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1ZHI
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BU of 1zhi by Molmil
Complex of the S. cerevisiae Orc1 and Sir1 interacting domains
Descriptor: Origin recognition complex subunit 1, Regulatory protein SIR1
Authors:Hou, Z, Bernstein, D.A, Fox, C.A, Keck, J.L.
Deposit date:2005-04-25
Release date:2005-06-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis of the Sir1-origin recognition complex interaction in transcriptional silencing.
Proc.Natl.Acad.Sci.Usa, 102, 2005
1Z1A
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BU of 1z1a by Molmil
S. cerevisiae Sir1 ORC-interaction domain
Descriptor: Regulatory protein SIR1
Authors:Hou, Z, Bernstein, D.A, Fox, C.A, Keck, J.L.
Deposit date:2005-03-03
Release date:2005-06-07
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of the Sir1-origin recognition complex interaction in transcriptional silencing.
Proc.Natl.Acad.Sci.Usa, 102, 2005
1CH8
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BU of 1ch8 by Molmil
STRUCTURE OF ADENYLOSUCCINATE SYNTHETASE FROM E. COLI COMPLEXED WITH A STRINGENT EFFECTOR, PPG2':3'P
Descriptor: GUANOSINE 5'-DIPHOSPHATE 2':3'-CYCLIC MONOPHOSPHATE, HADACIDIN, INOSINIC ACID, ...
Authors:Hou, Z, Cashel, M, Fromm, H.J, Honzatko, R.B.
Deposit date:1999-03-31
Release date:1999-12-29
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Effectors of the stringent response target the active site of Escherichia coli adenylosuccinate synthetase.
J.Biol.Chem., 274, 1999
1CIB
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BU of 1cib by Molmil
STRUCTURE OF ADENYLOSUCCINATE SYNTHETASE FROM E. COLI COMPLEXED WITH GDP, IMP, HADACIDIN, AND NO3
Descriptor: ADENYLOSUCCINATE SYNTHETASE, GUANOSINE-5'-DIPHOSPHATE, HADACIDIN, ...
Authors:Hou, Z, Cashel, M, Fromm, H.J, Honzatko, R.B.
Deposit date:1999-03-31
Release date:2000-04-05
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Effectors of the stringent response target the active site of Escherichia coli adenylosuccinate synthetase.
J.Biol.Chem., 274, 1999
1KKB
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BU of 1kkb by Molmil
Complex of Escherichia coli Adenylosuccinate Synthetase with IMP and Hadacidin
Descriptor: Adenylosuccinate Synthetase, HADACIDIN, INOSINIC ACID
Authors:Hou, Z, Wang, W, Fromm, H.J, Honzatko, R.B.
Deposit date:2001-12-06
Release date:2002-03-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:IMP Alone Organizes the Active Site of Adenylosuccinate Synthetase from Escherichia coli.
J.Biol.Chem., 277, 2002
1KKF
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BU of 1kkf by Molmil
Complex of E. coli Adenylosuccinate Synthetase with IMP, Hadacidin, Pyrophosphate, and Mg
Descriptor: Adenylosuccinate Synthetase, DIPHOSPHATE, HADACIDIN, ...
Authors:Hou, Z, Wang, W, Fromm, H.J, Honzatko, R.B.
Deposit date:2001-12-07
Release date:2002-03-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:IMP Alone Organizes the Active Site of Adenylosuccinate Synthetase from Escherichia coli.
J.Biol.Chem., 277, 2002
1KJX
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BU of 1kjx by Molmil
IMP Complex of E. Coli Adenylosuccinate Synthetase
Descriptor: Adenylosuccinate Synthetase, INOSINIC ACID
Authors:Hou, Z, Wang, W, Fromm, H.J, Honzatko, R.B.
Deposit date:2001-12-05
Release date:2002-03-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:IMP Alone Organizes the Active Site of Adenylosuccinate Synthetase from Escherichia coli.
J.Biol.Chem., 277, 2002
5VJX
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BU of 5vjx by Molmil
Crystal structure of the CLOCK Transcription Domain Exon19 in Complex with a Repressor
Descriptor: CLOCK-interacting pacemaker, Circadian locomoter output cycles protein kaput
Authors:Hou, Z, Su, L, Pei, J, Grishin, N.V, Zhang, H.
Deposit date:2017-04-20
Release date:2017-12-06
Last modified:2020-01-29
Method:X-RAY DIFFRACTION (2.695 Å)
Cite:Crystal Structure of the CLOCK Transactivation Domain Exon19 in Complex with a Repressor.
Structure, 25, 2017
5VJI
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BU of 5vji by Molmil
Crystal structure of the CLOCK Transcription Domain Exon19 in Complex with a Repressor
Descriptor: CLOCK-interacting pacemaker, Circadian locomoter output cycles protein kaput
Authors:Hou, Z, Su, L, Pei, J, Grishin, N.V, Zhang, H.
Deposit date:2017-04-19
Release date:2017-06-07
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Crystal Structure of the CLOCK Transactivation Domain Exon19 in Complex with a Repressor.
Structure, 25, 2017
3VAY
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BU of 3vay by Molmil
Crystal structure of 2-Haloacid Dehalogenase from Pseudomonas syringae pv. Tomato DC3000
Descriptor: HAD-superfamily hydrolase, IODIDE ION, MAGNESIUM ION
Authors:Hou, Z, Zhang, H, Li, M, Chang, W.
Deposit date:2011-12-30
Release date:2013-01-02
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.979 Å)
Cite:Structure of 2-haloacid dehalogenase from Pseudomonas syringae pv. tomato DC3000
Acta Crystallogr.,Sect.D, 69, 2013
2FL7
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BU of 2fl7 by Molmil
S. cerevisiae Sir3 BAH domain
Descriptor: Regulatory protein SIR3
Authors:Keck, J.L, Hou, Z, Daner, J.R, Fox, C.A.
Deposit date:2006-01-05
Release date:2006-05-09
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of the Sir3 protein bromo adjacent homology (BAH) domain from S. cerevisiae at 1.95 A resolution.
Protein Sci., 15, 2006
1HOP
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BU of 1hop by Molmil
STRUCTURE OF GUANINE NUCLEOTIDE (GPPCP) COMPLEX OF ADENYLOSUCCINATE SYNTHETASE FROM ESCHERICHIA COLI AT PH 6.5 AND 25 DEGREES CELSIUS
Descriptor: ADENYLOSUCCINATE SYNTHETASE, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
Authors:Poland, B.W, Hou, Z, Bruns, C, Fromm, H.J, Honzatko, R.B.
Deposit date:1996-04-26
Release date:1996-11-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Refined crystal structures of guanine nucleotide complexes of adenylosuccinate synthetase from Escherichia coli.
J.Biol.Chem., 271, 1996
1HOO
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BU of 1hoo by Molmil
STRUCTURE OF GUANINE NUCLEOTIDE (GPPCP) COMPLEX OF ADENYLOSUCCINATE SYNTHETASE FROM E. COLI AT PH 6.5 AND 25 DEGREES CELSIUS
Descriptor: ADENYLOSUCCINATE SYNTHETASE, AMINOPHOSPHONIC ACID-GUANYLATE ESTER, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Poland, B.W, Hou, Z, Bruns, C, Fromm, H.J, Honzatko, R.B.
Deposit date:1996-04-26
Release date:1997-02-12
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Refined crystal structures of guanine nucleotide complexes of adenylosuccinate synthetase from Escherichia coli.
J.Biol.Chem., 271, 1996
1HON
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BU of 1hon by Molmil
STRUCTURE OF GUANINE NUCLEOTIDE (GPPCP) COMPLEX OF ADENYLOSUCCINATE SYNTHETASE FROM ESCHERICHIA COLI AT PH 6.5 AND 25 DEGREE CELSIUS
Descriptor: ADENYLOSUCCINATE SYNTHETASE, AMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Poland, B.W, Hou, Z, Bruns, C, Fromm, H.J, Honzatko, R.B.
Deposit date:1996-04-26
Release date:1996-11-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Refined crystal structures of guanine nucleotide complexes of adenylosuccinate synthetase from Escherichia coli.
J.Biol.Chem., 271, 1996
3AXW
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BU of 3axw by Molmil
Crystal structure of human CK2alpha complexed with a potent inhibitor
Descriptor: 4-(5-amino-1,3,4-thiadiazol-2-yl)benzoic acid, Casein kinase II subunit alpha
Authors:Kinoshita, T, Nakanishi, I.
Deposit date:2011-04-18
Release date:2012-04-04
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-Based Design of Novel Potent Protein Kinase CK2 (CK2) Inhibitors with Phenyl-azole Scaffolds
J.Med.Chem., 55, 2012
1MD2
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BU of 1md2 by Molmil
CHOLERA TOXIN B-PENTAMER WITH DECAVALENT LIGAND BMSC-0013
Descriptor: 3-ETHYLAMINO-4-METHYLAMINO-CYCLOBUTANE-1,2-DIONE, CHOLERA TOXIN B SUBUNIT, CYANIDE ION, ...
Authors:Zhang, Z, Merritt, E.A, Ahn, M, Roach, C, Hol, W.G.J, Fan, E.
Deposit date:2002-08-06
Release date:2002-12-11
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Solution and crystallographic studies of branched multivalent ligands that inhibit the receptor-binding of cholera toxin.
J.Am.Chem.Soc., 124, 2002
4QLI
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BU of 4qli by Molmil
A novel phospho-switch in the linker region of the snail zinc finger protein which regulates 14-3-3 association, DNA binding and epithelial-mesenchymal differentiation
Descriptor: 14-3-3 protein sigma, GLYCEROL, MAGNESIUM ION, ...
Authors:Bier, D, Ottmann, C.
Deposit date:2014-06-12
Release date:2015-06-17
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:A novel phospho-switch in the linker region of the snail zinc finger protein which regulates 14-3-3 association, DNA binding and epithelial-mesenchymal differentiation
To be Published
3PL9
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BU of 3pl9 by Molmil
Crystal structure of spinach minor light-harvesting complex CP29 at 2.80 angstrom resolution
Descriptor: (1R,3R)-6-{(3E,5E,7E,9E,11E,13E,15E,17E)-18-[(1S,4R,6R)-4-HYDROXY-2,2,6-TRIMETHYL-7-OXABICYCLO[4.1.0]HEPT-1-YL]-3,7,12,16-TETRAMETHYLOCTADECA-1,3,5,7,9,11,13,15,17-NONAENYLIDENE}-1,5,5-TRIMETHYLCYCLOHEXANE-1,3-DIOL, (3R,3'R,6S)-4,5-DIDEHYDRO-5,6-DIHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, (3S,5R,6S,3'S,5'R,6'S)-5,6,5',6'-DIEPOXY-5,6,5',6'- TETRAHYDRO-BETA,BETA-CAROTENE-3,3'-DIOL, ...
Authors:Pan, X.W, Li, M, Wan, T, Wang, L.F, Jia, C.J, Hou, Z.Q, Zhao, X.L, Zhang, J.P, Chang, W.R.
Deposit date:2010-11-14
Release date:2011-02-09
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural insights into energy regulation of light-harvesting complex CP29 from spinach.
Nat.Struct.Mol.Biol., 18, 2011
5IZQ
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BU of 5izq by Molmil
Crystal structure of human folate receptor alpha in complex with novel antifolate AGF183
Descriptor: Folate receptor alpha, N-(4-{[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]amino}benzene-1-carbonyl)-L-glutamic acid
Authors:Ke, J, Gu, X, Brunzelle, J.S, Xu, H.E, Melcher, K.
Deposit date:2016-03-25
Release date:2016-08-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor alpha and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.
J.Med.Chem., 59, 2016
5J9F
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BU of 5j9f by Molmil
Human GAR transformylase in complex with GAR and (4-{[2-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]amino}benzoyl)-L-glutamic acid (AGF183)
Descriptor: GLYCINAMIDE RIBONUCLEOTIDE, N-(4-{[2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]amino}benzene-1-carbonyl)-L-glutamic acid, Trifunctional purine biosynthetic protein adenosine-3
Authors:Wong, J, Deis, S.M, Dann III, C.E.
Deposit date:2016-04-09
Release date:2016-08-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor alpha and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthesis.
J.Med.Chem., 59, 2016
6LCY
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BU of 6lcy by Molmil
Crystal structure of Synaptotagmin-7 C2B in complex with IP6
Descriptor: INOSITOL HEXAKISPHOSPHATE, Synaptotagmin-7
Authors:Zhang, Y, Zhang, X, Rao, F, Wang, C.
Deposit date:2019-11-20
Release date:2021-03-03
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:5-IP 7 is a GPCR messenger mediating neural control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis.
Nat Metab, 3, 2021
8T4P
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BU of 8t4p by Molmil
Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and di-glutamate AGF347 inhibitor
Descriptor: N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], N-{4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl}-L-gamma-glutamyl-L-glutamic acid, Serine hydroxymethyltransferase, ...
Authors:Katinas, J.M, Dann III, C.E.
Deposit date:2023-06-09
Release date:2024-02-21
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Structural Characterization of 5-Substituted Pyrrolo[3,2- d ]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2.
Biochemistry, 2024
8T4O
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BU of 8t4o by Molmil
Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and AGF347 inhibitor with no glutamate
Descriptor: 4-[4-(2-amino-4-oxo-3,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoic acid, N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], Serine hydroxymethyltransferase, ...
Authors:Katinas, J.M, Dann III, C.E.
Deposit date:2023-06-09
Release date:2024-02-21
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Structural Characterization of 5-Substituted Pyrrolo[3,2- d ]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2.
Biochemistry, 2024
8TLC
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BU of 8tlc by Molmil
Human mitochondrial serine hydroxymethyltransferase (SHMT2) in complex with PLP, glycine and tri-glutamate AGF347 inhibitor
Descriptor: N-{4-[4-(2-amino-4-oxo-1,4-dihydro-5H-pyrrolo[3,2-d]pyrimidin-5-yl)butyl]-2-fluorobenzoyl}-D-gamma-glutamyl-L-gamma-glutamyl-D-glutamic acid, Serine hydroxymethyltransferase, mitochondrial
Authors:Katinas, J.M, Dann III, C.E.
Deposit date:2023-07-26
Release date:2024-02-21
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Structural Characterization of 5-Substituted Pyrrolo[3,2- d ]pyrimidine Antifolate Inhibitors in Complex with Human Serine Hydroxymethyl Transferase 2.
Biochemistry, 2024
4ZYY
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BU of 4zyy by Molmil
Human GAR transformylase in complex with GAR and (S)-2-({5-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]-pyrimidin-6-yl)butyl]thiophene-3-carbonyl}amino)pentanedioic acid (AGF118)
Descriptor: (S)-2-({5-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]-pyrimidin-6-yl)butyl]thiophene-3-carbonyl}amino)pentanedioic acid, GLYCINAMIDE RIBONUCLEOTIDE, Trifunctional purine biosynthetic protein adenosine-3
Authors:Deis, S.M, Dann III, C.E.
Deposit date:2015-05-22
Release date:2016-04-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase.
Biochemistry, 55, 2016

 

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