Author results

6QGN
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CRYSTAL STRUCTURE OF APT1 BOUND TO 2-BROMOPALMITATE
Descriptor:Acyl-protein thioesterase 1, 2-Bromopalmitic acid
Authors:Marcaida, M.J., Audagnotto, M., Ho, S., Pojer, F., Van der Goot, G., Dal Peraro, M.
Deposit date:2019-01-12
Release date:2020-02-05
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Insights into the molecular mechanism of depalmitoylation by human acyl-protein thioesterases
To Be Published
6QGO
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CRYSTAL STRUCTURE OF APT1 S119A MUTANT BOUND TO PALMITIC ACID.
Descriptor:Acyl-protein thioesterase 1, PALMITIC ACID
Authors:Audagnotto, M., Marcaida, M.J., Ho, S., Pojer, F., Van der Goot, G., Dal Peraro, M.
Deposit date:2019-01-12
Release date:2020-02-05
Method:X-RAY DIFFRACTION (2.599 Å)
Cite:Insights into the molecular mechanism of depalmitoylation by human acyl-protein thioesterases
To Be Published
6QGQ
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CRYSTAL STRUCTURE OF APT1 C2S MUTANT BOUND TO PALMITIC ACID.
Descriptor:Acyl-protein thioesterase 1, GLYCEROL, PALMITIC ACID
Authors:Audagnotto, M., Marcaida, M.J., Ho, S., Pojer, F., Van der Goot, G., Dal Peraro, M.
Deposit date:2019-01-12
Release date:2020-02-05
Method:X-RAY DIFFRACTION (2.601 Å)
Cite:Insights into the molecular mechanism of depalmitoylation by human acyl-protein thioesterases
To Be Published
6QGS
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CRYSTAL STRUCTURE OF APT1 BOUND TO PALMITIC ACID.
Descriptor:Acyl-protein thioesterase 1, PALMITIC ACID, CHLORIDE ION
Authors:Audagnotto, M., Marcaida, M.J., Ho, S., Pojer, F., Van der Goot, G., Dal Peraro, M.
Deposit date:2019-01-12
Release date:2020-02-05
Method:X-RAY DIFFRACTION (2.755 Å)
Cite:Insights into the molecular mechanism of depalmitoylation by human acyl-protein thioesterases
To Be Published
5EHR
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NON-RECEPTOR PROTEIN TYROSINE PHOSPHATASE SHP2 IN COMPLEX WITH ALLOSTERIC INHIBITOR SHP099
Descriptor:Tyrosine-protein phosphatase non-receptor type 11, 6-(4-azanyl-4-methyl-piperidin-1-yl)-3-[2,3-bis(chloranyl)phenyl]pyrazin-2-amine, PHOSPHATE ION
Authors:Stams, T., Fodor, M.
Deposit date:2015-10-28
Release date:2016-06-29
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.
Nature, 535, 2016
5EHP
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NON-RECEPTOR PROTEIN TYROSINE PHOSPHATASE SHP2 IN COMPLEX WITH ALLOSTERIC INHIBITOR SHP836
Descriptor:Tyrosine-protein phosphatase non-receptor type 11, 5-[2,3-bis(chloranyl)phenyl]-2-[(3~{R},5~{S})-3,5-dimethylpiperazin-1-yl]pyrimidin-4-amine, PHOSPHATE ION
Authors:Stams, T., Fodor, M.
Deposit date:2015-10-28
Release date:2016-07-06
Last modified:2016-09-21
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor.
J.Med.Chem., 59, 2016
5FA5
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CRYSTAL STRUCTURE OF PRMT5:MEP50 IN COMPLEX WITH MTA AND H4 PEPTIDE
Descriptor:Protein arginine N-methyltransferase 5, Methylosome protein 50, Histone H4, ...
Authors:Sprague, E.R., McNamara, J.T.
Deposit date:2015-12-10
Release date:2016-02-24
Last modified:2016-03-23
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5.
Science, 351, 2016
2JO4
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TETRAMERIC STRUCTURE OF KIA7 PEPTIDE
Descriptor:KIA7
Authors:Lopez de la Osa, J., Gonzalez, C., Laurents, D.V., Chakrabartty, A., Bateman, D.A.
Deposit date:2007-02-21
Release date:2007-09-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Getting specificity from simplicity in putative proteins from the prebiotic earth.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2JO5
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TETRAMERIC STRUCTURE OF KIA7F PEPTIDE
Descriptor:KIA7F
Authors:Lopez de la Osa, J., Gonzalez, C., Laurents, D.V., Chakrabartty, A., Bateman, D.A.
Deposit date:2007-02-21
Release date:2007-09-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Getting specificity from simplicity in putative proteins from the prebiotic earth.
Proc.Natl.Acad.Sci.Usa, 104, 2007
2RMA
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CRYSTAL STRUCTURES OF CYCLOPHILIN A COMPLEXED WITH CYCLOSPORIN A AND N-METHYL-4-[(E)-2-BUTENYL]-4,4-DIMETHYLTHREONINE CYCLOSPORIN A
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE, CYCLOSPORIN A
Authors:Ke, H., Mayrose, D.
Deposit date:1994-01-07
Release date:1995-02-07
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of Cyclophilin a Complexed with Cyclosporin a and N-Methyl-4-[(E)-2-Butenyl]-4,4-Dimethylthreonine Cyclosporin A.
Structure, 2, 1994
2RMB
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CRYSTAL STRUCTURES OF CYCLOPHILIN A COMPLEXED WITH CYCLOSPORIN A AND N-METHYL-4-[(E)-2-BUTENYL]-4,4-DIMETHYLTHREONINE CYCLOSPORIN A
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE, CYCLOSPORIN A
Authors:Ke, H., Mayrose, D.
Deposit date:1994-01-07
Release date:1995-02-07
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of Cyclophilin a Complexed with Cyclosporin a and N-Methyl-4-[(E)-2-Butenyl]-4,4-Dimethylthreonine Cyclosporin A.
Structure, 2, 1994
3G4N
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CRYSTAL STRUCTURE OF THE ACTIVATED AEROLYSIN MUTANT H132D
Descriptor:Aerolysin
Authors:Pernot, L., Schiltz, M., van der Goot, G.
Deposit date:2009-02-04
Release date:2010-02-09
Last modified:2011-08-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Dual chaperone role of the C-terminal propeptide in folding and oligomerization of the pore-forming toxin aerolysin.
Plos Pathog., 7, 2011
3G4O
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CRYSTAL STRUCTURE OF THE ACTIVATED AEROLYSIN MUTANT H132N
Descriptor:Aerolysin
Authors:Pernot, L., Schiltz, M., van der Goot, G.
Deposit date:2009-02-04
Release date:2010-02-09
Last modified:2011-08-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Dual chaperone role of the C-terminal propeptide in folding and oligomerization of the pore-forming toxin aerolysin.
Plos Pathog., 7, 2011