Author results

2VHA
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DEBP
Descriptor:PERIPLASMIC BINDING TRANSPORT PROTEIN, GLUTAMIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Hu, Y.L., Fan, C.-P., Fu, G.S., Zhu, D.Y., Jin, Q., Wang, D.-C.
Deposit date:2007-11-20
Release date:2008-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1 Å)
Cite:Crystal Structure of a Glutamate/Aspartate Binding Protein Complexed with a Glutamate Molecule: Structural Basis of Ligand Specificity at Atomic Resolution.
J.Mol.Biol., 382, 2008
2ZJT
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CRYSTAL STRUCTURE OF DNA GYRASE B' DOMAIN SHEDS LIGHTS ON THE MECHANISM FOR T-SEGMENT NAVIGATION
Descriptor:DNA gyrase subunit B
Authors:Fu, G.S., Zhu, D.Y., Hu, Y.L., Wang, D.C.
Deposit date:2008-03-10
Release date:2009-03-10
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of DNA gyrase B' domain sheds lights on the mechanism for T-segment navigation
Nucleic Acids Res., 37, 2009
3GAS
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CRYSTAL STRUCTURE OF HELICOBACTER PYLORI HEME OXYGENASE HUGZ IN COMPLEX WITH HEME
Descriptor:heme oxygenase, PROTOPORPHYRIN IX CONTAINING FE, AZIDE ION, ...
Authors:Jiang, F., Hu, Y.L., Guo, Y., Guo, G., Zou, Q.M., Wang, D.C.
Deposit date:2009-02-18
Release date:2010-02-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of Helicobacter pylori Heme Oxygenase Hugz in Complex with Heme
To be Published
1B25
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FORMALDEHYDE FERREDOXIN OXIDOREDUCTASE FROM PYROCOCCUS FURIOSUS
Descriptor:PROTEIN (FORMALDEHYDE FERREDOXIN OXIDOREDUCTASE), IRON/SULFUR CLUSTER, TUNGSTOPTERIN
Authors:Hu, Y.L., Faham, S., Roy, R., Adams, M.W.W., Rees, D.C.
Deposit date:1998-12-04
Release date:1999-03-24
Last modified:2011-12-07
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Formaldehyde ferredoxin oxidoreductase from Pyrococcus furiosus: the 1.85 A resolution crystal structure and its mechanistic implications.
J.Mol.Biol., 286, 1999
1B4N
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FORMALDEHYDE FERREDOXIN OXIDOREDUCTASE FROM PYROCOCCUS FURIOSUS, COMPLEXED WITH GLUTARATE
Descriptor:FORMALDEHYDE FERREDOXIN OXIDOREDUCTASE, CALCIUM ION, IRON/SULFUR CLUSTER, ...
Authors:Hu, Y.L., Faham, S., Roy, R., Adams, M.W.W., Rees, D.C.
Deposit date:1998-12-24
Release date:1999-05-18
Last modified:2011-12-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Formaldehyde ferredoxin oxidoreductase from Pyrococcus furiosus: the 1.85 A resolution crystal structure and its mechanistic implications.
J.Mol.Biol., 286, 1999
4TQJ
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STRUCTURAL BASIS OF SPECIFIC RECOGNITION OF NON-REDUCING TERMINAL N-ACETYLGLUCOSAMINE BY AN AGROCYBE AEGERITA LECTION
Descriptor:Lectin 2
Authors:Hu, Y.L., Ren, X.M., Li, D.F., Jiang, S., Lan, X.Q., Sun, H., Wang, D.C.
Deposit date:2014-06-11
Release date:2015-06-03
Last modified:2015-08-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis of Specific Recognition of Non-Reducing Terminal N-Acetylglucosamine by an Agrocybe aegerita Lectin.
Plos One, 10, 2015
4TQK
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STRUCTURAL BASIS OF SPECIFIC RECOGNITION OF NON-REDUCING TERMINAL N-ACETYLGLUCOSAMINE BY AN AGROCYBE AEGERITA LECTION
Descriptor:Lectin 2, N-ACETYL-D-GLUCOSAMINE
Authors:Hu, Y.L., Ren, X.M., Li, D.F., Jiang, S., Lan, X.Q., Sun, H., Wang, D.C.
Deposit date:2014-06-11
Release date:2015-06-03
Last modified:2015-08-05
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis of Specific Recognition of Non-Reducing Terminal N-Acetylglucosamine by an Agrocybe aegerita Lectin.
Plos One, 10, 2015
4TQM
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STRUCTURAL BASIS OF SPECIFIC RECOGNITION OF NON-REDUCING TERMINAL N-ACETYLGLUCOSAMINE BY AN AGROCYBE AEGERITA LECTION
Descriptor:Lectin 2, N-ACETYL-D-GLUCOSAMINE, BETA-D-GALACTOSE
Authors:Hu, Y.L., Ren, X.M., Li, D.F., Jiang, S., Lan, X.Q., Sun, H., Wang, D.C.
Deposit date:2014-06-11
Release date:2015-06-03
Last modified:2015-08-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis of Specific Recognition of Non-Reducing Terminal N-Acetylglucosamine by an Agrocybe aegerita Lectin.
Plos One, 10, 2015
3VYN
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS L,D-TRANSPEPTIDASE LDTMT2 N55 TRUNCATION MUTANT (RESIDEUS 55-408)
Descriptor:Probable conserved lipoprotein LPPS
Authors:Li, W.J., Li, D.F., Bi, L.J., Wang, D.C.
Deposit date:2012-09-30
Release date:2013-06-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of L,D-transpeptidase LdtMt2 in complex with meropenem reveals the mechanism of carbapenem against Mycobacterium tuberculosis
Cell Res., 23, 2013
3VYO
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS L,D-TRANSPEPTIDASE LDTMT2 N140 TRUNCATION MUTANT (RESIDEUS 140-408)
Descriptor:Probable conserved lipoprotein LPPS
Authors:Li, W.J., Li, D.F., Bi, L.J., Wang, D.C.
Deposit date:2012-09-30
Release date:2013-06-19
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of L,D-transpeptidase LdtMt2 in complex with meropenem reveals the mechanism of carbapenem against Mycobacterium tuberculosis
Cell Res., 23, 2013
3VYP
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS L,D-TRANSPEPTIDASE LDTMT2-N140 ADDUCT WITH MEROPENEM
Descriptor:Probable conserved lipoprotein LPPS, GLYCEROL, (2S,3R,4S)-4-{[(3S,5R)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid
Authors:Li, W.J., Li, D.F., Bi, L.J., Wang, D.C.
Deposit date:2012-09-30
Release date:2013-06-19
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of L,D-transpeptidase LdtMt2 in complex with meropenem reveals the mechanism of carbapenem against Mycobacterium tuberculosis
Cell Res., 23, 2013
4FJY
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CRYSTAL STRUCTURE OF PI3K-GAMMA IN COMPLEX WITH QUINOLINE-INDOLINE INHIBITOR 24F
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, 4-[3,3-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1H-indol-1-yl]-7-fluoro-3-methyl-2-(pyridin-3-yl)quinoline
Authors:Whittington, D.A., Tang, J., Yakowec, P.
Deposit date:2012-06-12
Release date:2012-10-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Discovery and in Vivo Evaluation of Dual PI3K-beta/delta inhibitors
J.Med.Chem., 55, 2012
4FJZ
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CRYSTAL STRUCTURE OF PI3K-GAMMA IN COMPLEX WITH PYRROLO-PYRIDINE INHIBITOR 63
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, 1'-[7-fluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-yl]-6'-(morpholin-4-yl)-1',2,2',3,5,6-hexahydrospiro[pyran-4,3'-pyrrolo[3,2-b]pyridine]
Authors:Whittington, D.A., Tang, J., Yakowec, P.
Deposit date:2012-06-12
Release date:2012-10-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:Discovery and in Vivo Evaluation of Dual PI3K-beta/delta inhibitors
J.Med.Chem., 55, 2012
4WWN
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CRYSTAL STRUCTURE OF HUMAN PI3K-GAMMA IN COMPLEX WITH (S)-N-(1-(7-FLUORO-2-(PYRIDIN-2-YL)QUINOLIN-3-YL)ETHYL)-9H-PURIN-6-AMINE AMG319 INHIBITOR
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, N-{(1S)-1-[7-fluoro-2-(pyridin-2-yl)quinolin-3-yl]ethyl}-9H-purin-6-amine
Authors:Whittington, D.A., Tang, J., Yakowec, P.
Deposit date:2014-11-11
Release date:2014-12-17
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery and in Vivo Evaluation of (S)-N-(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and Related PI3K delta Inhibitors for Inflammation and Autoimmune Disease.
J.Med.Chem., 58, 2015
4WWO
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CRYSTAL STRUCTURE OF HUMAN PI3K-GAMMA IN COMPLEX WITH PHENYLQUINOLINE INHIBITOR N-{(1S)-1-[8-CHLORO-2-(3-FLUOROPHENYL)QUINOLIN-3-YL]ETHYL}-9H-PURIN-6-AMINE
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, N-{(1S)-1-[8-chloro-2-(3-fluorophenyl)quinolin-3-yl]ethyl}-9H-purin-6-amine
Authors:Whittington, D.A., Tang, J., Yakowec, P.
Deposit date:2014-11-11
Release date:2014-12-17
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery and in Vivo Evaluation of (S)-N-(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and Related PI3K delta Inhibitors for Inflammation and Autoimmune Disease.
J.Med.Chem., 58, 2015
4WWP
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CRYSTAL STRUCTURE OF HUMAN PI3K-GAMMA IN COMPLEX WITH PYRIDINYLQUINOLINE INHIBITOR N-{(1S)-1-[8-CHLORO-2-(2-METHYLPYRIDIN-3-YL)QUINOLIN-3-YL]ETHYL}-9H-PURIN-6-AMINE
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, N-{(1S)-1-[8-chloro-2-(2-methylpyridin-3-yl)quinolin-3-yl]ethyl}-9H-purin-6-amine, ...
Authors:Whittington, D.A., Tang, J., Yakowec, P.
Deposit date:2014-11-11
Release date:2014-12-17
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery and in Vivo Evaluation of (S)-N-(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and Related PI3K delta Inhibitors for Inflammation and Autoimmune Disease.
J.Med.Chem., 58, 2015
5EDS
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CRYSTAL STRUCTURE OF HUMAN PI3K-GAMMA IN COMPLEX WITH BENZIMIDAZOLE INHIBITOR 5
Descriptor:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, 4-azanyl-6-[[(1~{S})-1-[6-fluoranyl-1-(3-methylsulfonylphenyl)benzimidazol-2-yl]ethyl]amino]pyrimidine-5-carbonitrile
Authors:Whittington, D.A., Tang, J., Yakowec, P.
Deposit date:2015-10-21
Release date:2015-12-30
Last modified:2016-01-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Discovery, Optimization, and in Vivo Evaluation of Benzimidazole Derivatives AM-8508 and AM-9635 as Potent and Selective PI3K delta Inhibitors.
J.Med.Chem., 59, 2016