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3DDF
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GOLGI MANNOSIDASE II COMPLEX WITH (3R,4R,5R)-3,4-DIHYDROXY-5-({[(1R)-2-HYDROXY-1 PHENYLETHYL]AMINO}METHYL) PYRROLIDIN-2-ONE
Descriptor:alpha-mannosidase 2, N-ACETYL-D-GLUCOSAMINE, ZINC ION, ...
Authors:Kuntz, D.A., Rose, D.R., Hoffman, D.
Deposit date:2008-06-05
Release date:2008-07-01
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Functionalized pyrrolidine inhibitors of human type II alpha-mannosidases as anti-cancer agents: optimizing the fit to the active site
Bioorg.Med.Chem., 16, 2008
3DDG
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GOLGI MANNOSIDASE II COMPLEX WITH (3R,4R,5R)-3,4-DIHYDROXY-5-({[(1R)-2-HYDROXY-1 PHENYLETHYL]AMINO}METHYL) METHYLPYRROLIDIN-2-ONE
Descriptor:alpha-mannosidase 2, N-ACETYL-D-GLUCOSAMINE, PHOSPHATE ION, ...
Authors:Kuntz, D.A., Rose, D.R., Hoffman, D.
Deposit date:2008-06-05
Release date:2008-07-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Functionalized pyrrolidine inhibitors of human type II alpha-mannosidases as anti-cancer agents: optimizing the fit to the active site
Bioorg.Med.Chem., 16, 2008
2JVN
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DOMAIN C OF HUMAN PARP-1
Descriptor:Poly [ADP-ribose] polymerase 1, ZINC ION
Authors:Hoffman, D., Tao, Z., Liu, H.
Deposit date:2007-09-24
Release date:2008-05-13
Last modified:2013-05-01
Method:SOLUTION NMR
Cite:Domain C of human poly(ADP-ribose) polymerase-1 is important for enzyme activity and contains a novel zinc-ribbon motif.
Biochemistry, 47, 2008
2KTL
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STRUCTURE OF C-TERMINAL DOMAIN FROM MTTYRRS OF A. NIDULANS
Descriptor:Tyrosyl-tRNA synthetase
Authors:Chari, N.S.
Deposit date:2010-02-03
Release date:2011-05-04
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of C-terminal domain from mtTyrRS of A. nidulans
To be Published
1CQU
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SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF RIBOSOMAL PROTEIN L9
Descriptor:50S RIBOSOMAL PROTEIN L9
Authors:Hua, Y., Kuhlman, B., Hoffman, D., Raleigh, D.P.
Deposit date:1999-08-11
Release date:2002-04-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Effects of varying the local propensity to form secondary structure on the stability and folding kinetics of a rapid folding mixed alpha/beta protein: characterization of a truncation mutant of the N-terminal domain of the ribosomal protein L9.
J.Mol.Biol., 289, 1999
3CD8
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X-RAY STRUCTURE OF C-MET WITH TRIAZOLOPYRIDAZINE INHIBITOR.
Descriptor:Hepatocyte growth factor receptor, 7-methoxy-4-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline
Authors:Bellon, S.F., Albrecht, B.K., Harmange, J.-C., Bauer, D., Choquette, D., Dussault, I.
Deposit date:2008-02-26
Release date:2008-04-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase.
J.Med.Chem., 51, 2008
3CCN
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X-RAY STRUCTURE OF C-MET WITH TRIAZOLOPYRIDAZINE INHIBITOR.
Descriptor:Hepatocyte growth factor receptor, 4-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl]phenol
Authors:Abrecht, B.K., Harmange, J.-C., Bauer, D., Dussault, I., long, A., Bellon, S.F.
Deposit date:2008-02-26
Release date:2008-04-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase.
J.Med.Chem., 51, 2008
3EFJ
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STRUCTURE OF C-MET WITH PYRIMIDONE INHIBITOR 7
Descriptor:Hepatocyte growth factor receptor, 2-benzyl-5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-3-methylpyrimidin-4(3H)-one
Authors:D'Angelo, N., Bellon, S., Whittington, D.
Deposit date:2008-09-09
Release date:2008-10-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Design, synthesis, and biological evaluation of potent c-Met inhibitors.
J.Med.Chem., 51, 2008
3EFK
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STRUCTURE OF C-MET WITH PYRIMIDONE INHIBITOR 50
Descriptor:Hepatocyte growth factor receptor, 5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-2-[(4-fluorophenyl)amino]-3-methylpyrimidin-4(3H)-one
Authors:Bellon, S.F., D'Angelo, N., Whittington, D., Dussault, I.
Deposit date:2008-09-09
Release date:2008-10-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Design, synthesis, and biological evaluation of potent c-Met inhibitors.
J.Med.Chem., 51, 2008
2P2H
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CRYSTAL STRUCTURE OF THE VEGFR2 KINASE DOMAIN IN COMPLEX WITH A PYRIDINYL-TRIAZINE INHIBITOR
Descriptor:Vascular endothelial growth factor receptor 2, 4-(2-anilinopyridin-3-yl)-N-(3,4,5-trimethoxyphenyl)-1,3,5-triazin-2-amine
Authors:Whittington, D.A., Kim, J.L., Long, A.M., Rose, P., Gu, Y., Zhao, H.
Deposit date:2007-03-07
Release date:2007-03-20
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Evolution of a Highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor
J.Med.Chem., 50, 2007
2P2I
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CRYSTAL STRUCTURE OF THE VEGFR2 KINASE DOMAIN IN COMPLEX WITH A NICOTINAMIDE INHIBITOR
Descriptor:Vascular endothelial growth factor receptor 2, N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide
Authors:Whittington, D.A., Kim, J.L., Long, A.M., Rose, P., Gu, Y., Zhao, H.
Deposit date:2007-03-07
Release date:2007-03-20
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Evolution of a Highly Selective and Potent 2-(Pyridin-2-yl)-1,3,5-triazine Tie-2 Kinase Inhibitor
J.Med.Chem., 50, 2007
2P4I
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EVOLUTION OF A HIGHLY SELECTIVE AND POTENT 2-(PYRIDIN-2-YL)-1,3,5-TRIAZINE TIE-2 KINASE INHIBITOR
Descriptor:Angiopoietin-1 receptor, 4-METHYL-3-({3-[2-(METHYLAMINO)PYRIMIDIN-4-YL]PYRIDIN-2-YL}OXY)-N-[2-MORPHOLIN-4-YL-5-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
Authors:Bellon, S.F.
Deposit date:2007-03-12
Release date:2007-03-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor.
J.Med.Chem., 50, 2007
3L9L
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CRYSTAL STRUCTURE OF PKA WITH COMPOUND 36
Descriptor:cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 5-[2-({(2S)-2-amino-3-[4-(trifluoromethyl)phenyl]propyl}amino)-1,3-thiazol-5-yl]-1,3-dihydro-2H-indol-2-one
Authors:Huang, X.
Deposit date:2010-01-05
Release date:2011-01-19
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Azole-based inhibitors of AKT/PKB for the treatment of cancer.
Bioorg.Med.Chem.Lett., 20, 2010
3L9M
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CRYSTAL STRUCTURE OF PKAB3 (PKA TRIPLE MUTANT V123A, L173M, Q181K) WITH COMPOUND 18
Descriptor:cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, (2S)-N~1~-[5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl]-3-(4-methylphenyl)propane-1,2-diamine
Authors:Huang, X.
Deposit date:2010-01-05
Release date:2011-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Azole-based inhibitors of AKT/PKB for the treatment of cancer.
Bioorg.Med.Chem.Lett., 20, 2010
3L9N
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CRYSTAL STRUCTURE OF PKAB3 (PKA TRIPLE MUTANT V123A, L173M, Q181K) WITH COMPOUND 27
Descriptor:cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, (2S)-N~1~-[5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl]-3-(4-methylphenyl)propane-1,2-diamine
Authors:Huang, X.
Deposit date:2010-01-05
Release date:2011-01-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Azole-based inhibitors of AKT/PKB for the treatment of cancer.
Bioorg.Med.Chem.Lett., 20, 2010
4TW1
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CRYSTAL STRUCTURE OF THE OCTAMERIC PORE COMPLEX OF THE STAPHYLOCOCCUS AUREUS BI-COMPONENT TOXIN LUKGH
Descriptor:Possible leukocidin subunit
Authors:LOGAN, D.T., HAKANSSON, M., SALINE, M., KIMBUNG, R., BADARAU, A., ROUHA, H., NAGY, E.
Deposit date:2014-06-29
Release date:2014-11-12
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-Function Analysis of Heterodimer Formation, Oligomerization, and Receptor Binding of the Staphylococcus aureus Bi-component Toxin LukGH.
J.Biol.Chem., 290, 2015