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6HAC
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CRYSTAL STRUCTURE OF [FE]-HYDROGENASE (HMD) HOLOENZYME FROM METHANOCOCCUS AEOLICUS (OPEN FORM)
Descriptor:5,10-methenyltetrahydromethanopterin hydrogenase, iron-guanylyl pyridinol cofactor, PENTAETHYLENE GLYCOL, ...
Authors:Huang, G., Wagner, T., Wodrich, M.D., Ataka, K., Bill, E., Ermler, U., Hu, X., Shima, S.
Deposit date:2018-08-07
Release date:2019-08-28
Last modified:2019-09-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The atomic-resolution crystal structure of activated [Fe]-hydrogenase
Nat Catal, 2019
6HAE
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CRYSTAL STRUCTURE OF [FE]-HYDROGENASE (HMD) FROM METHANOCOCCUS AEOLICUS IN COMPLEX WITH FEGP COFACTOR AND METHENYL-TETRAHYDROMETHANOPTERIN (CLOSE FORM B)
Descriptor:5,10-methenyltetrahydromethanopterin hydrogenase, GLYCEROL, 1-{4-[(6S,6aR,7R)-3-amino-6,7-dimethyl-1-oxo-1,2,5,6,6a,7-hexahydro-8H-imidazo[1,5-f]pteridin-10-ium-8-yl]phenyl}-1-deoxy-5-O-{5-O-[(S)-{[(1S)-1,3-dicarboxypropyl]oxy}(hydroxy)phosphoryl]-alpha-D-ribofuranosyl}-D-ribitol, ...
Authors:Huang, G., Wagner, T., Wodrich, M.D., Ataka, K., Bill, E., Ermler, U., Hu, X., Shima, S.
Deposit date:2018-08-07
Release date:2019-08-28
Last modified:2019-09-04
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The atomic-resolution crystal structure of activated [Fe]-hydrogenase
Nat Catal, 2019
6HAV
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CRYSTAL STRUCTURE OF [FE]-HYDROGENASE (HMD) FROM METHANOCOCCUS AEOLICUS IN COMPLEX WITH FEGP AND METHENYL-TETRAHYDROMETHANOPTERIN (CLOSE FORM A) AT 1.06 A RESOLUTION
Descriptor:5,10-methenyltetrahydromethanopterin hydrogenase, iron-guanylyl pyridinol cofactor, GLYCEROL, ...
Authors:Huang, G., Wagner, T., Wodrich, M.D., Ataka, K., Bill, E., Ermler, U., Hu, X., Shima, S.
Deposit date:2018-08-08
Release date:2019-08-28
Last modified:2019-09-04
Method:X-RAY DIFFRACTION (1.06 Å)
Cite:The atomic-resolution crystal structure of activated [Fe]-hydrogenase
Nat Catal, 2019
6I28
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CRYSTAL STRUCTURE OF CYDIA POMONELLA PTP-2 PHOSPHATASE
Descriptor:ORF98 PTP-2, GLYCEROL, CALCIUM ION
Authors:Huang, G., Keown, J.P., Oliver, M.R., Metcalf, P.
Deposit date:2018-10-31
Release date:2019-02-20
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of protein tyrosine phosphatase-2 from Cydia pomonella granulovirus.
Acta Crystallogr.,Sect.F, 75, 2019
5OK4
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CRYSTAL STRUCTURE OF NATIVE [FE]-HYDROGENASE HMD FROM METHANOTHERMOBACTER MARBURGENSIS INACTIVATED BY O2.
Descriptor:5,10-methenyltetrahydromethanopterin hydrogenase, FE (III) ION, 5'-O-[(S)-{[2-(carboxymethyl)-6-hydroxy-3,5-dimethylpyridin-4-yl]oxy}(hydroxy)phosphoryl]guanosine, ...
Authors:Wagner, T., Huang, G., Bill, E., Ermler, U., Ataka, K., Shima, S.
Deposit date:2017-07-25
Release date:2018-05-16
Last modified:2018-05-30
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Dioxygen Sensitivity of [Fe]-Hydrogenase in the Presence of Reducing Substrates.
Angew. Chem. Int. Ed. Engl., 57, 2018
1NL1
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BOVINE PROTHROMBIN FRAGMENT 1 IN COMPLEX WITH CALCIUM ION
Descriptor:Prothrombin, N-ACETYL-D-GLUCOSAMINE, CALCIUM ION
Authors:Huang, M., Huang, G., Furie, B., Seaton, B., Furie, B.C.
Deposit date:2003-01-06
Release date:2003-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins.
Nat.Struct.Biol., 10, 2003
1NL2
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BOVINE PROTHROMBIN FRAGMENT 1 IN COMPLEX WITH CALCIUM AND LYSOPHOSPHOTIDYLSERINE
Descriptor:Prothrombin, N-ACETYL-D-GLUCOSAMINE, CALCIUM ION, ...
Authors:Huang, M., Huang, G., Furie, B., Seaton, B., Furie, B.C.
Deposit date:2003-01-06
Release date:2003-09-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis of membrane binding by Gla domains of vitamin K-dependent proteins.
Nat.Struct.Biol., 10, 2003
6J8E
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HUMAN NAV1.2-BETA2-KIIIA TERNARY COMPLEX
Descriptor:Sodium channel subunit beta-2, Sodium channel protein type 2 subunit alpha, Mu-conotoxin KIIIA, ...
Authors:Pan, X., Li, Z., Huang, X., Huang, G., Yan, N.
Deposit date:2019-01-18
Release date:2019-02-27
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Molecular basis for pore blockade of human Na+channel Nav1.2 by the mu-conotoxin KIIIA.
Science, 363, 2019
5C1U
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CRYSTAL STRUCTURE OF EV71 3C PROTEINASE IN COMPLEX WITH COMPOUND XB
Descriptor:3C proteinase, Nalpha-{(2E)-3-[4-(dimethylamino)phenyl]prop-2-enoyl}-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-phenylalaninamide
Authors:Zhang, L., Huang, G., Cai, Q., Zhao, C., Ren, H., Li, P., Li, N., Chen, S., Li, J., Lin, T.
Deposit date:2015-06-15
Release date:2016-06-01
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Optimize the interactions at S4 with efficient inhibitors targeting 3C proteinase from enterovirus 71
J.Mol.Recognit., 29, 2016
5C1X
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CRYSTAL STRUCTURE OF EV71 3C PROTEINASE IN COMPLEX WITH COMPOUND VIII
Descriptor:3C proteinase, Nalpha-[(benzyloxy)carbonyl]-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-phenylalaninamide
Authors:Zhang, L., Huang, G., Cai, Q., Zhao, C., Ren, H., Li, P., Li, N., Chen, S., Li, J., Lin, T.
Deposit date:2015-06-15
Release date:2016-06-01
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Optimize the interactions at S4 with efficient inhibitors targeting 3C proteinase from enterovirus 71
J.Mol.Recognit., 29, 2016
5C1Y
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CRYSTAL STRUCTURE OF EV71 3C PROTEINASE IN COMPLEX WITH COMPOUND 1
Descriptor:3C proteinase, N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-Nalpha-[(propan-2-yloxy)carbonyl]-L-phenylalaninamide
Authors:Zhang, L., Huang, G., Cai, Q., Zhao, C., Ren, H., Li, P., Li, N., Chen, S., Li, J., Lin, T.
Deposit date:2015-06-15
Release date:2016-06-01
Last modified:2016-10-26
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Optimize the interactions at S4 with efficient inhibitors targeting 3C proteinase from enterovirus 71
J.Mol.Recognit., 29, 2016
5C20
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CRYSTAL STRUCTURE OF EV71 3C PROTEINASE IN COMPLEX WITH COMPOUND 2
Descriptor:3C proteinase, Nalpha-[(2-methylpropoxy)carbonyl]-N-{(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-L-phenylalaninamide
Authors:Zhang, L., Huang, G., Cai, Q., Zhao, C., Ren, H., Li, P., Li, N., Chen, S., Li, J., Lin, T.
Deposit date:2015-06-15
Release date:2016-06-01
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Optimize the interactions at S4 with efficient inhibitors targeting 3C proteinase from enterovirus 71
J.Mol.Recognit., 29, 2016
3OCP
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CRYSTAL STRUCTURE OF CAMP BOUND CGMP-DEPENDENT PROTEIN KINASE(92-227)
Descriptor:PRKG1 protein, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
Authors:Kim, J.J., Huang, G., Kwon, T.K., Zwart, P., Headd, J., Kim, C.
Deposit date:2010-08-10
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Co-Crystal Structures of PKG Ibeta (92-227) with cGMP and cAMP Reveal the Molecular Details of Cyclic-Nucleotide Binding
Plos One, 6, 2011
3OD0
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CRYSTAL STRUCTURE OF CGMP BOUND CGMP-DEPENDENT PROTEIN KINASE(92-227)
Descriptor:PRKG1 protein, CYCLIC GUANOSINE MONOPHOSPHATE
Authors:Kim, J.J., Huang, G., Kwon, T.K., Zwart, P., Headd, J., Kim, C.
Deposit date:2010-08-10
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Co-Crystal Structures of PKG Ibeta (92-227) with cGMP and cAMP Reveal the Molecular Details of Cyclic-Nucleotide Binding
Plos One, 6, 2011
3OGJ
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CRYSTAL STRUCTURE OF PARTIAL APO (92-227) OF CGMP-DEPENDENT PROTEIN KINASE
Descriptor:PRKG1 protein, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, PHOSPHATE ION
Authors:Kim, J.J., Huang, G., Kwon, T.K., Zwart, P., Headd, J., Kim, C.
Deposit date:2010-08-16
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.751 Å)
Cite:Co-Crystal Structures of PKG Ibeta (92-227) with cGMP and cAMP Reveal the Molecular Details of Cyclic-Nucleotide Binding
Plos One, 6, 2011
4DZD
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CRYSTAL STRUCTURE OF THE CRISPR-ASSOCIATED PROTEIN CAS6E FROM ESCHERICHIA COLI STR. K-12
Descriptor:Uncharacterized protein ygcH, GLYCEROL
Authors:Wei, J., Huang, G., Wang, Y., Gong, W.
Deposit date:2012-03-01
Release date:2013-03-06
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Crystal Structure of endoribonuclease Cas6e from Escherichia coli
To be Published
5GM6
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CRYO-EM STRUCTURE OF THE ACTIVATED SPLICEOSOME (BACT COMPLEX) AT 3.5 ANGSTROM RESOLUTION
Descriptor:Pre-mRNA-splicing factor 8, Pre-mRNA-splicing helicase BRR2, Pre-mRNA-splicing factor SNU114, ...
Authors:Yan, C., Wan, R., Bai, R., Huang, G., Shi, Y.
Deposit date:2016-07-12
Release date:2016-09-21
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structure of a yeast activated spliceosome at 3.5 angstrom resolution
Science, 353, 2016
5GMK
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CRYO-EM STRUCTURE OF THE CATALYTIC STEP I SPLICEOSOME (C COMPLEX) AT 3.4 ANGSTROM RESOLUTION
Descriptor:Pre-mRNA-splicing factor 8, Pre-mRNA-splicing factor SNU114, U5 snRNA, ...
Authors:Wan, R., Yan, C., Bai, R., Huang, G., Shi, Y.
Deposit date:2016-07-14
Release date:2016-08-17
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structure of a yeast catalytic step I spliceosome at 3.4 angstrom resolution
Science, 353, 2016
5WSG
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CRYO-EM STRUCTURE OF THE CATALYTIC STEP II SPLICEOSOME (C* COMPLEX) AT 4.0 ANGSTROM RESOLUTION
Descriptor:Pre-mRNA-splicing factor 8, Pre-mRNA-splicing factor SNU114, Pre-mRNA-splicing factor CWC21, ...
Authors:Yan, C., Wan, R., Bai, R., Huang, G., Shi, Y.
Deposit date:2016-12-07
Release date:2017-01-25
Last modified:2019-10-09
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structure of a yeast step II catalytically activated spliceosome
Science, 355, 2017
6GGU
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CRYSTAL STRUCTURE OF NATIVE FE-HYDROGENASE FROM METHANOTHERMOBACTER MARBURGENSIS
Descriptor:5,10-methenyltetrahydromethanopterin hydrogenase, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SULFATE ION, ...
Authors:Wagner, T., Huang, G., Ermler, U., Shima, S.
Deposit date:2018-05-03
Release date:2019-05-22
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Self-protection of the catalytic iron center of a methanogenic [Fe]-hydrogenase via a dynamic dimer-to-hexamer transformation
To Be Published
6HUX
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HMDII FROM METHANOCALDOCOCCUS JANNASCHII RECONSTITUED WITH FE-GUANYLYLPYRIDINOL (FEGP) COFACTOR AND CO-CRYSTALLIZED WITH METHENYL-TETRAHYDROMETHANOPTERIN AT 2.5 A RESOLUTION
Descriptor:H(2)-forming methylenetetrahydromethanopterin dehydrogenase-related protein MJ1338, ACETATE ION, iron-guanylyl pyridinol cofactor, ...
Authors:Watanabe, T., Wagner, T., Huang, G., Kahnt, J., Ataka, K., Ermler, U., Shima, S.
Deposit date:2018-10-09
Release date:2019-01-09
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The Bacterial [Fe]-Hydrogenase Paralog HmdII Uses Tetrahydrofolate Derivatives as Substrates.
Angew. Chem. Int. Ed. Engl., 58, 2019
6HUY
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HMDII FROM DESULFUROBACTERIUM THERMOLITHOTROPHUM RECONSTITUED WITH FE-GUANYLYLPYRIDINOL (FEGP) COFACTOR AND CO-CRYSTALLIZED WITH METHENYL-TETRAHYDROFOLATE FORM A
Descriptor:Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase-related protein, iron-guanylyl pyridinol cofactor, GLYCEROL, ...
Authors:Watanabe, T., Wagner, T., Huang, G., Kahnt, J., Ataka, K., Ermler, U., Shima, S.
Deposit date:2018-10-09
Release date:2019-01-09
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The Bacterial [Fe]-Hydrogenase Paralog HmdII Uses Tetrahydrofolate Derivatives as Substrates.
Angew. Chem. Int. Ed. Engl., 58, 2019
6HUZ
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HMDII FROM DESULFUROBACTERIUM THERMOLITHOTROPHUM RECONSTITUTED WITH FE-GUANYLYLPYRIDINOL (FEGP) COFACTOR AND CO-CRYSTALLIZED WITH METHENYL-TETRAHYDROFOLATE FORM B
Descriptor:Coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase-related protein, iron-guanylyl pyridinol cofactor, 5,10-Methenyltetrahydrofolate, ...
Authors:Watanabe, T., Wagner, T., Huang, G., Kahnt, J., Ataka, K., Ermler, U., Shima, S.
Deposit date:2018-10-09
Release date:2019-01-09
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The Bacterial [Fe]-Hydrogenase Paralog HmdII Uses Tetrahydrofolate Derivatives as Substrates.
Angew. Chem. Int. Ed. Engl., 58, 2019
6JP5
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RABBIT CAV1.1-NIFEDIPINE COMPLEX
Descriptor:Voltage-dependent L-type calcium channel subunit alpha-1S, Voltage-dependent calcium channel gamma-1 subunit, Voltage-dependent calcium channel subunit alpha-2/delta-1, ...
Authors:Zhao, Y., Huang, G., Wu, J., Yan, N.
Deposit date:2019-03-25
Release date:2019-06-12
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+Channel.
Cell, 177, 2019
6JP8
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RABBIT CAV1.1-BAY K8644 COMPLEX
Descriptor:Voltage-dependent calcium channel gamma-1 subunit, Voltage-dependent L-type calcium channel subunit beta-1, Voltage-dependent L-type calcium channel subunit alpha-1S, ...
Authors:Zhao, Y., Huang, G., Wu, J., Yan, N.
Deposit date:2019-03-26
Release date:2019-06-12
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Molecular Basis for Ligand Modulation of a Mammalian Voltage-Gated Ca2+Channel.
Cell, 177, 2019
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