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6KCS
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BU of 6kcs by Molmil
Crystal structure of HIRAN domain of HLTF in complex with duplex DNA
Descriptor: DNA (5'-D(*AP*CP*TP*GP*TP*AP*CP*GP*TP*AP*CP*AP*GP*T)-3'), Helicase-like transcription factor
Authors:Hishiki, A, Hashimoto, A.
Deposit date:2019-06-28
Release date:2020-06-10
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of HIRAN domain of human HLTF bound to duplex DNA provides structural basis for DNA unwinding to initiate replication fork regression.
J.Biochem., 167, 2020
7YBD
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BU of 7ybd by Molmil
Crystal structure of sliding DNA clamp of Clostridioides difficile
Descriptor: Beta sliding clamp, TRIETHYLENE GLYCOL
Authors:Hishiki, A, Okazaki, S, Hara, K, Hashimoto, H.
Deposit date:2022-06-29
Release date:2022-10-19
Last modified:2023-01-11
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Crystal structure of the sliding DNA clamp from the Gram-positive anaerobic bacterium Clostridioides difficile.
J.Biochem., 173, 2022
4XZF
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BU of 4xzf by Molmil
Crystal structure of HIRAN domain of human HLTF in complex with DNA
Descriptor: (DA)(DC)(DC)(DG)(DC)(DC)(DG)(DG)(DG)(DT)(DG)(DC)(DC), Helicase-like transcription factor
Authors:Hishiki, A, Hashimoto, H.
Deposit date:2015-02-04
Release date:2015-04-15
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Structure of a Novel DNA-binding Domain of Helicase-like Transcription Factor (HLTF) and Its Functional Implication in DNA Damage Tolerance
J.Biol.Chem., 290, 2015
2ZVK
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BU of 2zvk by Molmil
Crystal structure of PCNA in complex with DNA polymerase eta fragment
Descriptor: DNA polymerase eta, Proliferating cell nuclear antigen
Authors:Hishiki, A, Hashimoto, H, Hanafusa, T, Kamei, K, Ohashi, E, Shimizu, T, Ohmori, H, Sato, M.
Deposit date:2008-11-11
Release date:2009-02-10
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen
J.Biol.Chem., 284, 2009
2ZVM
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BU of 2zvm by Molmil
Crystal structure of PCNA in complex with DNA polymerase iota fragment
Descriptor: DNA polymerase iota, Proliferating cell nuclear antigen
Authors:Hishiki, A, Hashimoto, H, Hanafusa, T, Kamei, K, Ohashi, E, Shimizu, T, Ohmori, H, Sato, M.
Deposit date:2008-11-11
Release date:2009-02-10
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen
J.Biol.Chem., 284, 2009
2ZVL
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BU of 2zvl by Molmil
Crystal structure of PCNA in complex with DNA polymerase kappa fragment
Descriptor: DNA polymerase kappa, Proliferating cell nuclear antigen, SULFATE ION, ...
Authors:Hishiki, A, Hashimoto, H, Hanafusa, T, Kamei, K, Ohashi, E, Shimizu, T, Ohmori, H, Sato, M.
Deposit date:2008-11-11
Release date:2009-02-10
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis for Novel Interactions between Human Translesion Synthesis Polymerases and Proliferating Cell Nuclear Antigen
J.Biol.Chem., 284, 2009
7V5N
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BU of 7v5n by Molmil
Crystal structure of Fab fragment of bevacizumab bound to DNA aptamer
Descriptor: 1,2-ETHANEDIOL, DNA (5'-D(*GP*CP*GP*GP*TP*TP*GP*GP*TP*GP*GP*TP*AP*GP*TP*TP*AP*CP*GP*TP*TP*CP*GP*C)-3'), IMIDAZOLE, ...
Authors:Hishiki, A, Tong, J, Todoroki, K, Hashimoto, H.
Deposit date:2021-08-17
Release date:2022-02-02
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Development of a DNA aptamer that binds to the complementarity-determining region of therapeutic monoclonal antibody and affinity improvement induced by pH-change for sensitive detection.
Biosens.Bioelectron., 203, 2022
3VKX
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BU of 3vkx by Molmil
Structure of PCNA
Descriptor: 3,5,3'TRIIODOTHYRONINE, CHLORIDE ION, Proliferating cell nuclear antigen, ...
Authors:Hashimoto, H, Hishiki, A, Shimizu, T, Sato, M, Punchihewa, C, Connelly, M, Actis, M, Waddell, B, Pagala, V, Fujii, N.
Deposit date:2011-11-26
Release date:2012-03-14
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication
J.Biol.Chem., 287, 2012
3ALR
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BU of 3alr by Molmil
Crystal structure of Nanos
Descriptor: Nanos protein, ZINC ION
Authors:Hashimoto, H, Hara, K, Hishiki, A, Kawaguchi, S, Shichijo, N, Nakamura, K, Unzai, S, Tamaru, Y, Shimizu, T, Sato, M.
Deposit date:2010-08-06
Release date:2011-02-02
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of zinc-finger domain of Nanos and its functional implications
Embo Rep., 11, 2010
4XZG
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BU of 4xzg by Molmil
Crystal structure of HIRAN domain of human HLTF
Descriptor: Helicase-like transcription factor
Authors:Ikegaya, Y, Hara, K, Hashimoto, H.
Deposit date:2015-02-04
Release date:2015-04-15
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of a Novel DNA-binding Domain of Helicase-like Transcription Factor (HLTF) and Its Functional Implication in DNA Damage Tolerance
J.Biol.Chem., 290, 2015
3B0T
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BU of 3b0t by Molmil
Human VDR ligand binding domain in complex with maxacalcitol
Descriptor: (1S,3R,5Z,7E,14beta,17alpha,20S)-20-(3-hydroxy-3-methylbutoxy)-9,10-secopregna-5,7,10-triene-1,3-diol, SULFATE ION, Vitamin D3 receptor
Authors:Hishiki, A, Hashimoto, H, Sato, M, Shimizu, T.
Deposit date:2011-06-14
Release date:2011-08-10
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Human VDR ligand binding domain in complex with maxacalcitol
To be Published
8WU8
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BU of 8wu8 by Molmil
Crystal structure of the human RAD9-RAD1(F64A/M256A/F266A)-HUS1-RHINO(88-99) complex
Descriptor: Cell cycle checkpoint control protein RAD9A, Cell cycle checkpoint protein RAD1, Checkpoint protein HUS1, ...
Authors:Hara, K, Nagata, K, Iida, N, Hashimoto, H.
Deposit date:2023-10-20
Release date:2024-02-14
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Structural basis for intra- and intermolecular interactions on RAD9 subunit of 9-1-1 checkpoint clamp implies functional 9-1-1 regulation by RHINO.
J.Biol.Chem., 300, 2024
8GNN
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BU of 8gnn by Molmil
Crystal structure of the human RAD9-RAD1-HUS1-RAD17 complex
Descriptor: Cell cycle checkpoint control protein RAD9A, Cell cycle checkpoint protein RAD1, Cell cycle checkpoint protein RAD17, ...
Authors:Hara, K, Nagata, K, Iida, N, Hashimoto, H.
Deposit date:2022-08-24
Release date:2023-03-08
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.119 Å)
Cite:The 9-1-1 DNA clamp subunit RAD1 forms specific interactions with clamp loader RAD17, revealing functional implications for binding-protein RHINO.
J.Biol.Chem., 299, 2023
6J8Y
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BU of 6j8y by Molmil
Crystal structure of the human RAD9-HUS1-RAD1-RHINO complex
Descriptor: Cell cycle checkpoint control protein RAD9A, Cell cycle checkpoint protein RAD1, Checkpoint protein HUS1, ...
Authors:Hara, K, Iida, N, Sakurai, H, Hashimoto, H.
Deposit date:2019-01-21
Release date:2019-12-04
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the RAD9-RAD1-HUS1 checkpoint clamp bound to RHINO sheds light on the other side of the DNA clamp.
J.Biol.Chem., 295, 2020
3WGW
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BU of 3wgw by Molmil
Structure of PCNA bound to a small molecule inhibitor
Descriptor: 4-{4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy}phenol, Proliferating cell nuclear antigen, SULFATE ION
Authors:Hashimoto, H.
Deposit date:2013-08-12
Release date:2014-02-05
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin.
J.Biol.Chem., 289, 2014
5XPT
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BU of 5xpt by Molmil
Crystal structure of MAD2L2/REV7 in complex with a CAMP fragment in a tetragonal crystal
Descriptor: Chromosome alignment-maintaining phosphoprotein 1, Mitotic spindle assembly checkpoint protein MAD2B
Authors:Hara, K, Taharazako, S, Hashimoto, H.
Deposit date:2017-06-05
Release date:2017-09-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.102 Å)
Cite:Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment-maintaining phosphoprotein (CAMP).
J. Biol. Chem., 292, 2017
5XPU
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BU of 5xpu by Molmil
Crystal structure of MAD2L2/REV7 in complex with a CAMP fragment in a monoclinic crystal
Descriptor: Chromosome alignment-maintaining phosphoprotein 1, Mitotic spindle assembly checkpoint protein MAD2B
Authors:Hara, K, Taharazako, S, Hashimoto, H.
Deposit date:2017-06-05
Release date:2017-09-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.304 Å)
Cite:Dynamic feature of mitotic arrest deficient 2-like protein 2 (MAD2L2) and structural basis for its interaction with chromosome alignment-maintaining phosphoprotein (CAMP).
J. Biol. Chem., 292, 2017
5YD8
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BU of 5yd8 by Molmil
Crystal structure of human PCNA in complex with APIM of human ZRANB3
Descriptor: Proliferating cell nuclear antigen, ZRANB3
Authors:Hashimoto, H, Tagata, R.
Deposit date:2017-09-12
Release date:2018-04-18
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of proliferating cell nuclear antigen (PCNA) bound to an APIM peptide reveals the universality of PCNA interaction.
Acta Crystallogr.,Sect.F, 74, 2018
3W08
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BU of 3w08 by Molmil
Crystal structure of aldoxime dehydratase
Descriptor: Aldoxime dehydratase, PROTOPORPHYRIN IX CONTAINING FE
Authors:Hashimoto, H, Nomura, J, Hashimoto, Y, Oinuma, K.I, Wada, K, Hishiki, A, Hara, K, Kobayashi, M.
Deposit date:2012-10-24
Release date:2013-02-20
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of aldoxime dehydratase and its catalytic mechanism involved in carbon-nitrogen triple-bond synthesis.
Proc.Natl.Acad.Sci.USA, 110, 2013

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