Author results

6AHY
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WNT SIGNALING COMPLEX
Descriptor:Frizzled-8, Proto-oncogene Wnt-3, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Hirai, H., Arimori, T., Matoba, K., Mihara, E., Takagi, J.
Deposit date:2018-08-21
Release date:2019-05-01
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of a mammalian Wnt-frizzled complex.
Nat.Struct.Mol.Biol., 26, 2019
5B4X
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CRYSTAL STRUCTURE OF THE APOER2 ECTODOMAIN IN COMPLEX WITH THE REELIN R56 FRAGMENT
Descriptor:Reelin, Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor, ...
Authors:Yasui, N., Hirai, H., Yamashita, K., Takagi, J., Nogi, T.
Deposit date:2016-04-20
Release date:2017-04-26
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of the ectodomain from a LDLR close homologue in complex with its physiological ligand.
To Be Published
5B4Y
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CRYSTAL STRUCTURE OF THE LA12 FRAGMENT OF APOER2
Descriptor:Low-density lipoprotein receptor-related protein 8, CALCIUM ION
Authors:Nogi, T., Tabata, S., Hirai, H., Yasui, N., Takagi, J.
Deposit date:2016-04-20
Release date:2017-04-26
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of the ectodomain from a LDLR close homologue in complex with its physiological ligand.
To Be Published
5GJE
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THREE-DIMENSIONAL RECONSTRUCTION OF HUMAN LRP6 ECTODOMAIN COMPLEXED WITH DKK1
Descriptor:Low-density lipoprotein receptor-related protein 6, Dickkopf-related protein 1, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Matoba, K., Mihara, E., Tamura-Kawakami, K., Hirai, H., Thompson, S., Iwasaki, K., Takagi, J.
Deposit date:2016-06-29
Release date:2017-01-18
Method:ELECTRON MICROSCOPY (21 Å)
Cite:Conformational Freedom of the LRP6 Ectodomain Is Regulated by N-glycosylation and the Binding of the Wnt Antagonist Dkk1
Cell Rep, 18, 2017
1GIH
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HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE CDK4 INHIBITOR
Descriptor:CELL DIVISION PROTEIN KINASE 2, 1-(5-OXO-2,3,5,9B-TETRAHYDRO-1H-PYRROLO[2,1-A]ISOINDOL-9-YL)-3-PYRIDIN-2-YL-UREA
Authors:Ikuta, M., Nishimura, S.
Deposit date:2001-02-06
Release date:2002-02-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystallographic approach to identification of cyclin-dependent kinase 4 (CDK4)-specific inhibitors by using CDK4 mimic CDK2 protein.
J.Biol.Chem., 276, 2001
1GII
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HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE CDK4 INHIBITOR
Descriptor:CELL DIVISION PROTEIN KINASE 2, 1-(5-OXO-2,3,5,9B-TETRAHYDRO-1H-PYRROLO[2,1-A]ISOINDOL-9-YL)-3-PYRIDIN-2-YL-UREA
Authors:Ikuta, M., Nishimura, S.
Deposit date:2001-02-06
Release date:2002-02-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystallographic approach to identification of cyclin-dependent kinase 4 (CDK4)-specific inhibitors by using CDK4 mimic CDK2 protein.
J.Biol.Chem., 276, 2001
1GIJ
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HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE CDK4 INHIBITOR
Descriptor:CELL DIVISION PROTEIN KINASE 2, 1-(5-OXO-2,3,5,9B-TETRAHYDRO-1H-PYRROLO[2,1-A]ISOINDOL-9-YL)-3-(5-PYRROLIDIN-2-YL-1H-PYRAZOL-3-YL)-UREA
Authors:Ikuta, M., Nishimura, S.
Deposit date:2001-02-06
Release date:2002-02-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystallographic approach to identification of cyclin-dependent kinase 4 (CDK4)-specific inhibitors by using CDK4 mimic CDK2 protein.
J.Biol.Chem., 276, 2002
2DS1
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HUMAN CYCLIN DEPENDENT KINASE 2 COMPLEXED WITH THE CDK4 INHIBITOR
Descriptor:Cell division protein kinase 2, (13R,15S)-13-METHYL-16-OXA-8,9,12,22,24-PENTAAZAHEXACYCLO[15.6.2.16,9.1,12,15.0,2,7.0,21,25]HEPTACOSA-1(24),2,4,6,17(25),18,20-HEPTAENE-23,26-DIONE
Authors:Ikuta, M.
Deposit date:2006-06-17
Release date:2007-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-based drug design of a highly potent CDK1,2,4,6 inhibitor with novel macrocyclic quinoxalin-2-one structure
Bioorg.Med.Chem.Lett., 16, 2006