Author results

1HIQ
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PARADOXICAL STRUCTURE AND FUNCTION IN A MUTANT HUMAN INSULIN ASSOCIATED WITH DIABETES MELLITUS
Descriptor:INSULIN
Authors:Hua, Q.X., Shoelson, S.E., Inouye, K., Weiss, M.A.
Deposit date:1993-03-05
Release date:1994-01-31
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Paradoxical structure and function in a mutant human insulin associated with diabetes mellitus.
Proc.Natl.Acad.Sci.USA, 90, 1993
1HIS
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STRUCTURE AND DYNAMICS OF DES-PENTAPEPTIDE-INSULIN IN SOLUTION: THE MOLTEN-GLOBULE HYPOTHESIS.
Descriptor:INSULIN
Authors:Hua, Q.X., Kochoyan, M., Weiss, M.A.
Deposit date:1992-02-28
Release date:1994-01-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and dynamics of des-pentapeptide-insulin in solution: the molten-globule hypothesis.
Proc.Natl.Acad.Sci.USA, 89, 1992
1XGL
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HUMAN INSULIN DISULFIDE ISOMER, NMR, 10 STRUCTURES
Descriptor:INSULIN
Authors:Hua, Q.X., Gozani, S.N., Chance, R.E., Hoffmann, J.A., Frank, B.H., Weiss, M.A.
Deposit date:1996-10-10
Release date:1997-04-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of a protein in a kinetic trap.
Nat.Struct.Biol., 2, 1995
2HIU
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NMR STRUCTURE OF HUMAN INSULIN IN 20% ACETIC ACID, ZINC-FREE, 10 STRUCTURES
Descriptor:INSULIN
Authors:Hua, Q.X., Gozani, S.N., Chance, R.E., Hoffmann, J.A., Frank, B.H., Weiss, M.A.
Deposit date:1996-10-08
Release date:1997-04-01
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Structure of a protein in a kinetic trap.
Nat.Struct.Biol., 2, 1995
1HIT
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RECEPTOR BINDING REDEFINED BY A STRUCTURAL SWITCH IN A MUTANT HUMAN INSULIN
Descriptor:INSULIN
Authors:Hua, Q.X., Kochoyan, M., Weiss, M.A.
Deposit date:1992-02-28
Release date:1994-01-31
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Receptor binding redefined by a structural switch in a mutant human insulin.
Nature, 354, 1991
1SJT
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MINI-PROINSULIN, TWO CHAIN INSULIN ANALOG MUTANT: DES B30, HIS(B 10)ASP, PRO(B 28)ASP, NMR, 20 STRUCTURES
Descriptor:PROINSULIN
Authors:Hua, Q.X., Hu, S.Q., Jia, W.H., Chu, Y.C., Burke, G.T., Wang, S.H., Katsoyannis, P.G., Weiss, M.A.
Deposit date:1997-10-09
Release date:1998-03-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Mini-proinsulin and mini-IGF-I: homologous protein sequences encoding non-homologous structures.
J.Mol.Biol., 277, 1998
1SJU
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MINI-PROINSULIN, SINGLE CHAIN INSULIN ANALOG MUTANT: DES B30, HIS(B 10)ASP, PRO(B 28)ASP AND PEPTIDE BOND BETWEEN LYS B 29 AND GLY A 1, NMR, 20 STRUCTURES
Descriptor:PROINSULIN
Authors:Hua, Q.X., Hu, S.Q., Jia, W.H., Chu, Y.C., Burke, G.T., Wang, S.H., Katsoyannis, P.G., Weiss, M.A.
Deposit date:1997-10-09
Release date:1998-03-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Mini-proinsulin and mini-IGF-I: homologous protein sequences encoding non-homologous structures.
J.Mol.Biol., 277, 1998
1VKT
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HUMAN INSULIN TWO DISULFIDE MODEL, NMR, 10 STRUCTURES
Descriptor:INSULIN
Authors:Hua, Q.X., Hu, S.Q., Frank, B.H., Jia, W.H., Chu, Y.C., Wang, S.H., Burke, G.T., Katsoyannis, P.G., Weiss, M.A.
Deposit date:1996-10-14
Release date:1997-04-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue.
J.Mol.Biol., 264, 1996
2H67
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NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B5-ALA, HIS-B10-ASP PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES
Descriptor:Insulin A chain, Insulin B chain
Authors:Hua, Q.X., Liu, M., Hu, S.Q., Jia, W., Arvan, P., Weiss, M.A.
Deposit date:2006-05-30
Release date:2006-07-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A Conserved Histidine in Insulin Is Required for the Foldability of Human Proinsulin: Structure and function of an Alab5 analog.
J.Biol.Chem., 281, 2006
2HH4
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NMR STRUCTURE OF HUMAN INSULIN MUTANT GLY-B8-D-SER, HIS-B10-ASP PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES
Descriptor:insulin A chain, insulin B chain
Authors:Hua, Q.X., Nakagawa, S., Hu, S.Q., Jia, W., Weiss, M.A.
Deposit date:2006-06-27
Release date:2006-07-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Toward the Active Conformation of Insulin: Stereospecific modulation of a structural switch in the B chain.
J.Biol.Chem., 281, 2006
2HHO
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NMR STRUCTURE OF HUMAN INSULIN MUTANT GLY-B8-SER, HIS-B10-ASP PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES
Descriptor:Insulin A chain, Insulin B chain
Authors:Hua, Q.X., Nakagawa, S., Hu, S.Q., Jia, W., Weiss, M.A.
Deposit date:2006-06-28
Release date:2006-07-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Toward the Active Conformation of Insulin: Stereospecific modulation of a structural switch in the B chain.
J.Biol.Chem., 281, 2006
2JMN
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NMR STRUCTURE OF HUMAN INSULIN MUTANT HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES
Descriptor:Insulin A chain, Insulin B chain
Authors:Hua, Q.X., Hu, S.Q., Frank, B.H., Jia, W.H., Chu, Y.C., Wang, S.H., Burke, G.T., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2006-11-21
Release date:2006-12-05
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue.
J.Mol.Biol., 264, 1996
2JZQ
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DESIGN OF AN ACTIVE ULTRA-STABLE SINGLE-CHAIN INSULIN ANALOG 20 STRUCTURES
Descriptor:Insulin
Authors:Hua, Q.X., Nakarawa, S., Jia, W.H., Huang, K., Philips, N.F., Hu, S.Q., Weiss, M.A.
Deposit date:2008-01-11
Release date:2008-02-26
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications.
J.Biol.Chem., 283, 2008
2K91
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ENHANCING THE ACTIVITY OF INSULIN BY STEREOSPECIFIC UNFOLDING
Descriptor:Insulin
Authors:Hua, Q.X., Xu, B., Huang, K., Hu, S.Q., Nakarawa, S., Jia, W.H., Philips, N.F.P., Wittaker, L., Wittaker, J., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2008-09-29
Release date:2008-11-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS.
J.Biol.Chem., 284, 2009
2K9R
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ENHANCING THE ACTIVITY OF INSULIN BY STEREOSPECIFIC UNFOLDING
Descriptor:Insulin
Authors:Hua, Q.X., Xu, B., Huang, K., Hu, S.Q., Nakarawa, S., Jia, W.H., Philips, N.F.P., Wittaker, L., Wittaker, J., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2008-10-23
Release date:2008-11-11
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS.
J.Biol.Chem., 284, 2009
2KJI
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A DIVERGENT INS PROTEIN IN C. ELEGANS STRUCTURALLY RESEMBLE INSULIN AND ACTIVATES THE HUMAN INSULIN RECEPTOR
Descriptor:Probable insulin-like peptide beta-type 5
Authors:Hua, Q.X., Nakarawa, S.H., Wilken, R., Ramos, R.R., Jia, W.H., Bass, J., Weiss, M.A.
Deposit date:2009-05-28
Release date:2009-06-16
Last modified:2019-09-18
Method:SOLUTION NMR
Cite:A divergent INS protein in Caenorhabditis elegans structurally resembles human insulin and activates the human insulin receptor.
Genes Dev., 17, 2003
2KJJ
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DYNAMICS OF INSULIN PROBED BY 1H-NMR AMIDE PROTON EXCHANGE ANOMALOUS FLEXIBILITY OF THE RECEPTOR-BINDING SURFACE
Descriptor:Insulin
Authors:Hua, Q.X., Weiss, M.A.
Deposit date:2009-05-29
Release date:2010-06-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Dynamics of Insulin Probed by 1H-NMR Amide Proton E Anomalous Flexibility of the Receptor-Binding Surfa
To be Published
2KJU
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NMR STRUCTURE OF HUMAN INSULIN MUTANT GLU-B21-D-GLU, HIS-B10 ASP PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES
Descriptor:Insulin
Authors:Hua, Q.X., Huang, K., Hu, S.Q., Katsoyanni, P., Weiss, M.A.
Deposit date:2009-06-10
Release date:2010-06-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Acceleration of Protein Fibrillation by Chiral Destabilization of Beta-Turn
To be Published
2KQQ
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NMR STRUCTURE OF HUMAN INSULIN MUTANT GLY-B8-D-ALA, HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES
Descriptor:Insulin B chain, Insulin A chain
Authors:Hua, Q.X., Wan, Z.L., Zhao, M., Jia, W., Huang, K., Weiss, M.A.
Deposit date:2009-11-13
Release date:2010-11-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and Dynamics of an Turn-Stabilize But Ina Insulin Analog.
To be Published
3P2X
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INSULIN FIBRILLATION IS THE JANUS FACE OF INDUCED FIT. A CHIARAL CLAMP STABILIZES THE NATIVE STATE AT THE EXPENSE OF ACTIVITY
Descriptor:Insulin, ZINC ION, CHLORIDE ION, ...
Authors:Hua, Q.X., Wan, Z.L., Huang, K., Hu, S.Q., Phillip, N.F., Jia, W.H., Whittingham, J., Dodson, G.G., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2010-10-04
Release date:2011-11-23
Last modified:2014-10-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
3P33
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INSULIN FIBRILLATION IS THE JANUS FACE OF INDUCED FIT. A CHIRAL CLAMP STABILIZES THE NATIVE STATE AT THE EXPENSE OF ACTIVITY
Descriptor:Insulin, PHENOL, ZINC ION, ...
Authors:Hua, Q.X., Wan, Z.L., Huang, K., Hu, S.Q., Phillip, N.F., Jia, W.H., Whittingham, J., Dodson, G.G., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2010-10-04
Release date:2011-11-23
Last modified:2014-10-15
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
1LKQ
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NMR STRUCTURE OF HUMAN INSULIN MUTANT ILE-A2-GLY, VAL-A3-GLY, HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 20 STRUCTURES
Descriptor:INSULIN
Authors:Weiss, M.A., Hua, Q.X., Chu, Y.C., Jia, W., Philips, N.F., Wang, R.Y., Katsoyannis, P.G.
Deposit date:2002-04-25
Release date:2002-05-22
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Mechanism of insulin chain combination. Asymmetric roles of A-chain alpha-helices in disulfide pairing
J.Biol.Chem., 277, 2002
1SF1
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NMR STRUCTURE OF HUMAN INSULIN UNDER AMYLOIDOGENIC CONDITION, 15 STRUCTURES
Descriptor:INSULIN A CHAIN, Insulin
Authors:Weiss, M.A., Hua, Q.X.
Deposit date:2004-02-19
Release date:2004-03-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Mechanism of insulin fibrillation: the structure of insulin under amyloidogenic conditions resembles a protein-folding intermediate
J.Biol.Chem., 279, 2004
1KMF
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NMR STRUCTURE OF HUMAN INSULIN MUTANT ILE-A2-ALLO-ILE, HIS-B10-ASP, PRO-B28-LYS, LYS-B29-PRO, 15 STRUCTURES
Descriptor:Insulin
Authors:Xu, B., Hua, Q.X., Nakagawa, S.H., Jia, W., Chu, Y.C., Katsoyannis, P.G., Weiss, M.A.
Deposit date:2001-12-14
Release date:2002-01-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Chiral mutagenesis of insulin's hidden receptor-binding surface: structure of an allo-isoleucine(A2) analogue.
J.Mol.Biol., 316, 2002
3JSD
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INSULIN'S BIOSYNTHESIS AND ACTIVITY HAVE OPPOSING STRUCTURAL REQUIREMENTS: A NEW FACTOR IN NEONATAL DIABETES MELLITUS
Descriptor:Insulin A chain, Insulin B chain, ZINC ION, ...
Authors:Weiss, M.A., Wan, Z.L., Dodson, E.J., Liu, M., Xu, B., Hua, Q.X., Turkenburg, M., Whittingham, J., Nakagawa, S.H., Huang, K., Hu, S.Q., Jia, W.H., Wang, S.H., Brange, J., Whittaker, J., Arvan, P., Katsoyannis, P.G., Dodson, G.G.
Deposit date:2009-09-10
Release date:2010-09-15
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
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