFONATE POTASSIUM
Descriptor:Serum albumin, heptadecafluoro-1-octanesulfonic acid
Authors:Luo, Z.P., Shi, X.L., Huang, M.D.
Deposit date:2012-03-20
Release date:2012-06-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural evidence of perfluorooctane sulfonate transport by human serum albumin
Chem.Res.Toxicol., 25, 2012
4IC0
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CRYSTAL STRUCTURE OF PAI-1 IN COMPLEX WITH GALLATE
Descriptor:Plasminogen activator inhibitor 1, 3,4,5-trihydroxybenzoic acid
Authors:Hong, Z.B., Lin, Z.H., Gong, L.H., Huang, M.D.
Deposit date:2012-12-09
Release date:2013-12-11
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Crystal Structure of PAI-1 in Complex with Gallate
To be Published
5YC6
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THE CRYSTAL STRUCTURE OF UPA IN COMPLEX WITH 4-BROMOBENZYLAMIRNE AT PH4.6
Descriptor:Urokinase-type plasminogen activator, 1-(4-BROMOPHENYL)METHANAMINE, SULFATE ION, ...
Authors:Jiang, L.G., Zhang, X., Huang, M.D.
Deposit date:2017-09-06
Release date:2018-10-03
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Halogen bonding for the design of inhibitors by targeting the S1 pocket of serine proteases
Rsc Adv, 8, 2018
5YC7
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THE CRYSTAL STRUCTURE OF UPA IN COMPLEX WITH 4-BROMOBENZYLAMIRNE AT PH7.4
Descriptor:Urokinase-type plasminogen activator, 1-(4-BROMOPHENYL)METHANAMINE, SULFATE ION
Authors:Jiang, L.G., Zhang, X., Huang, M.D.
Deposit date:2017-09-06
Release date:2018-10-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:Halogen bonding for the design of inhibitors by targeting the S1 pocket of serine proteases
Rsc Adv, 8, 2018
5YUP
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CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF FVIIA ANTIBODY MAB4F5
Descriptor:the heavy chain of the Fab fragment of FVIIa antibody mAb4F5, the light chain of the Fab fragment of FVIIa antibody mAb4F5
Authors:Jiang, L.G., Persson, E., Huang, M.D.
Deposit date:2017-11-22
Release date:2019-06-19
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Crystal Structure of the Fab fragment of FVIIa antibody mAb4F5
To Be Published
5Z1C
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THE CRYSTAL STRUCTURE OF UPA IN COMPLEX WITH 4-IODOBENZYLAMINE AT PH7.4
Descriptor:Urokinase-type plasminogen activator, 1-(4-iodophenyl)methanamine
Authors:Jiang, L.G., Zhang, X., Luo, Z.P., Huang, M.D.
Deposit date:2017-12-25
Release date:2018-12-26
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Halogen bonding for the design of inhibitors by targeting the S1 pocket of serine proteases
Rsc Adv, 49, 2018
6A8G
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THE CRYSTAL STRUCTURE OF MUPAIN-1-IG IN COMPLEX WITH MUPA-SPD AT PH8.5
Descriptor:muPAin-1-IG, Urokinase-type plasminogen activator chain B, PHOSPHATE ION
Authors:Wang, D., Yang, Y.S., Jiang, L.G., Huang, M.D., Li, J.Y., Andreasen, P.A., Xu, P., Chen, Z.
Deposit date:2018-07-08
Release date:2019-02-20
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:The crystal structure of muPAin-1-IG in complex with muPA-SPD at pH8.5
To Be Published
6A8N
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THE CRYSTAL STRUCTURE OF MUPAIN-1-IG-2 IN COMPLEX WITH MUPA-SPD AT PH8.5
Descriptor:Urokinase-type plasminogen activator B, CYS-PRO-ALA-TYR-SER-ARG-TYR-ILE-GLY-CYS
Authors:Wang, D., Yang, Y.S., Jiang, L.G., Huang, M.D., Li, J.Y., Andreasen, P.A., Xu, P., Chen, Z.
Deposit date:2018-07-09
Release date:2019-02-20
Method:X-RAY DIFFRACTION (2.489 Å)
Cite:The crystal structure of muPAin-1-IG-2 in complex with muPA-SPD at pH8.5
To Be Published
6AG7
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THE CRYSTAL STRUCTURE OF UPA IN COMPLEX WITH HMA-55F
Descriptor:Urokinase-type plasminogen activator, 3,5-diamino-N-carbamimidoyl-6-(1-methyl-1H-pyrazol-4-yl)pyrazine-2-carboxamide
Authors:Buckley, B., Jiang, L.G., Majed, H., Huang, M.D., Kelso, M., Ranson, M.
Deposit date:2018-08-09
Release date:2019-08-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:uPA-HMA
To Be Published
3U73
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CRYSTAL STRUCTURE OF STABILIZED HUMAN UPAR MUTANT IN COMPLEX WITH ATF
Descriptor:Urokinase plasminogen activator surface receptor, Urokinase-type plasminogen activator, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Huang, M.D., Xu, X., Yuan, C.
Deposit date:2011-10-13
Release date:2012-04-18
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Crystal structure of the urokinase receptor in a ligand-free form.
J.Mol.Biol., 416, 2012
3U74
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CRYSTAL STRUCTURE OF STABILIZED HUMAN UPAR MUTANT
Descriptor:Urokinase plasminogen activator surface receptor, N-ACETYL-D-GLUCOSAMINE
Authors:Huang, M.D., Xu, X., Yuan, C.
Deposit date:2011-10-13
Release date:2012-04-18
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Crystal structure of the urokinase receptor in a ligand-free form.
J.Mol.Biol., 416, 2012
4IS5
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CRYSTAL STRUCTURE OF THE LIGAND-FREE INACTIVE MATRIPTASE
Descriptor:Suppressor of tumorigenicity 14 protein, SULFATE ION, GLYCEROL, ...
Authors:Huang, M.D., Zhao, B.Y., Yuan, C., Li, R.
Deposit date:2013-01-16
Release date:2013-03-06
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1.
J.Biol.Chem., 288, 2013
4ISL
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CRYSTAL STRUCTURE OF THE INACTIVE MATRIPTASE IN COMPLEX WITH ITS INHIBITOR HAI-1
Descriptor:Kunitz-type protease inhibitor 1, Suppressor of tumorigenicity 14 protein, TETRAETHYLENE GLYCOL, ...
Authors:Huang, M.D., Zhao, B.Y., Yuan, C., Li, R.
Deposit date:2013-01-16
Release date:2013-03-06
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1.
J.Biol.Chem., 288, 2013
4ISN
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CRYSTAL STRUCTURE OF MATRIPTASE IN COMPLEX WITH ITS INHIBITOR HAI-1
Descriptor:Kunitz-type protease inhibitor 1, Suppressor of tumorigenicity 14 protein, TETRAETHYLENE GLYCOL, ...
Authors:Huang, M.D., Zhao, B.Y., Yuan, C., Li, R.
Deposit date:2013-01-16
Release date:2013-03-06
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1.
J.Biol.Chem., 288, 2013
4ISO
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CRYSTAL STRUCTURE OF MATRIPTASE IN COMPLEX WITH ITS INHIBITOR HAI-1
Descriptor:Suppressor of tumorigenicity 14 protein, Kunitz-type protease inhibitor 1, GLUTATHIONE, ...
Authors:Huang, M.D., Zhao, B.Y., Yuan, C., Li, R.
Deposit date:2013-01-16
Release date:2013-03-06
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1.
J.Biol.Chem., 288, 2013
4K24
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STRUCTURE OF ANTI-UPAR FAB ATN-658 IN COMPLEX WITH UPAR
Descriptor:Urokinase-type plasminogen activator, Vitronectin, anti-uPAR antibody, ...
Authors:Huang, M.D., Xu, X., Yuan, C.
Deposit date:2013-04-08
Release date:2014-02-26
Last modified:2014-03-05
Method:X-RAY DIFFRACTION (4.5 Å)
Cite:Identification of a New Epitope in uPAR as a Target for the Cancer Therapeutic Monoclonal Antibody ATN-658, a Structural Homolog of the uPAR Binding Integrin CD11b ( alpha M)
Plos One, 9, 2014
5ZA7
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UPA-HMA
Descriptor:Urokinase-type plasminogen activator chain B, 3-azanyl-5-(azepan-1-yl)-N-[bis(azanyl)methylidene]-6-chloranyl-pyrazine-2-carboxamide, SULFATE ION
Authors:Buckley, B.J., Jiang, L.G., Huang, M.D., Kelso, M.J., Ranson, M.
Deposit date:2018-02-06
Release date:2018-12-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
J. Med. Chem., 61, 2018
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