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8SMV
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BU of 8smv by Molmil
GPR161 Gs heterotrimer
Descriptor: CHOLESTEROL, G-protein coupled receptor 161, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Hoppe, N, Manglik, A, Harrison, S.
Deposit date:2023-04-26
Release date:2024-02-21
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.74 Å)
Cite:GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway.
Biorxiv, 2023
7T32
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BU of 7t32 by Molmil
CryoEM structure of the adenosine 2A receptor-BRIL/Anti BRIL Fab complex with ZM241385
Descriptor: 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, Adenosine receptor A2a/Soluble cytochrome b562 Fusion Protein
Authors:Zhang, K.H, Wu, H, Hoppe, N, Manglik, A, Cheng, Y.F.
Deposit date:2021-12-06
Release date:2022-08-10
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Fusion protein strategies for cryo-EM study of G protein-coupled receptors.
Nat Commun, 13, 2022
8CXO
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BU of 8cxo by Molmil
Cryo-EM structure of the unliganded mSMO-PGS2 in a lipidic environment
Descriptor: CHOLESTEROL, Smoothened homolog, GlgA glycogen synthase chimera
Authors:Zhang, K, Wu, H, Hoppe, N, Manglik, A, Cheng, Y.
Deposit date:2022-05-22
Release date:2022-08-03
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Fusion protein strategies for cryo-EM study of G protein-coupled receptors.
Nat Commun, 13, 2022
7KKJ
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BU of 7kkj by Molmil
Structure of anti-SARS-CoV-2 Spike nanobody mNb6
Descriptor: CHLORIDE ION, SULFATE ION, Synthetic nanobody mNb6
Authors:Schoof, M.S, Faust, B.F, Saunders, R.A, Sangwan, S, Rezelj, V, Hoppe, N, Boone, M, Billesboelle, C.B, Puchades, C, Azumaya, C.M, Kratochvil, H.T, Zimanyi, M, Desphande, I, Liang, J, Dickinson, S, Nguyen, H.C, Chio, C.M, Merz, G.E, Thompson, M.C, Diwanji, D, Schaefer, K, Anand, A.A, Dobzinski, N, Zha, B.S, Simoneau, C.R, Leon, K, White, K.M, Chio, U.S, Gupta, M, Jin, M, Li, F, Liu, Y, Zhang, K, Bulkley, D, Sun, M, Smith, A.M, Rizo, A.N, Moss, F, Brilot, A.F, Pourmal, S, Trenker, R, Pospiech, T, Gupta, S, Barsi-Rhyne, B, Belyy, V, Barile-Hill, A.W, Nock, S, Liu, Y, Krogan, N.J, Ralston, C.Y, Swaney, D.L, Garcia-Sastre, A, Ott, M, Vignuzzi, M, Walter, P, Manglik, A, QCRG Structural Biology Consortium
Deposit date:2020-10-27
Release date:2020-11-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
Science, 370, 2020
7KKK
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BU of 7kkk by Molmil
SARS-CoV-2 Spike in complex with neutralizing nanobody Nb6
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:Schoof, M.S, Faust, B.F, Saunders, R.A, Sangwan, S, Rezelj, V, Hoppe, N, Boone, M, Billesboelle, C.B, Puchades, C, Azumaya, C.M, Kratochvil, H.T, Zimanyi, M, Desphande, I, Liang, J, Dickinson, S, Nguyen, H.C, Chio, C.M, Merz, G.E, Thompson, M.C, Diwanji, D, Schaefer, K, Anand, A.A, Dobzinski, N, Zha, B.S, Simoneau, C.R, Leon, K, White, K.M, Chio, U.S, Gupta, M, Jin, M, Li, F, Liu, Y, Zhang, K, Bulkley, D, Sun, M, Smith, A.M, Rizo, A.N, Moss, F, Brilot, A.F, Pourmal, S, Trenker, R, Pospiech, T, Gupta, S, Barsi-Rhyne, B, Belyy, V, Barile-Hill, A.W, Nock, S, Liu, Y, Krogan, N.J, Ralston, C.Y, Swaney, D.L, Garcia-Sastre, A, Ott, M, Vignuzzi, M, Walter, P, Manglik, A, QCRG Structural Biology Consortium
Deposit date:2020-10-27
Release date:2020-11-11
Last modified:2021-04-21
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
Science, 370, 2020
7KKL
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BU of 7kkl by Molmil
SARS-CoV-2 Spike in complex with neutralizing nanobody mNb6
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:Schoof, M.S, Faust, B.F, Saunders, R.A, Sangwan, S, Rezelj, V, Hoppe, N, Boone, M, Billesboelle, C.B, Puchades, C, Azumaya, C.M, Kratochvil, H.T, Zimanyi, M, Desphande, I, Liang, J, Dickinson, S, Nguyen, H.C, Chio, C.M, Merz, G.E, Thompson, M.C, Diwanji, D, Schaefer, K, Anand, A.A, Dobzinski, N, Zha, B.S, Simoneau, C.R, Leon, K, White, K.M, Chio, U.S, Gupta, M, Jin, M, Li, F, Liu, Y, Zhang, K, Bulkley, D, Sun, M, Smith, A.M, Rizo, A.N, Moss, F, Brilot, A.F, Pourmal, S, Trenker, R, Pospiech, T, Gupta, S, Barsi-Rhyne, B, Belyy, V, Barile-Hill, A.W, Nock, S, Liu, Y, Krogan, N.J, Ralston, C.Y, Swaney, D.L, Garcia-Sastre, A, Ott, M, Vignuzzi, M, Walter, P, Manglik, A, QCRG Structural Biology Consortium
Deposit date:2020-10-27
Release date:2020-11-11
Last modified:2021-04-21
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
Science, 370, 2020
7UTZ
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BU of 7utz by Molmil
Human thyrotropin analog TR1402 bound to human Thyrotropin receptor in complex with miniGs399 (composite structure)
Descriptor: (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein hormones alpha chain analog TR1402, ...
Authors:Faust, B, Cheng, Y, Manglik, A.
Deposit date:2022-04-28
Release date:2022-08-03
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Autoantibody mimicry of hormone action at the thyrotropin receptor.
Nature, 609, 2022
7KDT
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BU of 7kdt by Molmil
Human Tom70 in complex with SARS CoV2 Orf9b
Descriptor: Mitochondrial import receptor subunit TOM70, ORF9b protein
Authors:QCRG Structural Biology Consortium
Deposit date:2020-10-09
Release date:2020-10-21
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
Science, 370, 2020
7K1A
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BU of 7k1a by Molmil
TtgR quadruple mutant (C137I I141W M167L F168Y)
Descriptor: HTH-type transcriptional regulator TtgR, MAGNESIUM ION
Authors:Bingman, C.A, Nishikawa, K.K, Smith, R.W, Raman, S.
Deposit date:2020-09-07
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Epistasis shapes the fitness landscape of an allosteric specificity switch.
Nat Commun, 12, 2021
7KD8
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BU of 7kd8 by Molmil
TtgR C137I I141W M167L F168Y mutant in complex with resveratrol
Descriptor: HTH-type transcriptional regulator TtgR, MAGNESIUM ION, RESVERATROL
Authors:Bingman, C.A, Nishikawa, K.K, Smith, R.W, Raman, S.
Deposit date:2020-10-08
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Epistasis shapes the fitness landscape of an allosteric specificity switch.
Nat Commun, 12, 2021
7K1C
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BU of 7k1c by Molmil
TtgR in complex with resveratrol
Descriptor: HTH-type transcriptional regulator TtgR, MAGNESIUM ION, RESVERATROL
Authors:Bingman, C.A, Nishikawa, K.K, Smith, R.W, Raman, S.
Deposit date:2020-09-07
Release date:2021-10-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Epistasis shapes the fitness landscape of an allosteric specificity switch.
Nat Commun, 12, 2021
7T9I
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BU of 7t9i by Molmil
Native human TSH bound to human Thyrotropin receptor in complex with miniGs399 (composite structure)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein hormones alpha chain, ...
Authors:Faust, B, Cheng, Y, Manglik, A.
Deposit date:2021-12-19
Release date:2022-08-03
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Autoantibody mimicry of hormone action at the thyrotropin receptor.
Nature, 609, 2022
7T9N
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BU of 7t9n by Molmil
M22 Agonist Autoantibody bound to Human Thyrotropin receptor in complex with miniGs399 (composite structure)
Descriptor: (2S)-3-hydroxypropane-1,2-diyl dihexadecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Faust, B, Cheng, Y, Manglik, A.
Deposit date:2021-12-19
Release date:2022-08-03
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Autoantibody mimicry of hormone action at the thyrotropin receptor.
Nature, 609, 2022
7T9M
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BU of 7t9m by Molmil
Human Thyrotropin receptor bound by CS-17 Inverse Agonist Fab/Org 274179-0 Antagonist
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CS-17 Heavy Chain, ...
Authors:Faust, B, Cheng, Y, Manglik, A.
Deposit date:2021-12-19
Release date:2022-08-10
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Autoantibody mimicry of hormone action at the thyrotropin receptor.
Nature, 609, 2022

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PDB entries from 2024-03-27

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