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1O0L
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THE STRUCTURE OF BCL-W REVEALS A ROLE FOR THE C-TERMINAL RESIDUES IN MODULATING BIOLOGICAL ACTIVITY
Descriptor:Apoptosis regulator Bcl-W
Authors:Hinds, M.G., Lackmann, M., Skea, G.L., Harrison, P.J., Huang, D.C.S., Day, C.L.
Deposit date:2003-02-22
Release date:2003-04-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity
Embo J., 22, 2003
2JBX
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CRYSTAL STRUCTURE OF THE MYXOMA VIRUS ANTI-APOPTOTIC PROTEIN M11L
Descriptor:M11L PROTEIN
Authors:Kvansakul, M., Van Delft, M.F., Lee, E.F., Gulbis, J.M., Fairlie, W.D., Huang, D.C.S., Colman, P.M.
Deposit date:2006-12-14
Release date:2007-03-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:A Structural Viral Mimic of Prosurvival Bcl-2: A Pivotal Role for Sequestering Proapoptotic Bax and Bak.
Mol.Cell, 25, 2007
2JM6
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SOLUTION STRUCTURE OF MCL-1 COMPLEXED WITH NOXAB
Descriptor:Noxa, Myeloid cell leukemia-1 protein Mcl-1 homolog
Authors:Czabotar, P.E., Lee, E.F., van Delft, M.F., Day, C.L., Smith, B.J., Huang, D.C.S., Fairlie, W.D., Hinds, M.G., Colman, P.M.
Deposit date:2006-10-17
Release date:2007-03-20
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural insights into the degradation of Mcl-1 induced by BH3 domains
Proc.Natl.Acad.Sci.Usa, 104, 2007
2VTY
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VACCINIA VIRUS ANTI-APOPTOTIC F1L IS A NOVEL BCL-2-LIKE DOMAIN SWAPPED DIMER
Descriptor:PROTEIN F1
Authors:Kvansakul, M., Yang, H., Fairlie, W.D., Czabotar, P.E., Fischer, S.F., Perugini, M.A., Huang, D.C.S., Colman, P.M.
Deposit date:2008-05-19
Release date:2008-06-24
Last modified:2012-01-18
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Vaccinia Virus Anti-Apoptotic F1L is a Novel Bcl-2-Like Domain-Swapped Dimer that Binds a Highly Selective Subset of Bh3-Containing Death Ligands.
Cell Death Differ., 15, 2008
2XPX
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CRYSTAL STRUCTURE OF BHRF1:BAK BH3 COMPLEX
Descriptor:APOPTOSIS REGULATOR BHRF1, BCL-2 HOMOLOGOUS ANTAGONIST/KILLER, NITRATE ION, ...
Authors:Kvansakul, M., Huang, D.C.S., Colman, P.M.
Deposit date:2010-08-31
Release date:2011-01-26
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus Bhrf1.
Plos Pathog., 6, 2010
2JBY
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A VIRAL PROTEIN UNEXPECTEDLY MIMICS THE STRUCTURE AND FUNCTION OF PRO- SURVIVAL BCL-2
Descriptor:M11L PROTEIN, BCL-2 HOMOLOGOUS ANTAGONIST/KILLER 2, SODIUM ION
Authors:Kvansakul, M., Van Delft, M.F., Lee, E.F., Gulbis, J.M., Fairlie, W.D., Huang, D.C.S., Colman, P.M.
Deposit date:2006-12-14
Release date:2007-03-27
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak.
Mol. Cell, 25, 2007
2V6Q
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CRYSTAL STRUCTURE OF A BHRF-1 : BIM BH3 COMPLEX
Descriptor:BHRF1 PROTEIN, BCL-2-LIKE PROTEIN 11, BROMIDE ION
Authors:Kvansakul, M., Huang, D.C.S., Colman, P.M.
Deposit date:2007-07-20
Release date:2008-08-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis for Apoptosis Inhibition by Epstein-Barr Virus Bhrf1.
Plos Pathog., 6, 2010
2WH6
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CRYSTAL STRUCTURE OF ANTI-APOPTOTIC BHRF1 IN COMPLEX WITH THE BIM BH3 DOMAIN
Descriptor:EARLY ANTIGEN PROTEIN R, BCL-2-LIKE PROTEIN 11, BROMIDE ION, ...
Authors:Kvansakul, M., Huang, D.C.S., Colman, P.M.
Deposit date:2009-05-01
Release date:2010-05-26
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for apoptosis inhibition by Epstein-Barr virus BHRF1.
PLoS Pathog., 6, 2010
2YQ6
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STRUCTURE OF BCL-XL BOUND TO BIMSAHB
Descriptor:BCL-2-LIKE PROTEIN 1, BIM BETA 5, GLYCEROL
Authors:Smith, B.J., Czabotar, P.E.
Deposit date:2012-11-06
Release date:2012-11-28
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.799 Å)
Cite:Stabilizing the Pro-Apoptotic Bimbh3 Helix (Bimsahb) Does not Necessarily Enhance Affinity or Biological Activity.
Acs Chem.Biol., 8, 2013
2YQ7
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STRUCTURE OF BCL-XL BOUND TO BIMLOCK
Descriptor:BCL-2-LIKE PROTEIN 1, BCL-2-LIKE PROTEIN 11, GLYCEROL
Authors:Smith, B.J., Czabotar, P.E.
Deposit date:2012-11-06
Release date:2012-11-28
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Stabilizing the Pro-Apoptotic Bimbh3 Helix (Bimsahb) Does not Necessarily Enhance Affinity or Biological Activity.
Acs Chem.Biol., 8, 2013
3D7V
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CRYSTAL STRUCTURE OF MCL-1 IN COMPLEX WITH AN MCL-1 SELECTIVE BH3 LIGAND
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, Bcl-2-like protein 11, ZINC ION
Authors:Lee, E.F., Czabotar, P.E., Colman, P.M., Fairlie, W.D.
Deposit date:2008-05-22
Release date:2008-06-24
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation.
J.Cell Biol., 180, 2008
3ZK6
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CRYSTAL STRUCTURE OF BCL-XL IN COMPLEX WITH INHIBITOR (COMPOUND 2).
Descriptor:BCL-2-LIKE PROTEIN 1, N-(3-(5-(1-(2-(benzo[d]thiazol-2-yl)hydrazono)ethyl)furan-2-yl)phenylsulfonyl)-6-phenylhexanamide
Authors:Czabotar, P.E., Lessene, G.L., Smith, B.J., Colman, P.M.
Deposit date:2013-01-22
Release date:2013-04-24
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Structure-Guided Design of a Selective Bcl-Xl Inhibitor
Nat.Chem.Biol., 9, 2013
3ZLN
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CRYSTAL STRUCTURE OF BCL-XL IN COMPLEX WITH INHIBITOR (COMPOUND 3)
Descriptor:BCL-2-LIKE PROTEIN 1, 6-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]pyridine-2-carboxylic acid, SULFATE ION, ...
Authors:Czabotar, P.E., Lessene, G.L., Smith, B.J., Colman, P.M.
Deposit date:2013-02-04
Release date:2013-04-24
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.288 Å)
Cite:Structure-Guided Design of a Selective Bcl-Xl Inhibitor
Nat.Chem.Biol., 9, 2013
3ZLO
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CRYSTAL STRUCTURE OF BCL-XL IN COMPLEX WITH INHIBITOR (COMPOUND 6)
Descriptor:BCL-2-LIKE PROTEIN 1, 2-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]-5-(4-phenylbutyl)-1,3-thiazole-4-carboxylic acid
Authors:Czabotar, P.E., Lessene, G.L., Smith, B.J., Colman, P.M.
Deposit date:2013-02-04
Release date:2013-04-24
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Structure-Guided Design of a Selective Bcl-Xl Inhibitor
Nat.Chem.Biol., 9, 2013
3ZLR
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CRYSTAL STRUCTURE OF BCL-XL IN COMPLEX WITH INHIBITOR (WEHI-539)
Descriptor:BCL-2-LIKE PROTEIN 1, 5-[3-[4-(aminomethyl)phenoxy]propyl]-2-[(8E)-8-(1,3-benzothiazol-2-ylhydrazinylidene)-6,7-dihydro-5H-naphthalen-2-yl]-1,3-thiazole-4-carboxylic acid, 1,2-ETHANEDIOL, ...
Authors:Czabotar, P.E., Lessene, G.L., Smith, B.J., Colman, P.M.
Deposit date:2013-02-04
Release date:2013-04-24
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (2.026 Å)
Cite:Structure-Guided Design of a Selective Bcl-Xl Inhibitor
Nat.Chem.Biol., 9, 2013
4B4S
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CRYSTAL STRUCTURE OF A PRO-SURVIVAL BCL-2:BIM BH3 COMPLEX
Descriptor:BCL-2-LIKE PROTEIN 10, BCL-2-LIKE PROTEIN 11, TETRAETHYLENE GLYCOL
Authors:Rautureau, G.J.P., Hinds, M.G., Kvansakul, M.
Deposit date:2012-08-01
Release date:2013-01-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Restricted Binding Repertoire of Bcl-B Leaves Bim as the Universal Bh3-Only Prosurvival Bcl-2 Protein Antagonist.
Cell Death Dis., 3, 2012
4C52
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CRYSTAL STRUCTURE OF BCL-XL IN COMPLEX WITH BENZOYLUREA COMPOUND (39B)
Descriptor:BCL-2-LIKE PROTEIN 1, (R)-2-(3-(3-((2,4-DIFLUOROPENYL)ETHYNYL)BENZOYL)-3-PROPYLUREIDO)-3-(ISOBUTYLTHIO) PROPANOIC ACID, SULFATE ION, ...
Authors:Roy, M.J., Brady, R.M., Lessene, G., Colman, P.M., Czabotar, P.E.
Deposit date:2013-09-10
Release date:2014-02-05
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (2.049 Å)
Cite:De-Novo Designed Library of Benzoylureas as Inhibitors of Bcl-Xl: Synthesis, Structural and Biochemical Characterization.
J.Med.Chem., 57, 2014
4C5D
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CRYSTAL STRUCTURE OF BCL-XL IN COMPLEX WITH BENZOYLUREA COMPOUND (42)
Descriptor:BCL-2-LIKE PROTEIN 1, (R)-3-(4-BROMOBENZYLTHIO)-2-(3-(3-((2,4-DIFLUOROPHENYL)ETHYNYL)BENZOYL)-3-PROPYLUREIDO)PROPANOIC ACID, SULFATE ION, ...
Authors:Roy, M.J., Brady, R.M., Lessene, G., Colman, P.M., Czabotar, P.E.
Deposit date:2013-09-11
Release date:2014-02-05
Last modified:2014-03-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:De-Novo Designed Library of Benzoylureas as Inhibitors of Bcl-Xl: Synthesis, Structural and Biochemical Characterization.
J.Med.Chem., 57, 2014
5U6V
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X-RAY CRYSTAL STRUCTURE OF 1,2,3-TRIAZOLOBENZODIAZEPINE IN COMPLEX WITH BRD2(D2)
Descriptor:Bromodomain-containing protein 2, 5-[7-(4-chlorophenyl)-1-methyl-6,7-dihydro-5H-[1,2,3]triazolo[1,5-d][1,4]benzodiazepin-9-yl]pyridin-2-amine, 1,2-ETHANEDIOL
Authors:Hatfaludi, T., Sharp, P.P., Garnier, J.-M., Burns, C.J., Czabotar, P.E.
Deposit date:2016-12-09
Release date:2017-12-13
Last modified:2018-01-03
Method:X-RAY DIFFRACTION (1.775 Å)
Cite:Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors.
ACS Med Chem Lett, 8, 2017