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1FQ4
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CRYSTAL STRUCTURE OF A COMPLEX BETWEEN HYDROXYETHYLENE INHIBITOR CP-108,420 AND YEAST ASPARTIC PROTEINASE A
Descriptor:SACCHAROPEPSIN, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Cronin, N.B., Badasso, M.O., Tickle, I.J., Dreyer, T., Hoover, D.J., Rosati, R.L., Humblet, C.C., Lunney, E.A., Cooper, J.B.
Deposit date:2000-09-03
Release date:2000-09-20
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity.
J.Mol.Biol., 303, 2000
1FQ5
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X-RAY STRUCTURE OF A CYCLIC STATINE INHIBITOR PD-129,541 BOUND TO YEAST PROTEINASE A
Descriptor:SACCHAROPEPSIN, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Cronin, N.B., Badasso, M.O., Tickle, I.J., Dreyer, T., Hoover, D.J., Rosati, R.L., Humblet, C.C., Lunney, E.A., Cooper, J.B.
Deposit date:2000-09-03
Release date:2000-09-20
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity.
J.Mol.Biol., 303, 2000
1FQ6
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X-RAY STRUCTURE OF GLYCOL INHIBITOR PD-133,450 BOUND TO SACCHAROPEPSIN
Descriptor:SACCHAROPEPSIN, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Cronin, N.B., Badasso, M.O., Tickle, I.J., Dreyer, T., Hoover, D.J., Rosati, R.L., Humblet, C.C., Lunney, E.A., Cooper, J.B.
Deposit date:2000-09-03
Release date:2000-09-20
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity.
J.Mol.Biol., 303, 2000
1FQ7
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X-RAY STRUCTURE OF INHIBITOR CP-72,647 BOUND TO SACCHAROPEPSIN
Descriptor:SACCHAROPEPSIN, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Cronin, N.B., Badasso, M.O., Tickle, I.J., Dreyer, T., Hoover, D.J., Rosati, R.L., Humblet, C.C., Lunney, E.A., Cooper, J.B.
Deposit date:2000-09-04
Release date:2000-09-20
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity.
J.Mol.Biol., 303, 2000
1FQ8
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X-RAY STRUCTURE OF DIFLUOROSTATINE INHIBITOR CP81,198 BOUND TO SACCHAROPEPSIN
Descriptor:SACCHAROPEPSIN, N-ACETYL-D-GLUCOSAMINE, ALPHA-D-MANNOSE, ...
Authors:Cronin, N.B., Badasso, M.O., Tickle, I.J., Dreyer, T., Hoover, D.J., Rosati, R.L., Humblet, C.C., Lunney, E.A., Cooper, J.B.
Deposit date:2000-09-04
Release date:2000-09-20
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:X-ray structures of five renin inhibitors bound to saccharopepsin: exploration of active-site specificity.
J.Mol.Biol., 303, 2000
1EM6
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HUMAN LIVER GLYCOGEN PHOSPHORYLASE A COMPLEXED WITH GLCNAC AND CP-526,423
Descriptor:LIVER GLYCOGEN PHOSPHORYLASE, 1-N-ACETYL-BETA-D-GLUCOSAMINE, BIS[5-CHLORO-1H-INDOL-2-YL-CARBONYL-AMINOETHYL]-ETHYLENE GLYCOL, ...
Authors:Rath, V.L., Ammirati, M., Danley, D.E., Ekstrom, J.L., Hynes, T.R., Olson, T.V., Hoover, D.J.
Deposit date:2000-03-16
Release date:2000-11-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Human liver glycogen phosphorylase inhibitors bind at a new allosteric site.
Chem.Biol., 7, 2000
1EXV
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HUMAN LIVER GLYCOGEN PHOSPHORYLASE A COMPLEXED WITH GLCNAC AND CP-403,700
Descriptor:LIVER GLYCOGEN PHOSPHORYLASE, 1-N-ACETYL-BETA-D-GLUCOSAMINE, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Rath, V.L., Ammirati, M., Danley, D.E., Ekstrom, J.L., Hynes, T.R., Olson, T.V., Hoover, D.J.
Deposit date:2000-05-04
Release date:2000-11-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Human liver glycogen phosphorylase inhibitors bind at a new allosteric site.
Chem.Biol., 7, 2000
1L5Q
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HUMAN LIVER GLYCOGEN PHOSPHORYLASE A COMPLEXED WITH CAFFEINE, N-ACETYL-BETA-D-GLUCOPYRANOSYLAMINE, AND CP-403700
Descriptor:Glycogen phosphorylase, liver form, 1-N-ACETYL-BETA-D-GLUCOSAMINE, ...
Authors:Ekstrom, J.L., Pauly, T.A., Carty, M.D., Soeller, W.C., Culp, J., Danley, D.E., Hoover, D.J., Treadway, J.L., Gibbs, E.M., Fletterick, R.J., Day, Y.S.N., Myszka, D.G., Rath, V.L.
Deposit date:2002-03-07
Release date:2002-12-04
Last modified:2012-05-02
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase.
Chem.Biol., 9, 2002
1L5R
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HUMAN LIVER GLYCOGEN PHOSPHORYLASE A COMPLEXED WITH RIBOFLAVIN, N-ACETYL-BETA-D-GLUCOPYRANOSYLAMINE AND CP-403,700
Descriptor:glycogen phosphorylase, liver form, 1-N-ACETYL-BETA-D-GLUCOSAMINE, ...
Authors:Ekstrom, J.L., Pauly, T.A., Carty, M.D., Soeller, W.C., Culp, J., Danley, D.E., Hoover, D.J., Treadway, J.L., Gibbs, E.M., Fletterick, R.J., Day, Y.S.N., Myszka, D.G., Rath, V.L.
Deposit date:2002-03-07
Release date:2002-12-04
Last modified:2012-05-02
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase.
Chem.Biol., 9, 2002
1L5S
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HUMAN LIVER GLYCOGEN PHOSPHORYLASE COMPLEXED WITH URIC ACID, N-ACETYL-BETA-D-GLUCOPYRANOSYLAMINE, AND CP-403,700
Descriptor:Glycogen phosphorylase, liver form, 1-N-ACETYL-BETA-D-GLUCOSAMINE, ...
Authors:Ekstrom, J.L., Pauly, T.A., Carty, M.D., Soeller, W.C., Culp, J., Danley, D.E., Hoover, D.J., Treadway, J.L., Gibbs, E.M., Fletterick, R.J., Day, Y.S.N., Myszka, D.G., Rath, V.L.
Deposit date:2002-03-07
Release date:2002-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase.
Chem.Biol., 9, 2002
1L7X
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HUMAN LIVER GLYCOGEN PHOSPHORYLASE B COMPLEXED WITH CAFFEINE, N-ACETYL-BETA-D-GLUCOPYRANOSYLAMINE, AND CP-403,700
Descriptor:Glycogen phosphorylase, liver form, 1-N-ACETYL-BETA-D-GLUCOSAMINE, ...
Authors:Ekstrom, J.L., Pauly, T.A., Carty, M.D., Soeller, W.C., Culp, J., Danley, D.E., Hoover, D.J., Treadway, J.L., Gibbs, E.M., Fletterick, R.J., Day, Y.S.N., Myszka, D.G., Rath, V.L.
Deposit date:2002-03-18
Release date:2002-12-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-activity analysis of the purine binding site of human liver glycogen phosphorylase.
Chem.Biol., 9, 2002
2JXR
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STRUCTURE OF YEAST PROTEINASE A
Descriptor:PROTEINASE A, N-(morpholin-4-ylcarbonyl)-L-phenylalanyl-N-[(1R)-1-(cyclohexylmethyl)-3,3-difluoro-2,2-dihydroxy-4-(methylamino)-4-oxobutyl]-L-norleucinamide, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Aguilar, C.F., Badasso, M., Dreyer, T., Cronin, N.B., Newman, M.P., Cooper, J.B., Hoover, D.J., Wood, S.P., Johnson, M.S., Blundell, T.L.
Deposit date:1997-04-24
Release date:1997-10-29
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The three-dimensional structure at 2.4 A resolution of glycosylated proteinase A from the lysosome-like vacuole of Saccharomyces cerevisiae.
J.Mol.Biol., 267, 1997
5ER2
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HIGH-RESOLUTION X-RAY DIFFRACTION STUDY OF THE COMPLEX BETWEEN ENDOTHIAPEPSIN AND AN OLIGOPEPTIDE INHIBITOR. THE ANALYSIS OF THE INHIBITOR BINDING AND DESCRIPTION OF THE RIGID BODY SHIFT IN THE ENZYME
Descriptor:ENDOTHIAPEPSIN, 6-ammonio-N-{[(2R,3R)-3-{[N-(tert-butoxycarbonyl)-L-phenylalanyl-3-(1H-imidazol-3-ium-4-yl)-L-alanyl]amino}-4-cyclohexyl-2-hydroxybutyl](2-methylpropyl)carbamoyl}-L-norleucyl-L-phenylalanine
Authors:Sali, A., Veerapandian, B., Cooper, J.B., Foundling, S.I., Hoover, D.J., Blundell, T.L.
Deposit date:1991-01-02
Release date:1991-04-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:High-resolution X-ray diffraction study of the complex between endothiapepsin and an oligopeptide inhibitor: the analysis of the inhibitor binding and description of the rigid body shift in the enzyme.
EMBO J., 8, 1989
1CZI
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CHYMOSIN COMPLEX WITH THE INHIBITOR CP-113972
Descriptor:CHYMOSIN, CP-113972 (NORSTATINE-S-METHYL CYSTEINE-IODO-PHENYLALANINE-PROLINE)
Authors:Groves, M.R., Dhanaraj, V., Pitts, J.E., Badasso, M., Hoover, D., Nugent, P., Blundell, T.L.
Deposit date:1997-01-15
Release date:1997-04-01
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A 2.3 A resolution structure of chymosin complexed with a reduced bond inhibitor shows that the active site beta-hairpin flap is rearranged when compared with the native crystal structure.
Protein Eng., 11, 1998
1EPO
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ENDOTHIA ASPARTIC PROTEINASE (ENDOTHIAPEPSIN) COMPLEXED WITH CP-81,282 (MOR PHE NLE CHF NME)
Descriptor:ENDOTHIAPEPSIN, N-(morpholin-4-ylcarbonyl)-L-phenylalanyl-N-[(1R)-1-(cyclohexylmethyl)-3,3-difluoro-2,2-dihydroxy-4-(methylamino)-4-oxobutyl]-L-norleucinamide
Authors:Veerapandian, B., Cooper, J.B., Blundell, T.L.
Deposit date:1994-07-27
Release date:1994-12-20
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Direct observation by X-ray analysis of the tetrahedral intermediate of aspartic proteinases.
Protein Sci., 1, 1992
1SMR
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THE 3-D STRUCTURE OF MOUSE SUBMAXILLARY RENIN COMPLEXED WITH A DECAPEPTIDE INHIBITOR CH-66 BASED ON THE 4-16 FRAGMENT OF RAT ANGIOTENSINOGEN
Descriptor:RENIN, INHIBITOR CH-66
Authors:Dealwis, C.G., Blundell, T.L.
Deposit date:1992-03-11
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray analysis at 2.0 A resolution of mouse submaxillary renin complexed with a decapeptide inhibitor CH-66, based on the 4-16 fragment of rat angiotensinogen.
J.Mol.Biol., 236, 1994
4LZ5
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CRYSTAL STRUCTURES OF GLUR2 LIGAND-BINDING-DOMAIN IN COMPLEX WITH GLUTAMATE AND POSITIVE ALLOSTERIC MODULATORS
Descriptor:Glutamate receptor 2, GLUTAMIC ACID, ZINC ION, ...
Authors:Pandit, J.
Deposit date:2013-07-31
Release date:2013-12-04
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Discovery and Characterization of a Novel Dihydroisoxazole Class of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Potentiators.
J.Med.Chem., 56, 2013
4LZ7
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CRYSTAL STRUCTURES OF GLUR2 LIGAND-BINDING-DOMAIN IN COMPLEX WITH GLUTAMATE AND POSITIVE ALLOSTERIC MODULATORS
Descriptor:Glutamate receptor 2, ZINC ION, GLUTAMIC ACID, ...
Authors:Pandit, J.
Deposit date:2013-07-31
Release date:2013-12-04
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery and Characterization of a Novel Dihydroisoxazole Class of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Potentiators.
J.Med.Chem., 56, 2013
4LZ8
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CRYSTAL STRUCTURES OF GLUR2 LIGAND-BINDING-DOMAIN IN COMPLEX WITH GLUTAMATE AND POSITIVE ALLOSTERIC MODULATORS
Descriptor:Glutamate receptor 2, GLUTAMIC ACID, N-[(3S)-1-{2-fluoro-4-[(5S)-5-{[(propan-2-ylsulfonyl)amino]methyl}-4,5-dihydro-1,2-oxazol-3-yl]phenyl}pyrrolidin-3-yl]acetamide, ...
Authors:Pandit, J.
Deposit date:2013-07-31
Release date:2013-12-04
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Discovery and Characterization of a Novel Dihydroisoxazole Class of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Potentiators.
J.Med.Chem., 56, 2013
1DP5
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THE STRUCTURE OF PROTEINASE A COMPLEXED WITH A IA3 MUTANT INHIBITOR
Descriptor:PROTEINASE A, PROTEINASE INHIBITOR IA3, BETA-D-MANNOSE, ...
Authors:Li, M., Phylip, H.L., Lees, W.E., Winther, J.R., Dunn, B.M., Wlodawer, A., Kay, J., Guschina, A.
Deposit date:1999-12-23
Release date:2000-05-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The aspartic proteinase from Saccharomyces cerevisiae folds its own inhibitor into a helix.
Nat.Struct.Biol., 7, 2000
1DPJ
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THE STRUCTURE OF PROTEINASE A COMPLEXED WITH IA3 PEPTIDE INHIBITOR
Descriptor:PROTEINASE A, PROTEINASE INHIBITOR IA3 PEPTIDE, BETA-D-MANNOSE, ...
Authors:Li, M., Phylip, H.L., Lees, W.E., Winther, J.R., Dunn, B.M., Wlodawer, A., Kay, J., Guschina, A.
Deposit date:1999-12-27
Release date:2000-05-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The aspartic proteinase from Saccharomyces cerevisiae folds its own inhibitor into a helix.
Nat.Struct.Biol., 7, 2000
1RNE
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THE CRYSTAL STRUCTURE OF RECOMBINANT GLYCOSYLATED HUMAN RENIN ALONE AND IN COMPLEX WITH A TRANSITION STATE ANALOG INHIBITOR
Descriptor:RENIN, N-ACETYL-D-GALACTOSAMINE, [[[3-(2-METHYL-PROPANE-2-SULFONYL)-1-BENZENYL]-2-PROPYL]-CARBONYL-HISTIDYL]-AMINO-[CYCLOHEXYLMETHYL]-[2-HYDROXY-4-ISOPROPYL]-PENTAN-5-OIC ACID BUTYLAMIDE
Authors:Gruetter, M.G., Rahuel, J., Priestle, J.P.
Deposit date:1991-12-12
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The crystal structures of recombinant glycosylated human renin alone and in complex with a transition state analog inhibitor.
J.Struct.Biol., 107, 1991
1WUT
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ACYL UREAS AS HUMAN LIVER GLYCOGEN PHOSPHORYLASE INHIBITORS FOR THE TREATMENT OF TYPE 2 DIABETES
Descriptor:Glycogen phosphorylase, muscle form, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Klabunde, T., Wendt, K.U., Kadereit, D., Brachvogel, V., Burger, H.-J., Herling, A.W., Oikonomakos, N.G., Kosmopoulou, M.N., Schmoll, D., Sarubbi, E., von Roedern, E., Schonafinger, K., Defossa, E.
Deposit date:2004-12-08
Release date:2005-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs
Protein Sci., 14, 2005