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2NVU
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BU of 2nvu by Molmil
Structure of APPBP1-UBA3~NEDD8-NEDD8-MgATP-Ubc12(C111A), a trapped ubiquitin-like protein activation complex
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Maltose binding protein/NEDD8-activating enzyme E1 catalytic subunit chimera, ...
Authors:Huang, D.T, Hunt, H.W, Zhuang, M, Ohi, M.D, Holton, J.M, Schulman, B.A.
Deposit date:2006-11-13
Release date:2007-01-30
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Basis for a ubiquitin-like protein thioester switch toggling E1-E2 affinity.
Nature, 445, 2007
3FN1
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BU of 3fn1 by Molmil
E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification.
Descriptor: NEDD8-activating enzyme E1 catalytic subunit, NEDD8-conjugating enzyme UBE2F
Authors:Huang, D.T, Ayrault, O, Hunt, H.W, Taherbhoy, A.M, Duda, D.M, Scott, D.C, Borg, L.A, Neale, G, Murray, P.J, Roussel, M.F, Schulman, B.A.
Deposit date:2008-12-22
Release date:2009-03-17
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification
Mol.Cell, 33, 2009
1TT5
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BU of 1tt5 by Molmil
Structure of APPBP1-UBA3-Ubc12N26: a unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8
Descriptor: Ubiquitin-conjugating enzyme E2 M, ZINC ION, amyloid protein-binding protein 1, ...
Authors:Huang, D.T, Miller, D.W, Mathew, R, Cassell, R, Holton, J.M, Roussel, M.F, Schulman, B.A.
Deposit date:2004-06-21
Release date:2004-09-14
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8.
Nat.Struct.Mol.Biol., 11, 2004
1Y8X
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BU of 1y8x by Molmil
Structural basis for recruitment of Ubc12 by an E2-binding domain in NEDD8's E1
Descriptor: Ubiquitin-activating enzyme E1C, Ubiquitin-conjugating enzyme E2 M
Authors:Huang, D.T, Paydar, A, Zhuang, M, Waddell, M.B, Holton, J.M, Schulman, B.A.
Deposit date:2004-12-13
Release date:2005-02-08
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1.
Mol.Cell, 17, 2005
5J3X
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BU of 5j3x by Molmil
Structure of c-CBL Y371F
Descriptor: CALCIUM ION, E3 ubiquitin-protein ligase CBL, ZINC ION
Authors:Huang, D.T, Buetow, L, Dou, H.
Deposit date:2016-03-31
Release date:2016-09-21
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.822 Å)
Cite:Casitas B-lineage lymphoma linker helix mutations found in myeloproliferative neoplasms affect conformation.
Bmc Biol., 14, 2016
4V3L
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BU of 4v3l by Molmil
RNF38-UB-UbcH5B-Ub complex
Descriptor: 1,2-ETHANEDIOL, E3 UBIQUITIN-PROTEIN LIGASE RNF38, POLYUBIQUITIN-C, ...
Authors:Buetow, L, Gabrielsen, M, Anthony, N.G, Dou, H, Patel, A, Aitkenhead, H, Sibbet, G.J, Smith, B.O, Huang, D.T.
Deposit date:2014-10-20
Release date:2015-04-08
Last modified:2019-07-31
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Activation of a Primed Ring E3-E2-Ubiquitin Complex by Non-Covalent Ubiquitin.
Mol.Cell, 58, 2015
4V3K
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BU of 4v3k by Molmil
RNF38-UbcH5B-UB complex
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, E3 UBIQUITIN-PROTEIN LIGASE RNF38, ...
Authors:Buetow, L, Gabrielsen, M, Anthony, N.G, Dou, H, Patel, A, Aitkenhead, H, Sibbet, G.J, Smith, B.O, Huang, D.T.
Deposit date:2014-10-20
Release date:2015-04-08
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Activation of a Primed Ring E3-E2-Ubiquitin Complex by Non-Covalent Ubiquitin.
Mol.Cell, 58, 2015
5O76
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BU of 5o76 by Molmil
Structure of phosphoY371 c-CBL in complex with ZAP70-peptide and UbV.pCBL ubiquitin variant
Descriptor: CALCIUM ION, E3 ubiquitin-protein ligase CBL, Tyrosine protein kinase ZAP70 peptide, ...
Authors:Gabrielsen, M, Buetow, L, Huang, D.T.
Deposit date:2017-06-08
Release date:2017-11-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.473 Å)
Cite:A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68, 2017
5O6T
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BU of 5o6t by Molmil
BIRC4 RING in complex with dimeric ubiquitin variant
Descriptor: 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase XIAP, Polyubiquitin-B, ...
Authors:Gabrielsen, M, Buetow, L, Huang, D.T.
Deposit date:2017-06-07
Release date:2017-11-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68, 2017
5O6S
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BU of 5o6s by Molmil
UbV.B4R, a dimeric ubiquitin variant binding to BIRC4 RING
Descriptor: Polyubiquitin-B
Authors:Gabrielsen, M, Buetow, L, Huang, D.T.
Deposit date:2017-06-07
Release date:2017-11-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68, 2017
5O75
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BU of 5o75 by Molmil
Ube4B U-box domain
Descriptor: SULFATE ION, Ubiquitin conjugation factor E4 B
Authors:Gabrielsen, M, Buetow, L, Nakasone, M.A, Huang, D.T.
Deposit date:2017-06-08
Release date:2017-11-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.483 Å)
Cite:A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68, 2017
2Y1M
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BU of 2y1m by Molmil
Structure of native c-Cbl
Descriptor: CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE, ZINC ION
Authors:Dou, H, Sibbet, G.J, Huang, D.T.
Deposit date:2010-12-08
Release date:2012-01-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl.
Nat.Struct.Mol.Biol., 19, 2012
2Y1N
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BU of 2y1n by Molmil
Structure of c-Cbl-ZAP-70 peptide complex
Descriptor: CALCIUM ION, E3 UBIQUITIN-PROTEIN LIGASE, TYROSINE-PROTEIN KINASE ZAP-70 ZAP-70,70 KDA ZETA-ASSOCIATED PROTEIN, ...
Authors:Dou, H, Sibbet, G.J, Huang, D.T.
Deposit date:2010-12-08
Release date:2012-01-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl.
Nat.Struct.Mol.Biol., 19, 2012
6QK9
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BU of 6qk9 by Molmil
A dimeric ubiquitin formed by a single amino acid substitution
Descriptor: Polyubiquitin-B
Authors:Gabrielsen, M, Kowalczyk, D, Buetow, L, Huang, D.T.
Deposit date:2019-01-28
Release date:2019-07-24
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.231 Å)
Cite:Identification and Characterization of Mutations in Ubiquitin Required for Non-covalent Dimer Formation.
Structure, 27, 2019
6Y5N
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BU of 6y5n by Molmil
RING-DTC domain of Deltex1
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, E3 ubiquitin-protein ligase DTX1, ...
Authors:Gabrielsen, M, Buetow, L, Huang, D.T.
Deposit date:2020-02-25
Release date:2020-09-30
Last modified:2020-10-07
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structural insights into ADP-ribosylation of ubiquitin by Deltex family E3 ubiquitin ligases.
Sci Adv, 6, 2020
6Y2X
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BU of 6y2x by Molmil
RING-DTC domains of Deltex 2, Form 2
Descriptor: Probable E3 ubiquitin-protein ligase DTX2, ZINC ION
Authors:Gabrielsen, M, Buetow, L, Huang, D.T.
Deposit date:2020-02-17
Release date:2020-09-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination.
Sci Adv, 6, 2020
6Y3J
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BU of 6y3j by Molmil
RING-DTC domains of Deltex 2, bound to ADP-ribose
Descriptor: ADENOSINE-5-DIPHOSPHORIBOSE, Probable E3 ubiquitin-protein ligase DTX2, ZINC ION
Authors:Gabrielssen, M, Buetow, L, Huang, D.T.
Deposit date:2020-02-18
Release date:2020-09-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination.
Sci Adv, 6, 2020
6Y5P
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BU of 6y5p by Molmil
RING-DTC domain of Deltex1 bound to NAD
Descriptor: 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase DTX1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Gabrielsen, M, Buetow, L, Huang, D.T.
Deposit date:2020-02-25
Release date:2020-09-30
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structural insights into ADP-ribosylation of ubiquitin by Deltex family E3 ubiquitin ligases.
Sci Adv, 6, 2020
6Y22
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BU of 6y22 by Molmil
RING-DTC domains of Deltex 2, Form 1
Descriptor: Probable E3 ubiquitin-protein ligase DTX2, ZINC ION
Authors:Gabrielssen, M, Buetow, L, Huang, D.T.
Deposit date:2020-02-14
Release date:2020-09-02
Last modified:2020-09-30
Method:X-RAY DIFFRACTION (2.069 Å)
Cite:DELTEX2 C-terminal domain recognizes and recruits ADP-ribosylated proteins for ubiquitination.
Sci Adv, 6, 2020
7OJX
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BU of 7ojx by Molmil
E2 UBE2K covalently linked to donor Ub, acceptor di-Ub, and RING E3 primed for K48-linked Ub chain synthesis
Descriptor: 1,1'-ethane-1,2-diylbis(1H-pyrrole-2,5-dione), E3 ubiquitin-protein ligase RNF38, Polyubiquitin-B, ...
Authors:Majorek, K.A, Nakasone, M.A, Huang, D.T.
Deposit date:2021-05-17
Release date:2022-01-12
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of UBE2K-Ub/E3/polyUb reveals mechanisms of K48-linked Ub chain extension.
Nat.Chem.Biol., 18, 2022
5MNJ
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BU of 5mnj by Molmil
Structure of MDM2-MDMX-UbcH5B-ubiquitin complex
Descriptor: E3 ubiquitin-protein ligase Mdm2, Polyubiquitin-B, Protein Mdm4, ...
Authors:Klejnot, M, Huang, D.T.
Deposit date:2016-12-13
Release date:2017-05-31
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Structural analysis of MDM2 RING separates degradation from regulation of p53 transcription activity.
Nat. Struct. Mol. Biol., 24, 2017
3ONG
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BU of 3ong by Molmil
Crystal structure of UBA2ufd-Ubc9: insights into E1-E2 interactions in Sumo pathways
Descriptor: SUMO-conjugating enzyme UBC9, Ubiquitin-activating enzyme E1-like
Authors:Wang, J, Taherbhoy, A.M, Hunt, H.W, Seyedin, S.N, Miller, D.W, Huang, D.T, Schulman, B.A.
Deposit date:2010-08-28
Release date:2011-01-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of UBA2(ufd)-Ubc9: insights into E1-E2 interactions in Sumo pathways.
Plos One, 5, 2010
3ONH
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BU of 3onh by Molmil
Crystal structure of UBA2ufd-Ubc9: insights into E1-E2 interactions in Sumo pathways
Descriptor: Ubiquitin-activating enzyme E1-like
Authors:Wang, J, Taherbhoy, A.M, Hunt, H.W, Seyedin, S.N, Miller, D.W, Huang, D.T, Schulman, B.A.
Deposit date:2010-08-28
Release date:2011-01-12
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.601 Å)
Cite:Crystal structure of UBA2(ufd)-Ubc9: insights into E1-E2 interactions in Sumo pathways.
Plos One, 5, 2010
6SQO
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BU of 6sqo by Molmil
Crystal structure of human MDM2 RING domain homodimer bound to UbcH5B-Ub
Descriptor: CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, NITRATE ION, ...
Authors:Magnussen, H.M, Ahmed, S.F, Huang, D.T.
Deposit date:2019-09-04
Release date:2020-05-06
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain.
Nat Commun, 11, 2020
6SQS
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BU of 6sqs by Molmil
Crystal structure of cat phospho-Ser429 MDM2 RING domain bound to UbcH5B-Ub
Descriptor: E3 ubiquitin-protein ligase Mdm2, Ubiquitin-40S ribosomal protein S27a, Ubiquitin-conjugating enzyme E2 D2, ...
Authors:Magnussen, H.M, Ahmed, S.F, Huang, D.T.
Deposit date:2019-09-04
Release date:2020-05-06
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain.
Nat Commun, 11, 2020

 

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