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6OF4
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BU of 6of4 by Molmil
Precursor ribosomal RNA processing complex, apo-state.
Descriptor: CLP1_P domain-containing protein, Ribonuclease
Authors:Pillon, M.C, Hsu, A.L, Krahn, J.M, Williams, J.G, Goslen, K.H, Sobhany, M, Borgnia, M.J, Stanley, R.E.
Deposit date:2019-03-28
Release date:2019-09-11
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Cryo-EM reveals active site coordination within a multienzyme pre-rRNA processing complex.
Nat.Struct.Mol.Biol., 26, 2019
6OO3
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BU of 6oo3 by Molmil
Cryo-EM structure of the C4-symmetric TRPV2/RTx complex in amphipol resolved to 2.9 A
Descriptor: TRPV2, resiniferatoxin
Authors:Zubcevic, L, Hsu, A.L, Borgnia, M.J, Lee, S.-Y.
Deposit date:2019-04-22
Release date:2019-05-29
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes.
Elife, 8, 2019
6OT5
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BU of 6ot5 by Molmil
Structure of the TRPV3 K169A sensitized mutant in the presence of 2-APB at 3.6 A resolution
Descriptor: 2-aminoethyl diphenylborinate, Transient receptor potential cation channel subfamily V member 3,Transient receptor potential cation channel subfamily V member 3
Authors:Zubcevic, L, Borschel, W.F, Hsu, A.L, Borgnia, M.J, Lee, S.-Y.
Deposit date:2019-05-02
Release date:2019-05-22
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Regulatory switch at the cytoplasmic interface controls TRPV channel gating.
Elife, 8, 2019
6OO4
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BU of 6oo4 by Molmil
Cryo-EM structure of the C2-symmetric TRPV2/RTx complex in amphipol resolved to 3.3 A
Descriptor: TRPV2, resiniferatoxin
Authors:Zubcevic, L, Hsu, A.L, Borgnia, M.J, Lee, S.-Y.
Deposit date:2019-04-22
Release date:2019-05-29
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes.
Elife, 8, 2019
6OT2
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BU of 6ot2 by Molmil
Structure of the TRPV3 K169A sensitized mutant in apo form at 4.1 A resolution
Descriptor: Transient receptor potential cation channel subfamily V member 3
Authors:Zubcevic, L, Borschel, W.F, Hsu, A.L, Borgnia, M.J, Lee, S.-Y.
Deposit date:2019-05-02
Release date:2019-05-22
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Regulatory switch at the cytoplasmic interface controls TRPV channel gating.
Elife, 8, 2019
6PKW
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BU of 6pkw by Molmil
Cryo-EM structure of the zebrafish TRPM2 channel in the apo conformation, processed with C2 symmetry (pseudo C4 symmetry)
Descriptor: Transient receptor potential cation channel subfamily M member 2
Authors:Yin, Y, Wu, M, Hsu, A.L, Borschel, W.F, Borgnia, M.J, Lander, G.C, Lee, S.-Y.
Deposit date:2019-06-30
Release date:2019-08-28
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Nat Commun, 10, 2019
6PKV
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BU of 6pkv by Molmil
Cryo-EM structure of the zebrafish TRPM2 channel in the apo conformation, processed with C4 symmetry
Descriptor: Transient receptor potential cation channel subfamily M member 2
Authors:Yin, Y, Wu, M, Hsu, A.L, Borschel, W.F, Borgnia, M.J, Lander, G.C, Lee, S.-Y.
Deposit date:2019-06-30
Release date:2019-08-28
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Nat Commun, 10, 2019
6PQP
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BU of 6pqp by Molmil
Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist BITC
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-benzylthioformamide, ...
Authors:Suo, Y, Wang, Z, Zubcevic, L, Hsu, A.L, He, Q, Borgnia, M.J, Ji, R.-R, Lee, S.-Y.
Deposit date:2019-07-09
Release date:2020-01-08
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel.
Neuron, 105, 2020
6PKX
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BU of 6pkx by Molmil
Cryo-EM structure of the zebrafish TRPM2 channel in the presence of ADPR and Ca2+
Descriptor: CALCIUM ION, Transient receptor potential cation channel subfamily M member 2, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE
Authors:Yin, Y, Wu, M, Hsu, A.L, Borschel, W.F, Borgnia, M.J, Lander, G.C, Lee, S.-Y.
Deposit date:2019-06-30
Release date:2019-08-28
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Nat Commun, 10, 2019
6PQQ
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BU of 6pqq by Molmil
Cryo-EM structure of human TRPA1 C621S mutant in the apo state
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily A member 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate
Authors:Suo, Y, Wang, Z, Zubcevic, L, Hsu, A.L, He, Q, Borgnia, M.J, Ji, R.-R, Lee, S.-Y.
Deposit date:2019-07-09
Release date:2020-01-08
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.81 Å)
Cite:Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel.
Neuron, 105, 2020
6PQO
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BU of 6pqo by Molmil
Cryo-EM structure of the human TRPA1 ion channel in complex with the covalent agonist JT010
Descriptor: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-chloro-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-N-(3-methoxypropyl)acetamide, ...
Authors:Suo, Y, Wang, Z, Zubcevic, L, Hsu, A.L, He, Q, Borgnia, M.J, Ji, R.-R, Lee, S.-Y.
Deposit date:2019-07-09
Release date:2020-01-08
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (2.88 Å)
Cite:Structural Insights into Electrophile Irritant Sensing by the Human TRPA1 Channel.
Neuron, 105, 2020
7TU5
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BU of 7tu5 by Molmil
Structure of the L. blandensis dGTPase in the apo form
Descriptor: MAGNESIUM ION, dGTP triphosphohydrolase
Authors:Klemm, B.P, Sikkema, A.P, Hsu, A.L, Borgnia, M.J, Schaaper, R.M.
Deposit date:2022-02-02
Release date:2022-06-01
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (2.1 Å)
Cite:High-resolution structures of the SAMHD1 dGTPase homolog from Leeuwenhoekiella blandensis reveal a novel mechanism of allosteric activation by dATP.
J.Biol.Chem., 298, 2022
7TU6
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BU of 7tu6 by Molmil
Structure of the L. blandensis dGTPase bound to dATP
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, dGTP triphosphohydrolase
Authors:Klemm, B.P, Sikkema, A.P, Hsu, A.L, Borgnia, M.J, Schaaper, R.M.
Deposit date:2022-02-02
Release date:2022-06-01
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:High-resolution structures of the SAMHD1 dGTPase homolog from Leeuwenhoekiella blandensis reveal a novel mechanism of allosteric activation by dATP.
J.Biol.Chem., 298, 2022
7TU8
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BU of 7tu8 by Molmil
Structure of the L. blandensis dGTPase H125A mutant bound to dGTP and dATP
Descriptor: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Klemm, B.P, Sikkema, A.P, Hsu, A.L, Borgnia, M.J, Schaaper, R.M.
Deposit date:2022-02-02
Release date:2022-06-01
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:High-resolution structures of the SAMHD1 dGTPase homolog from Leeuwenhoekiella blandensis reveal a novel mechanism of allosteric activation by dATP.
J.Biol.Chem., 298, 2022
7TU7
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BU of 7tu7 by Molmil
Structure of the L. blandensis dGTPase H125A mutant bound to dGTP
Descriptor: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, dGTP triphosphohydrolase
Authors:Klemm, B.P, Sikkema, A.P, Hsu, A.L, Borgnia, M.J, Schaaper, R.M.
Deposit date:2022-02-02
Release date:2022-06-01
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:High-resolution structures of the SAMHD1 dGTPase homolog from Leeuwenhoekiella blandensis reveal a novel mechanism of allosteric activation by dATP.
J.Biol.Chem., 298, 2022
6UKS
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BU of 6uks by Molmil
ATPgammaS bound mBcs1
Descriptor: MAGNESIUM ION, Mitochondrial chaperone BCS1, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:Tang, W.K, Borgnia, M.J, Hsu, A.L, Xia, D.
Deposit date:2019-10-05
Release date:2020-02-05
Last modified:2020-02-26
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein.
Nat.Struct.Mol.Biol., 27, 2020
6UKP
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BU of 6ukp by Molmil
Apo mBcs1
Descriptor: Mitochondrial chaperone BCS1
Authors:Tang, W.K, Borgnia, M.J, Hsu, A.L, Xia, D.
Deposit date:2019-10-05
Release date:2020-02-12
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.81 Å)
Cite:Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein.
Nat.Struct.Mol.Biol., 27, 2020
7U65
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BU of 7u65 by Molmil
Structure of E. coli dGTPase bound to T7 bacteriophage protein Gp1.2
Descriptor: Deoxyguanosinetriphosphate triphosphohydrolase, Inhibitor of dGTPase
Authors:Klemm, B.P, Hsu, A.L, Borgnia, M.J, Schaaper, R.M.
Deposit date:2022-03-03
Release date:2022-08-31
Last modified:2022-09-21
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Mechanism by which T7 bacteriophage protein Gp1.2 inhibits Escherichia coli dGTPase.
Proc.Natl.Acad.Sci.USA, 119, 2022
7U67
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BU of 7u67 by Molmil
Structure of E. coli dGTPase bound to T7 bacteriophage protein Gp1.2 and GTP
Descriptor: Deoxyguanosinetriphosphate triphosphohydrolase, GUANOSINE-5'-TRIPHOSPHATE, Inhibitor of dGTPase, ...
Authors:Klemm, B.P, Hsu, A.L, Borgnia, M.J, Schaaper, R.M.
Deposit date:2022-03-03
Release date:2022-08-31
Last modified:2022-09-21
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Mechanism by which T7 bacteriophage protein Gp1.2 inhibits Escherichia coli dGTPase.
Proc.Natl.Acad.Sci.USA, 119, 2022
6MAT
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BU of 6mat by Molmil
Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Rix7 mutant, unknown protein
Authors:Lo, Y.H, Sobhany, M, Hsu, A.L, Ford, B.L, Krahn, J.M, Borgnia, M.J, Stanley, R.E.
Deposit date:2018-08-28
Release date:2019-02-06
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7.
Nat Commun, 10, 2019
6NR3
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BU of 6nr3 by Molmil
Cryo-EM structure of the TRPM8 ion channel in complex with high occupancy icilin, PI(4,5)P2, and calcium
Descriptor: (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl icosa-5,8,11,14-tetraenoate, CALCIUM ION, Icilin, ...
Authors:Yin, Y, Le, S.C, Hsu, A.L, Borgnia, M.J, Yang, H, Lee, S.-Y.
Deposit date:2019-01-22
Release date:2019-02-20
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel.
Science, 363, 2019
6NR4
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BU of 6nr4 by Molmil
Cryo-EM structure of the TRPM8 ion channel with low occupancy icilin, PI(4,5)P2, and calcium
Descriptor: Transient receptor potential cation channel subfamily M member 8
Authors:Yin, Y, Le, S.C, Hsu, A.L, Borgnia, M.J, Yang, H, Lee, S.-Y.
Deposit date:2019-01-22
Release date:2019-02-20
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel.
Science, 363, 2019
6NR2
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BU of 6nr2 by Molmil
Cryo-EM structure of the TRPM8 ion channel in complex with the menthol analog WS-12 and PI(4,5)P2
Descriptor: (1R,2S,5R)-N-(4-methoxyphenyl)-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamide, (2S)-1-{[(R)-hydroxy{[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}-3-(octadecanoyloxy)propan-2-yl icosa-5,8,11,14-tetraenoate, Transient receptor potential cation channel subfamily M member 8
Authors:Yin, Y, Le, S.C, Hsu, A.L, Borgnia, M.J, Yang, H, Lee, S.-Y.
Deposit date:2019-01-22
Release date:2019-02-20
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel.
Science, 363, 2019
6OF2
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BU of 6of2 by Molmil
Precursor ribosomal RNA processing complex, State 2.
Descriptor: CLP1_P domain-containing protein, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Pillon, M.C, Hsu, A.L, Krahn, J.M, Williams, J.G, Goslen, K.H, Sobhany, M, Borgnia, M.J, Stanley, R.E.
Deposit date:2019-03-28
Release date:2019-09-11
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Cryo-EM reveals active site coordination within a multienzyme pre-rRNA processing complex.
Nat.Struct.Mol.Biol., 26, 2019
6OF3
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BU of 6of3 by Molmil
Precursor ribosomal RNA processing complex, State 1.
Descriptor: CLP1_P domain-containing protein, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Pillon, M.C, Hsu, A.L, Krahn, J.M, Williams, J.G, Goslen, K.H, Sobhany, M, Borgnia, M.J, Stanley, R.E.
Deposit date:2019-03-28
Release date:2019-09-11
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Cryo-EM reveals active site coordination within a multienzyme pre-rRNA processing complex.
Nat.Struct.Mol.Biol., 26, 2019

 

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