Author results

6BFQ
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THE MECHANISM OF GM-CSF INHIBITION BY HUMAN GM-CSF AUTO-ANTIBODIES
Descriptor:Fab Heavy chain, Fab Light Chain, Granulocyte-macrophage colony-stimulating factor
Authors:Dhagat, U., Hercus, T.R., Broughton, S.E., Nero, T.L., Lopez, A.F., Parker, M.W.
Deposit date:2017-10-26
Release date:2018-09-12
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities.
MAbs, 10, 2018
1EGJ
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DOMAIN 4 OF THE BETA COMMON CHAIN IN COMPLEX WITH AN ANTIBODY
Descriptor:CYTOKINE RECEPTOR COMMON BETA CHAIN PRECURSOR, ANTIBODY (LIGHT CHAIN), ANTIBODY (HEAVY CHAIN), ...
Authors:Rossjohn, J., McKinstry, W.J., Woodcock, J.M., McClure, B.J., Hercus, T.R., Parker, M.W., Lopez, A.F., Bagley, C.J.
Deposit date:2000-02-15
Release date:2001-02-15
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the activation domain of the GM-CSF/IL-3/IL-5 receptor common beta-chain bound to an antagonist.
Blood, 95, 2000
6BFS
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THE MECHANISM OF GM-CSF INHIBITION BY HUMAN GM-CSF AUTO-ANTIBODIES
Descriptor:Fab light Chain, Fab Heavy Chain, Granulocyte-macrophage colony-stimulating factor
Authors:Dhagat, U., Hercus, T.R., Broughton, S.E., Nero, T.L., Lopez, A.F., Parker, M.W.
Deposit date:2017-10-26
Release date:2018-09-12
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities.
MAbs, 10, 2018
4NKQ
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STRUCTURE OF A CYTOKINE RECEPTOR COMPLEX
Descriptor:Cytokine receptor common subunit beta, Granulocyte-macrophage colony-stimulating factor, Granulocyte-macrophage colony-stimulating factor receptor subunit alpha, ...
Authors:Parker, M.W., Broughton, S.E.
Deposit date:2013-11-13
Release date:2015-09-23
Last modified:2016-09-28
Method:X-RAY DIFFRACTION (3.301 Å)
Cite:Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.
Structure, 24, 2016
4JZJ
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CRYSTAL STRUCTURE OF RECEPTOR-FAB COMPLEX
Descriptor:Interleukin-3 receptor subunit alpha, Fab Heavy Chain, Fab Light Chain, ...
Authors:Broughton, S.E., Parker, M.W.
Deposit date:2013-04-03
Release date:2014-04-09
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody
Cell Rep, 8, 2014
4RS1
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CRYSTAL STRUCTURE OF RECEPTOR-CYTOKINE COMPLEX
Descriptor:Granulocyte-macrophage colony-stimulating factor receptor subunit alpha, Granulocyte-macrophage colony-stimulating factor, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Broughton, S.E., Parker, M.W., Dhagat, U.
Deposit date:2014-11-06
Release date:2015-11-11
Last modified:2016-09-07
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.
Structure, 24, 2016
5DWU
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BETA COMMON RECEPTOR IN COMPLEX WITH A FAB
Descriptor:Cytokine receptor common subunit beta, Fab - Heavy Chain, Fab - Light Chain, ...
Authors:Dhagat, U., Parker, M.W.
Deposit date:2015-09-23
Release date:2015-12-30
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.97 Å)
Cite:CSL311, a novel, potent, therapeutic monoclonal antibody for the treatment of diseases mediated by the common beta chain of the IL-3, GM-CSF and IL-5 receptors.
Mabs, 8, 2016
5UV8
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INTERLEUKIN-3 RECEPTOR COMPLEX
Descriptor:Interleukin-3 receptor subunit alpha, Interleukin-3, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Broughton, S.E., Parker, M.W.
Deposit date:2017-02-19
Release date:2018-02-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.
Nat Commun, 9, 2018
5UWC
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CYTOKINE-RECEPTOR COMPLEX
Descriptor:Interleukin-3 receptor subunit alpha, Interleukin-3, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Broughton, S.E., Parker, M.W.
Deposit date:2017-02-21
Release date:2018-02-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.
Nat Commun, 9, 2018