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1R58
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CRYSTAL STRUCTURE OF METAP2 COMPLEXED WITH A357300
分子名称:Methionine aminopeptidase 2, MANGANESE (II) ION, N'-((2S,3R)-3-AMINO-2-HYDROXY-5-(ISOPROPYLSULFANYL)PENTANOYL)-N-3-CHLOROBENZOYL HYDRAZIDE
著者Sheppard, G.S., Wang, J., Kawai, M., BaMaung, N.Y., Craig, R.A., Ericken, S.A., Lynch, L., Patel, J., Yang, F., Searle, X.B., Lou, P., Park, C., Kim, K.H., Henkin, J., Lesniewski, R.
登録日2003-10-09
公開日2004-10-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2.
Bioorg.Med.Chem.Lett., 14, 2004
1R5G
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CRYSTAL STRUCTURE OF METAP2 COMPLEXED WITH A311263
分子名称:Methionine aminopeptidase 2, MANGANESE (II) ION, (2S,3R)-3-AMINO-2-HYDROXY-5-(ETHYLSULFANYL)PENTANOYL-((S)-(-)-(1-NAPHTHYL)ETHYL)AMIDE
著者Sheppard, G.S., Wang, J., Kawai, M., BaMaung, N.Y., Craig, R.A., Erickson, S.A., Lynch, L., Patel, J., Yang, F., Searle, X.B., Lou, P., Park, C., Kim, K.H., Henkin, J., Lesniewski, R.
登録日2003-10-10
公開日2004-10-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2.
Bioorg.Med.Chem.Lett., 14, 2004
1R5H
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CRYSTAL STRUCTURE OF METAP2 COMPLEXED WITH A320282
分子名称:Methionine aminopeptidase 2, MANGANESE (II) ION, N'-(2S,3R)-3-AMINO-4-CYCLOHEXYL-2-HYDROXY-BUTANO-N-(4-METHYLPHENYL)HYDRAZIDE
著者Sheppard, G.S., Wang, J., Kawai, M., BaMaung, N.Y., Craig, R.A., Erickson, S.A., Lynch, L., Patel, J., Yang, F., Searle, X.B., Lou, P., Park, C., Kim, K.H., Henkin, J., Lesniewski, R.
登録日2003-10-10
公開日2004-10-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献3-Amino-2-hydroxyamides and related compounds as inhibitors of methionine aminopeptidase-2.
Bioorg.Med.Chem.Lett., 14, 2004
1URK
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SOLUTION STRUCTURE OF THE AMINO TERMINAL FRAGMENT OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR
分子名称:PLASMINOGEN ACTIVATOR, ALPHA-L-FUCOSE
著者Hansen, A.P., Petros, A.M., Meadows, R.P., Nettesheim, D.G., Mazar, A.P., Olejniczak, E.T., Xu, R.X., Pederson, T.M., Henkin, J., Fesik, S.W.
登録日1994-01-10
公開日1995-05-08
最終更新日2017-11-29
実験手法SOLUTION NMR
主引用文献Solution structure of the amino-terminal fragment of urokinase-type plasminogen activator.
Biochemistry, 33, 1994
2GA2
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H-METAP2 COMPLEXED WITH A193400
分子名称:Methionine aminopeptidase 2, MANGANESE (II) ION, 5-BROMO-2-{[(4-CHLOROPHENYL)SULFONYL]AMINO}BENZOIC ACID
著者Park, C.
登録日2006-03-07
公開日2007-03-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties.
Bioorg.Med.Chem.Lett., 16, 2006
1YW7
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H-METAP2 COMPLEXED WITH A444148
分子名称:Methionine aminopeptidase 2, MANGANESE (II) ION, 5-METHYL-2-[(PHENYLSULFONYL)AMINO]BENZOIC ACID
著者Park, C.H.
登録日2005-02-17
公開日2006-02-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.
J.Med.Chem., 49, 2006
1YW8
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H-METAP2 COMPLEXED WITH A751277
分子名称:Methionine aminopeptidase 2, MANGANESE (II) ION, 2-[(PHENYLSULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID
著者Park, C.H.
登録日2005-02-17
公開日2006-02-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.
J.Med.Chem., 49, 2006
1YW9
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H-METAP2 COMPLEXED WITH A849519
分子名称:Methionine aminopeptidase 2, MANGANESE (II) ION, 2-[({2-[(1Z)-3-(DIMETHYLAMINO)PROP-1-ENYL]-4-FLUOROPHENYL}SULFONYL)AMINO]-5,6,7,8-TETRAHYDRONAPHTHALENE-1-CARBOXYLIC ACID
著者Park, C.H.
登録日2005-02-17
公開日2006-02-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.
J.Med.Chem., 49, 2006