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4E26
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BU of 4e26 by Molmil
BRAF in complex with an organic inhibitor 7898734
Descriptor: 5-chloro-7-[(R)-furan-2-yl(pyridin-2-ylamino)methyl]quinolin-8-ol, Serine/threonine-protein kinase B-raf
Authors:Qin, J, Xie, P, Ventocilla, C, Zhou, G, Vultur, A, Chen, Q, Herlyn, M, Winkler, J, Marmorstein, R.
Deposit date:2012-03-07
Release date:2012-05-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Identification of a Novel Family of BRAF(V600E) Inhibitors.
J.Med.Chem., 55, 2012
2FB8
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BU of 2fb8 by Molmil
Structure of the B-Raf kinase domain bound to SB-590885
Descriptor: (1Z)-5-(2-{4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL}-5-PYRIDIN-4-YL-1H-IMIDAZOL-4-YL)INDAN-1-ONE OXIME, B-Raf proto-oncogene serine/threonine-protein kinase
Authors:Lougheed, J.C, Lee, J, Chau, D.C, Stout, T.J.
Deposit date:2005-12-08
Release date:2006-12-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Demonstration of a genetic therapeutic index for tumors expressing oncogenic BRAF by the kinase inhibitor SB-590885.
Cancer Res., 66, 2006
3CST
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BU of 3cst by Molmil
Crystal structure of PI3K p110gamma catalytical domain in complex with organoruthenium inhibitor E5E2
Descriptor: Methylated Ruthenium Pyridocarbazole, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Authors:Xie, P, Marmorstein, R.
Deposit date:2008-04-10
Release date:2008-05-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure-based design of an organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity.
Acs Chem.Biol., 3, 2008
3CSF
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BU of 3csf by Molmil
Crystal structure of PI3K p110gamma catalytical domain in complex with organoruthenium inhibitor DW2
Descriptor: Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, RU-PYRIDOCARBAZOLE-2
Authors:Xie, P, Marmorstein, R.
Deposit date:2008-04-09
Release date:2008-05-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-based design of an organoruthenium phosphatidyl-inositol-3-kinase inhibitor reveals a switch governing lipid kinase potency and selectivity.
Acs Chem.Biol., 3, 2008
3C4C
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BU of 3c4c by Molmil
B-Raf Kinase in Complex with PLX4720
Descriptor: B-Raf proto-oncogene serine/threonine-protein kinase, N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide
Authors:Zhang, K.Y.J, Wang, W.
Deposit date:2008-01-29
Release date:2008-02-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
Proc.Natl.Acad.Sci.Usa, 105, 2008
3BWF
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BU of 3bwf by Molmil
Crystal structure of the human Pim1 in complex with an osmium compound
Descriptor: PYRIDOCARBAZOLE CYCLOPENTADIENYL OS(CO) COMPLEX, Proto-oncogene serine/threonine-protein kinase Pim-1, SULFATE ION
Authors:Maksimoska, J, Filippakopoulos, P, Knapp, S, Meggers, E.
Deposit date:2008-01-09
Release date:2008-06-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Similar biological activities of two isostructural ruthenium and osmium complexes.
Chemistry, 14, 2008
3C4E
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BU of 3c4e by Molmil
Pim-1 Kinase Domain in Complex with 3-aminophenyl-7-azaindole
Descriptor: IMIDAZOLE, N-phenyl-1H-pyrrolo[2,3-b]pyridin-3-amine, Proto-oncogene serine/threonine-protein kinase Pim-1
Authors:Zhang, K.Y.J, Wang, W.
Deposit date:2008-01-29
Release date:2008-02-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
Proc.Natl.Acad.Sci.Usa, 105, 2008
3C4F
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BU of 3c4f by Molmil
FGFR TYROSINE KINASE DOMAIN IN COMPLEX WITH 3-(3-methoxybenzyl)-7-azaindole
Descriptor: 3-(3-methoxybenzyl)-1H-pyrrolo[2,3-b]pyridine, Basic fibroblast growth factor receptor 1
Authors:Zhang, K.Y.J, Wang, W.
Deposit date:2008-01-29
Release date:2008-02-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
Proc.Natl.Acad.Sci.Usa, 105, 2008
6P7G
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BU of 6p7g by Molmil
The co-crystal structure of BRAF(V600E) with PHI1
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 3-[(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-[4-({[2-(morpholin-4-yl)ethyl]amino}methyl)-3-(trifluoromethyl)phenyl]benzamide, Serine/threonine-protein kinase B-raf
Authors:Agianian, B, Gavathiotis, E.
Deposit date:2019-06-05
Release date:2020-09-23
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Inhibitors of BRAF dimers using an allosteric site.
Nat Commun, 11, 2020
6P3D
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BU of 6p3d by Molmil
The co-crystal structure of BRAF(V600E) with ponatinib
Descriptor: 1,2-ETHANEDIOL, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, AMMONIUM ION, ...
Authors:Agianian, B, Gavathiotis, E.
Deposit date:2019-05-23
Release date:2020-09-23
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Inhibitors of BRAF dimers using an allosteric site.
Nat Commun, 11, 2020

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PDB entries from 2024-03-27

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