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1KC6
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BU of 1kc6 by Molmil
HincII Bound to Cognate DNA
Descriptor: 5'-D(P*CP*CP*GP*GP*TP*CP*GP*AP*CP*CP*GP*G)-3', SODIUM ION, TYPE II RESTRICTION ENZYME HINCII
Authors:Horton, N.C, Dorner, L.F, Perona, J.J.
Deposit date:2001-11-07
Release date:2001-12-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Sequence selectivity and degeneracy of a restriction endonuclease mediated by DNA intercalation.
Nat.Struct.Biol., 9, 2002
1RV5
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BU of 1rv5 by Molmil
COMPLEX OF ECORV ENDONUCLEASE WITH D(AAAGAT)/D(ATCTT)
Descriptor: 5'-D(*AP*AP*AP*GP*AP*T*AP*TP*CP*TP*T)-3', ECORV ENDONUCLEASE
Authors:Horton, N.C, Perona, J.J.
Deposit date:1998-06-01
Release date:1998-11-11
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Role of protein-induced bending in the specificity of DNA recognition: crystal structure of EcoRV endonuclease complexed with d(AAAGAT) + d(ATCTT).
J.Mol.Biol., 277, 1998
2AUD
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BU of 2aud by Molmil
Unliganded HincII
Descriptor: Type II restriction enzyme HincII
Authors:Horton, N.C, Little, E.J.
Deposit date:2005-08-27
Release date:2005-10-04
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:DNA-induced conformational changes in Type II restriction endonucleases: The structure of unliganded HincII
J.Mol.Biol., 351, 2005
1SX5
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BU of 1sx5 by Molmil
K38A EcoRV bound to cleaved DNA and Mn2+: P1 crystal form
Descriptor: 5'-D(*AP*AP*AP*GP*AP*T)-3', 5'-D(P*AP*TP*CP*TP*T)-3', MANGANESE (II) ION, ...
Authors:Horton, N.C, Perona, J.J.
Deposit date:2004-03-30
Release date:2004-04-06
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:DNA cleavage by EcoRV endonuclease: Two metal ions in three metal ion binding sites
Biochemistry, 43, 2004
1SX8
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BU of 1sx8 by Molmil
EcoRV bound to cognate DNA and Mn2+
Descriptor: 5'-D(*C*AP*AP*GP*AP*TP*AP*TP*CP*TP*T)-3', MANGANESE (II) ION, Type II restriction enzyme EcoRV
Authors:Horton, N.C, Perona, J.J.
Deposit date:2004-03-30
Release date:2004-04-06
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:DNA Cleavage by EcoRV Endonuclease: Two Metal Ions in Three Metal Ion Binding Sites
Biochemistry, 43, 2004
1SUZ
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BU of 1suz by Molmil
The structure of K92A EcoRV bound to cognate DNA and Mg2+
Descriptor: 5'-D(*C*AP*AP*GP*AP*TP*AP*TP*CP*TP*T)-3', MAGNESIUM ION, SODIUM ION, ...
Authors:Horton, N.C, Perona, J.J.
Deposit date:2004-03-26
Release date:2004-04-06
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:DNA Cleavage by EcoRV Endonuclease: Two Metal Ions in Three Metal Ion Binding Sites.
Biochemistry, 43, 2004
1STX
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BU of 1stx by Molmil
Structure of the K38A mutant of EcoRV bound to cognate DNA and Mn2+
Descriptor: 5'-D(*AP*AP*AP*GP*AP*T)-3', 5'-D(P*AP*TP*CP*TP*T)-3', MANGANESE (II) ION, ...
Authors:Horton, N.C, Perona, J.J.
Deposit date:2004-03-25
Release date:2004-04-06
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:DNA cleavage by EcoRV endonuclease: two metal ions in three metal ion binding sites
Biochemistry, 43, 2004
1EON
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BU of 1eon by Molmil
ECORV BOUND TO 3'-S-PHOSPHOROTHIOLATE DNA AND CA2+
Descriptor: ACETIC ACID, CHLORIDE ION, DNA (5'-D(*AP*AP*AP*GP*AP*(TSP)P*AP*TP*CP*TP*T)-3'), ...
Authors:Horton, N.C, Connolly, B.A, Perona, J.J.
Deposit date:2000-03-23
Release date:2000-04-04
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Inhibition of EcoRV Endonuclease by Deoxyribo-3'-S-phosphorothiolates: A High-Resolution X-ray Crystallographic Study
J.Am.Chem.Soc., 122, 2000
1EO3
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BU of 1eo3 by Molmil
INHIBITION OF ECORV ENDONUCLEASE BY DEOXYRIBO-3'-S-PHOSPHOROTHIOLATES: A HIGH RESOLUTION X-RAY CRYSTALLOGRAPHIC STUDY
Descriptor: ACETIC ACID, DNA (5'-D(*CP*AP*AP*GP*AP*(TSP)P*AP*TP*CP*TP*T)-3'), MAGNESIUM ION, ...
Authors:Horton, N.C, Connolly, B.A, Perona, J.J.
Deposit date:2000-03-21
Release date:2000-04-04
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inhibition of EcoRV Endonuclease by Deoxyribo-3'-S-phosphorothiolates: A High-Resolution X-ray Crystallographic Study
J.Am.Chem.Soc., 122, 2000
1EO4
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BU of 1eo4 by Molmil
ECORV BOUND TO MN2+ AND COGNATE DNA CONTAINING A 3'S SUBSTITION AT THE CLEAVAGE SITE
Descriptor: ACETIC ACID, DNA (5'-D(*CP*AP*AP*GP*AP*(TSP)P*AP*TP*CP*TP*T)-3'), MANGANESE (II) ION, ...
Authors:Horton, N.C, Connolly, B.A, Perona, J.J.
Deposit date:2000-03-21
Release date:2000-04-04
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Inhibition of EcoRV Endonuclease by Deoxyribo-3'-S-phosphorothiolates: A High-Resolution X-ray Crystallographic Study
J.Am.Chem.Soc., 122, 2000
1EOO
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BU of 1eoo by Molmil
ECORV BOUND TO COGNATE DNA
Descriptor: DNA (5'-D(*GP*AP*AP*GP*AP*TP*AP*TP*CP*TP*TP*C)-3'), TYPE II RESTRICTION ENZYME ECORV
Authors:Horton, N.C, Perona, J.J.
Deposit date:2000-03-23
Release date:2000-04-04
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Crystallographic snapshots along a protein-induced DNA-bending pathway.
Proc.Natl.Acad.Sci.USA, 97, 2000
1EOP
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BU of 1eop by Molmil
ECORV BOUND TO COGNATE DNA
Descriptor: DNA (5'-D(*GP*AP*AP*GP*AP*TP*AP*TP*CP*TP*TP*C)-3'), TYPE II RESTRICTION ENZYME ECORV
Authors:Horton, N.C, Perona, J.J.
Deposit date:2000-03-23
Release date:2000-04-04
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystallographic snapshots along a protein-induced DNA-bending pathway.
Proc.Natl.Acad.Sci.USA, 97, 2000
1FIX
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BU of 1fix by Molmil
THE STRUCTURE OF AN RNA/DNA HYBRID: A SUBSTRATE OF THE RIBONUCLEASE ACTIVITY OF HIV-1 REVERSE TRANSCRIPTASE
Descriptor: DNA (5'-D(*GP*GP*CP*GP*CP*CP*CP*GP*AP*A)-3'), RNA (5'-R(*UP*UP*CP*GP*GP*GP*CP*GP*CP*C)-3')
Authors:Horton, N.C, Finzel, B.C.
Deposit date:1996-10-24
Release date:1996-12-11
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of an RNA/DNA hybrid: a substrate of the ribonuclease activity of HIV-1 reverse transcriptase.
J.Mol.Biol., 264, 1996
1BGB
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BU of 1bgb by Molmil
ECORV ENDONUCLEASE COMPLEX WITH 5'-CGGGATATCCC DNA
Descriptor: DNA (5'-D(*CP*GP*GP*GP*AP*TP*AP*TP*CP*CP*C)-3'), ECORV ENDONUCLEASE
Authors:Perona, J, Horton, N.C.
Deposit date:1998-05-28
Release date:1998-10-28
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Recognition of flanking DNA sequences by EcoRV endonuclease involves alternative patterns of water-mediated contacts.
J.Biol.Chem., 273, 1998
1BSS
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BU of 1bss by Molmil
ECORV-T93A/DNA/CA2+
Descriptor: 5'-D(*AP*AP*AP*GP*AP*TP*AP*TP*CP*TP*T)-3', CALCIUM ION, ECORV ENDONUCLEASE
Authors:Perona, J.J, Horton, N.C.
Deposit date:1998-08-30
Release date:1998-09-02
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Metal ion-mediated substrate-assisted catalysis in type II restriction endonucleases
Proc.Natl.Acad.Sci.USA, 95, 1998
1TX3
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BU of 1tx3 by Molmil
HINCII BOUND TO COGNATE DNA
Descriptor: 5'-D(*GP*CP*CP*GP*GP*TP*CP*GP*AP*CP*CP*GP*G)-3', SODIUM ION, Type II restriction enzyme HindII
Authors:Horton, N.C, Dorner, L.F, Perona, J.J.
Deposit date:2004-07-01
Release date:2005-02-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Ca2+ binding in the active site of HincII: implications for the catalytic mechanism
Biochemistry, 43, 2004
2GIH
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BU of 2gih by Molmil
Q138F HincII bound to cognate DNA GTCGAC and Ca2+
Descriptor: 5'-D(*GP*CP*CP*GP*GP*TP*CP*GP*AP*CP*CP*GP*GP*C)-3', CALCIUM ION, Type II restriction enzyme HincII
Authors:Horton, N.C, Joshi, H.K, Etzkorn, C, Chatwell, L, Bitinaite, J.
Deposit date:2006-03-28
Release date:2006-07-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Alteration of Sequence Specificity of the Type II Restriction Endonuclease HincII through an Indirect Readout Mechanism.
J.Biol.Chem., 281, 2006
2GIJ
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BU of 2gij by Molmil
Q138F HincII bound to cognate DNA GTTAAC and Ca2+
Descriptor: 5'-D(*GP*CP*CP*GP*GP*TP*TP*AP*AP*CP*CP*GP*GP*C)-3', CALCIUM ION, SODIUM ION, ...
Authors:Horton, N.C, Joshi, H.K.
Deposit date:2006-03-28
Release date:2006-07-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Alteration of Sequence Specificity of the Type II Restriction Endonuclease HincII through an Indirect Readout Mechanism.
J.Biol.Chem., 281, 2006
2GII
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BU of 2gii by Molmil
Q138F HincII bound to cognate DNA GTTAAC
Descriptor: 5'-D(*GP*CP*CP*GP*GP*TP*TP*AP*AP*CP*CP*GP*GP*C)-3', Type II restriction enzyme HincII
Authors:Horton, N.C, Joshi, H.K.
Deposit date:2006-03-28
Release date:2006-07-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Alteration of Sequence Specificity of the Type II Restriction Endonuclease HincII through an Indirect Readout Mechanism.
J.Biol.Chem., 281, 2006
2GIG
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BU of 2gig by Molmil
Alteration of sequence specificity of the type II restriction endonuclease HINCII through an indirect readout mechanism
Descriptor: 5'-D(*GP*CP*CP*GP*GP*TP*CP*GP*AP*CP*CP*GP*GP*C)-3', SODIUM ION, Type II restriction enzyme HincII
Authors:Horton, N.C, Joshi, H.K, Etzkorn, C, Chatwell, L, Bitinaite, J.
Deposit date:2006-03-28
Release date:2006-07-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Alteration of Sequence Specificity of the Type II Restriction Endonuclease HincII through an Indirect Readout Mechanism.
J.Biol.Chem., 281, 2006
2GIE
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BU of 2gie by Molmil
HincII bound to cognate DNA GTTAAC
Descriptor: 5'-D(*GP*CP*CP*GP*GP*TP*TP*AP*AP*CP*CP*GP*G)-3', SODIUM ION, Type II restriction enzyme HincII
Authors:Horton, N.C, Joshi, H.K, Etzkorn, C, Chatwell, L, Bitinaite, J.
Deposit date:2006-03-28
Release date:2006-07-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Alteration of Sequence Specificity of the Type II Restriction Endonuclease HincII through an Indirect Readout Mechanism.
J.Biol.Chem., 281, 2006
3N7B
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BU of 3n7b by Molmil
SgrAI bound to secondary site DNA and Ca(II)
Descriptor: CALCIUM ION, DNA (5'-D(*AP*GP*TP*CP*CP*AP*CP*CP*GP*GP*GP*GP*GP*AP*CP*T)-3'), DNA (5'-D(*AP*GP*TP*CP*CP*CP*CP*CP*GP*GP*TP*GP*GP*AP*CP*T)-3'), ...
Authors:Horton, N.C, Little, E.J, Dunten, P.W.
Deposit date:2010-05-26
Release date:2010-11-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:New clues in the allosteric activation of DNA cleavage by SgrAI: structures of SgrAI bound to cleaved primary-site DNA and uncleaved secondary-site DNA.
Acta Crystallogr.,Sect.D, 67, 2011
3N78
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BU of 3n78 by Molmil
SgrAI bound to Secondary Site DNA and Mg(II)
Descriptor: DNA (5'-D(*AP*GP*TP*CP*CP*AP*CP*CP*GP*GP*GP*GP*GP*AP*CP*T)-3'), DNA (5'-D(*AP*GP*TP*CP*CP*CP*CP*CP*GP*GP*TP*GP*GP*AP*CP*T)-3'), MAGNESIUM ION, ...
Authors:Horton, N.C, Little, E.J, Dunten, P.W.
Deposit date:2010-05-26
Release date:2010-11-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:New clues in the allosteric activation of DNA cleavage by SgrAI: structures of SgrAI bound to cleaved primary-site DNA and uncleaved secondary-site DNA.
Acta Crystallogr.,Sect.D, 67, 2011
2I13
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BU of 2i13 by Molmil
Aart, a six finger zinc finger designed to recognize ANN triplets
Descriptor: 5'-D(*CP*AP*GP*AP*TP*GP*TP*AP*GP*GP*GP*AP*AP*AP*AP*GP*CP*CP*CP*GP*GP*G)-3', 5'-D(*GP*CP*CP*CP*GP*GP*GP*CP*TP*TP*TP*TP*CP*CP*CP*TP*AP*CP*AP*TP*CP*T)-3', Aart, ...
Authors:Horton, N.C, Segal, D.J, Bhakta, M, Crotty, J.W, Barbas III, C.F.
Deposit date:2006-08-12
Release date:2006-10-03
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Structure of Aart, a Designed Six-finger Zinc Finger Peptide, Bound to DNA.
J.Mol.Biol., 363, 2006
3E45
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BU of 3e45 by Molmil
Q138F HincII bound to Noncognate DNA (GTGCAC) and Ca2+
Descriptor: 5'-D(*DGP*DCP*DCP*DGP*DGP*DTP*DGP*DCP*DAP*DCP*DCP*DGP*DGP*DC)-3', CALCIUM ION, SODIUM ION, ...
Authors:Horton, N.C, Babic, A.C, Little, E.J, Manohar, V.M.
Deposit date:2008-08-08
Release date:2008-08-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:DNA distortion and specificity in a sequence-specific endonuclease.
J.Mol.Biol., 383, 2008

 

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