Author results

1AXR
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COOPERATIVITY BETWEEN HYDROGEN-BONDING AND CHARGE-DIPOLE INTERACTIONS IN THE INHIBITION OF BETA-GLYCOSIDASES BY AZOLOPYRIDINES: EVIDENCE FROM A STUDY WITH GLYCOGEN PHOSPHORYLASE B
Descriptor:GLYCOGEN PHOSPHORYLASE, PHOSPHATE ION, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Oikonomakos, N.G., Heightman, T.D.
Deposit date:1997-10-20
Release date:1998-01-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Cooperative interactions of the catalytic nucleophile and the catalytic acid in the inhibition of beta-glycosidases. Calculations and their validation by comparative kinetic and structural studies of the inhibition of glycogen phosphorylase b.
HELV.CHIM.ACTA, 81, 1998
1JZ6
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E. COLI (LACZ) BETA-GALACTOSIDASE IN COMPLEX WITH GALACTO-TETRAZOLE
Descriptor:Beta-Galactosidase, (5R, 6S, ...
Authors:Juers, D.H., Heightman, T.D., Vasella, A., Matthews, B.W.
Deposit date:2001-09-13
Release date:2001-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Structural View of the Action of Escherichia Coli (Lacz) Beta-Galactosidase
Biochemistry, 40, 2001
3NJY
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CRYSTAL STRUCTURE OF JMJD2A COMPLEXED WITH 5-CARBOXY-8-HYDROXYQUINOLINE
Descriptor:Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ...
Authors:King, O.N.F., Clifton, I.J., Wang, M., Maloney, D.J., Jadhav, A., Oppermann, U., Heightman, T.D., Simeonov, A., McDonough, M.A., Schofield, C.J.
Deposit date:2010-06-18
Release date:2010-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors
Plos One, 5, 2010
3OD4
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CRYSTAL STRUCTURE OF FACTOR INHIBITING HIF-1 ALPHA COMPLEXED WITH INHIBITOR
Descriptor:Hypoxia-inducible factor 1-alpha inhibitor, ZINC ION, 8-hydroxyquinoline-5-carboxylic acid, ...
Authors:King, O.N.F., Bashford-Rogers, R., Maloney, D.J., Jadhav, A., Heightman, T.D., Simeonov, A., Clifton, I.J., McDonough, M.A., Schofield, C.J.
Deposit date:2010-08-10
Release date:2011-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of Factor Inhibiting HIF-1 Alpha Complexed with Inhibitor
To be Published
3RVH
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CRYSTAL STRUCTURE OF JMJD2A COMPLEXED WITH INHIBITOR
Descriptor:Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ...
Authors:King, O.N.F., Maloney, D.J., Tumber, A., Rai, G., Jadhav, A., Clifton, I.J., Heightman, T.D., Simeonov, A., McDonough, M.A., Schofield, C.J.
Deposit date:2011-05-06
Release date:2012-05-09
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.251 Å)
Cite:Crystal Structure of JMJD2A Complexed with Inhibitor
To be Published
4CC5
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FRAGMENT-BASED DISCOVERY OF 6 AZAINDAZOLES AS INHIBITORS OF BACTERIAL DNA LIGASE
Descriptor:DNA LIGASE, SULFATE ION, 2-chloranyl-6-(1H-1,2,4-triazol-3-yl)pyrazine
Authors:Howard, S., Amin, N., Benowitz, A.B., Chiarparin, E., Cui, H., Deng, X., Heightman, T.D., Holmes, D.J., Hopkins, A., Huang, J., Jin, Q., Kreatsoulas, C., Martin, A.C.L., Massey, F., McCloskey, L., Mortenson, P.N., Pathuri, P., Tisi, D., Williams, P.A.
Deposit date:2013-10-18
Release date:2014-06-18
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Fragment-Based Discovery of 6-Azaindazoles as Inhibitors of Bacterial DNA Ligase.
Acs Med.Chem.Lett., 4, 2013
4CC6
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FRAGMENT-BASED DISCOVERY OF 6 AZAINDAZOLES AS INHIBITORS OF BACTERIAL DNA LIGASE
Descriptor:DNA LIGASE, SULFATE ION, 2-{[2-(1H-pyrazolo[3,4-c]pyridin-3-yl)-6-(trifluoromethyl)pyridin-4-yl]amino}ethanol
Authors:Howard, S., Amin, N., Benowitz, A.B., Chiarparin, E., Cui, H., Deng, X., Heightman, T.D., Holmes, D.J., Hopkins, A., Huang, J., Jin, Q., Kreatsoulas, C., Martin, A.C.L., Massey, F., McCloskey, L., Mortenson, P.N., Pathuri, P., Tisi, D., Williams, P.A.
Deposit date:2013-10-18
Release date:2014-06-18
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Fragment-Based Discovery of 6-Azaindazoles as Inhibitors of Bacterial DNA Ligase.
Acs Med.Chem.Lett., 4, 2013
4GPJ
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH A ISOXAZOLYLBENZIMIDAZOLE LIGAND
Descriptor:Bromodomain-containing protein 4, (1R)-6-(3,5-dimethyl-1,2-oxazol-4-yl)-1-phenyl-2,3-dihydro-1H-inden-1-ol, 1,2-ETHANEDIOL, ...
Authors:Filippakopoulos, P., Picaud, S., Qi, J., Felletar, I., Heightman, T.D., Brennan, P., von Delft, F., Bountra, C., Arrowsmith, C.H., Edwards, A., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2012-08-21
Release date:2012-10-17
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The design and synthesis of 5- and 6-isoxazolylbenzimidazoles as selective inhibitors of the BET Bromodomains
TO BE PUBLISHED
5FNQ
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STRUCTURE OF THE KEAP1 KELCH DOMAIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR.
Descriptor:KELCH-LIKE ECH-ASSOCIATED PROTEIN 1, 3-(4-CHLOROPHENYL)PROPANOIC ACID
Authors:Davies, T.G., Wixted, W.E., Coyle, J.E., Griffiths-Jones, C., Hearn, K., McMenamin, R., Norton, D., Rich, S.J., Richardson, C., Saxty, G., Willems, H.M.G., Woolford, A.J., Cottom, J.E., Kou, J., Yonchuk, J.G., Feldser, H.G., Sanchez, Y., Foley, J.P., Bolognese, B.J., Logan, G., Podolin, P.L., Yan, H., Callahan, J.F., Heightman, T.D., Kerns, J.K.
Deposit date:2015-11-16
Release date:2016-04-13
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Mono-Acidic Inhibitors of the Kelch-Like Ech-Associated Protein 1 : Nuclear Factor Erythroid 2-Related Factor 2 (Keap1:Nrf2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
J.Med.Chem., 59, 2016
5FNR
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STRUCTURE OF THE KEAP1 KELCH DOMAIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR.
Descriptor:KELCH-LIKE ECH-ASSOCIATED PROTEIN 1, (3S)-3-(4-chlorophenyl)-3-(1-methylbenzotriazol-5-yl)propanoic acid
Authors:Davies, T.G., Wixted, W.E., Coyle, J.E., Griffiths-Jones, C., Hearn, K., McMenamin, R., Norton, D., Rich, S.J., Richardson, C., Saxty, G., Willems, H.M.G., Woolford, A.J., Cottom, J.E., Kou, J., Yonchuk, J.G., Feldser, H.G., Sanchez, Y., Foley, J.P., Bolognese, B.J., Logan, G., Podolin, P.L., Yan, H., Callahan, J.F., Heightman, T.D., Kerns, J.K.
Deposit date:2015-11-16
Release date:2016-04-13
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Mono-Acidic Inhibitors of the Kelch-Like Ech-Associated Protein 1 : Nuclear Factor Erythroid 2-Related Factor 2 (Keap1:Nrf2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
J.Med.Chem., 59, 2016
5FNS
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STRUCTURE OF THE KEAP1 KELCH DOMAIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR.
Descriptor:KELCH-LIKE ECH-ASSOCIATED PROTEIN 1, (3s)-{4-Chloro-3-[(N-methylmethanesulfonamido) methyl]phenyl}-3-(1-methyl-1H-1,2,3-benzotriazol-5-yl) propanoic acid, CHLORIDE ION
Authors:Davies, T.G., Wixted, W.E., Coyle, J.E., Griffiths-Jones, C., Hearn, K., McMenamin, R., Norton, D., Rich, S.J., Richardson, C., Saxty, G., Willems, H.M.G., Woolford, A.J., Cottom, J.E., Kou, J., Yonchuk, J.G., Feldser, H.G., Sanchez, Y., Foley, J.P., Bolognese, B.J., Logan, G., Podolin, P.L., Yan, H., Callahan, J.F., Heightman, T.D., Kerns, J.K.
Deposit date:2015-11-16
Release date:2016-04-13
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Mono-Acidic Inhibitors of the Kelch-Like Ech-Associated Protein 1 : Nuclear Factor Erythroid 2-Related Factor 2 (Keap1:Nrf2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
J.Med.Chem., 59, 2016
5FNT
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STRUCTURE OF THE KEAP1 KELCH DOMAIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR.
Descriptor:KELCH-LIKE ECH-ASSOCIATED PROTEIN 1, CHLORIDE ION, (3S)-3-{4-Chloro-3-[(N-methylbenzenesulfonamido) methyl]phenyl}-3-(1-methyl-1H-1,2,3-benzotriazol-5-yl)propanoic acid
Authors:Davies, T.G., Wixted, W.E., Coyle, J.E., Griffiths-Jones, C., Hearn, K., McMenamin, R., Norton, D., Rich, S.J., Richardson, C., Saxty, G., Willems, H.M.G., Woolford, A.J., Cottom, J.E., Kou, J., Yonchuk, J.G., Feldser, H.G., Sanchez, Y., Foley, J.P., Bolognese, B.J., Logan, G., Podolin, P.L., Yan, H., Callahan, J.F., Heightman, T.D., Kerns, J.K.
Deposit date:2015-11-16
Release date:2016-04-13
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Mono-Acidic Inhibitors of the Kelch-Like Ech-Associated Protein 1 : Nuclear Factor Erythroid 2-Related Factor 2 (Keap1:Nrf2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
J.Med.Chem., 59, 2016
5FNU
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STRUCTURE OF THE KEAP1 KELCH DOMAIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR.
Descriptor:KELCH-LIKE ECH-ASSOCIATED PROTEIN 1, (3S)-3-(7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazol-5-yl)-3-(4-methyl-3-(((R)-4-methyl-1,1-dioxido-3,4-dihydro-2H-benzo[b][1,4,5]oxathiazepin-2-yl)methyl)phenyl)propanoic acid, CHLORIDE ION
Authors:Davies, T.G., Wixted, W.E., Coyle, J.E., Griffiths-Jones, C., Hearn, K., McMenamin, R., Norton, D., Rich, S.J., Richardson, C., Saxty, G., Willems, H.M.G., Woolford, A.J., Cottom, J.E., Kou, J., Yonchuk, J.G., Feldser, H.G., Sanchez, Y., Foley, J.P., Bolognese, B.J., Logan, G., Podolin, P.L., Yan, H., Callahan, J.F., Heightman, T.D., Kerns, J.K.
Deposit date:2015-11-16
Release date:2016-04-13
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Mono-Acidic Inhibitors of the Kelch-Like Ech-Associated Protein 1 : Nuclear Factor Erythroid 2-Related Factor 2 (Keap1:Nrf2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
J.Med.Chem., 59, 2016
5FZJ
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STRUCTURE OF THE KEAP1 KELCH DOMAIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR.
Descriptor:KELCH-LIKE ECH-ASSOCIATED PROTEIN 1, 2,6-DIMETHYL-4H-PYRANO[3,4-D][1,3]OXAZOL-4-ONE
Authors:Davies, T.G., Wixted, W.E., Coyle, J.E., Griffiths-Jones, C., Hearn, K., McMenamin, R., Norton, D., Rich, S.J., Richardson, C., Saxty, G., Willems, H.M.G., Woolford, A.J., Cottom, J.E., Kou, J., Yonchuk, J.G., Feldser, H.G., Sanchez, Y., Foley, J.P., Bolognese, B.J., Logan, G., Podolin, P.L., Yan, H., Callahan, J.F., Heightman, T.D., Kerns, J.K.
Deposit date:2016-03-14
Release date:2016-04-13
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Mono-Acidic Inhibitors of the Kelch-Like Ech-Associated Protein 1 : Nuclear Factor Erythroid 2-Related Factor 2 (Keap1:Nrf2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
J.Med.Chem., 59, 2016
5FZN
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STRUCTURE OF THE KEAP1 KELCH DOMAIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR.
Descriptor:KELCH-LIKE ECH-ASSOCIATED PROTEIN 1, SULFATE ION, benzenesulfonamide
Authors:Davies, T.G., Wixted, W.E., Coyle, J.E., Griffiths-Jones, C., Hearn, K., McMenamin, R., Norton, D., Rich, S.J., Richardson, C., Saxty, G., Willems, H.M.G., Woolford, A.J., Cottom, J.E., Kou, J., Yonchuk, J.G., Feldser, H.G., Sanchez, Y., Foley, J.P., Bolognese, B.J., Logan, G., Podolin, P.L., Yan, H., Callahan, J.F., Heightman, T.D., Kerns, J.K.
Deposit date:2016-03-15
Release date:2016-04-13
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Mono-Acidic Inhibitors of the Kelch-Like Ech-Associated Protein 1 : Nuclear Factor Erythroid 2-Related Factor 2 (Keap1:Nrf2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.
J.Med.Chem., 59, 2016
6G8X
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FRAGMENT-BASED DISCOVERY OF A HIGHLY POTENT, ORALLY BIOAVAILABLE INHIBITOR WHICH MODULATES THE PHOSPHORYLATION AND CATALYTIC ACTIVITY OF ERK1/2
Descriptor:Mitogen-activated protein kinase 1, SULFATE ION, 4-chloranyl-1~{H}-indazol-3-amine
Authors:O'Reilly, M.
Deposit date:2018-04-10
Release date:2018-05-30
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
J. Med. Chem., 61, 2018
6G91
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FRAGMENT-BASED DISCOVERY OF A HIGHLY POTENT, ORALLY BIOAVAILABLE INHIBITOR WHICH MODULATES THE PHOSPHORYLATION AND CATALYTIC ACTIVITY OF ERK1/2
Descriptor:Mitogen-activated protein kinase 1, SULFATE ION, 5-chloranyl-~{N}-(oxan-4-yl)pyrimidin-2-amine
Authors:O'Reilly, M.
Deposit date:2018-04-10
Release date:2018-05-30
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
J. Med. Chem., 61, 2018
6G92
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FRAGMENT-BASED DISCOVERY OF A HIGHLY POTENT, ORALLY BIOAVAILABLE INHIBITOR WHICH MODULATES THE PHOSPHORYLATION AND CATALYTIC ACTIVITY OF ERK1/2
Descriptor:Mitogen-activated protein kinase 1, SULFATE ION, ~{N}-(1,5-dimethylpyrazol-4-yl)-5-methyl-pyrimidin-2-amine
Authors:O'Reilly, M.
Deposit date:2018-04-10
Release date:2018-05-30
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
J. Med. Chem., 61, 2018
6G93
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FRAGMENT-BASED DISCOVERY OF A HIGHLY POTENT, ORALLY BIOAVAILABLE INHIBITOR WHICH MODULATES THE PHOSPHORYLATION AND CATALYTIC ACTIVITY OF ERK1/2
Descriptor:Mitogen-activated protein kinase 1, SULFATE ION, 6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2,3-dihydroisoindol-1-one
Authors:O'Reilly, M.
Deposit date:2018-04-10
Release date:2018-05-30
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
J. Med. Chem., 61, 2018
6G97
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FRAGMENT-BASED DISCOVERY OF A HIGHLY POTENT, ORALLY BIOAVAILABLE INHIBITOR WHICH MODULATES THE PHOSPHORYLATION AND CATALYTIC ACTIVITY OF ERK1/2
Descriptor:Mitogen-activated protein kinase 1, SULFATE ION, 6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2-(2-methoxyethyl)-3~{H}-isoindol-1-one
Authors:O'Reilly, M.
Deposit date:2018-04-10
Release date:2018-05-30
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
J. Med. Chem., 61, 2018
6G9A
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FRAGMENT-BASED DISCOVERY OF A HIGHLY POTENT, ORALLY BIOAVAILABLE INHIBITOR WHICH MODULATES THE PHOSPHORYLATION AND CATALYTIC ACTIVITY OF ERK1/2
Descriptor:Mitogen-activated protein kinase 1, SULFATE ION, 6-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-2-(2-morpholin-4-ylethyl)-3~{H}-isoindol-1-one
Authors:O'Reilly, M.
Deposit date:2018-04-10
Release date:2018-05-30
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
J. Med. Chem., 61, 2018
6G9D
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FRAGMENT-BASED DISCOVERY OF A HIGHLY POTENT, ORALLY BIOAVAILABLE INHIBITOR WHICH MODULATES THE PHOSPHORYLATION AND CATALYTIC ACTIVITY OF ERK1/2
Descriptor:Mitogen-activated protein kinase 1, SULFATE ION, ~{N}-~{tert}-butyl-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]ethanamide
Authors:O'Reilly, M.
Deposit date:2018-04-10
Release date:2018-05-30
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
J. Med. Chem., 61, 2018
6G9H
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FRAGMENT-BASED DISCOVERY OF A HIGHLY POTENT, ORALLY BIOAVAILABLE INHIBITOR WHICH MODULATES THE PHOSPHORYLATION AND CATALYTIC ACTIVITY OF ERK1/2
Descriptor:Mitogen-activated protein kinase 1, SULFATE ION, ~{N}-~{tert}-butyl-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-methyl-ethanamide
Authors:O'Reilly, M.
Deposit date:2018-04-10
Release date:2018-05-30
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
J. Med. Chem., 61, 2018
6G9J
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FRAGMENT-BASED DISCOVERY OF A HIGHLY POTENT, ORALLY BIOAVAILABLE INHIBITOR WHICH MODULATES THE PHOSPHORYLATION AND CATALYTIC ACTIVITY OF ERK1/2
Descriptor:Mitogen-activated protein kinase 1, SULFATE ION, 2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-[(1~{R})-1-phenylethyl]ethanamide
Authors:O'Reilly, M.
Deposit date:2018-04-10
Release date:2018-05-30
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
J. Med. Chem., 61, 2018
6G9K
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FRAGMENT-BASED DISCOVERY OF A HIGHLY POTENT, ORALLY BIOAVAILABLE INHIBITOR WHICH MODULATES THE PHOSPHORYLATION AND CATALYTIC ACTIVITY OF ERK1/2
Descriptor:Mitogen-activated protein kinase 1, SULFATE ION, 2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-[(1~{S})-2-oxidanyl-1-phenyl-ethyl]ethanamide
Authors:O'Reilly, M.
Deposit date:2018-04-11
Release date:2018-05-30
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2.
J. Med. Chem., 61, 2018
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