Author results

4Z08
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DIRECTED EVOLUTIONARY CHANGES IN KEMP ELIMINASE KE07 - CRYSTAL 1 KE07 DESIGN
Descriptor:de novo designed kemp eliminase KE07
Authors:Jackson, C.J., Hong, N.-S., Carr, P.D.
Deposit date:2015-03-25
Release date:2016-04-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 1 KE07 design
To Be Published
5D2T
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DIRECTED EVOLUTIONARY CHANGES IN KEMP ELIMINASE KE07 - CRYSTAL 3 WILD TYPE
Descriptor:De novo designed kemp eliminase KE07, 5-nitro-2-oxidanyl-benzenecarbonitrile
Authors:Jackson, C.J., Hong, N.-S., Carr, P.D.
Deposit date:2015-08-06
Release date:2016-09-07
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 1 Wild Type
To Be Published
5D2V
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DIRECTED EVOLUTIONARY CHANGES IN KEMP ELIMINASE KE07 - CRYSTAL 4 WILD TYPE
Descriptor:De novo designed kemp eliminase KE07
Authors:Jackson, C.J., Hong, N.-S., Carr, P.D.
Deposit date:2015-08-06
Release date:2016-09-07
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 1 Wild Type
To Be Published
5D2W
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DIRECTED EVOLUTIONARY CHANGES IN KEMP ELIMINASE KE07 - CRYSTAL 5 WILD TYPE
Descriptor:De novo designed kemp eliminase KE07, 5-nitro-2-oxidanyl-benzenecarbonitrile
Authors:Jackson, C.J., Hong, N.-S., Carr, P.D.
Deposit date:2015-08-06
Release date:2016-09-07
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:evolutionary changes in Kemp Eliminase KE07 - Crystal 5 Wild Type
To Be Published
5D2X
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DIRECTED EVOLUTIONARY CHANGES IN KEMP ELIMINASE KE07 - CRYSTAL 6 ROUND5
Descriptor:De novo desinged kemp eliminase KE07, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Jackson, C.J., Hong, N.-S., Carr, P.D.
Deposit date:2015-08-06
Release date:2016-09-21
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 1 Wild Type
To Be Published
5D2Y
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DIRECTED EVOLUTIONARY CHANGES IN KEMP ELIMINASE KE07 - CRYSTAL 7 ROUND 5
Descriptor:De novo designed kemp eliminase KE07
Authors:Jackson, C.J., Hong, N.-S., Carr, P.D.
Deposit date:2015-08-06
Release date:2016-09-07
Method:X-RAY DIFFRACTION (1.984 Å)
Cite:Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 7 Round 5
To Be Published
5D30
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DIRECTED EVOLUTIONARY CHANGES IN KEMP ELIMINASE KE07 - CRYSTAL 9 ROUND 5
Descriptor:De novo kemp eliminase KE07 round 5
Authors:Jackson, C.J., Hong, N.-S., Carr, P.D.
Deposit date:2015-08-06
Release date:2016-09-07
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 9 Round 5
To Be Published
5D32
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DIRECTED EVOLUTIONARY CHANGES IN KEMP ELIMINASE KE07 - CRYSTAL 11 ROUND 6
Descriptor:De novo kemp eliminase KE07 round 6
Authors:Jackson, C.J., Hong, N.-S., Carr, P.D.
Deposit date:2015-08-06
Release date:2016-09-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 11 round 6
To Be Published
5D33
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DIRECTED EVOLUTIONARY CHANGES IN KEMP ELIMINASE KE07 - CRYSTAL 12 ROUND 7
Descriptor:de novo kemp eliminase KE07 round 7
Authors:Jackson, C.J., Hong, N.-S., Carr, P.D.
Deposit date:2015-08-06
Release date:2016-09-07
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 12 round 7
To Be Published
5D37
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DIRECTED EVOLUTIONARY CHANGES IN KEMP ELIMINASE KE07 - CRYSTAL 16 ROUND 7
Descriptor:De novo kemp eliminase KE07 round 7
Authors:Jackson, C.J., Hong, N.-S., Carr, P.D.
Deposit date:2015-08-06
Release date:2016-09-07
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 16 round 7
To Be Published
5D38
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DIRECTED EVOLUTIONARY CHANGES IN KEMP ELIMINASE KE07 - CRYSTAL 17 ROUND 7-2
Descriptor:De novo kemp eliminase KE07 round 7-2
Authors:Jackson, C.J., Hong, N.-S., Carr, P.D.
Deposit date:2015-08-06
Release date:2016-09-07
Method:X-RAY DIFFRACTION (1.427 Å)
Cite:Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 17 round 7-2
To Be Published
5JQJ
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DIRECTED EVOLUTIONARY CHANGES IN MBL SUPER FAMILY - NDM-1 ROUND 10 CRYSTAL-1
Descriptor:Metallo-beta-lactamase type 2, ZINC ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Hong, N.-S., Jackson, C.J., Carr, P.D.
Deposit date:2016-05-05
Release date:2017-05-10
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Enzyme evolvability is contingent on the initial sequence background
To Be Published
5K4M
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DIRECTED EVOLUTIONARY CHANGES IN MBL SUPER FAMILY - NDM-1 ROUND 10 CRYSTAL-3
Descriptor:Metallo-beta-lactamase type 2, ZINC ION, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
Authors:Hong, N.-S., Jackson, C.J., Carr, P.D.
Deposit date:2016-05-20
Release date:2017-04-26
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Enzyme evolvability is contingent on the initial sequence background
To Be Published
6C2C
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THE MOLECULAR BASIS FOR THE FUNCTIONAL EVOLUTION OF AN ORGANOPHOSPHATE HYDROLYSING ENZYME
Descriptor:dihydrocoumarin hydrolase, AncDHCH1, ZINC ION, ...
Authors:Hong, N.-S., Jackson, C.J., Carr, P.D., Tokuriki, N., Baier, F., Yang, G.
Deposit date:2018-01-08
Release date:2019-01-16
Last modified:2019-01-23
Method:X-RAY DIFFRACTION (1.597 Å)
Cite:Higher-order epistatic networks underlie the evolutionary fitness landscape of a xenobiotic-degrading enzyme
Biorxiv, 2019
6DC1
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DIRECTED EVOLUTIONARY CHANGES IN KEMP ELIMINASE KE07 - CRYSTAL 25 ROUND 7
Descriptor:Kemp eliminase KE07, 5-nitro-2-oxidanyl-benzenecarbonitrile, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
Authors:Jackson, C.J., Hong, N.-S., Carr, P.D.
Deposit date:2018-05-03
Release date:2018-08-01
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 25 round 7
To Be Published
6DKV
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DIRECTED EVOLUTIONARY CHANGES IN KEMP ELIMINASE KE07 - CRYSTAL 21 ROUND 5
Descriptor:Kemp eliminase KE07, DI(HYDROXYETHYL)ETHER, 5-nitro-2-oxidanyl-benzenecarbonitrile
Authors:Jackson, C.J., Hong, N.-S., Carr, P.D.
Deposit date:2018-05-30
Release date:2018-08-01
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Directed evolutionary changes in Kemp Eliminase KE07 - Crystal 17 round 7-2
To Be Published
5EH9
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INDIRECT CONTRIBUTIONS OF MUTATIONS UNDERLIE OPTIMIZATION OF NEW ENZYME FUNCTION
Descriptor:N-acyl homoserine lactonase AiiA, ZINC ION, GLYCEROL, ...
Authors:Hong, N.-S., Jackson, C.J., Tokuriki, N., Yang, G., Baier, F.
Deposit date:2015-10-28
Release date:2016-09-07
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Conformational Tinkering Drives Evolution of a Promiscuous Activity through Indirect Mutational Effects.
Biochemistry, 55, 2016
6BM9
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DIRECTED EVOLUTIONARY CHANGES IN MBL SUPER FAMILY - VIM-2 ROUND 10
Descriptor:Metallo-beta-lactamase, ZINC ION, GLYCEROL
Authors:Hong, N.-S., Jackson, C.J., Carr, P.D.
Deposit date:2017-11-13
Release date:2018-11-21
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Cryptic genetic variation shapes the adaptive evolutionary potential of enzymes.
Elife, 8, 2019
5EHT
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INDIRECT CONTRIBUTIONS OF MUTATIONS UNDERLIE OPTIMIZATION OF NEW ENZYME FUNCTION
Descriptor:N-acyl homoserine lactonase, ZINC ION, GLYCEROL
Authors:Jackson, C.J., Hong, N.-S.
Deposit date:2015-10-28
Release date:2016-09-07
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Conformational Tinkering Drives Evolution of a Promiscuous Activity through Indirect Mutational Effects.
Biochemistry, 55, 2016
6C7H
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DIRECTED EVOLUTIONARY CHANGES IN KEMP ELIMINASE KE07 - CRYSTAL 18 DESIGN TRP50ALA MUTANT
Descriptor:Kemp eliminase KE07
Authors:Jackson, C.J., Hong, N.-S., Carr, P.D.
Deposit date:2018-01-22
Release date:2018-08-01
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:The evolution of multiple active site configurations in a designed enzyme.
Nat Commun, 9, 2018
6C7M
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DIRECTED EVOLUTIONARY CHANGES IN KEMP ELIMINASE KE07 - CRYSTAL 19 ROUND 5
Descriptor:Kemp Eliminase KE07, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Jackson, C.J., Hong, N.-S., Carr, P.D.
Deposit date:2018-01-22
Release date:2018-08-01
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:The evolution of multiple active site configurations in a designed enzyme.
Nat Commun, 9, 2018
6C7T
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DIRECTED EVOLUTIONARY CHANGES IN KEMP ELIMINASE KE07 - CRYSTAL 20 ROUND 5
Descriptor:Kemp Eliminase KE07
Authors:Jackson, C.J., Hong, N.-S., Carr, P.D.
Deposit date:2018-01-23
Release date:2018-08-01
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:The evolution of multiple active site configurations in a designed enzyme.
Nat Commun, 9, 2018
6C7V
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DIRECTED EVOLUTIONARY CHANGES IN KEMP ELIMINASE KE07 - CRYSTAL 22 ROUND 5
Descriptor:Kemp eliminase KE07
Authors:Jackson, C.J., Hong, N.-S., Carr, P.D.
Deposit date:2018-01-23
Release date:2018-08-01
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:The evolution of multiple active site configurations in a designed enzyme.
Nat Commun, 9, 2018
6C8B
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DIRECTED EVOLUTIONARY CHANGES IN KEMP ELIMINASE KE07 - CRYSTAL 23 ROUND 6
Descriptor:Kemp eliminase KE07
Authors:Jackson, C.J., Hong, N.-S., Carr, P.D.
Deposit date:2018-01-24
Release date:2018-08-01
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:The evolution of multiple active site configurations in a designed enzyme.
Nat Commun, 9, 2018
6CAI
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DIRECTED EVOLUTIONARY CHANGES IN KEMP ELIMINASE KE07 - CRYSTAL 24 ROUND 7
Descriptor:Kemp Eliminase KE07, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Jackson, C.J., Hong, N.-S., Carr, P.D.
Deposit date:2018-01-30
Release date:2018-08-01
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:The evolution of multiple active site configurations in a designed enzyme.
Nat Commun, 9, 2018
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