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4TMB
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CRYSTAL STRUCTURE OF OLD YELLOW ENZYME FROM CANDIDA MACEDONIENSIS AKU4588
Descriptor:Old yellow enzyme, FLAVIN MONONUCLEOTIDE
Authors:Horita, S., Kataoka, M., Kitamura, N., Nakagawa, T., Miyakawa, T., Ohtsuka, J., Nagata, K., Shimizu, S., Tanokura, M.
Deposit date:2014-05-31
Release date:2015-02-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:An Engineered Old Yellow Enzyme that Enables Efficient Synthesis of (4R,6R)-Actinol in a One-Pot Reduction System
Chembiochem, 16, 2015
4TMC
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CRYSTAL STRUCTURE OF OLD YELLOW ENZYME FROM CANDIDA MACEDONIENSIS AKU4588 COMPLEXED WITH P-HYDROXYBENZALDEHYDE
Descriptor:Old yellow enzyme, FLAVIN MONONUCLEOTIDE, P-HYDROXYBENZALDEHYDE
Authors:Horita, S., Kataoka, M., Kitamura, N., Nakagawa, T., Miyakawa, T., Ohtsuka, J., Nagata, K., Shimizu, S., Tanokura, M.
Deposit date:2014-05-31
Release date:2015-02-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:An Engineered Old Yellow Enzyme that Enables Efficient Synthesis of (4R,6R)-Actinol in a One-Pot Reduction System
Chembiochem, 16, 2015
5B8C
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HIGH RESOLUTION STRUCTURE OF THE HUMAN PD-1 IN COMPLEX WITH PEMBROLIZUMAB FV
Descriptor:Pembrolizumab light chain variable region (PemVL), Pembrolizumab heavy chain variable region (PemVH), Programmed cell death protein 1
Authors:Horita, S., Shimamura, T., Iwata, S., Nomura, N.
Deposit date:2016-06-14
Release date:2016-10-26
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.146 Å)
Cite:High-resolution crystal structure of the therapeutic antibody pembrolizumab bound to the human PD-1
Sci Rep, 6, 2016
6AGZ
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CRYSTAL STRUCTURE OF OLD YELLOW ENZYME FROM PICHIA SP. AKU4542
Descriptor:Old Yellow Enzyme, FLAVIN MONONUCLEOTIDE
Authors:Horita, S., Kataoka, M., Kitamura, N., Nakagawa, T., Miyakawa, T., Ohtsuka, J., Nagata, K., Shimizu, S., Tanokura, M.
Deposit date:2018-08-15
Release date:2019-06-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis of different substrate preferences of two old yellow enzymes from yeasts in the asymmetric reduction of enone compounds.
Biosci.Biotechnol.Biochem., 83, 2019
2KSW
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BACKBONE 1H, 13C, AND 15N CHEMICAL SHIFT ASSIGNMENTS FOR ORYCTIN
Descriptor:Oryctin
Authors:Horita, S., Ishibashi, J., Nagata, K., Miyakawa, T., Yamakawa, M., Tanokura, M.
Deposit date:2010-01-14
Release date:2010-07-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Isolation, cDNA cloning, and structure-based functional characterization of oryctin, a hemolymph protein from the coconut rhinoceros beetle, Oryctes rhinoceros, as a novel serine protease inhibitor
J.Biol.Chem., 285, 2010
2LDS
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SOLUTION STRUCTURE OF A SHORT-CHAIN LAIT1 FROM THE VENOM OF SCORPION LIOCHELES AUSTRALASIAE
Descriptor:Insecticidal toxin LaIT1
Authors:Horita, S., Miyakawa, T., Nagata, K., Tanokura, M.
Deposit date:2011-06-01
Release date:2011-09-14
Last modified:2011-10-12
Method:SOLUTION NMR
Cite:Solution structure of a short-chain insecticidal toxin LaIT1 from the venom of scorpion Liocheles australasiae.
Biochem.Biophys.Res.Commun., 411, 2011
4NHX
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CRYSTAL STRUCTURE OF HUMAN OGFOD1, 2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN CONTAINING 1, IN COMPLEX WITH N-OXALYLGLYCINE (NOG)
Descriptor:2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1, MANGANESE (II) ION, SODIUM ION, ...
Authors:Horita, S., McDonough, M.A., Schofield, C.J.
Deposit date:2013-11-05
Release date:2014-11-19
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.105 Å)
Cite:Structure of the Ribosomal Oxygenase OGFOD1 Provides Insights into the Regio- and Stereoselectivity of Prolyl Hydroxylases.
Structure, 23, 2015
4NHY
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CRYSTAL STRUCTURE OF HUMAN OGFOD1, 2-OXOGLUTARATE AND IRON-DEPENDENT OXYGENASE DOMAIN CONTAINING 1, IN COMPLEX WITH PYRIDINE-2,4-DICARBOXYLIC ACID (2,4-PDCA)
Descriptor:2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1, MANGANESE (II) ION, GLYCEROL, ...
Authors:Horita, S., McDonough, M.A., Schofield, C.J.
Deposit date:2013-11-05
Release date:2014-11-19
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (2.603 Å)
Cite:Structure of the Ribosomal Oxygenase OGFOD1 Provides Insights into the Regio- and Stereoselectivity of Prolyl Hydroxylases.
Structure, 23, 2015
5YC8
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CRYSTAL STRUCTURE OF RATIONALLY THERMOSTABILIZED M2 MUSCARINIC ACETYLCHOLINE RECEPTOR BOUND WITH NMS (HG-DERIVATIVE)
Descriptor:Muscarinic acetylcholine receptor M2,Redesigned apo-cytochrome b562,Muscarinic acetylcholine receptor M2, N-methyl scopolamine, MERCURY (II) ION
Authors:Suno, R., Maeda, S., Yasuda, S., Yamashita, K., Hirata, K., Horita, S., Tawaramoto, M.S., Tsujimoto, H., Murata, T., Kinoshita, M., Yamamoto, M., Kobilka, B.K., Iwata, S., Kobayashi, T.
Deposit date:2017-09-06
Release date:2018-11-21
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor
Nat. Chem. Biol., 14, 2018
5YFI
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CRYSTAL STRUCTURE OF THE ANTI-HUMAN PROSTAGLANDIN E RECEPTOR EP4 ANTIBODY FAB FRAGMENT
Descriptor:Light chain of Fab fragment, Heavy chain of Fab fragment, ZINC ION
Authors:Toyoda, Y., Morimoto, K., Suno, R., Horita, S., Iwata, S., Kobayashi, T.
Deposit date:2017-09-21
Release date:2018-12-05
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.848 Å)
Cite:Ligand binding to human prostaglandin E receptor EP4at the lipid-bilayer interface.
Nat. Chem. Biol., 15, 2019
5YHL
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CRYSTAL STRUCTURE OF THE HUMAN PROSTAGLANDIN E RECEPTOR EP4 IN COMPLEX WITH FAB AND AN ANTAGONIST BR-DERIVATIVE
Descriptor:Prostaglandin E2 receptor EP4 subtype, Heavy chain of Fab fragment, Light chain of Fab fragment, ...
Authors:Toyoda, Y., Morimoto, K., Suno, R., Horita, S., Iwata, S., Kobayashi, T.
Deposit date:2017-09-28
Release date:2018-12-05
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:Ligand binding to human prostaglandin E receptor EP4at the lipid-bilayer interface.
Nat. Chem. Biol., 15, 2019
5YWY
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CRYSTAL STRUCTURE OF THE HUMAN PROSTAGLANDIN E RECEPTOR EP4 IN COMPLEX WITH FAB AND ONO-AE3-208
Descriptor:Prostaglandin E2 receptor EP4 subtype,Prostaglandin E2 receptor EP4 subtype, Heavy chain of Fab fragment, Light chain of Fab fragment, ...
Authors:Toyoda, Y., Morimoto, K., Suno, R., Horita, S., Iwata, S., Kobayashi, T.
Deposit date:2017-11-30
Release date:2018-12-05
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Ligand binding to human prostaglandin E receptor EP4at the lipid-bilayer interface.
Nat. Chem. Biol., 15, 2019
5ZK3
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CRYSTAL STRUCTURE OF RATIONALLY THERMOSTABILIZED M2 MUSCARINIC ACETYLCHOLINE RECEPTOR BOUND WITH QNB
Descriptor:Muscarinic acetylcholine receptor M2,Apo-cytochrome b562,Muscarinic acetylcholine receptor M2, (3R)-1-azabicyclo[2.2.2]oct-3-yl hydroxy(diphenyl)acetate
Authors:Suno, R., Maeda, S., Yasuda, S., Yamashita, K., Hirata, K., Horita, S., Tawaramoto, M.S., Tsujimoto, H., Murata, T., Kinoshita, M., Yamamoto, M., Kobilka, B.K., Iwata, S., Kobayashi, T.
Deposit date:2018-03-23
Release date:2018-11-21
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor
Nat. Chem. Biol., 14, 2018
5ZK8
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CRYSTAL STRUCTURE OF M2 MUSCARINIC ACETYLCHOLINE RECEPTOR BOUND WITH NMS
Descriptor:Muscarinic acetylcholine receptor M2,Redesigned apo-cytochrome b562,Muscarinic acetylcholine receptor M2, N-methyl scopolamine
Authors:Suno, R., Maeda, S., Yasuda, S., Yamashita, K., Hirata, K., Horita, S., Tawaramoto, M.S., Tsujimoto, H., Murata, T., Kinoshita, M., Yamamoto, M., Kobilka, B.K., Iwata, S., Kobayashi, T.
Deposit date:2018-03-23
Release date:2018-11-21
Last modified:2018-12-12
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor
Nat. Chem. Biol., 14, 2018
5ZKB
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CRYSTAL STRUCTURE OF RATIONALLY THERMOSTABILIZED M2 MUSCARINIC ACETYLCHOLINE RECEPTOR BOUND WITH AF-DX 384
Descriptor:Muscarinic acetylcholine receptor M2,Apo-cytochrome b562,Muscarinic acetylcholine receptor M2, N-[2-[(2S)-2-[(dipropylamino)methyl]piperidin-1-yl]ethyl]-6-oxidanylidene-5H-pyrido[2,3-b][1,4]benzodiazepine-11-carboxamide
Authors:Suno, R., Maeda, S., Yasuda, S., Yamashita, K., Hirata, K., Horita, S., Tawaramoto, M.S., Tsujimoto, H., Murata, T., Kinoshita, M., Yamamoto, M., Kobilka, B.K., Iwata, S., Kobayashi, T.
Deposit date:2018-03-23
Release date:2018-11-21
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor
Nat. Chem. Biol., 14, 2018
5ZKC
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CRYSTAL STRUCTURE OF RATIONALLY THERMOSTABILIZED M2 MUSCARINIC ACETYLCHOLINE RECEPTOR BOUND WITH NMS
Descriptor:Muscarinic acetylcholine receptor M2,Apo-cytochrome b562,Muscarinic acetylcholine receptor M2, N-methyl scopolamine
Authors:Suno, R., Maeda, S., Yasuda, S., Yamashita, K., Hirata, K., Horita, S., Tawaramoto, M.S., Tsujimoto, H., Murata, T., Kinoshita, M., Yamamoto, M., Kobilka, B.K., Iwata, S., Kobayashi, T.
Deposit date:2018-03-23
Release date:2018-11-21
Last modified:2018-11-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor
Nat. Chem. Biol., 14, 2018
3A4I
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CRYSTAL STRUCTURE OF GMP SYNTHETASE PH1347 FROM PYROCOCCUS HORIKOSHII OT3
Descriptor:GMP synthase [glutamine-hydrolyzing] subunit B
Authors:Maruoka, S., Horita, S., Lee, W.C., Nagata, K., Tanokura, M.
Deposit date:2009-07-07
Release date:2009-07-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Crystal structure of the ATPPase subunit and its substrate-dependent association with the GATase Subunit: a novel regulatory mechanism for a two-subunit-type GMP synthetase from Pyrococcus horikoshii OT3.
J.Mol.Biol., 395, 2010
3WAE
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X-RAY STRUCTURE OF FE(III)-BICARBONATES-TTFBPA, A FERRIC ION-BINDING PROTEIN FROM THERMUS THERMOPHILUS HB8
Descriptor:IRON ABC TRANSPORTER, PERIPLASMIC IRON-BINDING PROTEIN, FE (III) ION, ...
Authors:Wang, S., Ogata, M., Horita, S., Ohtsuka, J., Nagata, K., Tanokura, M.
Deposit date:2013-05-02
Release date:2014-05-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A novel mode of ferric ion coordination by the periplasmic ferric ion-binding subunit FbpA of an ABC-type iron transporter from Thermus thermophilus HB8.
Acta Crystallogr.,Sect.D, 70, 2014
3WAF
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X-RAY STRUCTURE OF APO-TTFBPA, A FERRIC ION-BINDING PROTEIN FROM THERMUS THERMOPHILUS HB8
Descriptor:Iron ABC transporter, periplasmic iron-binding protein, ISOPROPYL ALCOHOL
Authors:Wang, S., Ogata, M., Horita, S., Ohtsuka, J., Nagata, K., Tanokura, M.
Deposit date:2013-05-02
Release date:2014-05-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A novel mode of ferric ion coordination by the periplasmic ferric ion-binding subunit FbpA of an ABC-type iron transporter from Thermus thermophilus HB8.
Acta Crystallogr.,Sect.D, 70, 2014
5WQC
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CRYSTAL STRUCTURE OF HUMAN OREXIN 2 RECEPTOR BOUND TO THE SELECTIVE ANTAGONIST EMPA DETERMINED BY THE SYNCHROTRON LIGHT SOURCE AT SPRING-8.
Descriptor:Orexin receptor type 2,GlgA glycogen synthase,Orexin receptor type 2, N-ethyl-2-[(6-methoxypyridin-3-yl)-(2-methylphenyl)sulfonyl-amino]-N-(pyridin-3-ylmethyl)ethanamide, OLEIC ACID, ...
Authors:Suno, R., Hirata, K., Yamashita, K., Tsujimoto, H., Sasanuma, M., Horita, S., Yamamoto, M., Rosenbaum, D.M., Iwata, S., Shimamura, T., Kobayashi, T.
Deposit date:2016-11-25
Release date:2017-11-29
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA
Structure, 26, 2018
5WS3
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CRYSTAL STRUCTURES OF HUMAN OREXIN 2 RECEPTOR BOUND TO THE SELECTIVE ANTAGONIST EMPA DETERMINED BY SERIAL FEMTOSECOND CRYSTALLOGRAPHY AT SACLA
Descriptor:Orexin receptor type 2,GlgA glycogen synthase,Orexin receptor type 2, N-ethyl-2-[(6-methoxypyridin-3-yl)-(2-methylphenyl)sulfonyl-amino]-N-(pyridin-3-ylmethyl)ethanamide, OLEIC ACID, ...
Authors:Suno, R., Kimura, K., Nakane, T., Yamashita, K., Wang, J., Fujiwara, T., Yamanaka, Y., Im, D., Tsujimoto, H., Sasanuma, M., Horita, S., Hirokawa, T., Nango, E., Tono, K., Kameshima, T., Hatsui, T., Joti, Y., Yabashi, M., Shimamoto, K., Yamamoto, M., Rosenbaum, D.M., Iwata, S., Shimamura, T., Kobayashi, T.
Deposit date:2016-12-05
Release date:2017-12-13
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA.
Structure, 26, 2018
5XJM
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COMPLEX STRUCTURE OF ANGIOTENSIN II TYPE 2 RECEPTOR WITH FAB
Descriptor:Type-2 angiotensin II receptor,Soluble cytochrome b562,Type-2 angiotensin II receptor, FabH, FabL, ...
Authors:Asada, H., Horita, S., Shimamura, T., Iwata, S.
Deposit date:2017-05-02
Release date:2018-07-11
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog
Nat. Struct. Mol. Biol., 25, 2018
5XLI
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STRUCTURE OF ANTI-ANGIOTENSIN II TYPE2 RECEPTOR ANTIBODY (D5711-4A03)
Descriptor:FabL, FabH
Authors:Asada, H., Horita, S., Iwata, S., Hirata, K.
Deposit date:2017-05-10
Release date:2018-07-11
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (1.696 Å)
Cite:Crystal structure of the human angiotensin II type 2 receptor bound to an angiotensin II analog.
Nat. Struct. Mol. Biol., 25, 2018
5YOY
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CRYSTAL STRUCTURE OF THE HUMAN TUMOR NECROSIS FACTOR IN COMPLEX WITH GOLIMUMAB FV
Descriptor:Tumor necrosis factor, Golimumab light chain variable region, Golimumab heavy chain variable region
Authors:Ono, M., Horita, S., Sato, Y., Nomura, Y., Iwata, S., Nomura, N.
Deposit date:2017-10-31
Release date:2018-05-09
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.727 Å)
Cite:Structural basis for tumor necrosis factor blockade with the therapeutic antibody golimumab
Protein Sci., 27, 2018
4IJ5
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CRYSTAL STRUCTURE OF A NOVEL-TYPE PHOSPHOSERINE PHOSPHATASE FROM HYDROGENOBACTER THERMOPHILUS TK-6
Descriptor:Phosphoserine phosphatase 1, CHLORIDE ION, 1,2-ETHANEDIOL
Authors:Chiba, Y., Horita, S., Ohtsuka, J., Arai, H., Nagata, K., Igarashi, Y., Tanokura, M., Ishii, M.
Deposit date:2012-12-21
Release date:2013-03-20
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural units important for activity of a novel-type phosphoserine phosphatase from Hydrogenobacter thermophilus TK-6 revealed by crystal structure analysis
J.Biol.Chem., 288, 2013
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