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5GGQ
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CRYSTAL STRUCTURE OF NIVOLUMAB FAB FRAGMENT
Descriptor:nivolumab light chain, nivolumab heavy chain
Authors:Heo, Y.S.
Deposit date:2016-06-16
Release date:2016-11-09
Last modified:2016-11-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy
Nat Commun, 7, 2016
5GGR
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PD-1 IN COMPLEX WITH NIVOLUMAB FAB
Descriptor:heavy chain, light chain, Programmed cell death protein 1
Authors:Heo, Y.S.
Deposit date:2016-06-16
Release date:2016-11-09
Last modified:2016-11-16
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy
Nat Commun, 7, 2016
5GGS
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PD-1 IN COMPLEX WITH PEMBROLIZUMAB FAB
Descriptor:heavy chain, light chain, Programmed cell death protein 1
Authors:Heo, Y.S.
Deposit date:2016-06-16
Release date:2016-11-09
Last modified:2016-11-16
Method:X-RAY DIFFRACTION (1.997 Å)
Cite:Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy
Nat Commun, 7, 2016
5GGT
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PD-L1 IN COMPLEX WITH BMS-936559 FAB
Descriptor:Programmed cell death 1 ligand 1, IgG H chain, IGK@ protein
Authors:Heo, Y.S.
Deposit date:2016-06-16
Release date:2016-11-09
Last modified:2016-11-16
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy
Nat Commun, 7, 2016
5GGU
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CRYSTAL STRUCTURE OF TREMELIMUMAB FAB
Descriptor:heavy chain, light chain
Authors:Heo, Y.S.
Deposit date:2016-06-16
Release date:2016-11-09
Last modified:2016-11-16
Method:X-RAY DIFFRACTION (2.292 Å)
Cite:Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy
Nat Commun, 7, 2016
5GGV
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CTLA-4 IN COMPLEX WITH TREMELIMUMAB FAB
Descriptor:light chain, heavy chain, Cytotoxic T-lymphocyte protein 4
Authors:Heo, Y.S.
Deposit date:2016-06-16
Release date:2016-11-09
Last modified:2016-11-16
Method:X-RAY DIFFRACTION (1.998 Å)
Cite:Structural basis of checkpoint blockade by monoclonal antibodies in cancer immunotherapy
Nat Commun, 7, 2016
4HQ6
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BC DOMAIN IN THE PRESENCE OF CITRATE
Descriptor:Acetyl-CoA carboxylase 2
Authors:Heo, Y.S.
Deposit date:2012-10-25
Release date:2013-10-09
Last modified:2014-09-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Insights into the Regulation of ACC2 by Citrate
Bull.Korean Chem.Soc., 34, 2013
3LPX
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CRYSTAL STRUCTURE OF GYRA
Descriptor:DNA gyrase, A subunit
Authors:Jung, H.Y., Heo, Y.S.
Deposit date:2010-02-07
Release date:2011-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of GyrA
To be Published
5WUV
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CRYSTAL STRUCTURE OF CERTOLIZUMAB FAB
Descriptor:light chain, heavy chain
Authors:Heo, Y.S., Lee, J.U., Son, J.Y., Shin, W., Yoo, K.Y.
Deposit date:2016-12-21
Release date:2017-06-07
Method:X-RAY DIFFRACTION (1.952 Å)
Cite:Molecular Basis for the Neutralization of Tumor Necrosis Factor alpha by Certolizumab Pegol in the Treatment of Inflammatory Autoimmune Diseases
Int J Mol Sci, 18, 2017
5WUX
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TNFALPHA-CERTOLIZUMAB FAB
Descriptor:heavy, light, Tumor necrosis factor alpha
Authors:Heo, Y.S., Lee, J.U.
Deposit date:2016-12-21
Release date:2017-06-07
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Molecular Basis for the Neutralization of Tumor Necrosis Factor alpha by Certolizumab Pegol in the Treatment of Inflammatory Autoimmune Diseases
Int J Mol Sci, 18, 2017
5X8L
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PD-L1 IN COMPLEX WITH ATEZOLIZUMAB
Descriptor:Programmed cell death 1 ligand 1, atezolizumab light chain, atezolizumab heavy chain
Authors:Heo, Y.S., Lee, H.T.
Deposit date:2017-03-03
Release date:2017-08-16
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Molecular mechanism of PD-1/PD-L1 blockade via anti-PD-L1 antibodies atezolizumab and durvalumab
Sci Rep, 7, 2017
5X8M
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PD-L1 IN COMPLEX WITH DURVALUMAB
Descriptor:Programmed cell death 1 ligand 1, durvalumab heavy chain, durvalumab light chain
Authors:Heo, Y.S., Lee, H.T.
Deposit date:2017-03-03
Release date:2017-08-16
Method:X-RAY DIFFRACTION (2.661 Å)
Cite:Molecular mechanism of PD-1/PD-L1 blockade via anti-PD-L1 antibodies atezolizumab and durvalumab
Sci Rep, 7, 2017
2O5K
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CRYSTAL STRUCTURE OF GSK3BETA IN COMPLEX WITH A BENZOIMIDAZOL INHIBITOR
Descriptor:Glycogen synthase kinase-3 beta, 2-(2,4-DICHLORO-PHENYL)-7-HYDROXY-1H-BENZOIMIDAZOLE-4-CARBOXYLIC ACID [2-(4-METHANESULFONYLAMINO-PHENYL)-ETHYL]-AMIDE
Authors:Shin, D., Lee, S.C., Heo, Y.S., Cho, Y.S., Kim, Y.E., Hyun, Y.L., Cho, J.M., Lee, Y.S., Ro, S.
Deposit date:2006-12-06
Release date:2007-10-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Design and synthesis of 7-hydroxy-1H-benzoimidazole derivatives as novel inhibitors of glycogen synthase kinase-3beta
Bioorg.Med.Chem.Lett., 17, 2007
2HJW
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CRYSTAL STRUCTURE OF THE BC DOMAIN OF ACC2
Descriptor:Acetyl-CoA carboxylase 2
Authors:Cho, Y.S., Lee, J.I., Shin, D., Kim, H.T., Lee, T.G., Heo, Y.S.
Deposit date:2006-07-02
Release date:2007-07-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the biotin carboxylase domain of human acetyl-CoA carboxylase 2.
Proteins, 70, 2008
3JRW
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PHOSPHORYLATED BC DOMAIN OF ACC2
Descriptor:Acetyl-CoA carboxylase 2
Authors:Cho, Y.S., Lee, J.I., Shin, D., Kim, H.T., Lee, T.G., Heo, Y.S.
Deposit date:2009-09-09
Release date:2010-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK
Biochem.Biophys.Res.Commun., 391, 2010
3JRX
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CRYSTAL STRUCTURE OF THE BC DOMAIN OF ACC2 IN COMPLEX WITH SORAPHEN A
Descriptor:Acetyl-CoA carboxylase 2, SORAPHEN A
Authors:Cho, Y.S., Lee, J.I., Shin, D., Kim, H.T., Lee, T.G., Heo, Y.S.
Deposit date:2009-09-09
Release date:2010-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular mechanism for the regulation of human ACC2 through phosphorylation by AMPK.
Biochem.Biophys.Res.Commun., 391, 2010
1L8L
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MOLECULAR BASIS FOR THE LOCAL CONFOMATIONAL REARRANGEMENT OF HUMAN PHOSPHOSERINE PHOSPHATASE
Descriptor:L-3-phosphoserine phosphatase, D-2-AMINO-3-PHOSPHONO-PROPIONIC ACID
Authors:Kim, H.Y., Heo, Y.S., Kim, J.H., Park, M.H., Moon, J., Park, S.Y., Lee, T.G., Jeon, Y.H., Ro, S., Hwang, K.Y.
Deposit date:2002-03-21
Release date:2003-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase.
J.Biol.Chem., 277, 2002
1L8O
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MOLECULAR BASIS FOR THE LOCAL CONFORMATIONAL REARRANGEMENT OF HUMAN PHOSPHOSERINE PHOSPHATASE
Descriptor:L-3-phosphoserine phosphatase, PHOSPHATE ION, SERINE
Authors:Kim, H.Y., Heo, Y.S., Kim, J.H., Park, M.H., Moon, J., Park, S.Y., Lee, T.G., Jeon, Y.H., Ro, S., Hwang, K.Y.
Deposit date:2002-03-21
Release date:2003-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase
J.Biol.Chem., 277, 2002
3NJ4
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FLUORO-NEPLANOCIN A IN HUMAN S-ADENOSYLHOMOCYSTEINE HYDROLASE
Descriptor:Adenosylhomocysteinase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, (4S,5S)-4-(6-amino-9H-purin-9-yl)-3-fluoro-5-hydroxy-2-(hydroxymethyl)cyclopent-2-en-1-one
Authors:Jeong, L.S., Lee, K.M., Hwang, K.Y., Choi, S., Heo, Y.S.
Deposit date:2010-06-17
Release date:2011-05-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:X-ray crystal structure and binding mode analysis of human S-adenosylhomocysteine hydrolase complexed with novel mechanism-based inhibitors, haloneplanocin A analogues.
J.Med.Chem., 54, 2011
3V3V
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STRUCTURAL AND FUNCTIONAL ANALYSIS OF QUERCETAGETIN, A NATURAL JNK1 INHIBITOR
Descriptor:Mitogen-activated protein kinase 8, C-Jun-amino-terminal kinase-interacting protein 1, 3,5,6,7-TETRAHYDROXY-2-(3,4-DIHYDROXYPHENYL)-4H-CHROMEN-4-ONE, ...
Authors:Baek, S., Kang, N.J., Popowicz, G.M., Arciniega, M., Jung, S.K., Byun, S., Song, N.R., Heo, Y.S., Kim, B.Y., Lee, H.J., Holak, T.A., Augustin, M., Bode, A.M., Huber, R., Dong, Z., Lee, K.W.
Deposit date:2011-12-14
Release date:2012-12-05
Last modified:2013-01-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Functional Analysis of the Natural JNK1 Inhibitor Quercetagetin.
J.Mol.Biol., 425, 2013
4Y7I
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CRYSTAL STRUCTURE OF MTMR8
Descriptor:Myotubularin-related protein 8, PHOSPHATE ION
Authors:Yoo, K., Lee, J., Son, J., Shin, W., Im, D., Heo, Y.S.
Deposit date:2015-02-15
Release date:2015-07-15
Method:X-RAY DIFFRACTION (2.802 Å)
Cite:Structure of the catalytic phosphatase domain of MTMR8: implications for dimerization, membrane association and reversible oxidation.
Acta Crystallogr.,Sect.D, 71, 2015