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1CH8
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STRUCTURE OF ADENYLOSUCCINATE SYNTHETASE FROM E. COLI COMPLEXED WITH A STRINGENT EFFECTOR, PPG2':3'P
Descriptor:PROTEIN (ADENYLOSUCCINATE SYNTHETASE), NITRATE ION, MAGNESIUM ION, ...
Authors:Hou, Z., Cashel, M., Fromm, H.J., Honzatko, R.B.
Deposit date:1999-03-31
Release date:1999-12-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Effectors of the stringent response target the active site of Escherichia coli adenylosuccinate synthetase.
J.Biol.Chem., 274, 1999
1CIB
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STRUCTURE OF ADENYLOSUCCINATE SYNTHETASE FROM E. COLI COMPLEXED WITH GDP, IMP, HADACIDIN, AND NO3
Descriptor:ADENYLOSUCCINATE SYNTHETASE, NITRATE ION, MAGNESIUM ION, ...
Authors:Hou, Z., Cashel, M., Fromm, H.J., Honzatko, R.B.
Deposit date:1999-03-31
Release date:2000-04-05
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Effectors of the stringent response target the active site of Escherichia coli adenylosuccinate synthetase.
J.Biol.Chem., 274, 1999
1KJX
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IMP COMPLEX OF E. COLI ADENYLOSUCCINATE SYNTHETASE
Descriptor:Adenylosuccinate Synthetase, INOSINIC ACID
Authors:Hou, Z., Wang, W., Fromm, H.J., Honzatko, R.B.
Deposit date:2001-12-05
Release date:2002-03-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:IMP Alone Organizes the Active Site of Adenylosuccinate Synthetase from Escherichia coli.
J.Biol.Chem., 277, 2002
1KKB
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COMPLEX OF ESCHERICHIA COLI ADENYLOSUCCINATE SYNTHETASE WITH IMP AND HADACIDIN
Descriptor:Adenylosuccinate Synthetase, HADACIDIN, INOSINIC ACID
Authors:Hou, Z., Wang, W., Fromm, H.J., Honzatko, R.B.
Deposit date:2001-12-06
Release date:2002-03-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:IMP Alone Organizes the Active Site of Adenylosuccinate Synthetase from Escherichia coli.
J.Biol.Chem., 277, 2002
1KKF
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COMPLEX OF E. COLI ADENYLOSUCCINATE SYNTHETASE WITH IMP, HADACIDIN, PYROPHOSPHATE, AND MG
Descriptor:Adenylosuccinate Synthetase, MAGNESIUM ION, DIPHOSPHATE, ...
Authors:Hou, Z., Wang, W., Fromm, H.J., Honzatko, R.B.
Deposit date:2001-12-07
Release date:2002-03-20
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:IMP Alone Organizes the Active Site of Adenylosuccinate Synthetase from Escherichia coli.
J.Biol.Chem., 277, 2002
1Z1A
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S. CEREVISIAE SIR1 ORC-INTERACTION DOMAIN
Descriptor:Regulatory protein SIR1
Authors:Hou, Z., Bernstein, D.A., Fox, C.A., Keck, J.L.
Deposit date:2005-03-03
Release date:2005-06-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of the Sir1-origin recognition complex interaction in transcriptional silencing.
Proc.Natl.Acad.Sci.Usa, 102, 2005
1ZHI
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COMPLEX OF THE S. CEREVISIAE ORC1 AND SIR1 INTERACTING DOMAINS
Descriptor:Origin recognition complex subunit 1, Regulatory protein SIR1
Authors:Hou, Z., Bernstein, D.A., Fox, C.A., Keck, J.L.
Deposit date:2005-04-25
Release date:2005-06-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis of the Sir1-origin recognition complex interaction in transcriptional silencing.
Proc.Natl.Acad.Sci.Usa, 102, 2005
3VAY
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CRYSTAL STRUCTURE OF 2-HALOACID DEHALOGENASE FROM PSEUDOMONAS SYRINGAE PV. TOMATO DC3000
Descriptor:HAD-superfamily hydrolase, MAGNESIUM ION, IODIDE ION
Authors:Hou, Z., Zhang, H., Li, M., Chang, W.
Deposit date:2011-12-30
Release date:2013-01-02
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.979 Å)
Cite:Structure of 2-haloacid dehalogenase from Pseudomonas syringae pv. tomato DC3000
Acta Crystallogr.,Sect.D, 69, 2013
5VJI
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CRYSTAL STRUCTURE OF THE CLOCK TRANSCRIPTION DOMAIN EXON19 IN COMPLEX WITH A REPRESSOR
Descriptor:Circadian locomoter output cycles protein kaput, CLOCK-interacting pacemaker
Authors:Hou, Z., Su, L., Pei, J., Grishin, N.V., Zhang, H.
Deposit date:2017-04-19
Release date:2017-06-07
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Crystal Structure of the CLOCK Transactivation Domain Exon19 in Complex with a Repressor.
Structure, 25, 2017
5VJX
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CRYSTAL STRUCTURE OF THE CLOCK TRANSCRIPTION DOMAIN EXON19 IN COMPLEX WITH A REPRESSOR
Descriptor:CLOCK-interacting pacemaker, Circadian locomoter output cycles protein kaput
Authors:Hou, Z., Su, L., Pei, J., Grishin, N.V., Zhang, H.
Deposit date:2017-04-20
Release date:2017-12-06
Method:X-RAY DIFFRACTION (2.695 Å)
Cite:Crystal Structure of the CLOCK Transactivation Domain Exon19 in Complex with a Repressor.
Structure, 25, 2017
2FL7
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S. CEREVISIAE SIR3 BAH DOMAIN
Descriptor:Regulatory protein SIR3
Authors:Keck, J.L., Hou, Z., Daner, J.R., Fox, C.A.
Deposit date:2006-01-05
Release date:2006-05-09
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of the Sir3 protein bromo adjacent homology (BAH) domain from S. cerevisiae at 1.95 A resolution.
Protein Sci., 15, 2006
1HON
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STRUCTURE OF GUANINE NUCLEOTIDE (GPPCP) COMPLEX OF ADENYLOSUCCINATE SYNTHETASE FROM ESCHERICHIA COLI AT PH 6.5 AND 25 DEGREE CELSIUS
Descriptor:ADENYLOSUCCINATE SYNTHETASE, AMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Poland, B.W., Hou, Z., Bruns, C., Fromm, H.J., Honzatko, R.B.
Deposit date:1996-04-26
Release date:1996-11-08
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Refined crystal structures of guanine nucleotide complexes of adenylosuccinate synthetase from Escherichia coli.
J.Biol.Chem., 271, 1996
1HOO
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STRUCTURE OF GUANINE NUCLEOTIDE (GPPCP) COMPLEX OF ADENYLOSUCCINATE SYNTHETASE FROM E. COLI AT PH 6.5 AND 25 DEGREES CELSIUS
Descriptor:ADENYLOSUCCINATE SYNTHETASE, AMINOPHOSPHONIC ACID-GUANYLATE ESTER, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Poland, B.W., Hou, Z., Bruns, C., Fromm, H.J., Honzatko, R.B.
Deposit date:1996-04-26
Release date:1997-02-12
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Refined crystal structures of guanine nucleotide complexes of adenylosuccinate synthetase from Escherichia coli.
J.Biol.Chem., 271, 1996
1HOP
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STRUCTURE OF GUANINE NUCLEOTIDE (GPPCP) COMPLEX OF ADENYLOSUCCINATE SYNTHETASE FROM ESCHERICHIA COLI AT PH 6.5 AND 25 DEGREES CELSIUS
Descriptor:ADENYLOSUCCINATE SYNTHETASE, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
Authors:Poland, B.W., Hou, Z., Bruns, C., Fromm, H.J., Honzatko, R.B.
Deposit date:1996-04-26
Release date:1996-11-08
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Refined crystal structures of guanine nucleotide complexes of adenylosuccinate synthetase from Escherichia coli.
J.Biol.Chem., 271, 1996
3AXW
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CRYSTAL STRUCTURE OF HUMAN CK2ALPHA COMPLEXED WITH A POTENT INHIBITOR
Descriptor:Casein kinase II subunit alpha, 4-(5-amino-1,3,4-thiadiazol-2-yl)benzoic acid
Authors:Kinoshita, T., Nakanishi, I.
Deposit date:2011-04-18
Release date:2012-04-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-Based Design of Novel Potent Protein Kinase CK2 (CK2) Inhibitors with Phenyl-azole Scaffolds
J.Med.Chem., 55, 2012
1MD2
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CHOLERA TOXIN B-PENTAMER WITH DECAVALENT LIGAND BMSC-0013
Descriptor:CHOLERA TOXIN B SUBUNIT, [5-(3,4,5-TRIHYDROXY-6-HYDROXYMETHYL-TETRAHYDRO-PYRAN-2-YLCARBAMOYL)-PENTYL]-CARBAMIC ACID METHYL ESTER, 3-ETHYLAMINO-4-METHYLAMINO-CYCLOBUTANE-1,2-DIONE, ...
Authors:Zhang, Z., Merritt, E.A., Ahn, M., Roach, C., Hol, W.G.J., Fan, E.
Deposit date:2002-08-06
Release date:2002-12-11
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Solution and crystallographic studies of branched multivalent ligands that inhibit the receptor-binding of cholera toxin.
J.Am.Chem.Soc., 124, 2002
4QLI
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A NOVEL PHOSPHO-SWITCH IN THE LINKER REGION OF THE SNAIL ZINC FINGER PROTEIN WHICH REGULATES 14-3-3 ASSOCIATION, DNA BINDING AND EPITHELIAL-MESENCHYMAL DIFFERENTIATION
Descriptor:14-3-3 protein sigma, Zinc finger protein SNAI1, MAGNESIUM ION, ...
Authors:Bier, D., Ottmann, C.
Deposit date:2014-06-12
Release date:2015-06-17
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:A novel phospho-switch in the linker region of the snail zinc finger protein which regulates 14-3-3 association, DNA binding and epithelial-mesenchymal differentiation
To be Published
4ZYT
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HUMAN GAR TRANSFORMYLASE IN COMPLEX WITH GAR AND N-{4-[4-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)BENZYL]BENZOYL}-L-GLUTAMIC ACID (AGF23)
Descriptor:Trifunctional purine biosynthetic protein adenosine-3, GLYCINAMIDE RIBONUCLEOTIDE, N-{4-[4-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]benzoyl}-L-glutamic acid
Authors:Deis, S.M., Dann III, C.E.
Deposit date:2015-05-22
Release date:2016-04-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.702 Å)
Cite:Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase.
Biochemistry, 55, 2016
4ZYU
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HUMAN GAR TRANSFORMYLASE IN COMPLEX WITH GAR AND N-{4-[4-(2-AMINO-4-OXO-3,4-DIHYDROTHIENO[2,3-D]PYRIMIDIN-6-YL)-BUTYL]BENZOYL}-L-GLUTAMIC ACID (AGF50)
Descriptor:Trifunctional purine biosynthetic protein adenosine-3, GLYCINAMIDE RIBONUCLEOTIDE, N-{4-[4-(2-amino-4-oxo-1,4-dihydrothieno[2,3-d]pyrimidin-6-yl)butyl]benzoyl}-L-glutamic acid
Authors:Deis, S.M., Dann III, C.E.
Deposit date:2015-05-22
Release date:2016-04-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase.
Biochemistry, 55, 2016
4ZYV
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HUMAN GAR TRANSFORMYLASE IN COMPLEX WITH GAR AND N-({5-[(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)BUTYL]THIOPHEN-2-YL}CARBONYL)-L-GLUTAMIC ACID (AGF71)
Descriptor:Trifunctional purine biosynthetic protein adenosine-3, GLYCINAMIDE RIBONUCLEOTIDE, N-({5-[4-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]thiophen-2-yl}carbonyl)-L-glutamic acid
Authors:Deis, S.M., Dann III, C.E.
Deposit date:2015-05-22
Release date:2016-04-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.053 Å)
Cite:Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase.
Biochemistry, 55, 2016
4ZYW
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HUMAN GAR TRANSFORMYLASE IN COMPLEX WITH GAR AND N-({5-[(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)PROPYL]THIOPHEN-2-YL}CARBONYL)-L-GLUTAMIC ACID (AGF94)
Descriptor:Trifunctional purine biosynthetic protein adenosine-3, GLYCINAMIDE RIBONUCLEOTIDE, N-({5-[3-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-6-yl)propyl]thiophen-2-yl}carbonyl)-L-glutamic acid
Authors:Deis, S.M., Dann III, C.E.
Deposit date:2015-05-22
Release date:2016-04-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase.
Biochemistry, 55, 2016
4ZYX
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HUMAN GAR TRANSFORMYLASE IN COMPLEX WITH GAR AND (S)-2-({4-[4-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]-PYRIMIDIN-6-YL)BUTYL]THIOPHENE-2-CARBONYL}AMINO)PENTANEDIOIC ACID (AGF117)
Descriptor:Trifunctional purine biosynthetic protein adenosine-3, GLYCINAMIDE RIBONUCLEOTIDE, N-({4-[4-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)butyl]thiophen-2-yl}carbonyl)-L-glutamic acid
Authors:Deis, S.M., Dann III, C.E.
Deposit date:2015-05-22
Release date:2016-04-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase.
Biochemistry, 55, 2016
4ZYY
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HUMAN GAR TRANSFORMYLASE IN COMPLEX WITH GAR AND (S)-2-({5-[4-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]-PYRIMIDIN-6-YL)BUTYL]THIOPHENE-3-CARBONYL}AMINO)PENTANEDIOIC ACID (AGF118)
Descriptor:Trifunctional purine biosynthetic protein adenosine-3, GLYCINAMIDE RIBONUCLEOTIDE, (S)-2-({5-[4-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]-pyrimidin-6-yl)butyl]thiophene-3-carbonyl}amino)pentanedioic acid
Authors:Deis, S.M., Dann III, C.E.
Deposit date:2015-05-22
Release date:2016-04-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase.
Biochemistry, 55, 2016
4ZYZ
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HUMAN GAR TRANSFORMYLASE IN COMPLEX WITH GAR AND (S)-2-(7-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)HEPTANAMIDO)PENTANEDIOIC ACID (AGF145)
Descriptor:Trifunctional purine biosynthetic protein adenosine-3, GLYCINAMIDE RIBONUCLEOTIDE, (S)-2-(7-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)heptanamido)pentanedioic acid
Authors:Deis, S.M., Dann III, C.E.
Deposit date:2015-05-22
Release date:2016-04-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase.
Biochemistry, 55, 2016
4ZZ0
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HUMAN GAR TRANSFORMYLASE IN COMPLEX WITH GAR AND (S)-2-(8-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)OCTANAMIDO)PENTANEDIOIC ACID (AGF147)
Descriptor:Trifunctional purine biosynthetic protein adenosine-3, GLYCINAMIDE RIBONUCLEOTIDE, (S)-2-(8-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)octanamido)pentanedioic acid
Authors:Deis, S.M., Dann III, C.E.
Deposit date:2015-05-22
Release date:2016-04-20
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural and Enzymatic Analysis of Tumor-Targeted Antifolates That Inhibit Glycinamide Ribonucleotide Formyltransferase.
Biochemistry, 55, 2016
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