Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
3N6R
DownloadVisualize
BU of 3n6r by Molmil
CRYSTAL STRUCTURE OF the holoenzyme of PROPIONYL-COA CARBOXYLASE (PCC)
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, Propionyl-CoA carboxylase, alpha subunit, ...
Authors:Huang, C.S, Sadre-Bazzaz, K, Tong, L.
Deposit date:2010-05-26
Release date:2010-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the alpha(6)beta(6) holoenzyme of propionyl-coenzyme A carboxylase.
Nature, 466, 2010
5WNM
DownloadVisualize
BU of 5wnm by Molmil
Crystal structure of murine receptor-interacting protein 4 (Ripk4) D143N bound to tozasertib (VX-680)
Descriptor: CHLORIDE ION, CYCLOPROPANECARBOXYLIC ACID {4-[4-(4-METHYL-PIPERAZIN-1-YL)-6-(5-METHYL-2H-PYRAZOL-3-YLAMINO)-PYRIMIDIN-2-YLSULFANYL]-PHENYL}-AMIDE, Receptor-interacting serine/threonine-protein kinase 4
Authors:Huang, C.S, Hymowitz, S.G.
Deposit date:2017-08-01
Release date:2018-05-09
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity.
Structure, 26, 2018
6V3F
DownloadVisualize
BU of 6v3f by Molmil
Structure of NPC1-like intracellular cholesterol transporter 1 (NPC1L1)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ...
Authors:Huang, C.S, Yu, X, Min, X, Wang, Z.
Deposit date:2019-11-25
Release date:2020-07-01
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition
Sci Adv, 6, 2020
6V3H
DownloadVisualize
BU of 6v3h by Molmil
Structure of NPC1-like intracellular cholesterol transporter 1 (NPC1L1) in complex with an ezetimibe analog
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(2S,3R)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-1-(4-{3-[(methylsulfonyl)amino]prop-1-yn-1-yl}phenyl)-4-oxoazetidin-2-yl]phenyl beta-D-glucopyranosiduronic acid, ...
Authors:Huang, C.S, Yu, X, Min, X, Wang, Z.
Deposit date:2019-11-25
Release date:2020-07-01
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM structures of NPC1L1 reveal mechanisms of cholesterol transport and ezetimibe inhibition
Sci Adv, 6, 2020
3U9R
DownloadVisualize
BU of 3u9r by Molmil
Crystal structure of P. aeruginosa 3-methylcrotonyl-CoA carboxylase (MCC), beta subunit
Descriptor: Methylcrotonyl-CoA carboxylase, beta-subunit, PENTAETHYLENE GLYCOL, ...
Authors:Huang, C.S, Tong, L.
Deposit date:2011-10-19
Release date:2011-12-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:An unanticipated architecture of the 750-kDa {alpha}6{beta}6 holoenzyme of 3-methylcrotonyl-CoA carboxylase
Nature, 481, 2012
3U9T
DownloadVisualize
BU of 3u9t by Molmil
Crystal structure of P. aeruginosa 3-methylcrotonyl-CoA carboxylase (MCC) 750 kD holoenzyme, free enzyme
Descriptor: Methylcrotonyl-CoA carboxylase, alpha-subunit, beta-subunit
Authors:Huang, C.S, Tong, L.
Deposit date:2011-10-19
Release date:2011-12-14
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:An unanticipated architecture of the 750-kDa {alpha}6{beta}6 holoenzyme of 3-methylcrotonyl-CoA carboxylase
Nature, 481, 2012
3U9S
DownloadVisualize
BU of 3u9s by Molmil
Crystal structure of P. aeruginosa 3-methylcrotonyl-CoA carboxylase (MCC) 750 kD holoenzyme, CoA complex
Descriptor: 5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL, COENZYME A, Methylcrotonyl-CoA carboxylase, ...
Authors:Huang, C.S, Tong, L.
Deposit date:2011-10-19
Release date:2011-12-14
Last modified:2013-01-23
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:An unanticipated architecture of the 750-kDa {alpha}6{beta}6 holoenzyme of 3-methylcrotonyl-CoA carboxylase
Nature, 481, 2012
5WNL
DownloadVisualize
BU of 5wnl by Molmil
Crystal structure of murine receptor-interacting protein 4 (Ripk4) D143N bound to staurosporine
Descriptor: CHLORIDE ION, Receptor-interacting serine/threonine-protein kinase 4, STAUROSPORINE
Authors:Huang, C.S, Hymowitz, S.G.
Deposit date:2017-08-01
Release date:2018-05-09
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity.
Structure, 26, 2018
5WNJ
DownloadVisualize
BU of 5wnj by Molmil
Crystal structure of murine receptor-interacting protein kinase 4 (Ripk4) D143N in complex with lestaurtinib
Descriptor: CHLORIDE ION, Lestaurtinib, Receptor-interacting serine/threonine-protein kinase 4
Authors:Huang, C.S, Hymowitz, S.G.
Deposit date:2017-08-01
Release date:2018-05-09
Last modified:2022-12-07
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity.
Structure, 26, 2018
5WNK
DownloadVisualize
BU of 5wnk by Molmil
Crystal structure of murine receptor-interacting protein 4 (Ripk4) D143N bound to TG100-115
Descriptor: 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol, CHLORIDE ION, Receptor-interacting serine/threonine-protein kinase 4
Authors:Huang, C.S, Hymowitz, S.G.
Deposit date:2017-08-01
Release date:2018-05-09
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity.
Structure, 26, 2018
5WNI
DownloadVisualize
BU of 5wni by Molmil
Crystal structure of murine receptor-interacting protein kinase 4 (Ripk4) D143N in complex with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Huang, C.S, Hymowitz, S.G.
Deposit date:2017-08-01
Release date:2018-05-09
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Crystal Structure of Ripk4 Reveals Dimerization-Dependent Kinase Activity.
Structure, 26, 2018
6PPG
DownloadVisualize
BU of 6ppg by Molmil
Crystal structure of IL17FF bound to Fab fragments of MCAF5352A
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CADMIUM ION, Fab MCAF5352A heavy chain, ...
Authors:Huang, C.S, Yin, J.P, Hymowitz, S.G.
Deposit date:2019-07-06
Release date:2019-12-11
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Dissecting the molecular basis of high viscosity of monospecific and bispecific IgG antibodies.
Mabs, 12
5UQW
DownloadVisualize
BU of 5uqw by Molmil
Crystal structure of human KRAS G12V mutant in complex with GDP
Descriptor: GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Huang, C.S, Kaplan, A, Stockwell, B.R, Tong, L.
Deposit date:2017-02-08
Release date:2017-03-22
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Multivalent Small-Molecule Pan-RAS Inhibitors.
Cell, 168, 2017
5USJ
DownloadVisualize
BU of 5usj by Molmil
Crystal Structure of human KRAS G12D mutant in complex with GDPNP
Descriptor: GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Huang, C.S, Kaplan, A, Stockwell, B.R, Tong, L.
Deposit date:2017-02-13
Release date:2017-03-22
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Multivalent Small-Molecule Pan-RAS Inhibitors.
Cell, 168, 2017
5IKL
DownloadVisualize
BU of 5ikl by Molmil
Crystal structure of P. aeruginosa geranyl-CoA carboxylase (GCC), beta subunit
Descriptor: Geranyl-CoA carboxylase, beta-subunit
Authors:Huang, C.S, Jurado, A.R, Tong, L.
Deposit date:2016-03-03
Release date:2016-04-13
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure and substrate selectivity of the 750-kDa alpha6beta6 holoenzyme of geranyl-CoA carboxylase
Nat Commun, 6, 2015
6NYQ
DownloadVisualize
BU of 6nyq by Molmil
Crystal structure of glycosylated lysosomal membrane protein (GLMP) luminal domain bound to a Fab fragment
Descriptor: 1H3 Fab heavy chain, 1H3 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Huang, C.S, Boenig, G, Hymowitz, S.G.
Deposit date:2019-02-12
Release date:2020-01-22
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:GLMP is essential for bone-marrow hematopoiesis and lysosomal glycolipid metabolism
To Be Published
7JR7
DownloadVisualize
BU of 7jr7 by Molmil
Cryo-EM structure of ABCG5/G8 in complex with Fab 2E10 and 11F4
Descriptor: ATP-binding cassette sub-family G member 5, ATP-binding cassette sub-family G member 8, Fab 11F4 heavy chain, ...
Authors:Huang, C.S, Yu, X, Min, X, Wang, Z, Zhang, H.
Deposit date:2020-08-11
Release date:2021-04-07
Last modified:2021-05-12
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structure of ABCG5/G8 in complex with modulating antibodies
Commun Biol, 4, 2021
3KCW
DownloadVisualize
BU of 3kcw by Molmil
Crystal structure of Ganoderma fungal immunomodulatory protein, GMI
Descriptor: immunomodulatory protein
Authors:Hsu, M.F, Wang, A.H.J, Yang, C.S, Huang, C.T, Hseu, R.S, Lin, C.W, Wu, M.Y, Huang, C.S, Fu, H.Y.
Deposit date:2009-10-22
Release date:2010-11-03
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Single cysteine replacement at Leu6 increase the potent and thermostability in Ganoderma fungal immunomodulatory proteins
To be Published
5MRW
DownloadVisualize
BU of 5mrw by Molmil
Structure of the KdpFABC complex
Descriptor: 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, POTASSIUM ION, Potassium-transporting ATPase ATP-binding subunit, ...
Authors:Huang, C, Pedersen, B.P, Stokes, D.L.
Deposit date:2016-12-27
Release date:2017-06-21
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of the potassium-importing KdpFABC membrane complex.
Nature, 546, 2017
5QTT
DownloadVisualize
BU of 5qtt by Molmil
FACTOR XIA IN COMPLEX WITH THE INHIBITOR methyl [(3R,7S)-7-{[5-amino-1-(3-chloro-2-fluorophenyl)-1H-pyrazole-4-carbonyl]amino}-3-methyl-2-oxo-2,3,4,5,6,7-hexahydro-1H-12,8-(metheno)-1,9-benzodiazacyclotetradecin-15-yl]carbamate
Descriptor: 1,2-ETHANEDIOL, Coagulation factor XI, SULFATE ION, ...
Authors:Sheriff, S.
Deposit date:2019-10-16
Release date:2019-12-25
Last modified:2021-05-12
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Potent, Orally Bioavailable and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups.
J.Med.Chem., 63, 2019
5QTU
DownloadVisualize
BU of 5qtu by Molmil
FACTOR XIA IN COMPLEX WITH THE INHIBITOR methyl [(3R,7S)-7-{[1-(3-chloro-2-fluorophenyl)-5-methyl-1H-imidazole-4-carbonyl]amino}-3-methyl-2-oxo-2,3,4,5,6,7-hexahydro-1H-12,8-(metheno)-1,9-benzodiazacyclotetradecin-15-yl]carbamate
Descriptor: 1,2-ETHANEDIOL, Coagulation factor XI, SULFATE ION, ...
Authors:Sheriff, S.
Deposit date:2019-10-16
Release date:2019-12-25
Last modified:2021-05-12
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Potent, Orally Bioavailable and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups.
J.Med.Chem., 63, 2019
5US4
DownloadVisualize
BU of 5us4 by Molmil
Crystal structure of human KRAS G12D mutant in complex with GDP
Descriptor: GLYCEROL, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Tran, T, Kaplan, A, Stockwell, B.R, Tong, L.
Deposit date:2017-02-13
Release date:2017-03-22
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Multivalent Small-Molecule Pan-RAS Inhibitors.
Cell, 168, 2017
6UMI
DownloadVisualize
BU of 6umi by Molmil
Crystal structure of erenumab Fab-b
Descriptor: erenumab Fab heavy chain, IgG1, erenumab Fab light chain
Authors:Mohr, C.
Deposit date:2019-10-09
Release date:2020-02-12
Last modified:2020-02-26
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular Insight into Recognition of the CGRPR Complex by Migraine Prevention Therapy Aimovig (Erenumab).
Cell Rep, 30, 2020
6UMH
DownloadVisualize
BU of 6umh by Molmil
Crystal structure of erenumab Fab-a
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,3-PROPANDIOL, PHOSPHATE ION, ...
Authors:Mohr, C.
Deposit date:2019-10-09
Release date:2020-02-12
Last modified:2020-02-26
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Molecular Insight into Recognition of the CGRPR Complex by Migraine Prevention Therapy Aimovig (Erenumab).
Cell Rep, 30, 2020
6UMJ
DownloadVisualize
BU of 6umj by Molmil
Crystal structure of erenumab Fab-c
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,3-BUTANEDIOL, erenumab Fab heavy chain, ...
Authors:Mohr, C.
Deposit date:2019-10-09
Release date:2020-02-12
Last modified:2020-02-26
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular Insight into Recognition of the CGRPR Complex by Migraine Prevention Therapy Aimovig (Erenumab).
Cell Rep, 30, 2020

 

12>

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon