Author results

4LCE
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CTBP1 IN COMPLEX WITH SUBSTRATE MTOB
Descriptor:C-terminal-binding protein 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 4-(METHYLSULFANYL)-2-OXOBUTANOIC ACID
Authors:Hilbert, B.J., Schiffer, C.A., Royer Jr., W.E.
Deposit date:2013-06-21
Release date:2014-03-19
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design.
Febs Lett., 588, 2014
4LCJ
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CTBP2 IN COMPLEX WITH SUBSTRATE MTOB
Descriptor:C-terminal-binding protein 2, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 4-(METHYLSULFANYL)-2-OXOBUTANOIC ACID
Authors:Hilbert, B.J., Schiffer, C.A., Royer Jr., W.E.
Deposit date:2013-06-21
Release date:2014-03-19
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Crystal structures of human CtBP in complex with substrate MTOB reveal active site features useful for inhibitor design.
Febs Lett., 588, 2014
4U6Q
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CTBP1 BOUND TO INHIBITOR 2-(HYDROXYIMINO)-3-PHENYLPROPANOIC ACID
Descriptor:C-terminal-binding protein 1, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, (2E)-2-(hydroxyimino)-3-phenylpropanoic acid, ...
Authors:Hilbert, B.J., Morris, B.L., Ellis, K.C., Paulsen, J.L., Schiffer, C.A., Grossman, S.R., Royer Jr., W.E.
Deposit date:2014-07-29
Release date:2015-02-11
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-Guided Design of a High Affinity Inhibitor to Human CtBP.
Acs Chem.Biol., 10, 2015
4U6S
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CTBP1 IN COMPLEX WITH SUBSTRATE PHENYLPYRUVATE
Descriptor:C-terminal-binding protein 1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 3-PHENYLPYRUVIC ACID, ...
Authors:Hilbert, B.J., Morris, B.L., Ellis, K.C., Paulsen, J.L., Schiffer, C.A., Grossman, S.R., Royer Jr., W.E.
Deposit date:2014-07-29
Release date:2015-02-11
Last modified:2015-04-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-Guided Design of a High Affinity Inhibitor to Human CtBP.
Acs Chem.Biol., 10, 2015
4ZNI
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THERMUS PHAGE P74-26 LARGE TERMINASE ATPASE DOMAIN (I 2 3 SPACE GROUP)
Descriptor:Phage terminase large subunit, SULFATE ION
Authors:Hilbert, B.J., Hayes, J.A., Stone, N.P., Duffy, C.M., Sankaran, B., Kelch, B.A.
Deposit date:2015-05-04
Release date:2015-07-08
Last modified:2015-08-05
Method:X-RAY DIFFRACTION (2.097 Å)
Cite:Structure and mechanism of the ATPase that powers viral genome packaging.
Proc.Natl.Acad.Sci.USA, 112, 2015
4ZNJ
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THERMUS PHAGE P74-26 LARGE TERMINASE ATPASE DOMAIN MUTANT R139A (I 2 3 SPACE GROUP)
Descriptor:Phage terminase large subunit, SULFATE ION
Authors:Hilbert, B.J., Hayes, J.A., Stone, N.P., Duffy, C.M., Kelch, B.A.
Deposit date:2015-05-04
Release date:2015-07-08
Last modified:2015-08-05
Method:X-RAY DIFFRACTION (2.532 Å)
Cite:Structure and mechanism of the ATPase that powers viral genome packaging.
Proc.Natl.Acad.Sci.USA, 112, 2015
4ZNK
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THERMUS PHAGE P74-26 LARGE TERMINASE ATPASE DOMAIN FROM (P 32 2 1 SPACE GROUP)
Descriptor:Phage terminase large subunit, SULFATE ION
Authors:Hilbert, B.J., Hayes, J.A., Stone, N.P., Duffy, C.M., Kelch, B.A.
Deposit date:2015-05-04
Release date:2015-07-08
Last modified:2015-08-05
Method:X-RAY DIFFRACTION (1.931 Å)
Cite:Structure and mechanism of the ATPase that powers viral genome packaging.
Proc.Natl.Acad.Sci.USA, 112, 2015
4ZNL
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THERMUS PHAGE P74-26 LARGE TERMINASE ATPASE DOMAIN BOUND TO ADP BERYLLIUM FLUORIDE
Descriptor:Phage terminase large subunit, MAGNESIUM ION, BERYLLIUM TRIFLUORIDE ION, ...
Authors:Hilbert, B.J., Hayes, J.A., Stone, N.P., Duffy, C.M., Kelch, B.A.
Deposit date:2015-05-04
Release date:2015-07-08
Last modified:2015-08-05
Method:X-RAY DIFFRACTION (2.068 Å)
Cite:Structure and mechanism of the ATPase that powers viral genome packaging.
Proc.Natl.Acad.Sci.USA, 112, 2015
5E0T
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HUMAN PCNA MUTANT - S228I
Descriptor:Proliferating cell nuclear antigen
Authors:Duffy, C.M., Hilbert, B.J., Kelch, B.A.
Deposit date:2015-09-29
Release date:2016-04-20
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.6653 Å)
Cite:A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site.
J.Mol.Biol., 428, 2016
5E0U
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HUMAN PCNA VARIANT (S228I) COMPLEXED WITH P21 AT 1.9 ANGSTROMS
Descriptor:Proliferating cell nuclear antigen, Cyclin-dependent kinase inhibitor 1
Authors:Duffy, C.M., Hilbert, B.J., Kelch, B.A.
Deposit date:2015-09-29
Release date:2016-04-20
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site.
J.Mol.Biol., 428, 2016
5E0V
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HUMAN PCNA VARIANT (S228I) COMPLEXED WITH FEN1 AT 2.1 ANGSTROMS
Descriptor:Proliferating cell nuclear antigen, Flap endonuclease 1
Authors:Duffy, C.M., Hilbert, B.J., Kelch, B.A.
Deposit date:2015-09-29
Release date:2016-04-20
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.074 Å)
Cite:A Disease-Causing Variant in PCNA Disrupts a Promiscuous Protein Binding Site.
J.Mol.Biol., 428, 2016
5TGE
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THERMUS PHAGE P74-26 LARGE TERMINASE NUCLEASE DOMAIN
Descriptor:Phage terminase large subunit
Authors:Hilbert, B.J., Hayes, J.A., Stone, N.P., Kelch, B.A.
Deposit date:2016-09-27
Release date:2017-01-25
Last modified:2017-05-03
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The large terminase DNA packaging motor grips DNA with its ATPase domain for cleavage by the flexible nuclease domain.
Nucleic Acids Res., 45, 2017
5KEG
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CRYSTAL STRUCTURE OF APOBEC3A IN COMPLEX WITH A SINGLE-STRANDED DNA
Descriptor:DNA dC->dU-editing enzyme APOBEC-3A, DNA (5'-D(*TP*TP*CP*TP*T)-3'), ZINC ION, ...
Authors:Kouno, T., Hilbert, B.J., Silvas, T., Royer, W.E., Matsuo, H., Schiffer, C.A.
Deposit date:2016-06-09
Release date:2017-05-10
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity.
Nat Commun, 8, 2017
6BL5
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HEAD DECORATION PROTEIN FROM THE HYPERTHERMOPHILIC PHAGE P74-26
Descriptor:Head decoration protein
Authors:Stone, N.P., Hilbert, B.J., Hidalgo, D., Halloran, K.T., Kelch, B.A.
Deposit date:2017-11-09
Release date:2018-02-21
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:A Hyperthermophilic Phage Decoration Protein Suggests Common Evolutionary Origin with Herpesvirus Triplex Proteins and an Anti-CRISPR Protein.
Structure, 26, 2018