Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
7A8P
DownloadVisualize
BU of 7a8p by Molmil
Structure of human mitochondrial RNA polymerase in complex with IMT inhibitor.
Descriptor: (3~{R})-1-[(2~{R})-2-[4-(2-chloranyl-4-fluoranyl-phenyl)-2-oxidanylidene-chromen-7-yl]oxypropanoyl]piperidine-3-carboxylic acid, DNA-directed RNA polymerase, mitochondrial
Authors:Hillen, H.S, Bonekamp, N, Peter, B, Felser, A, Bergbrede, T, Choidas, A, Horn, M, Unger, A, di Lucrezia, R, Atanassov, I, Li, X, Koch, U, Menninger, S, Boros, J, Habenberger, P, Giavalisco, P, Cramer, P, Denzel, M, Nussbaumer, P, Klebl, B, Falkenberg, M, Gustafsson, C.M, Larsson, N.G.
Deposit date:2020-08-30
Release date:2020-12-30
Last modified:2021-01-06
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Small-molecule inhibitors of human mitochondrial DNA transcription.
Nature, 588, 2020
3S3Q
DownloadVisualize
BU of 3s3q by Molmil
Structure of cathepsin B1 from Schistosoma mansoni in complex with K11017 inhibitor
Descriptor: ACETATE ION, Cathepsin B-like peptidase (C01 family), N~2~-(morpholin-4-ylcarbonyl)-N-[(3S)-1-phenyl-5-(phenylsulfonyl)pentan-3-yl]-L-leucinamide
Authors:Rezacova, P, Jilkova, A, Brynda, J, Horn, M, Mares, M.
Deposit date:2011-05-18
Release date:2011-08-10
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni.
J.Biol.Chem., 286, 2011
3S3R
DownloadVisualize
BU of 3s3r by Molmil
Structure of cathepsin B1 from Schistosoma mansoni in complex with K11777 inhibitor
Descriptor: Cathepsin B-like peptidase (C01 family), Nalpha-[(4-methylpiperazin-1-yl)carbonyl]-N-[(3S)-1-phenyl-5-(phenylsulfonyl)pentan-3-yl]-L-phenylalaninamide
Authors:Rezacova, P, Jilkova, A, Brynda, J, Horn, M, Mares, M.
Deposit date:2011-05-18
Release date:2011-08-10
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni.
J.Biol.Chem., 286, 2011
1LB8
DownloadVisualize
BU of 1lb8 by Molmil
Crystal structure of the Non-desensitizing GluR2 ligand binding core mutant (S1S2J-L483Y) in complex with AMPA at 2.3 resolution
Descriptor: (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID, Glutamate receptor 2
Authors:Sun, Y, Olson, R, Horning, M, Armstrong, N, Mayer, M, Gouaux, E.
Deposit date:2002-04-02
Release date:2002-06-05
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mechanism of glutamate receptor desensitization.
Nature, 417, 2002
1LB9
DownloadVisualize
BU of 1lb9 by Molmil
Crystal structure of the Non-desensitizing GluR2 ligand binding core mutant (S1S2J-L483Y) in complex with antagonist DNQX at 2.3 A resolution
Descriptor: 6,7-DINITROQUINOXALINE-2,3-DIONE, Glutamate receptor 2, SULFATE ION
Authors:Sun, Y, Olson, R, Horning, M, Armstrong, N, Mayer, M, Gouaux, E.
Deposit date:2002-04-02
Release date:2002-06-05
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Mechanism of glutamate receptor desensitization.
Nature, 417, 2002
1LBB
DownloadVisualize
BU of 1lbb by Molmil
Crystal structure of the GluR2 ligand binding domain mutant (S1S2J-N754D) in complex with kainate at 2.1 A resolution
Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamine receptor 2
Authors:Sun, Y, Olson, R, Horning, M, Armstrong, N, Mayer, M, Gouaux, E.
Deposit date:2002-04-02
Release date:2002-06-05
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Mechanism of glutamate receptor desensitization.
Nature, 417, 2002
1LBC
DownloadVisualize
BU of 1lbc by Molmil
Crystal structure of GluR2 ligand binding core (S1S2J-N775S) in complex with cyclothiazide (CTZ) as well as glutamate at 1.8 A resolution
Descriptor: CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamine Receptor 2, ...
Authors:Sun, Y, Olson, R, Horning, M, Armstrong, N, Mayer, M, Gouaux, E.
Deposit date:2002-04-02
Release date:2002-05-29
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mechanism of glutamate receptor desensitization.
Nature, 417, 2002
3QSD
DownloadVisualize
BU of 3qsd by Molmil
Structure of cathepsin B1 from Schistosoma mansoni in complex with CA074 inhibitor
Descriptor: ACETATE ION, Cathepsin B-like peptidase (C01 family), DI(HYDROXYETHYL)ETHER, ...
Authors:Rezacova, P, Jilkova, A, Brynda, J, Horn, M, Mares, M.
Deposit date:2011-02-21
Release date:2011-08-10
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni.
J.Biol.Chem., 286, 2011
4I05
DownloadVisualize
BU of 4i05 by Molmil
Structure of intermediate processing form of cathepsin B1 from Schistosoma mansoni
Descriptor: Cathepsin B-like peptidase (C01 family), SODIUM ION
Authors:Rezacova, P, Jilkova, A, Brynda, J, Horn, M, Mares, M.
Deposit date:2012-11-16
Release date:2014-02-05
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Activation route of the Schistosoma mansoni cathepsin B1 drug target: structural map with a glycosaminoglycan switch
Structure, 22, 2014
4I04
DownloadVisualize
BU of 4i04 by Molmil
Structure of zymogen of cathepsin B1 from Schistosoma mansoni
Descriptor: 1,2-ETHANEDIOL, Cathepsin B-like peptidase (C01 family)
Authors:Rezacova, P, Jilkova, A, Brynda, J, Horn, M, Mares, M.
Deposit date:2012-11-16
Release date:2014-02-05
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Activation route of the Schistosoma mansoni cathepsin B1 drug target: structural map with a glycosaminoglycan switch
Structure, 22, 2014
4I07
DownloadVisualize
BU of 4i07 by Molmil
Structure of mature form of cathepsin B1 from Schistosoma mansoni
Descriptor: ACETATE ION, CHLORIDE ION, Cathepsin B-like peptidase (C01 family)
Authors:Rezacova, P, Jilkova, A, Brynda, J, Horn, M, Mares, M.
Deposit date:2012-11-16
Release date:2014-02-05
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Activation route of the Schistosoma mansoni cathepsin B1 drug target: structural map with a glycosaminoglycan switch
Structure, 22, 2014
6SVP
DownloadVisualize
BU of 6svp by Molmil
Crystal structure of human GFAT-1 in complex with Glucose-6-Phosphate, L-Glu, and UDP-GlcNAc
Descriptor: GLUCOSE-6-PHOSPHATE, GLUTAMIC ACID, Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1, ...
Authors:Ruegenberg, S, Horn, M, Pichlo, C, Allmeroth, K, Baumann, U, Denzel, M.S.
Deposit date:2019-09-18
Release date:2020-01-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.531 Å)
Cite:Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis.
Nat Commun, 11, 2020
6SVQ
DownloadVisualize
BU of 6svq by Molmil
Crystal structure of human GFAT-1 G461E after UDP-GlcNAc soaking
Descriptor: GLUCOSE-6-PHOSPHATE, GLUTAMIC ACID, Glutamine--fructose-6-phosphate-aminotransferase [isomerizing] 1
Authors:Ruegenberg, S, Horn, M, Pichlo, C, Allmeroth, K, Baumann, U, Denzel, M.S.
Deposit date:2019-09-18
Release date:2020-01-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.717 Å)
Cite:Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis.
Nat Commun, 11, 2020
6SVM
DownloadVisualize
BU of 6svm by Molmil
Crystal structure of human GFAT-1 in complex with Glucose-6-Phosphate, L-Glu, and UDP-GalNAc
Descriptor: GLUCOSE-6-PHOSPHATE, GLUTAMIC ACID, Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1, ...
Authors:Ruegenberg, S, Horn, M, Pichlo, C, Allmeroth, K, Baumann, U, Denzel, M.S.
Deposit date:2019-09-18
Release date:2020-01-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.481 Å)
Cite:Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis.
Nat Commun, 11, 2020
6SVO
DownloadVisualize
BU of 6svo by Molmil
Crystal structure of human GFAT-1 in complex with Glucosamine-6-Phosphate and L-Glu
Descriptor: 2-DEOXY-2-AMINO GLUCITOL-6-PHOSPHATE, GLUTAMIC ACID, Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
Authors:Ruegenberg, S, Horn, M, Pichlo, C, Allmeroth, K, Baumann, U, Denzel, M.S.
Deposit date:2019-09-18
Release date:2020-01-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.328 Å)
Cite:Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis.
Nat Commun, 11, 2020
1MM7
DownloadVisualize
BU of 1mm7 by Molmil
Crystal Structure of the GluR2 Ligand Binding Core (S1S2J) in Complex with Quisqualate in a Zinc Crystal Form at 1.65 Angstroms Resolution
Descriptor: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, GLUTAMATE RECEPTOR 2, ZINC ION
Authors:Jin, R, Horning, M, Mayer, M.L, Gouaux, E.
Deposit date:2002-09-03
Release date:2003-02-04
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Mechanism of Activation and Selectivity in a Ligand-Gated Ion Channel: Structural and Functional Studies of GluR2 and Quisqualate
Biochemistry, 41, 2003
1MM6
DownloadVisualize
BU of 1mm6 by Molmil
crystal structure of the GluR2 ligand binding core (S1S2J) in complex with quisqualate in a non zinc crystal form at 2.15 angstroms resolution
Descriptor: (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, GLUTAMATE RECEPTOR 2, GLYCEROL, ...
Authors:Jin, R, Horning, M, Mayer, M.L, Gouaux, E.
Deposit date:2002-09-03
Release date:2003-02-04
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Mechanism of activation and selectivity in a ligand-gated ion channel: Structural and functional studies of GluR2 and quisqualate
Biochemistry, 41, 2002
6R4F
DownloadVisualize
BU of 6r4f by Molmil
Crystal structure of human GFAT-1 in complex with Glucose-6-Phosphate
Descriptor: GLUCOSE-6-PHOSPHATE, Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
Authors:Ruegenberg, S, Horn, M, Pichlo, C, Allmeroth, K, Baumann, U, Denzel, M.S.
Deposit date:2019-03-22
Release date:2020-01-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis.
Nat Commun, 11, 2020
6R4G
DownloadVisualize
BU of 6r4g by Molmil
Crystal structure of human GFAT-1 in complex with UDP-GlcNAc
Descriptor: GLUCOSE-6-PHOSPHATE, Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1, MAGNESIUM ION, ...
Authors:Ruegenberg, S, Horn, M, Pichlo, C, Allmeroth, K, Baumann, U, Denzel, M.S.
Deposit date:2019-03-22
Release date:2020-01-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis.
Nat Commun, 11, 2020
6R4J
DownloadVisualize
BU of 6r4j by Molmil
Crystal structure of human GFAT-1 G451E in complex with UDP-GlcNAc
Descriptor: GLUCOSE-6-PHOSPHATE, GLUTAMIC ACID, Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1, ...
Authors:Ruegenberg, S, Horn, M, Pichlo, C, Allmeroth, K, Baumann, U, Denzel, M.S.
Deposit date:2019-03-22
Release date:2020-01-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis.
Nat Commun, 11, 2020
6R4E
DownloadVisualize
BU of 6r4e by Molmil
Crystal structure of human GFAT-1 in complex with Glucose-6-Phosphate and L-Glu
Descriptor: GLUCOSE-6-PHOSPHATE, GLUTAMIC ACID, Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
Authors:Ruegenberg, S, Horn, M, Pichlo, C, Allmeroth, K, Baumann, U, Denzel, M.S.
Deposit date:2019-03-22
Release date:2020-01-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.353 Å)
Cite:Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis.
Nat Commun, 11, 2020
6R4H
DownloadVisualize
BU of 6r4h by Molmil
Crystal structure of human GFAT-1 G451E
Descriptor: GLUCOSE-6-PHOSPHATE, GLUTAMIC ACID, Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
Authors:Ruegenberg, S, Horn, M, Pichlo, C, Allmeroth, K, Baumann, U, Denzel, M.S.
Deposit date:2019-03-22
Release date:2020-01-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.244 Å)
Cite:Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis.
Nat Commun, 11, 2020
6R4I
DownloadVisualize
BU of 6r4i by Molmil
Crystal structure of human GFAT-1 G461E
Descriptor: GLUCOSE-6-PHOSPHATE, GLUTAMIC ACID, Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1
Authors:Ruegenberg, S, Horn, M, Pichlo, C, Allmeroth, K, Baumann, U, Denzel, M.S.
Deposit date:2019-03-22
Release date:2020-01-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.586 Å)
Cite:Loss of GFAT-1 feedback regulation activates the hexosamine pathway that modulates protein homeostasis.
Nat Commun, 11, 2020
8R6T
DownloadVisualize
BU of 8r6t by Molmil
NMR solution structure of thyropin IrThy-Cd from the hard tick Ixodes ricinus
Descriptor: Putative two thyropin protein (Fragment)
Authors:Srb, P, Veverka, V, Matouskova, Z, Orsaghova, K, Mares, M.
Deposit date:2023-11-23
Release date:2024-02-28
Last modified:2024-03-06
Method:SOLUTION NMR
Cite:An Unusual Two-Domain Thyropin from Tick Saliva: NMR Solution Structure and Highly Selective Inhibition of Cysteine Cathepsins Modulated by Glycosaminoglycans.
Int J Mol Sci, 25, 2024
5OGR
DownloadVisualize
BU of 5ogr by Molmil
Structure of cathepsin B1 from Schistosoma mansoni in complex with WRR286 inhibitor
Descriptor: 3-[[N-[4-METHYL-PIPERAZINYL]CARBONYL]-PHENYLALANINYL-AMINO]-5-PHENYL-PENTANE-1-SULFONIC ACID BENZYLOXY-AMIDE, ACETATE ION, Cathepsin B-like peptidase (C01 family)
Authors:Jilkova, A, Rezacova, P, Brynda, J, Mares, M.
Deposit date:2017-07-13
Release date:2018-11-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors.
Acs Infect Dis., 2020

 

123>

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon