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6MYE
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BU of 6mye by Molmil
Crystal structure of human Scribble PDZ1 domain in complex with internal PDZ binding motif of Src homology 3 domain-containing guanine nucleotide exchange factor (SGEF)
Descriptor: FORMIC ACID, Protein scribble homolog, Rho guanine nucleotide exchange factor 26, ...
Authors:Sun, Y.J, Hou, T, Gakhar, L, Fuentes, E.J.
Deposit date:2018-11-01
Release date:2019-04-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:SGEF forms a complex with Scribble and Dlg1 and regulates epithelial junctions and contractility.
J.Cell Biol., 218, 2019
6MYF
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BU of 6myf by Molmil
Crystal structure of free human Scribble PDZ1 domain
Descriptor: Protein scribble homolog
Authors:Sun, Y.J, Hou, T, Gakhar, L, Fuentes, E.J.
Deposit date:2018-11-01
Release date:2019-04-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:SGEF forms a complex with Scribble and Dlg1 and regulates epithelial junctions and contractility.
J.Cell Biol., 218, 2019
7Y1J
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BU of 7y1j by Molmil
Structure of SUR2A in complex with Mg-ATP and repaglinide in the inward-facing conformation.
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 9, MAGNESIUM ION, ...
Authors:Chen, L, Ding, D, Hou, T.
Deposit date:2022-06-08
Release date:2023-06-14
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (3 Å)
Cite:The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix.
Nat Commun, 14, 2023
7Y1M
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BU of 7y1m by Molmil
Structure of SUR2B in complex with Mg-ATP, Mg-ADP, and repaglinide in the inward-facing conformation
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Isoform SUR2B of ATP-binding cassette sub-family C member 9, ...
Authors:Chen, L, Ding, D, Hou, T.
Deposit date:2022-06-08
Release date:2023-06-14
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (3.57 Å)
Cite:The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix.
Nat Commun, 14, 2023
7Y1N
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BU of 7y1n by Molmil
Structure of SUR2B in complex with Mg-ATP, Mg-ADP, and repaglinide in the partially occluded state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Isoform SUR2B of ATP-binding cassette sub-family C member 9, ...
Authors:Chen, L, Ding, D, Hou, T.
Deposit date:2022-06-08
Release date:2023-06-14
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (3.61 Å)
Cite:The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix.
Nat Commun, 14, 2023
7Y1K
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BU of 7y1k by Molmil
Structure of SUR2A in complex with Mg-ATP, Mg-ADP and repaglinide in the inward-facing conformation
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 9, ...
Authors:Chen, L, Ding, D, Hou, T.
Deposit date:2022-06-08
Release date:2023-06-14
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix.
Nat Commun, 14, 2023
7Y1L
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BU of 7y1l by Molmil
Structure of SUR2B in complex with Mg-ATP and repaglinide in the inward-facing conformation
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Isoform SUR2B of ATP-binding cassette sub-family C member 9, MAGNESIUM ION, ...
Authors:Chen, L, Ding, D, Hou, T.
Deposit date:2022-06-08
Release date:2023-06-14
Last modified:2023-10-11
Method:ELECTRON MICROSCOPY (3.73 Å)
Cite:The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix.
Nat Commun, 14, 2023
7EB2
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BU of 7eb2 by Molmil
Cryo-EM structure of human GABA(B) receptor-Gi protein complex
Descriptor: (3S)-5,7-ditert-butyl-3-oxidanyl-3-(trifluoromethyl)-1-benzofuran-2-one, Gamma-aminobutyric acid type B receptor subunit 1, Gamma-aminobutyric acid type B receptor subunit 2, ...
Authors:Shen, C, Mao, C, Xu, C, Jin, N, Zhang, H, Shen, D, Shen, Q, Wang, X, Hou, T, Rondard, P, Chen, Z, Pin, J, Zhang, Y, Liu, J.
Deposit date:2021-03-08
Release date:2021-05-05
Last modified:2021-07-07
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural basis of GABA B receptor-G i protein coupling.
Nature, 594, 2021
6NID
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BU of 6nid by Molmil
Crystal structure of a human calcium/calmodulin dependent serine protein kinase (CASK) PDZ domain in complex with Neurexin-1 peptide
Descriptor: 1,2-ETHANEDIOL, Neurexin-1, Peripheral plasma membrane protein CASK
Authors:Sun, Y.J, Gakhar, L, Fuentes, E.J.
Deposit date:2018-12-27
Release date:2020-01-01
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:CASK PDZ domain specificity
To be published
6NH9
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BU of 6nh9 by Molmil
Crystal structure of a human calcium/calmodulin dependent serine protein kinase (CASK) PDZ domain
Descriptor: Peripheral plasma membrane protein CASK
Authors:Sun, Y.J, Gakhar, L, Fuentes, E.J.
Deposit date:2018-12-21
Release date:2019-12-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:CASK PDZ domain specificity
To be published
7F55
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BU of 7f55 by Molmil
Cryo-EM structure of bremelanotide-MC4R-Gs_Nb35 complex
Descriptor: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J.
Deposit date:2021-06-21
Release date:2021-11-03
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural insights into ligand recognition and activation of the melanocortin-4 receptor.
Cell Res., 31, 2021
7F54
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BU of 7f54 by Molmil
Cryo-EM structure of afamelanotide-MC4R-Gs_Nb35 complex
Descriptor: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J.
Deposit date:2021-06-21
Release date:2021-11-03
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural insights into ligand recognition and activation of the melanocortin-4 receptor.
Cell Res., 31, 2021
7F53
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BU of 7f53 by Molmil
Cryo-EM structure of a-MSH-MC4R-Gs_Nb35 complex
Descriptor: CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J.
Deposit date:2021-06-21
Release date:2021-11-03
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural insights into ligand recognition and activation of the melanocortin-4 receptor.
Cell Res., 31, 2021
7F58
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BU of 7f58 by Molmil
Cryo-EM structure of THIQ-MC4R-Gs_Nb35 complex
Descriptor: (3R)-N-[(2R)-3-(4-chlorophenyl)-1-[4-cyclohexyl-4-(1,2,4-triazol-1-ylmethyl)piperidin-1-yl]-1-oxidanylidene-propan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide, CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Zhang, H, Chen, L, Mao, C, Shen, Q, Yang, D, Shen, D, Qin, J.
Deposit date:2021-06-21
Release date:2021-11-03
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural insights into ligand recognition and activation of the melanocortin-4 receptor.
Cell Res., 31, 2021
7EPZ
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BU of 7epz by Molmil
Overall structure of Erastin-bound xCT-4F2hc complex
Descriptor: 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHATE, 2-[(1S)-1-[4-[2-(4-chloranylphenoxy)ethanoyl]piperazin-1-yl]ethyl]-3-(2-ethoxyphenyl)quinazolin-4-one, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Yan, R.H, Li, Y.N, Zhang, Y.Y, Chi, X.M, Zhou, Q.
Deposit date:2021-04-28
Release date:2022-04-06
Last modified:2022-07-13
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:The structure of erastin-bound xCT-4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis.
Cell Res., 32, 2022

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