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3V19
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FORESTALLING INSULIN FIBRILLATION BY INSERTION OF A CHIRAL CLAMP MECHANISM-BASED APPLICATION OF PROTEIN ENGINEERING TO GLOBAL HEALTH
Descriptor:Insulin, ZINC ION, CHLORIDE ION, ...
Authors:Wan, Z.L., Hua, Q.X., Wickramasinghe, N.P., Huang, K., Petkova, A.T., Hu, S.Q., Phillips, N.B., Yeh, I.J., Whittake, J., Ismail-Beigi, F., Katsoyyannis, P.G., Tycko, R., Weiss, M.A.
Deposit date:2011-12-09
Release date:2012-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published
3V1G
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FORESTALLING INSULIN FIBRILLATION BY INSERTION OF A CHIRAL CLAMP MECHANISM-BASED APPLICATION OF PROTEIN ENGINEERING TO GLOBAL HEALTH
Descriptor:Insulin, ZINC ION, PHENOL, ...
Authors:Wan, Z.L., Hua, Q.X., Wickramasinghe, N.P., Huang, K., Petkova, A.T., Hu, S.Q., Phillips, N.B., Yeh, I.J., Whittake, J., Ismail-Beigi, F., Katsoyyannis, P.G., Tycko, R., Weiss, M.A.
Deposit date:2011-12-09
Release date:2012-12-12
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Forestalling insulin fibrillation by insertion of a chiral clamp mechanism-based application of protein engineering to global health
To be Published
3ROV
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INSULIN'S BIOSYNTHESIS AND ACTIVITY HAVE OPPOSING STRUCTURAL REQUIREMENTS: A NEW FACTOR IN NEONATAL DIABETES MELLITUS
Descriptor:Insulin, PHENOL, ZINC ION, ...
Authors:Weiss, M.A., Wan, Z.L., Dodson, E.J., Liu, M., Xu, B., Hua, Q.X., Turkenburg, M., Whittingham, J., Nakagawa, S.H., Huang, K., Hu, S.Q., Jia, W.H., Wang, S.H., Brange, J., Whittaker, J., Arvan, P., Katsoyannis, P.G., Dodson, G.G.
Deposit date:2011-04-26
Release date:2012-05-02
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
3P2X
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INSULIN FIBRILLATION IS THE JANUS FACE OF INDUCED FIT. A CHIARAL CLAMP STABILIZES THE NATIVE STATE AT THE EXPENSE OF ACTIVITY
Descriptor:Insulin, ZINC ION, CHLORIDE ION, ...
Authors:Hua, Q.X., Wan, Z.L., Huang, K., Hu, S.Q., Phillip, N.F., Jia, W.H., Whittingham, J., Dodson, G.G., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2010-10-04
Release date:2011-11-23
Last modified:2014-10-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
3P33
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INSULIN FIBRILLATION IS THE JANUS FACE OF INDUCED FIT. A CHIRAL CLAMP STABILIZES THE NATIVE STATE AT THE EXPENSE OF ACTIVITY
Descriptor:Insulin, PHENOL, ZINC ION, ...
Authors:Hua, Q.X., Wan, Z.L., Huang, K., Hu, S.Q., Phillip, N.F., Jia, W.H., Whittingham, J., Dodson, G.G., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2010-10-04
Release date:2011-11-23
Last modified:2014-10-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
2L1Y
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NMR STRUCTURE OF HUMAN INSULIN MUTANT GLY-B20-D-ALA, GLY-B23-D-ALA PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES
Descriptor:Insulin A chain, Insulin B chain
Authors:Wan, Z.L., Hua, Q.X., Huang, K., Hu, S.Q., Philips, N.B., Katsoyannis, J.W., Weiss, M.A.
Deposit date:2010-08-09
Release date:2011-08-31
Method:SOLUTION NMR
Cite:Chiral Protein Engineering and its Application in G Health
To be Published
2L1Z
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NMR STRUCTURE OF HUMAN INSULIN MUTANT GLY-B20-D-ALA, GLY-B23-D-ALA PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES
Descriptor:Insulin A chain, Insulin B chain
Authors:Wan, Z.L., Hua, Q.X., Huang, K., Hu, S.Q., Philips, N.B., Katsoyannis, J.W., Weiss, M.A.
Deposit date:2010-08-09
Release date:2011-08-31
Method:SOLUTION NMR
Cite:Chiral Protein Engineering and its Application in G Health
To be Published
3KQ6
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ENHANCING THE THERAPEUTIC PROPERTIES OF A PROTEIN BY A DESIGNED ZINC-BINDING SITE, STRUCTURAL PRINCIPLES OF A NOVEL LONG-ACTING INSULIN ANALOG
Descriptor:Insulin A chain, Insulin B chain, ZINC ION, ...
Authors:Wan, Z.L., Hu, S.Q., Whittaker, L., Phillips, N.B., Whittake, J., Ismail-Beigi, F., Weiss, M.A.
Deposit date:2009-11-17
Release date:2010-02-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Supramolecular protein engineering: design of zinc-stapled insulin hexamers as a long acting depot.
J.Biol.Chem., 285, 2010
2KQQ
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NMR STRUCTURE OF HUMAN INSULIN MUTANT GLY-B8-D-ALA, HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES
Descriptor:Insulin B chain, Insulin A chain
Authors:Hua, Q.X., Wan, Z.L., Zhao, M., Jia, W., Huang, K., Weiss, M.A.
Deposit date:2009-11-13
Release date:2010-11-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and Dynamics of an Turn-Stabilize But Ina Insulin Analog.
To be Published
2KQP
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NMR STRUCTURE OF PROINSULIN
Descriptor:Insulin
Authors:Yang, Y., Hua, Q.X., Mackin, R.B., Weiss, M.A.
Deposit date:2009-11-12
Release date:2010-01-26
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of proinsulin: connecting domain flexibility and prohormone processing.
J.Biol.Chem., 285, 2010
3JSD
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INSULIN'S BIOSYNTHESIS AND ACTIVITY HAVE OPPOSING STRUCTURAL REQUIREMENTS: A NEW FACTOR IN NEONATAL DIABETES MELLITUS
Descriptor:Insulin A chain, Insulin B chain, ZINC ION, ...
Authors:Weiss, M.A., Wan, Z.L., Dodson, E.J., Liu, M., Xu, B., Hua, Q.X., Turkenburg, M., Whittingham, J., Nakagawa, S.H., Huang, K., Hu, S.Q., Jia, W.H., Wang, S.H., Brange, J., Whittaker, J., Arvan, P., Katsoyannis, P.G., Dodson, G.G.
Deposit date:2009-09-10
Release date:2010-09-15
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
2KJU
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NMR STRUCTURE OF HUMAN INSULIN MUTANT GLU-B21-D-GLU, HIS-B10 ASP PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES
Descriptor:Insulin
Authors:Hua, Q.X., Huang, K., Hu, S.Q., Katsoyanni, P., Weiss, M.A.
Deposit date:2009-06-10
Release date:2010-06-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Acceleration of Protein Fibrillation by Chiral Destabilization of Beta-Turn
To be Published
2KJJ
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DYNAMICS OF INSULIN PROBED BY 1H-NMR AMIDE PROTON EXCHANGE ANOMALOUS FLEXIBILITY OF THE RECEPTOR-BINDING SURFACE
Descriptor:Insulin
Authors:Hua, Q.X., Weiss, M.A.
Deposit date:2009-05-29
Release date:2010-06-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Dynamics of Insulin Probed by 1H-NMR Amide Proton E Anomalous Flexibility of the Receptor-Binding Surfa
To be Published
2KJI
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A DIVERGENT INS PROTEIN IN C. ELEGANS STRUCTURALLY RESEMBLE INSULIN AND ACTIVATES THE HUMAN INSULIN RECEPTOR
Descriptor:Probable insulin-like peptide beta-type 5
Authors:Hua, Q.X., Nakarawa, S.H., Wilken, R., Ramos, R.R., Jia, W.H., Bass, J., Weiss, M.A.
Deposit date:2009-05-28
Release date:2009-06-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Insulin worms its way into the spotlight.
Genes Dev., 17, 2003
3GKY
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THE STRUCTURAL BASIS OF AN ER STRESS-ASSOCIATED BOTTLENECK IN A PROTEIN FOLDING LANDSCAPE
Descriptor:Insulin A chain, Insulin B chain, ZINC ION, ...
Authors:Liu, M., Wan, Z.L., Chu, Y.C., Alddin, H., Klaproth, B., Weiss, M.A.
Deposit date:2009-03-11
Release date:2009-03-24
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of a "nonfoldable" insulin: IMPAIRED FOLDING EFFICIENCY DESPITE NATIVE ACTIVITY.
J.Biol.Chem., 284, 2009
2K9R
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ENHANCING THE ACTIVITY OF INSULIN BY STEREOSPECIFIC UNFOLDING
Descriptor:Insulin
Authors:Hua, Q.X., Xu, B., Huang, K., Hu, S.Q., Nakarawa, S., Jia, W.H., Philips, N.F.P., Wittaker, L., Wittaker, J., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2008-10-23
Release date:2008-11-11
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS.
J.Biol.Chem., 284, 2009
2K91
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ENHANCING THE ACTIVITY OF INSULIN BY STEREOSPECIFIC UNFOLDING
Descriptor:Insulin
Authors:Hua, Q.X., Xu, B., Huang, K., Hu, S.Q., Nakarawa, S., Jia, W.H., Philips, N.F.P., Wittaker, L., Wittaker, J., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2008-09-29
Release date:2008-11-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS.
J.Biol.Chem., 284, 2009
3BXQ
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THE STRUCTURE OF A MUTANT INSULIN UNCOUPLES RECEPTOR BINDING FROM PROTEIN ALLOSTERY. AN ELECTROSTATIC BLOCK TO THE TR TRANSITION
Descriptor:insulin A chain, insulin B chain, ZINC ION
Authors:Wan, Z.L., Huang, K., Hu, S.Q., Whittaker, J., Weiss, M.A.
Deposit date:2008-01-14
Release date:2008-05-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications.
J.Biol.Chem., 283, 2008
2JZQ
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DESIGN OF AN ACTIVE ULTRA-STABLE SINGLE-CHAIN INSULIN ANALOG 20 STRUCTURES
Descriptor:Insulin
Authors:Hua, Q.X., Nakarawa, S., Jia, W.H., Huang, K., Philips, N.F., Hu, S.Q., Weiss, M.A.
Deposit date:2008-01-11
Release date:2008-02-26
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications.
J.Biol.Chem., 283, 2008
2JUV
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ABAA3-DKP-INSULIN
Descriptor:Insulin A chain, Insulin B chain
Authors:Huang, K., Chan, S., Hua, Q., Chu, Y., Wang, R., Klaproth, B., Jia, W., Whittaker, J., De Meyts, P., Nakagawa, S.H., Steiner, D.F., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2007-09-05
Release date:2007-10-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE.
J.Biol.Chem., 282, 2007
2JUU
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ALLO-THRA3 DKP-INSULIN
Descriptor:Insulin A chain, Insulin B chain
Authors:Huang, K., Chan, S., Hua, Q., Chu, Y., Wang, R., Klaproth, B., Jia, W., Whittaker, J., De Meyts, P., Nakagawa, S.H., Steiner, D.F., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2007-09-03
Release date:2007-10-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE.
J.Biol.Chem., 282, 2007
2JUM
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THRA3-DKP-INSULIN
Descriptor:Insulin A chain, Insulin B chain
Authors:Huang, K., Chan, S., Hua, Q., Chu, Y., Wang, R., Klaproth, B., Jia, W., Whittaker, J., De Meyts, P., Nakagawa, S.H., Steiner, D.F., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2007-08-31
Release date:2007-10-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE.
J.Biol.Chem., 282, 2007
2JMN
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NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES
Descriptor:Insulin A chain, Insulin B chain
Authors:Hua, Q.X., Hu, S.Q., Frank, B.H., Jia, W.H., Chu, Y.C., Wang, S.H., Burke, G.T., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2006-11-21
Release date:2006-12-05
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue.
J.Mol.Biol., 264, 1996
2HHO
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NMR STRUCTURE OF HUMAN INSULIN MUTANT GLY-B8-SER, HIS-B10-ASP PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES
Descriptor:Insulin A chain, Insulin B chain
Authors:Hua, Q.X., Nakagawa, S., Hu, S.Q., Jia, W., Weiss, M.A.
Deposit date:2006-06-28
Release date:2006-07-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Toward the Active Conformation of Insulin: Stereospecific modulation of a structural switch in the B chain.
J.Biol.Chem., 281, 2006
2HH4
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NMR STRUCTURE OF HUMAN INSULIN MUTANT GLY-B8-D-SER, HIS-B10-ASP PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES
Descriptor:insulin A chain, insulin B chain
Authors:Hua, Q.X., Nakagawa, S., Hu, S.Q., Jia, W., Weiss, M.A.
Deposit date:2006-06-27
Release date:2006-07-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Toward the Active Conformation of Insulin: Stereospecific modulation of a structural switch in the B chain.
J.Biol.Chem., 281, 2006
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