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1DSO
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BU of 1dso by Molmil
CYTOCHROME C PEROXIDASE H175G MUTANT, IMIDAZOLE COMPLEX AT PH 6, ROOM TEMPERATURE.
Descriptor: CYTOCHROME C PEROXIDASE, IMIDAZOLE, PROTOPORPHYRIN IX CONTAINING FE
Authors:Hirst, J, Wilcox, S.K, Williams, P.A, McRee, D.E, Goodin, D.B.
Deposit date:2000-01-07
Release date:2001-03-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 1. Effects on structure.
Biochemistry, 40, 2001
1DSE
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BU of 1dse by Molmil
CYTOCHROME C PEROXIDASE H175G MUTANT, IMIDAZOLE COMPLEX, WITH PHOSPHATE BOUND, PH 6, 100K
Descriptor: CYTOCHROME C PEROXIDASE, IMIDAZOLE, PHOSPHATE ION, ...
Authors:Hirst, J, Wilcox, S.K, Williams, P.A, McRee, D.E, Goodin, D.B.
Deposit date:2000-01-07
Release date:2001-03-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 1. Effects on structure.
Biochemistry, 40, 2001
1DS4
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BU of 1ds4 by Molmil
CYTOCHROME C PEROXIDASE H175G MUTANT, IMIDAZOLE COMPLEX, PH 6, 100K
Descriptor: CYTOCHROME C PEROXIDASE, IMIDAZOLE, PROTOPORPHYRIN IX CONTAINING FE
Authors:Hirst, J, Wilcox, S.K, Williams, P.A, McRee, D.E, Goodin, D.B.
Deposit date:2000-01-07
Release date:2001-03-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 1. Effects on structure.
Biochemistry, 40, 2001
1DSP
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BU of 1dsp by Molmil
CYTOCHROME C PEROXIDASE H175G MUTANT, IMIDAZOLE COMPLEX AT PH 7, ROOM TEMPERATURE.
Descriptor: CYTOCHROME C PEROXIDASE, IMIDAZOLE, PROTOPORPHYRIN IX CONTAINING FE
Authors:Hirst, J, Wilcox, S.K, Williams, P.A, McRee, D.E, Goodin, D.B.
Deposit date:2000-01-07
Release date:2001-03-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 1. Effects on structure.
Biochemistry, 40, 2001
1DSG
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BU of 1dsg by Molmil
CYTOCHROME C PEROXIDASE H175G MUTANT, IMIDAZOLE COMPLEX AT PH 5, ROOM TEMPERATURE.
Descriptor: CYTOCHROME C PEROXIDASE, IMIDAZOLE, PROTOPORPHYRIN IX CONTAINING FE
Authors:Hirst, J, Wilcox, S.K, Williams, P.A, McRee, D.E, Goodin, D.B.
Deposit date:2000-01-07
Release date:2001-03-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Replacement of the axial histidine ligand with imidazole in cytochrome c peroxidase. 1. Effects on structure.
Biochemistry, 40, 2001
1DJ1
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BU of 1dj1 by Molmil
CRYSTAL STRUCTURE OF R48A MUTANT OF CYTOCHROME C PEROXIDASE
Descriptor: CYTOCHROME C PEROXIDASE, PROTOPORPHYRIN IX CONTAINING FE
Authors:Hirst, J, Goodin, D.B.
Deposit date:1999-11-30
Release date:1999-12-10
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Unusual oxidative chemistry of N(omega)-hydroxyarginine and N-hydroxyguanidine catalyzed at an engineered cavity in a heme peroxidase.
J.Biol.Chem., 275, 2000
1DJ5
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BU of 1dj5 by Molmil
CRYSTAL STRUCTURE OF R48A MUTANT OF CYTOCHROME C PEROXIDASE WITH N-HYDROXYGUANIDINE BOUND
Descriptor: CYTOCHROME C PEROXIDASE, N-HYDROXYGUANIDINE, PROTOPORPHYRIN IX CONTAINING FE
Authors:Hirst, J, Goodin, D.B.
Deposit date:1999-12-01
Release date:1999-12-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Unusual oxidative chemistry of N(omega)-hydroxyarginine and N-hydroxyguanidine catalyzed at an engineered cavity in a heme peroxidase.
J.Biol.Chem., 275, 2000
6YJ4
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BU of 6yj4 by Molmil
Structure of Yarrowia lipolytica complex I at 2.7 A
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, Acyl carrier protein ACPM1 of NADH:Ubiquinone Oxidoreductase (Complex I), Acyl carrier protein ACPM2 of NADH:Ubiquinone Oxidoreductase (Complex I), ...
Authors:Hirst, J, Grba, D.
Deposit date:2020-04-02
Release date:2020-08-12
Last modified:2021-03-17
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Mitochondrial complex I structure reveals ordered water molecules for catalysis and proton translocation.
Nat.Struct.Mol.Biol., 27, 2020
6YJ5
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BU of 6yj5 by Molmil
Focused refinement cryo-EM structure of the yeast mitochondrial complex I sub-stoichiometric sulfur transferase subunit
Descriptor: Rhodanese-like domain-containing protein
Authors:Hirst, J, Grba, D.
Deposit date:2020-04-02
Release date:2020-08-12
Last modified:2021-02-10
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Intrinsic curvature of the HIV-1 CA hexamer underlies capsid topology and interaction with cyclophilin A.
Nat.Struct.Mol.Biol., 27, 2020
7B0N
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BU of 7b0n by Molmil
A 3.7-angstrom structure of Yarrowia lipolytica complex I with an R121M mutation in NUCM.
Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, CARDIOLIPIN, ...
Authors:Hirst, J, Grba, D.
Deposit date:2020-11-20
Release date:2021-03-10
Last modified:2022-12-07
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:A conserved arginine residue is critical for stabilizing the N2 FeS cluster in mitochondrial complex I.
J.Biol.Chem., 296, 2021
5COD
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BU of 5cod by Molmil
Bovine heart complex I membrane domain
Descriptor: NADH-ubiquinone oxidoreductase chain 4, NADH-ubiquinone oxidoreductase chain 5, SDAP, ...
Authors:Zhu, J, Hirst, J, King, M.S, Yu, M, Leslie, A.G.W, Klipcan, L.
Deposit date:2015-07-20
Release date:2015-09-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (6.74 Å)
Cite:Structure of subcomplex I beta of mammalian respiratory complex I leads to new supernumerary subunit assignments.
Proc.Natl.Acad.Sci.USA, 112, 2015
7QSD
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BU of 7qsd by Molmil
Bovine complex I in the active state at 3.1 A
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ...
Authors:Bridges, H.R, Blaza, J.N, Yin, Z, Chung, I, Hirst, J.
Deposit date:2022-01-13
Release date:2022-03-02
Last modified:2023-03-08
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of mammalian respiratory complex I inhibition by medicinal biguanides.
Science, 379, 2023
2V08
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BU of 2v08 by Molmil
Structure of wild-type Phormidium laminosum cytochrome c6
Descriptor: CHLORIDE ION, CYTOCHROME C6, HEME C, ...
Authors:Worrall, J.A.R, Schlarb-Ridley, B.G, Reda, T, Marcaida, M.J, Moorlen, R.J, Wastl, J, Hirst, J, Bendall, D.S, Luisi, B.F, Howe, C.J.
Deposit date:2007-05-10
Release date:2007-07-24
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Modulation of heme redox potential in the cytochrome c6 family.
J. Am. Chem. Soc., 129, 2007
2V07
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BU of 2v07 by Molmil
Structure of the Arabidopsis thaliana cytochrome c6A V52Q variant
Descriptor: CYTOCHROME C6, HEME C
Authors:Worrall, J.A.R, Schlarb-Ridley, B.G, Reda, T, Marcaida, M.J, Moorlen, R.J, Wastl, J, Hirst, J, Bendall, D.S, Luisi, B.F, Howe, C.J.
Deposit date:2007-05-09
Release date:2007-07-24
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Modulation of heme redox potential in the cytochrome c6 family.
J. Am. Chem. Soc., 129, 2007
5O31
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BU of 5o31 by Molmil
Mitochondrial complex I in the deactive state
Descriptor: Acyl carrier protein, mitochondrial, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Blaza, J.N, Vinothkumar, K.R, Hirst, J.
Deposit date:2017-05-23
Release date:2018-01-17
Last modified:2019-10-23
Method:ELECTRON MICROSCOPY (4.13 Å)
Cite:Structure of the Deactive State of Mammalian Respiratory Complex I.
Structure, 26, 2018
6G72
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BU of 6g72 by Molmil
Mouse mitochondrial complex I in the deactive state
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Acyl carrier protein, mitochondrial, ...
Authors:Agip, A.N.A, Blaza, J.N, Bridges, H.R, Viscomi, C, Rawson, S, Muench, S.P, Hirst, J.
Deposit date:2018-04-04
Release date:2018-06-06
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states.
Nat. Struct. Mol. Biol., 25, 2018
4UQ8
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BU of 4uq8 by Molmil
Electron cryo-microscopy of bovine Complex I
Descriptor: ACYL CARRIER PROTEIN, MITOCHONDRIAL, FE2/S2 (INORGANIC) CLUSTER, ...
Authors:Vinothkumar, K.R, Zhu, J, Hirst, J.
Deposit date:2014-06-21
Release date:2014-10-01
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (4.95 Å)
Cite:Architecture of Mammalian Respiratory Complex I.
Nature, 515, 2014
7PSA
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BU of 7psa by Molmil
The acetogenin-bound complex I of Mus musculus resolved to 3.4 angstroms
Descriptor: (3~{S},5~{S})-5-methyl-3-[(13~{R})-13-oxidanyl-13-[(2~{R},5~{R})-5-[(2~{R},5~{R})-5-[(1~{R})-1-oxidanylundecyl]oxolan-2-yl]oxolan-2-yl]tridecyl]oxolan-2-one, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, ...
Authors:Grba, D, Hirst, J.
Deposit date:2021-09-22
Release date:2022-04-06
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-electron microscopy reveals how acetogenins inhibit mitochondrial respiratory complex I.
J.Biol.Chem., 298, 2022
8OLT
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BU of 8olt by Molmil
Mitochondrial complex I from Mus musculus in the active state bound with piericidin A
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ...
Authors:Grba, D.N, Chung, I, Bridges, H.R, Agip, A.N.A, Hirst, J.
Deposit date:2023-03-30
Release date:2023-08-09
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Investigation of hydrated channels and proton pathways in a high-resolution cryo-EM structure of mammalian complex I.
Sci Adv, 9, 2023
8OM1
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BU of 8om1 by Molmil
Mitochondrial complex I from Mus musculus in the active state
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Grba, D.N, Chung, I, Bridges, H.R, Agip, A.N.A, Hirst, J.
Deposit date:2023-03-31
Release date:2023-08-09
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (2.39 Å)
Cite:Investigation of hydrated channels and proton pathways in a high-resolution cryo-EM structure of mammalian complex I.
Sci Adv, 9, 2023
8CA1
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BU of 8ca1 by Molmil
Cryo-EM structure of the ACADVL dimer from Mus musculus.
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Very long-chain specific acyl-CoA dehydrogenase, mitochondrial
Authors:Yin, Z, Bridges, H.R, Agip, A.N.A, Hirst, J.
Deposit date:2023-01-24
Release date:2023-12-20
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structural insights into respiratory complex I deficiency and assembly from the mitochondrial disease-related ndufs4 -/- mouse.
Embo J., 43, 2024
8CA3
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BU of 8ca3 by Molmil
Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 2).
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ...
Authors:Yin, Z, Bridges, H.R, Agip, A.N.A, Hirst, J.
Deposit date:2023-01-24
Release date:2023-12-20
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural insights into respiratory complex I deficiency and assembly from the mitochondrial disease-related ndufs4 -/- mouse.
Embo J., 43, 2024
8CA4
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BU of 8ca4 by Molmil
Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 2 N-domain).
Descriptor: FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, IRON/SULFUR CLUSTER, ...
Authors:Yin, Z, Bridges, H.R, Agip, A.N.A, Hirst, J.
Deposit date:2023-01-24
Release date:2023-12-20
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Structural insights into respiratory complex I deficiency and assembly from the mitochondrial disease-related ndufs4 -/- mouse.
Embo J., 43, 2024
8CA5
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BU of 8ca5 by Molmil
Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 3).
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ...
Authors:Yin, Z, Bridges, H.R, Agip, A.N.A, Hirst, J.
Deposit date:2023-01-24
Release date:2023-12-20
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural insights into respiratory complex I deficiency and assembly from the mitochondrial disease-related ndufs4 -/- mouse.
Embo J., 43, 2024
8C2S
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BU of 8c2s by Molmil
Cryo-EM structure NDUFS4 knockout complex I from Mus musculus heart (Class 1).
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1,2-Distearoyl-sn-glycerophosphoethanolamine, Acyl carrier protein, ...
Authors:Yin, Z, Bridges, H.R, Agip, A.N.A, Hirst, J.
Deposit date:2022-12-22
Release date:2023-12-20
Last modified:2024-01-31
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural insights into respiratory complex I deficiency and assembly from the mitochondrial disease-related ndufs4 -/- mouse.
Embo J., 43, 2024

 

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