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7NBV
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BU of 7nbv by Molmil
Structure of 2A protein from Theilers murine encephalomyelitis virus (TMEV)
Descriptor: BROMIDE ION, Capsid protein VP0
Authors:Hill, C.H, Cook, G.M, Napthine, S, Kibe, A, Brown, K, Caliskan, N, Firth, A.E, Graham, S.C, Brierley, I.
Deposit date:2021-01-28
Release date:2021-12-08
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Investigating molecular mechanisms of 2A-stimulated ribosomal pausing and frameshifting in Theilovirus.
Nucleic Acids Res., 49, 2021
7NWT
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BU of 7nwt by Molmil
Initiated 70S ribosome in complex with 2A protein from encephalomyocarditis virus (EMCV)
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Hill, C.H, Napthine, S, Pekarek, L, Kibe, A, Firth, A.E, Graham, S.C, Caliskan, N, Brierley, I.
Deposit date:2021-03-17
Release date:2021-12-15
Method:ELECTRON MICROSCOPY (2.66 Å)
Cite:Structural and molecular basis for Cardiovirus 2A protein as a viral gene expression switch
Nat Commun, 12, 2021
7BNY
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BU of 7bny by Molmil
Structure of 2A protein from encephalomyocarditis virus (EMCV)
Descriptor: Genome polyprotein, SULFATE ION
Authors:Hill, C.H, Napthine, S, Pekarek, L, Kibe, A, Firth, A.E, Graham, S.C, Caliskan, N, Brierley, I.
Deposit date:2021-01-22
Release date:2021-12-08
Last modified:2022-02-02
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structural and molecular basis for Cardiovirus 2A protein as a viral gene expression switch.
Nat Commun, 12, 2021
4UFI
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BU of 4ufi by Molmil
Mouse Galactocerebrosidase complexed with aza-galacto-fagomine AGF
Descriptor: (3R,4S,5R)-3-(hydroxymethyl)-1,2-diazinane-4,5-diol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Hill, C.H, Viuff, A.H, Spratley, S.J, Salamone, S, Christensen, S.H, Read, R.J, Moriarty, N.W, Jensen, H.H, Deane, J.E.
Deposit date:2015-03-17
Release date:2015-03-25
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Azasugar Inhibitors as Pharmacological Chaperones for Krabbe Disease.
Chem.Sci., 6, 2015
4UFK
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BU of 4ufk by Molmil
Mouse Galactocerebrosidase complexed with dideoxy-imino-lyxitol DIL
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Hill, C.H, Viuff, A.H, Spratley, S.J, Salamone, S, Christensen, S.H, Read, R.J, Moriarty, N.W, Jensen, H.H, Deane, J.E.
Deposit date:2015-03-17
Release date:2015-03-25
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.402 Å)
Cite:Azasugar Inhibitors as Pharmacological Chaperones for Krabbe Disease.
Chem.Sci., 6, 2015
4UFH
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BU of 4ufh by Molmil
Mouse Galactocerebrosidase complexed with iso-galacto-fagomine IGF
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Hill, C.H, Viuff, A.H, Spratley, S.J, Salamone, S, Christensen, S.H, Read, R.J, Moriarty, N.W, Jensen, H.H, Deane, J.E.
Deposit date:2015-03-17
Release date:2015-03-25
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Azasugar Inhibitors as Pharmacological Chaperones for Krabbe Disease.
Chem.Sci., 6, 2015
4UFJ
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BU of 4ufj by Molmil
Mouse Galactocerebrosidase complexed with iso-galacto-fagomine lactam IGL
Descriptor: (3S,4S,5R)-5-(hydroxymethyl)-3,4-bis(oxidanyl)piperidin-2-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Hill, C.H, Viuff, A.H, Spratley, S.J, Salamone, S, Christensen, S.H, Read, R.J, Moriarty, N.W, Jensen, H.H, Deane, J.E.
Deposit date:2015-03-17
Release date:2015-03-25
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Azasugar Inhibitors as Pharmacological Chaperones for Krabbe Disease.
Chem.Sci., 6, 2015
4UFL
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BU of 4ufl by Molmil
Mouse Galactocerebrosidase complexed with deoxy-galacto-noeurostegine DGN
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Hill, C.H, Viuff, A.H, Spratley, S.J, Salamone, S, Christensen, S.H, Read, R.J, Moriarty, N.W, Jensen, H.H, Deane, J.E.
Deposit date:2015-03-17
Release date:2015-03-25
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Azasugar Inhibitors as Pharmacological Chaperones for Krabbe Disease.
Chem.Sci., 6, 2015
4UFM
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BU of 4ufm by Molmil
Mouse Galactocerebrosidase complexed with 1-deoxy-galacto-nojirimycin DGJ
Descriptor: (2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Hill, C.H, Viuff, A.H, Spratley, S.J, Salamone, S, Christensen, S.H, Read, R.J, Moriarty, N.W, Jensen, H.H, Deane, J.E.
Deposit date:2015-03-17
Release date:2015-04-01
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Azasugar Inhibitors as Pharmacological Chaperones for Krabbe Disease.
Chem.Sci., 6, 2015
4UEX
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BU of 4uex by Molmil
Structure of human Saposin A at lysosomal pH
Descriptor: PROSAPOSIN
Authors:Hill, C.H, Read, R.J, Deane, J.E.
Deposit date:2014-12-20
Release date:2015-07-15
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of Human Saposin a at Lysosomal Ph.
Acta Crystallogr.,Sect.D, 71, 2015
4CCC
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BU of 4ccc by Molmil
STRUCTURE OF MOUSE GALACTOCEREBROSIDASE WITH 4NBDG: ENZYME-SUBSTRATE COMPLEX
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-nitrophenyl beta-D-galactopyranoside, ...
Authors:Hill, C.H, Graham, S.C, Read, R.J, Deane, J.E.
Deposit date:2013-10-21
Release date:2013-12-11
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structural Snapshots Illustrate the Catalytic Cycle of Beta-Galactocerebrosidase, the Defective Enzyme in Krabbe Disease
Proc.Natl.Acad.Sci.USA, 110, 2013
4CCE
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BU of 4cce by Molmil
STRUCTURE OF MOUSE GALACTOCEREBROSIDASE WITH GALACTOSE: ENZYME- PRODUCT COMPLEX
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Hill, C.H, Graham, S.C, Read, R.J, Deane, J.E.
Deposit date:2013-10-21
Release date:2013-12-11
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structural Snapshots Illustrate the Catalytic Cycle of Beta-Galactocerebrosidase, the Defective Enzyme in Krabbe Disease
Proc.Natl.Acad.Sci.USA, 110, 2013
4CCD
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BU of 4ccd by Molmil
STRUCTURE OF MOUSE GALACTOCEREBROSIDASE WITH D-GALACTAL: ENZYME- INTERMEDIATE COMPLEX
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-deoxy-alpha-D-galactopyranose, ...
Authors:Hill, C.H, Graham, S.C, Read, R.J, Deane, J.E.
Deposit date:2013-10-21
Release date:2013-12-11
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structural Snapshots Illustrate the Catalytic Cycle of Beta-Galactocerebrosidase, the Defective Enzyme in Krabbe Disease
Proc.Natl.Acad.Sci.USA, 110, 2013
6I1D
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BU of 6i1d by Molmil
Structure of the Ysh1-Mpe1 nuclease complex from S.cerevisiae
Descriptor: Endoribonuclease YSH1, GLYCEROL, Protein MPE1, ...
Authors:Hill, C.H, Boreikaite, V, Kumar, A, Casanal, A, Kubik, P, Degliesposti, G, Maslen, S, Mariani, A, von Loeffelholz, O, Girbig, M, Skehel, M, Passmore, L.A.
Deposit date:2018-10-28
Release date:2019-02-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Activation of the Endonuclease that Defines mRNA 3' Ends Requires Incorporation into an 8-Subunit Core Cleavage and Polyadenylation Factor Complex.
Mol.Cell, 73, 2019
5NXB
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BU of 5nxb by Molmil
Mouse galactocerebrosidase in complex with saposin A
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Graham, S.C, Hill, C.H, Deane, J.E.
Deposit date:2017-05-09
Release date:2017-05-24
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:The mechanism of glycosphingolipid degradation revealed by a GALC-SapA complex structure.
Nat Commun, 9, 2018
8RDV
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BU of 8rdv by Molmil
Cryo-EM structure of P. urativorans 70S ribosome in complex with hibernation factor Balon, mRNA and P-site tRNA (structure 2).
Descriptor: 16S rRNA, 23S rRNA, 5S rRNA, ...
Authors:Helena-Bueno, K, Rybak, M.Y, Gagnon, M.G, Hill, C.H, Melnikov, S.V.
Deposit date:2023-12-08
Release date:2024-02-21
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:A new family of bacterial ribosome hibernation factors.
Nature, 626, 2024
8RDW
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BU of 8rdw by Molmil
Cryo-EM structure of P. urativorans 70S ribosome in complex with hibernation factor Balon and EF-Tu(GDP) (structure 3).
Descriptor: 16S rRNA, 23S rRNA, 5S rRNA, ...
Authors:Helena-Bueno, K, Rybak, M.Y, Gagnon, M.G, Hill, C.H, Melnikov, S.V.
Deposit date:2023-12-08
Release date:2024-02-21
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (2.74 Å)
Cite:A new family of bacterial ribosome hibernation factors.
Nature, 626, 2024
8RD8
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BU of 8rd8 by Molmil
Cryo-EM structure of P. urativorans 70S ribosome in complex with hibernation factors Balon and RaiA (structure 1).
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S30, ...
Authors:Helena-Bueno, K, Rybak, M.Y, Gagnon, M.G, Hill, C.H, Melnikov, S.V.
Deposit date:2023-12-07
Release date:2024-02-21
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (2.62 Å)
Cite:A new family of bacterial ribosome hibernation factors.
Nature, 626, 2024
8V9J
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BU of 8v9j by Molmil
Cryo-EM structure of the Mycobacterium smegmatis 70S ribosome in complex with hibernation factor Msmeg1130 (Balon) (Structure 4)
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S14, ...
Authors:Rybak, M.Y, Helena-Bueno, K, Hill, C.H, Melnikov, S.V, Gagnon, M.G.
Deposit date:2023-12-08
Release date:2024-02-07
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:A new family of bacterial ribosome hibernation factors.
Nature, 626, 2024
8V9L
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BU of 8v9l by Molmil
Cryo-EM structure of the Mycobacterium smegmatis 70S ribosome in complex with hibernation factor Msmeg1130 (Balon) and MsmegEF-Tu(GDP) (Composite structure 6)
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S2, ...
Authors:Rybak, M.Y, Helena-Bueno, K, Hill, C.H, Melnikov, S.V, Gagnon, M.G.
Deposit date:2023-12-08
Release date:2024-02-07
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3 Å)
Cite:A new family of bacterial ribosome hibernation factors.
Nature, 626, 2024
8V9K
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BU of 8v9k by Molmil
Cryo-EM structure of the Mycobacterium smegmatis 70S ribosome in complex with hibernation factor Rv2629 (Balon) (Structure 5)
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S2, ...
Authors:Rybak, M.Y, Helena-Bueno, K, Hill, C.H, Melnikov, S.V, Gagnon, M.G.
Deposit date:2023-12-08
Release date:2024-02-07
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:A new family of bacterial ribosome hibernation factors.
Nature, 626, 2024
6R9J
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BU of 6r9j by Molmil
Structure of Saccharomyces cerevisiae apo Pan2 pseudoubiquitin hydrolase-RNA exonuclease (UCH-Exo) module in complex with A7 RNA
Descriptor: A7 RNA, PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Authors:Tang, T.T.L, Stowell, J.A.W, Hill, C.H, Passmore, L.A.
Deposit date:2019-04-03
Release date:2019-05-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.326 Å)
Cite:The intrinsic structure of poly(A) RNA determines the specificity of Pan2 and Caf1 deadenylases.
Nat.Struct.Mol.Biol., 26, 2019
6R9P
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BU of 6r9p by Molmil
Structure of Saccharomyces cerevisiae apo Pan2 pseudoubiquitin hydrolase-RNA exonuclease (UCH-Exo) module in complex with AAUUAA RNA
Descriptor: AAUUAA RNA, PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Authors:Tang, T.T.L, Stowell, J.A.W, Hill, C.H, Passmore, L.A.
Deposit date:2019-04-03
Release date:2019-05-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:The intrinsic structure of poly(A) RNA determines the specificity of Pan2 and Caf1 deadenylases.
Nat.Struct.Mol.Biol., 26, 2019
6R9O
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BU of 6r9o by Molmil
Structure of Saccharomyces cerevisiae apo Pan2 pseudoubiquitin hydrolase-RNA exonuclease (UCH-Exo) module in complex with AAGGA RNA
Descriptor: AAGGA RNA, PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Authors:Tang, T.T.L, Stowell, J.A.W, Hill, C.H, Passmore, L.A.
Deposit date:2019-04-03
Release date:2019-05-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.319 Å)
Cite:The intrinsic structure of poly(A) RNA determines the specificity of Pan2 and Caf1 deadenylases.
Nat.Struct.Mol.Biol., 26, 2019
6R9I
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BU of 6r9i by Molmil
Structure of Saccharomyces cerevisiae apo Pan2 pseudoubiquitin hydrolase-RNA exonuclease (UCH-Exo) module
Descriptor: PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Authors:Tang, T.T.L, Stowell, J.A.W, Hill, C.H, Passmore, L.A.
Deposit date:2019-04-03
Release date:2019-05-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:The intrinsic structure of poly(A) RNA determines the specificity of Pan2 and Caf1 deadenylases.
Nat.Struct.Mol.Biol., 26, 2019

 

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