Author results

1EV7
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CRYSTAL STRUCTURE OF DNA RESTRICTION ENDONUCLEASE NAEI
Descriptor:TYPE IIE RESTRICTION ENDONUCLEASE NAEI
Authors:Huai, Q., Colandene, J.D., Chen, Y., Luo, F., Zhao, Y.
Deposit date:2000-04-19
Release date:2000-10-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Crystal structure of NaeI-an evolutionary bridge between DNA endonuclease and topoisomerase.
EMBO J., 19, 2000
1IAW
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CRYSTAL STRUCTURE OF NAEI COMPLEXED WITH 17MER DNA
Descriptor:5'-D(*TP*GP*CP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*TP*GP*GP*C)-3', TYPE II RESTRICTION ENZYME NAEI
Authors:Huai, Q., Colandene, J.D., Topal, M.D., Ke, H.
Deposit date:2001-03-23
Release date:2001-08-03
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of NaeI-DNA complex reveals dual-mode DNA recognition and complete dimer rearrangement.
Nat.Struct.Biol., 8, 2001
1IAX
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CRYSTAL STRUCTURE OF ACC SYNTHASE COMPLEXED WITH PLP
Descriptor:1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE 2, SULFATE ION, PYRIDOXAL-5'-PHOSPHATE
Authors:Huai, Q., Xia, Y., Chen, Y., Callahan, B., Li, N., Ke, H.
Deposit date:2001-03-24
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of 1-aminocyclopropane-1-carboxylate (ACC) synthase in complex with aminoethoxyvinylglycine and pyridoxal-5'-phosphate provide new insight into catalytic mechanisms
J.Biol.Chem., 276, 2001
1IAY
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CRYSTAL STRUCTURE OF ACC SYNTHASE COMPLEXED WITH COFACTOR PLP AND INHIBITOR AVG
Descriptor:1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE 2, PYRIDOXAL-5'-PHOSPHATE, 2-AMINO-4-(2-AMINO-ETHOXY)-BUTYRIC ACID
Authors:Huai, Q., Xia, Y., Chen, Y., Callahan, B., Li, N., Ke, H.
Deposit date:2001-03-24
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of 1-aminocyclopropane-1-carboxylate (ACC) synthase in complex with aminoethoxyvinylglycine and pyridoxal-5'-phosphate provide new insight into catalytic mechanisms
J.Biol.Chem., 276, 2001
1M63
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CRYSTAL STRUCTURE OF CALCINEURIN-CYCLOPHILIN-CYCLOSPORIN SHOWS COMMON BUT DISTINCT RECOGNITION OF IMMUNOPHILIN-DRUG COMPLEXES
Descriptor:SERINE/THREONINE PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT, ALPHA ISOFORM, CALCINEURIN B SUBUNIT ISOFORM 1, ...
Authors:Huai, Q., Kim, H.-Y., Liu, Y., Zhao, Y., Mondragon, A., Liu, J.O., Ke, H.
Deposit date:2002-07-12
Release date:2002-09-25
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of Calcineurin-Cyclophilin-Cyclosporin Shows Common But Distinct Recognition of Immunophilin-Drug Complexes
Proc.Natl.Acad.Sci.USA, 99, 2002
1OYN
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CRYSTAL STRUCTURE OF PDE4D2 IN COMPLEX WITH (R,S)-ROLIPRAM
Descriptor:cAMP-specific phosphodiesterase PDE4D2, ZINC ION, ROLIPRAM
Authors:Huai, Q., Wang, H., Sun, Y., Kim, H.Y., Liu, Y., Ke, H.
Deposit date:2003-04-05
Release date:2003-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Three-dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity
Structure, 11, 2003
1PTW
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THE CRYSTAL STRUCTURE OF AMP-BOUND PDE4 SUGGESTS A MECHANISM FOR PHOSPHODIESTERASE CATALYSIS
Descriptor:cAMP-specific phosphodiesterase PDE4D2, ZINC ION, ADENOSINE MONOPHOSPHATE
Authors:Huai, Q., Colicelli, J., Ke, H.
Deposit date:2003-06-23
Release date:2003-11-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structure of AMP-bound PDE4 suggests a mechanism for phosphodiesterase catalysis
Biochemistry, 42, 2003
1Q2U
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CRYSTAL STRUCTURE OF DJ-1/RS AND IMPLICATION ON FAMILIAL PARKINSON'S DISEASE
Descriptor:RNA-binding protein regulatory subunit
Authors:Huai, Q., Sun, Y., Wang, H., Chin, L.S., Li, L., Robinson, H., Ke, H.
Deposit date:2003-07-26
Release date:2003-10-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of DJ-1/RS and implication on familial Parkinson's disease
Febs Lett., 549, 2003
1Q9M
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THREE DIMENSIONAL STRUCTURES OF PDE4D IN COMPLEX WITH ROLIPRAMS AND IMPLICATION ON INHIBITOR SELECTIVITY
Descriptor:cAMP-specific phosphodiesterase PDE4D2, ZINC ION, ROLIPRAM
Authors:Huai, Q., Wang, H., Sun, Y., Kim, H.Y., Liu, Y., Ke, H.
Deposit date:2003-08-25
Release date:2003-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Three dimensional structures of PDE4D in complex with roliprams and implication on inhibitor selectivity
Structure, 11, 2003
1RKP
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CRYSTAL STRUCTURE OF PDE5A1-IBMX
Descriptor:cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ...
Authors:Huai, Q., Liu, Y., Francis, S.H., Corbin, J.D., Ke, H.
Deposit date:2003-11-22
Release date:2004-03-30
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor IBMX suggest a conformation determinant of inhibitor selectivity
J.Biol.Chem., 279, 2004
1Y4S
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CONFORMATION REARRANGEMENT OF HEAT SHOCK PROTEIN 90 UPON ADP BINDING
Descriptor:Chaperone protein htpG, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE
Authors:Huai, Q., Wang, H., Liu, Y., Kim, H., Toft, D., Ke, H.
Deposit date:2004-12-01
Release date:2005-04-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of the N-terminal and middle domains of E. coli Hsp90 and conformation changes upon ADP binding.
Structure, 13, 2005
1Y4U
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CONFORMATION REARRANGEMENT OF HEAT SHOCK PROTEIN 90 UPON ADP BINDING
Descriptor:Chaperone protein htpG
Authors:Huai, Q., Wang, H., Liu, Y., Kim, H., Toft, D., Ke, H.
Deposit date:2004-12-01
Release date:2005-04-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structures of the N-terminal and middle domains of E. coli Hsp90 and conformation changes upon ADP binding.
Structure, 13, 2005
1ZKN
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STRUCTURE OF PDE4D2-IBMX
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Huai, Q., Liu, Y., Francis, S.H., Corbin, J.D., Ke, H.
Deposit date:2005-05-03
Release date:2005-05-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of Phosphodiesterases 4 and 5 in Complex with Inhibitor 3-Isobutyl-1-Methylxanthine Suggest a Conformation Determinant of Inhibitor Selectivity
J.Biol.Chem., 279, 2004
2FM0
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CRYSTAL STRUCTURE OF PDE4D IN COMPLEX WITH L-869298
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Huai, Q., Sun, Y., Wang, H., Macdonald, D., Aspiotis, R., Robinson, H., Huang, Z., Ke, H.
Deposit date:2006-01-06
Release date:2006-03-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Enantiomer Discrimination Illustrated by the High Resolution Crystal Structures of Type 4 Phosphodiesterase
J.Med.Chem., 49, 2006
2FM5
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CRYSTAL STRUCTURE OF PDE4D2 IN COMPLEX WITH INHIBITOR L-869299
Descriptor:cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ...
Authors:Huai, Q., Sun, Y., Wang, H., Macdonald, D., Aspiotis, R., Robinson, H., Huang, Z., Ke, H.
Deposit date:2006-01-07
Release date:2006-03-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Enantiomer Discrimination Illustrated by the High Resolution Crystal Structures of Type 4 Phosphodiesterase
J.Med.Chem., 49, 2006
2HD1
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CRYSTAL STRUCTURE OF PDE9 IN COMPLEX WITH IBMX
Descriptor:Phosphodiesterase 9A, ZINC ION, MAGNESIUM ION, ...
Authors:Huai, Q., Wang, H., Zhang, W., Colman, R.W., Robinson, H., Ke, H.
Deposit date:2006-06-19
Release date:2006-06-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Crystal structure of phosphodiesterase 9 shows orientation variation of inhibitor IBMX binding
Proc.Natl.Acad.Sci.USA, 101, 2004
2FD6
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STRUCTURE OF HUMAN UROKINASE PLASMINOGEN ACTIVATOR IN COMPLEX WITH UROKINASE RECEPTOR AND AN ANTI-UPAR ANTIBODY AT 1.9 A
Descriptor:Urokinase-type plasminogen activator, L chain of Fab of ATN-615 anti-uPAR antibody, H chain of Fab of ATN-615 anti-uPAR antibody, ...
Authors:Huang, M., Huai, Q., Li, Y.
Deposit date:2005-12-13
Release date:2006-02-21
Last modified:2012-07-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of human urokinase plasminogen activator in complex with its receptor
Science, 311, 2006
2H40
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF UNLIGANDED PDE5
Descriptor:cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION
Authors:Wang, H., Liu, Y., Huai, Q., Cai, J., Zoraghi, R., Francis, S.H., Corbin, J.D., Robinson, H., Xin, Z., Lin, G., Ke, H.
Deposit date:2006-05-23
Release date:2006-06-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development
J.Biol.Chem., 281, 2006
3BT1
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STRUCTURE OF UROKINASE RECEPTOR, UROKINASE AND VITRONECTIN COMPLEX
Descriptor:Urokinase-type plasminogen activator, Vitronectin, Urokinase plasminogen activator surface receptor, ...
Authors:Huang, M.
Deposit date:2007-12-27
Release date:2008-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes
Nat.Struct.Mol.Biol., 15, 2008
3BT2
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STRUCTURE OF UROKINASE RECEPTOR, UROKINASE AND VITRONECTIN COMPLEX
Descriptor:Urokinase-type plasminogen activator, Vitronectin, anti-uPAR antibody, ...
Authors:Huang, M.
Deposit date:2007-12-27
Release date:2008-03-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes
Nat.Struct.Mol.Biol., 15, 2008
2H42
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CRYSTAL STRUCTURE OF PDE5 IN COMPLEX WITH SILDENAFIL
Descriptor:cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ...
Authors:Wang, H., Ke, H.
Deposit date:2006-05-23
Release date:2006-06-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development
J.Biol.Chem., 281, 2006
2H44
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CRYSTAL STRUCTURE OF PDE5A1 IN COMPLEX WITH ICARISID II
Descriptor:cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ...
Authors:Wang, H., Ke, H.
Deposit date:2006-05-23
Release date:2006-06-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Multiple Conformations of Phosphodiesterase-5: Implications for enzyme function and drug development
J.Biol.Chem., 281, 2006
2PQS
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CRYSTAL STRUCTURE OF THE BOVINE LACTADHERIN C2 DOMAIN
Descriptor:Lactadherin
Authors:Huang, M., Furie, B.C.
Deposit date:2007-05-02
Release date:2007-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the bovine lactadherin C2 domain, a membrane binding motif, shows similarity to the C2 domains of factor V and factor VIII.
J.Mol.Biol., 371, 2007
3LAQ
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STRUCTURE-BASED ENGINEERING OF SPECIES SELECTIVITY IN THE UPA-UPAR INTERACTION
Descriptor:Urokinase-type plasminogen activator, Urokinase plasminogen activator surface receptor, N-ACETYL-D-GLUCOSAMINE
Authors:Huang, M.
Deposit date:2010-01-06
Release date:2010-02-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure-based engineering of species selectivity in the interaction between urokinase and its receptor: implication for preclinical cancer therapy.
J.Biol.Chem., 285, 2010