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1B43
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FEN-1 FROM P. FURIOSUS
Descriptor:PROTEIN (FEN-1)
Authors:Hosfield, D.J., Mol, C.D., Shen, B., Tainer, J.A.
Deposit date:1999-01-05
Release date:2000-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the DNA repair and replication endonuclease and exonuclease FEN-1: coupling DNA and PCNA binding to FEN-1 activity.
Cell(Cambridge,Mass.), 95, 1998
1QTW
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HIGH-RESOLUTION CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI DNA REPAIR ENZYME ENDONUCLEASE IV
Descriptor:ENDONUCLEASE IV, ZINC ION
Authors:Hosfield, D.J., Guan, Y., Haas, B.J., Cunningham, R.P., Tainer, J.A.
Deposit date:1999-06-29
Release date:1999-08-31
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.02 Å)
Cite:Structure of the DNA repair enzyme endonuclease IV and its DNA complex: double-nucleotide flipping at abasic sites and three-metal-ion catalysis.
Cell(Cambridge,Mass.), 98, 1999
1QUM
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI ENDONUCLEASE IV IN COMPLEX WITH DAMAGED DNA
Descriptor:5'-D(*CP*GP*TP*CP*C)-3', 5'-D(*(3DR)P*CP*GP*AP*CP*GP*A)-3', 5'-D(*TP*CP*GP*TP*CP*GP*GP*GP*GP*AP*CP*G)-3', ...
Authors:Hosfield, D.J., Guan, Y., Haas, B.J., Cunningham, R.P., Tainer, J.A.
Deposit date:1999-07-01
Release date:1999-08-31
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure of the DNA repair enzyme endonuclease IV and its DNA complex: double-nucleotide flipping at abasic sites and three-metal-ion catalysis.
Cell(Cambridge,Mass.), 98, 1999
1RQI
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ACTIVE CONFORMATION OF FARNESYL PYROPHOSPHATE SYNTHASE BOUND TO ISOPENTYL PYROPHOSPHATE AND DIMETHYLALLYL S-THIOLODIPHOSPHATE
Descriptor:Geranyltranstransferase, MAGNESIUM ION, DIMETHYLALLYL S-THIOLODIPHOSPHATE, ...
Authors:Hosfield, D.J., Zhang, Y., Dougan, D.R., Brooun, A., Tari, L.W., Swanson, R.V., Finn, J.
Deposit date:2003-12-05
Release date:2004-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis
J.Biol.Chem., 279, 2004
1RQJ
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ACTIVE CONFORMATION OF FARNESYL PYROPHOSPHATE SYNTHASE BOUND TO ISOPENTYL PYROPHOSPHATE AND RISEDRONATE
Descriptor:Geranyltranstransferase, MAGNESIUM ION, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ...
Authors:Hosfield, D.J., Zhang, Y., Dougan, D.R., Brooun, A., Tari, L.W., Swanson, R.V., Finn, J.
Deposit date:2003-12-05
Release date:2004-03-02
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis
J.Biol.Chem., 279, 2004
1RTR
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CRYSTAL STRUCTURE OF S. AUREUS FARNESYL PYROPHOSPHATE SYNTHASE
Descriptor:geranyltranstransferase
Authors:Hosfield, D.J., Zhang, Y., Dougan, D.R., Brooun, A., Tari, L.W., Swanson, R.V., Finn, J.
Deposit date:2003-12-10
Release date:2004-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for bisphosphonate-mediated inhibition of isoprenoid biosynthesis
J.Mol.Biol., 279, 2004
1XU7
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CRYSTAL STRUCTURE OF THE INTERFACE OPEN CONFORMATION OF TETRAMERIC 11B-HSD1
Descriptor:Corticosteroid 11-beta-dehydrogenase, isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Hosfield, D.J., Wu, Y., Skene, R.J., Hilger, M., Jennings, A., Snell, G.P., Aertgeerts, K.
Deposit date:2004-10-25
Release date:2004-11-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Conformational Flexibility in Crystal Structures of Human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation.
J.Biol.Chem., 280, 2005
1XU9
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CRYSTAL STRUCTURE OF THE INTERFACE CLOSED CONFORMATION OF 11B-HYDROXYSTEROID DEHYDROGENASE ISOZYME 1
Descriptor:Corticosteroid 11-beta-dehydrogenase, isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Hosfield, D.J., Wu, Y., Skene, R.J., Hilger, M., Jennings, A., Snell, G.P., Aertgeerts, K.
Deposit date:2004-10-25
Release date:2004-11-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Conformational Flexibility in Crystal Structures of Human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation.
J.Biol.Chem., 280, 2005
5VGI
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CRYSTAL STRUCTURE OF KDM4 WITH THE SMALL MOLECULE INHIBITOR QC6352
Descriptor:Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ...
Authors:Hosfield, D.J.
Deposit date:2017-04-11
Release date:2017-09-27
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models.
ACS Med Chem Lett, 8, 2017
5VMP
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CRYSTAL STRUCTURE OF HUMAN KDM4 WITH SMALL MOLECULE INHIBITOR QC5714
Descriptor:Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ...
Authors:Hosfield, D.J.
Deposit date:2017-04-28
Release date:2017-09-27
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Design of KDM4 Inhibitors with Antiproliferative Effects in Cancer Models.
ACS Med Chem Lett, 8, 2017
6CG1
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CRYSTAL STRUCTURE OF KDM4A WITH COMPOUND 14
Descriptor:Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ...
Authors:Hosfield, D.J., Nie, Z.
Deposit date:2018-02-19
Release date:2018-04-18
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Structure-based design and discovery of potent and selective KDM5 inhibitors.
Bioorg. Med. Chem. Lett., 28, 2018
6CG2
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CRYSTAL STRUCTURE OF KDM4A WITH COMPOUND 8
Descriptor:Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ...
Authors:Hosfield, D.J., Nie, Z.
Deposit date:2018-02-19
Release date:2018-04-18
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Structure-based design and discovery of potent and selective KDM5 inhibitors.
Bioorg. Med. Chem. Lett., 28, 2018
6CKR
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CRYSTAL STRUCTURE OF BRD4 WITH QC4956
Descriptor:Bromodomain-containing protein 4, N-{3-[2-methyl-6-(1-methyl-1H-pyrazol-4-yl)-1-oxo-1,2-dihydroisoquinolin-4-yl]phenyl}methanesulfonamide
Authors:Hosfield, D.J.
Deposit date:2018-02-28
Release date:2018-05-02
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors.
Bioorg. Med. Chem. Lett., 28, 2018
6CKS
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CRYSTAL STRUCTURE OF BRD4 WITH QC4956
Descriptor:Bromodomain-containing protein 4, 4-[5-(ethylsulfonyl)-2-methoxyphenyl]-2-methyl-6-(1-methyl-1H-pyrazol-4-yl)isoquinolin-1(2H)-one
Authors:Hosfield, D.J.
Deposit date:2018-02-28
Release date:2018-05-02
Last modified:2018-05-16
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Design, synthesis and biological evaluation of novel 4-phenylisoquinolinone BET bromodomain inhibitors.
Bioorg. Med. Chem. Lett., 28, 2018
2NQ9
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HIGH RESOLUTION CRYSTAL STRUCTURE OF ESCHERICHIA COLI ENDONUCLEASE IV (ENDO IV) Y72A MUTANT BOUND TO DAMAGED DNA
Descriptor:5'-D(*AP*TP*AP*TP*CP*T)-3', 5'-D(P*(3DR)P*AP*GP*AP*T)-3', 5'-D(*AP*TP*CP*TP*GP*AP*AP*GP*TP*AP*T)-3', ...
Authors:Garcin-Hosfield, E.D., Hosfield, D.J., Tainer, J.A.
Deposit date:2006-10-30
Release date:2007-11-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:DNA apurinic-apyrimidinic site binding and excision by endonuclease IV.
Nat.Struct.Mol.Biol., 15, 2008
2NQH
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HIGH RESOLUTION CRYSTAL STRUCTURE OF ESCHERICHIA COLI ENDONUCLEASE IV (ENDO IV) E261Q MUTANT
Descriptor:Endonuclease 4, ZINC ION, PHOSPHATE ION
Authors:Garcin-Hosfield, E.D., Hosfield, D.J., Tainer, J.A.
Deposit date:2006-10-31
Release date:2007-11-06
Last modified:2015-01-21
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:DNA apurinic-apyrimidinic site binding and excision by endonuclease IV.
Nat.Struct.Mol.Biol., 15, 2008
2NQJ
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI ENDONUCLEASE IV (ENDO IV) E261Q MUTANT BOUND TO DAMAGED DNA
Descriptor:5'-D(*GP*CP*GP*TP*CP*CP*(3DR)P*CP*GP*AP*CP*GP*AP*CP*G)-3', 5'-D(*CP*GP*TP*CP*GP*TP*CP*GP*GP*GP*GP*AP*CP*GP*C)-3', Endonuclease 4, ...
Authors:Garcin-Hosfield, E.D., Hosfield, D.J., Tainer, J.A.
Deposit date:2006-10-31
Release date:2007-11-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:DNA apurinic-apyrimidinic site binding and excision by endonuclease IV.
Nat.Struct.Mol.Biol., 15, 2008
1TLL
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CRYSTAL STRUCTURE OF RAT NEURONAL NITRIC-OXIDE SYNTHASE REDUCTASE MODULE AT 2.3 A RESOLUTION.
Descriptor:Nitric-oxide synthase, brain, SULFITE ION, ...
Authors:Garcin, E.D., Bruns, C.M., Lloyd, S.J., Hosfield, D.J., Tiso, M., Gachhui, R., Stuehr, D.J., Tainer, J.A., Getzoff, E.D.
Deposit date:2004-06-09
Release date:2004-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase
J.Biol.Chem., 279, 2004
1I39
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RNASE HII FROM ARCHAEOGLOBUS FULGIDUS
Descriptor:RIBONUCLEASE HII
Authors:Chapados, B.R., Chai, Q., Hosfield, D.J., Qiu, J., Shen, B., Tainer, J.A.
Deposit date:2001-02-13
Release date:2001-04-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural biochemistry of a type 2 RNase H: RNA primer recognition and removal during DNA replication.
J.Mol.Biol., 307, 2001
1I3A
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RNASE HII FROM ARCHAEOGLOBUS FULGIDUS WITH COBALT HEXAMMINE CHLORIDE
Descriptor:RIBONUCLEASE HII, COBALT HEXAMMINE(III)
Authors:Chapados, B.R., Chai, Q., Hosfield, D.J., Qiu, J., Shen, B., Tainer, J.A.
Deposit date:2001-02-13
Release date:2001-04-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural biochemistry of a type 2 RNase H: RNA primer recognition and removal during DNA replication.
J.Mol.Biol., 307, 2001
1RWZ
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CRYSTAL STRUCTURE OF PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) FROM A. FULGIDUS
Descriptor:DNA polymerase sliding clamp
Authors:Chapados, B.R., Hosfield, D.J., Han, S., Qiu, J., Yelent, B., Shen, B., Tainer, J.A.
Deposit date:2003-12-17
Release date:2004-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for FEN-1 Substrate Specificity and PCNA-Mediated Activation in DNA Replication and Repair
Cell(Cambridge,Mass.), 116, 2004
1RXM
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C-TERMINAL REGION OF FEN-1 BOUND TO A. FULGIDUS PCNA
Descriptor:DNA polymerase sliding clamp, consensus FEN-1 peptide
Authors:Chapados, B.R., Hosfield, D.J., Han, S., Qiu, J., Yelent, B., Shen, B., Tainer, J.A.
Deposit date:2003-12-18
Release date:2004-01-27
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for FEN-1 Substrate Specificity and PCNA-Mediated Activation in DNA Replication and Repair
Cell(Cambridge,Mass.), 116, 2004
1RXV
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CRYSTAL STRUCTURE OF A. FULGIDUS FEN-1 BOUND TO DNA
Descriptor:5'-d(*T*pA*pG*pC*pA*pT*pC*pG*pG), Flap structure-specific endonuclease
Authors:Chapados, B.R., Hosfield, D.J., Han, S., Qiu, J., Yelent, B., Shen, B., Tainer, J.A.
Deposit date:2003-12-18
Release date:2004-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis for FEN-1 Substrate Specificity and PCNA-Mediated Activation in DNA Replication and Repair
Cell(Cambridge,Mass.), 116, 2004
1RXW
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CRYSTAL STRUCTURE OF A. FULGIDUS FEN-1 BOUND TO DNA
Descriptor:5'-d(*C*pG*pA*pT*pG*pC*pT*pA)-3', 5'-d(*T*pA*pG*pC*pA*pT*pC*pG*pG)-3', Flap structure-specific endonuclease
Authors:Chapados, B.R., Hosfield, D.J., Han, S., Qiu, J., Yelent, B., Shen, B., Tainer, J.A.
Deposit date:2003-12-18
Release date:2004-01-27
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for FEN-1 Substrate Specificity and PCNA-Mediated Activation in DNA Replication and Repair
Cell(Cambridge,Mass.), 116, 2004
1RXZ
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C-TERMINAL REGION OF A. FULGIDUS FEN-1 COMPLEXED WITH A. FULGIDUS PCNA
Descriptor:DNA polymerase sliding clamp, Flap structure-specific endonuclease
Authors:Chapados, B.R., Hosfield, D.J., Han, S., Qiu, J., Yelent, B., Shen, B., Tainer, J.A.
Deposit date:2003-12-18
Release date:2004-01-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for FEN-1 Substrate Specificity and PCNA-Mediated Activation in DNA Replication and Repair
Cell(Cambridge,Mass.), 116, 2004
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