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6BUW
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THERMUS THERMOPHILUS 70S COMPLEX CONTAINING 16S G299A RAM MUTATION AND EMPTY A SITE.
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Hoffer, E.D., Maehigashi, T., Fagan, C.E., Dunham, C.M.
Deposit date:2017-12-11
Release date:2018-11-14
Last modified:2019-07-03
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Ribosomal ambiguity (ram) mutations promote the open (off) to closed (on) transition and thereby increase miscoding.
Nucleic Acids Res., 47, 2019
6BZ6
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THERMUS THERMOPHILUS 70S COMPLEX CONTAINING 16S G347U RAM MUTATION AND EMPTY A SITE
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Hoffer, E.D., Maehigashi, T., Fagan, C.E., Dunham, C.M.
Deposit date:2017-12-22
Release date:2018-11-14
Last modified:2019-07-03
Method:X-RAY DIFFRACTION (3.18 Å)
Cite:Ribosomal ambiguity (ram) mutations promote the open (off) to closed (on) transition and thereby increase miscoding.
Nucleic Acids Res., 47, 2019
6BZ7
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THERMUS THERMOPHILUS 70S CONTAINING 16S G299A POINT MUTATION AND NEAR-COGNATE ASL LEUCINE IN A SITE.
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Hoffer, E.D., Maehigashi, T., Fagan, C.E., Dunham, C.M.
Deposit date:2017-12-22
Release date:2018-11-14
Last modified:2019-07-03
Method:X-RAY DIFFRACTION (3.68 Å)
Cite:Ribosomal ambiguity (ram) mutations promote the open (off) to closed (on) transition and thereby increase miscoding.
Nucleic Acids Res., 47, 2019
6BZ8
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THERMUS THERMOPHILUS 70S CONTAINING 16S G347U POINT MUTATION AND NEAR-COGNATE ASL LEUCINE IN A SITE
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Hoffer, E.D., Maehigashi, T., Fagan, C.E., Dunham, C.M.
Deposit date:2017-12-22
Release date:2018-11-14
Last modified:2019-07-03
Method:X-RAY DIFFRACTION (3.74 Å)
Cite:Ribosomal ambiguity (ram) mutations promote the open (off) to closed (on) transition and thereby increase miscoding.
Nucleic Acids Res., 47, 2019
5CZP
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70S TERMINATION COMPLEX CONTAINING E. COLI RF2
Descriptor:23S rRNA, 5S rRNA, 50S ribosomal protein L2, ...
Authors:Hoffer, E.D., Dunham, C.M.
Deposit date:2015-07-31
Release date:2016-10-12
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.299959 Å)
Cite:Uniformity of Peptide Release Is Maintained by Methylation of Release Factors.
Cell Rep, 17, 2016
5DFE
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70S TERMINATION COMPLEX CONTAINING E. COLI RF2
Descriptor:P-site tRNA fMet, messenger RNA, Peptide chain release factor 2, ...
Authors:Hoffer, E.D., Dunham, C.M.
Deposit date:2015-08-26
Release date:2016-10-12
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (3.099976 Å)
Cite:Uniformity of Peptide Release Is Maintained by Methylation of Release Factors.
Cell Rep, 17, 2016
5J30
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THERMUS THERMOPHILUS 70S TERMINATION COMPLEX CONTAINING E. COLI RF1
Descriptor:23S rRNA, 5S rRNA, 50S ribosomal protein L2, ...
Authors:Hoffer, E.D., Dunham, C.M.
Deposit date:2016-03-30
Release date:2016-10-12
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Uniformity of Peptide Release Is Maintained by Methylation of Release Factors.
Cell Rep, 17, 2016
5J3C
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THERMUS THERMOPHILUS 70S TERMINATION COMPLEX CONTAINING E. COLI RF1
Descriptor:23S rRNA, 5S rRNA, 50S ribosomal protein L2, ...
Authors:Hoffer, E.D., Dunham, C.M.
Deposit date:2016-03-30
Release date:2016-10-12
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.04 Å)
Cite:Uniformity of Peptide Release Is Maintained by Methylation of Release Factors.
Cell Rep, 17, 2016
6CF1
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PROTEUS VULGARIS HIGA ANTITOXIN STRUCTURE
Descriptor:Antitoxin HigA, POTASSIUM ION
Authors:Schureck, M.A., Hoffer, E.D., Ei Cho, S., Dunham, C.M.
Deposit date:2018-02-13
Release date:2019-02-27
Last modified:2019-09-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of transcriptional regulation by the HigA antitoxin.
Mol.Microbiol., 111, 2019
6CHV
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PROTEUS VULGARIS HIGA ANTITOXIN BOUND TO DNA
Descriptor:Antitoxin HigA, pHigCryst3, pHigCryst4, ...
Authors:Schureck, M.A., Hoffer, E.D., Onuoha, N., Dunham, C.M.
Deposit date:2018-02-23
Release date:2019-02-27
Last modified:2019-06-26
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis of transcriptional regulation by the HigA antitoxin.
Mol.Microbiol., 111, 2019
6M9A
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BORDETELLA PERTUSSIS GLOBIN COUPLED SENSOR REGULATORY DOMAIN (BPEGREG)
Descriptor:Signaling protein, PROTOPORPHYRIN IX CONTAINING FE, HYDROGEN PEROXIDE, ...
Authors:Rivera, S.R., Hoffer, E.D., Dunham, C.M., Weinert, E.E.
Deposit date:2018-08-23
Release date:2018-11-14
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Insights into Oxygen-Dependent Signal Transduction within Globin Coupled Sensors.
Inorg Chem, 57, 2018
6NDK
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STRUCTURE OF ASLSUFA6 A37.5 BOUND TO THE 70S A SITE
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Nguyen, H.T., Hoffer, E.D., Dunham, C.M.
Deposit date:2018-12-13
Release date:2019-02-27
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (3.64 Å)
Cite:Importance of a tRNA anticodon loop modification and a conserved, noncanonical anticodon stem pairing intRNACGGProfor decoding
J. Biol. Chem., 294, 2019
6NY6
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STRUCTURE OF DIMERIC ESCHERICHIA COLI TOXIN YOEB BOUND TO THE THERMUS THERMOPHILUS 30S RIBOSOME
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Pavelich, I.J., Hoffer, E.D., Maehigashi, T., Dunham, C.M.
Deposit date:2019-02-11
Release date:2019-08-21
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (3.74 Å)
Cite:Monomeric YoeB toxin retains RNase activity but adopts an obligate dimeric form for thermal stability.
Nucleic Acids Res., 47, 2019
6OTR
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DIMERIC E.COLI YOEB BOUND TO THERMUS THERMOPHILUS 70S POST-CLEAVAGE (AAU)
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Pavelich, I.P., Hoffer, E.D., Maehigashi, T., Dunham, C.M.
Deposit date:2019-05-03
Release date:2019-08-21
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:Monomeric YoeB toxin retains RNase activity but adopts an obligate dimeric form for thermal stability.
Nucleic Acids Res., 47, 2019
6OXA
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DIMERIC E.COLI YOEB BOUND TO THERMUS THERMOPHILUS 70S PRE-CLEAVAGE (AAU)
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Pavelich, I.J., Hoffer, E.D., Maehigashi, T., Dunham, C.M.
Deposit date:2019-05-13
Release date:2019-08-21
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Monomeric YoeB toxin retains RNase activity but adopts an obligate dimeric form for thermal stability.
Nucleic Acids Res., 47, 2019
6OXI
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DIMERIC E.COLI YOEB BOUND TO THERMUS THERMOPHILUS 70S POST-CLEAVAGE (UAA)
Descriptor:16S rRNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ...
Authors:Pavelich, I.J., Hoffer, E.D., Maehigashi, T., Dunham, C.M.
Deposit date:2019-05-13
Release date:2019-08-21
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (3.495 Å)
Cite:Monomeric YoeB toxin retains RNase activity but adopts an obligate dimeric form for thermal stability.
Nucleic Acids Res., 47, 2019
6PQB
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CRYSTAL STRUCTURE OF AMINOGLYCOSIDE-RESISTANCE METHYLTRANSFERASE RMTC BOUND TO S-ADENOSYLHOMOCYSTEINE (SAH)
Descriptor:16S rRNA (guanine(1405)-N(7))-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Nosrati, M., Hoffer, E.D., Conn, G.L.
Deposit date:2019-07-08
Release date:2019-10-16
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:Functionally critical residues in the aminoglycoside resistance-associated methyltransferase RmtC play distinct roles in 30S substrate recognition.
J.Biol.Chem., 294, 2019
5UCT
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MYCOBACTERIUM TUBERCULOSIS TOXIN MAZF-MT6
Descriptor:Endoribonuclease MazF3, SULFATE ION
Authors:Hoffer, E.H., Dunham, C.M.
Deposit date:2016-12-22
Release date:2017-03-22
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The structure and function of Mycobacterium tuberculosis MazF-mt6 toxin provide insights into conserved features of MazF endonucleases.
J. Biol. Chem., 292, 2017
6CEP
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SUS SCROFA HEART L-LACTATE DEHYDROGENASE TERNARY COMPLEX WITH NADH AND OXAMATE
Descriptor:L-lactate dehydrogenase B chain, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, OXAMIC ACID
Authors:Hoffer, E.D., Andrews, B., Dunham, C.M., Dyer, R.B.
Deposit date:2018-02-12
Release date:2018-06-27
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Small molecule cores demonstrate non-competitive inhibition of lactate dehydrogenase.
Medchemcomm, 9, 2018
5VPO
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THE 70S P-SITE ASL SUFA6 COMPLEX
Descriptor:messenger RNA, 16S rRNA, 30S ribosomal protein S2, ...
Authors:Hong, S., Sunita, S., Dunkle, J.A., Maehigashi, T., Dunham, C.M.
Deposit date:2017-05-05
Release date:2018-09-26
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (3.34 Å)
Cite:Mechanism of tRNA-mediated +1 ribosomal frameshifting.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5VPP
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THE 70S P-SITE TRNA SUFA6 COMPLEX
Descriptor:23S rRNA, 5S rRNA, 50S ribosomal protein L2, ...
Authors:Hong, S., Sunita, S., Dunkle, J.A., Maehigashi, T., Dunham, C.M.
Deposit date:2017-05-05
Release date:2018-09-26
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Mechanism of tRNA-mediated +1 ribosomal frameshifting.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018