Author results

1G84
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THE SOLUTION STRUCTURE OF THE C EPSILON2 DOMAIN FROM IGE
Descriptor:IMMUNOGLOBULIN E
Authors:McDonnell, J.M., Cowburn, D., Gould, H.J., Sutton, B.J., Calvert, R., Beavil, R.E., Beavil, A.J., Henry, A.J.
Deposit date:2000-11-16
Release date:2001-05-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The structure of the IgE Cepsilon2 domain and its role in stabilizing the complex with its high-affinity receptor FcepsilonRIalpha.
Nat.Struct.Biol., 8, 2001
1O0V
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THE CRYSTAL STRUCTURE OF IGE FC REVEALS AN ASYMMETRICALLY BENT CONFORMATION
Descriptor:Immunoglobulin heavy chain epsilon-1, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Wan, T., Beavil, R.L., Fabiane, S.M., Beavil, A.J., Sohi, M.K., Keown, M., Young, R.J., Henry, A.J., Owens, R.J., Gould, H.J., Sutton, B.J.
Deposit date:2002-09-06
Release date:2002-09-18
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The crystal structure of IgE Fc reveals an asymmetrically bent conformation
NAT.IMMUNOL., 3, 2002
5G64
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THE COMPLEX BETWEEN HUMAN IGE-FC AND TWO ANTI-IGE FAB FRAGMENTS
Descriptor:IG EPSILON CHAIN C REGION, FAB FRAGMENT, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Davies, A.M., Allan, E.G., Keeble, A.H., Delgado, J., Cossins, B.P., Mitropoulou, A.N., Pang, M.O.Y., Ceska, T., Beavil, A.J., Craggs, G., Westwood, M., Henry, A.J., McDonnell, J.M., Sutton, B.J.
Deposit date:2016-06-14
Release date:2017-05-03
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (3.715 Å)
Cite:Allosteric mechanism of action of the therapeutic anti-IgE antibody omalizumab.
J. Biol. Chem., 292, 2017
2M2D
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HUMAN PROGRAMMED CELL DEATH 1 RECEPTOR
Descriptor:Programmed cell death protein 1
Authors:Veverka, V., Cheng, X., Waters, L.C., Muskett, F.W., Morgan, S., Lesley, A., Griffiths, M., Stubberfield, C., Griffin, R., Henry, A.J., Robinson, M.K., Jansson, A., Ladbury, J.E., Ikemizu, S., Davis, S.J., Carr, M.D.
Deposit date:2012-12-18
Release date:2013-02-27
Last modified:2013-05-15
Method:SOLUTION NMR
Cite:Structure and interactions of the human programmed cell death 1 receptor.
J.Biol.Chem., 288, 2013
2K8P
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CHARACTERISATION OF THE STRUCTURAL FEATURES AND INTERACTIONS OF SCLEROSTIN: MOLECULAR INSIGHT INTO A KEY REGULATOR OF WNT-MEDIATED BONE FORMATION
Descriptor:Sclerostin
Authors:Veverka, V., Henry, A.J., Slocombe, P.M., Ventom, A., Mulloy, B., Muskett, F.W., Muzylak, M., Greenslade, K., Moore, A., Zhang, L., Gong, J., Qian, X., Paszty, C., Taylor, R.J., Robinson, M.K., Carr, M.D.
Deposit date:2008-09-18
Release date:2009-02-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Characterization of the Structural Features and Interactions of Sclerostin: Molecular insight into a key regulator of Wnt-mediated bone formation
J.Biol.Chem., 284, 2009
2KH2
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SOLUTION STRUCTURE OF A SCFV-IL-1B COMPLEX
Descriptor:Interleukin-1 beta, scFv
Authors:Wilkinson, I.C., Hall, C.J., Veverka, V., Muskett, F.W., Stephens, P.E., Taylor, R.J., Henry, A.J., Carr, M.D.
Deposit date:2009-03-23
Release date:2009-09-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:High resolution NMR-based model for the structure of a scFv-IL-1beta complex: potential for NMR as a key tool in therapeutic antibody design and development.
J.Biol.Chem., 284, 2009
2KZT
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STRUCTURE OF THE TANDEM MA-3 REGION OF PDCD4
Descriptor:Programmed cell death protein 4
Authors:Waters, L.C., Strong, S.L., Oka, O., Muskett, F.W., Veverka, V., Banerjee, S., Schmedt, T., Henry, A.J., Klempnauer, K.H., Carr, M.D.
Deposit date:2010-06-24
Release date:2011-03-16
Last modified:2011-11-23
Method:SOLUTION NMR
Cite:Structure of the tandem MA-3 region of Pdcd4 protein and characterization of its interactions with eIF4A and eIF4G: molecular mechanisms of a tumor suppressor
J.Biol.Chem., 286, 2011
2L3Y
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SOLUTION STRUCTURE OF MOUSE IL-6
Descriptor:Interleukin-6
Authors:Veverka, V., Redpath, N.T., Carrington, B., Muskett, F.W., Taylor, R.J., Henry, A.J., Carr, M.D.
Deposit date:2010-09-25
Release date:2011-09-28
Last modified:2013-01-02
Method:SOLUTION NMR
Cite:Conservation of functional sites on interleukin-6 and implications for evolution of signaling complex assembly and therapeutic intervention.
J.Biol.Chem., 287, 2012
4EZM
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CRYSTAL STRUCTURE OF THE HUMAN IGE-FC(EPSILON)3-4 BOUND TO ITS B CELL RECEPTOR DERCD23
Descriptor:Ig epsilon chain C region, Low affinity immunoglobulin epsilon Fc receptor, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Dhaliwal, B., Yuan, D., Sutton, B.J.
Deposit date:2012-05-03
Release date:2012-07-18
Last modified:2012-08-15
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor Fc{varepsilon}RI.
Proc.Natl.Acad.Sci.USA, 109, 2012
4J4P
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THE COMPLEX OF HUMAN IGE-FC WITH TWO BOUND FAB FRAGMENTS
Descriptor:Ig epsilon chain C region, Immunoglobulin G Fab Fragment Heavy Chain, Immunoglobulin G Fab Fragment Light Chain, ...
Authors:Drinkwater, N., Sutton, B.J.
Deposit date:2013-02-07
Release date:2014-03-12
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Human immunoglobulin E flexes between acutely bent and extended conformations.
Nat.Struct.Mol.Biol., 21, 2014
4DG6
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CRYSTAL STRUCTURE OF DOMAINS 1 AND 2 OF LRP6
Descriptor:Low-density lipoprotein receptor-related protein 6, N-ACETYL-D-GLUCOSAMINE, PHOSPHATE ION
Authors:Ceska, T.A., Doyle, C., Slocombe, P.
Deposit date:2012-01-25
Release date:2012-06-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Characterization of the interaction of sclerostin with the LRP family of Wnt co-receptors
To be Published
5O57
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SOLUTION STRUCTURE OF THE N-TERMINAL REGION OF DKK4
Descriptor:Dickkopf-related protein 4
Authors:Waters, L.C., Patel, S., Barkell, A.M., Muskett, F.W., Robinson, M.K., Holdsworth, G., Carr, M.D.
Deposit date:2017-06-01
Release date:2018-06-13
Last modified:2018-08-15
Method:SOLUTION NMR
Cite:Structural and functional analysis of Dickkopf 4 (Dkk4): New insights into Dkk evolution and regulation of Wnt signaling by Dkk and Kremen proteins.
J. Biol. Chem., 293, 2018
2WQR
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THE HIGH RESOLUTION CRYSTAL STRUCTURE OF IGE FC
Descriptor:IG EPSILON CHAIN C REGION, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Dhaliwal, B., Sutton, B.J., Beavil, A.J.
Deposit date:2009-08-26
Release date:2010-11-03
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Conformational Changes in Ige Contribute to its Uniquely Slow Dissociation Rate from Receptor Fceri
Nat.Struct.Mol.Biol., 18, 2011
2Y7Q
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THE HIGH-AFFINITY COMPLEX BETWEEN IGE AND ITS RECEPTOR FC EPSILON RI
Descriptor:HIGH AFFINITY IMMUNOGLOBULIN EPSILON RECEPTOR SUBUNIT ALPHA, IG EPSILON CHAIN C REGION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Davies, A.M., Holdom, M.D., Nettleship, J.E., Beavil, A.J., Owens, R.J., Sutton, B.J.
Deposit date:2011-02-01
Release date:2011-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Conformational Changes in Ige Contribute to its Uniquely Slow Dissociation Rate from Receptor Fceri
Nat.Struct.Mol.Biol., 18, 2011