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4CFH
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BU of 4cfh by Molmil
Structure of an active form of mammalian AMPK
Descriptor: 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ...
Authors:Xiao, B, Sanders, M.J, Underwood, E, Heath, R, Mayer, F, Carmena, D, Jing, C, Walker, P.A, Eccleston, J.F, Haire, L.F, Saiu, P, Howell, S.A, Aasland, R, Martin, S.R, Carling, D, Gamblin, S.J.
Deposit date:2013-11-18
Release date:2013-12-25
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.24 Å)
Cite:Structure of Mammalian Ampk and its Regulation by Adp
Nature, 472, 2011
1W9R
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BU of 1w9r by Molmil
Solution Structure of Choline Binding Protein A, Domain R2, the Major Adhesin of Streptococcus pneumoniae
Descriptor: CHOLINE BINDING PROTEIN A
Authors:Luo, R, Mann, B, Lewis, W.S, Rowe, A, Heath, R, Stewart, M.L, Hamburger, A.E, Bjorkman, P.J, Sivakolundu, S, Lacy, E.R, Tuomanen, E, Kriwacki, R.W.
Deposit date:2004-10-15
Release date:2005-02-22
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of Choline Binding Protein A, the Major Adhesin of Streptococcus Pneumoniae
Embo J., 24, 2005
2Y8L
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BU of 2y8l by Molmil
Structure of the regulatory fragment of mammalian aMPK in complex with two ADP
Descriptor: 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ...
Authors:Xiao, B, Sanders, M.J, Underwood, E, Heath, R, Mayer, F, Carmena, D, Jing, C, Walker, P.A, Eccleston, J.F, Haire, L.F, Saiu, P, Howell, S.A, Aasland, R, Martin, S.R, Carling, D, Gamblin, S.J.
Deposit date:2011-02-07
Release date:2011-03-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of Mammalian Ampk and its Regulation by Adp
Nature, 472, 2011
2Y8Q
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BU of 2y8q by Molmil
Structure of the regulatory fragment of mammalian AMPK in complex with one ADP
Descriptor: 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ...
Authors:Xiao, B, Sanders, M.J, Underwood, E, Heath, R, Mayer, F, Carmena, D, Jing, C, Walker, P.A, Eccleston, J.F, Haire, L.F, Saiu, P, Howell, S.A, Aasland, R, Martin, S.R, Carling, D, Gamblin, S.J.
Deposit date:2011-02-09
Release date:2011-03-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of Mammalian Ampk and its Regulation by Adp
Nature, 472, 2011
2YA3
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BU of 2ya3 by Molmil
STRUCTURE OF THE REGULATORY FRAGMENT OF MAMMALIAN AMPK IN COMPLEX WITH COUMARIN ADP
Descriptor: 3'-(7-diethylaminocoumarin-3-carbonylamino)-3'-deoxy-ADP, 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2, ...
Authors:Xiao, B, Sanders, M.J, Underwood, E, Heath, R, Mayer, F, Carmena, D, Jing, C, Walker, P.A, Eccleston, J.F, Haire, L.F, Saiu, P, Howell, S.A, Aasland, R, Martin, S.R, Carling, D, Gamblin, S.J.
Deposit date:2011-02-17
Release date:2011-03-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Structure of Mammalian Ampk and its Regulation by Adp
Nature, 472, 2011
7PPX
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BU of 7ppx by Molmil
ATAD2 in complex with FragLite3
Descriptor: 1,2-ETHANEDIOL, 4-bromanyl-1,2-oxazole, ATPase family AAA domain-containing protein 2, ...
Authors:Turberville, S, Martin, M.P, Hope, I, Wood, D.J, Ng, Y.M, Heath, R, Endicott, J.A, Noble, M.E.M.
Deposit date:2021-09-15
Release date:2022-09-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions.
J.Med.Chem., 65, 2022
3T4N
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BU of 3t4n by Molmil
Structure of the regulatory fragment of Saccharomyces cerevisiae AMPK in complex with ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Carbon catabolite-derepressing protein kinase, Nuclear protein SNF4, ...
Authors:Mayer, F.V, Heath, R, Underwood, E, Sanders, M.J, Carmena, D, McCartney, R, Leiper, F.C, Xiao, B, Jing, C, Walker, P.A, Haire, L.F, Ogrodowicz, R, Martin, S.R, Schmdit, M.C, Gamblin, S.J, Carling, D.
Deposit date:2011-07-26
Release date:2011-11-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:ADP Regulates SNF1, the Saccharomyces cerevisiae Homolog of AMP-Activated Protein Kinase.
Cell Metab, 14, 2011
3TE5
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BU of 3te5 by Molmil
structure of the regulatory fragment of sacchromyces cerevisiae ampk in complex with NADH
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Carbon catabolite-derepressing protein kinase, Nuclear protein SNF4, ...
Authors:Mayer, F.V, Heath, R, Underwood, E, Sanders, M.J, Carmena, D, McCartney, R, Leiper, F.C, Xiao, B, Jing, C, Walker, P.A, Haire, L.F, Ogrodowicz, R, Martin, S.R, Schmidt, M.C, Gamblin, S.J, Carling, D.
Deposit date:2011-08-12
Release date:2011-11-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:ADP Regulates SNF1, the Saccharomyces cerevisiae Homolog of AMP-Activated Protein Kinase.
Cell Metab, 14, 2011
3TDH
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BU of 3tdh by Molmil
Structure of the regulatory fragment of sccharomyces cerevisiae AMPK in complex with AMP
Descriptor: ADENOSINE MONOPHOSPHATE, Carbon catabolite-derepressing protein kinase, Nuclear protein SNF4, ...
Authors:Mayer, F.V, Heath, R, Underwood, E, Sanders, M.J, Carmena, D, McCartney, R, Leiper, F.C, Xiao, B, Jing, C, Walker, P.A, Haire, L.F, Ogrodowicz, R, Martin, S.R, Schmidt, M.C, Gamblin, S.J, Carling, D.
Deposit date:2011-08-11
Release date:2011-11-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:ADP Regulates SNF1, the Saccharomyces cerevisiae Homolog of AMP-Activated Protein Kinase.
Cell Metab, 14, 2011
2V8Q
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BU of 2v8q by Molmil
Crystal structure of the regulatory fragment of mammalian AMPK in complexes with AMP
Descriptor: 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ...
Authors:Xiao, B, Heath, R, Saiu, P, Leiper, F.C, Leone, P, Jing, C, Walker, P.A, Haire, L, Eccleston, J.F, Davis, C.T, Martin, S.R, Carling, D, Gamblin, S.J.
Deposit date:2007-08-13
Release date:2007-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis for AMP Binding to Mammalian AMP-Activated Protein Kinase
Nature, 449, 2007
2V92
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BU of 2v92 by Molmil
Crystal structure of the regulatory fragment of mammalian AMPK in complexes with ATP-AMP
Descriptor: 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ...
Authors:Xiao, B, Heath, R, Saiu, P, Leiper, F.C, Leone, P, Jing, C, Walker, P.A, Haire, L, Eccleston, J.F, Davis, C.T, Martin, S.R, Carling, D, Gamblin, S.J.
Deposit date:2007-08-20
Release date:2007-09-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Basis for AMP Binding to Mammalian AMP-Activated Protein Kinase
Nature, 449, 2007
2V9J
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BU of 2v9j by Molmil
Crystal structure of the regulatory fragment of mammalian AMPK in complexes with Mg.ATP-AMP
Descriptor: 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2, 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ...
Authors:Xiao, B, Heath, R, Saiu, P, Leiper, F.C, Leone, P, Jing, C, Walker, P.A, Haire, L, Eccleston, J.F, Davis, C.T, Martin, S.R, Carling, D, Gamblin, S.J.
Deposit date:2007-08-23
Release date:2007-09-25
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Structural Basis for AMP Binding to Mammalian AMP-Activated Protein Kinase
Nature, 449, 2007
6SG4
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BU of 6sg4 by Molmil
Structure of CDK2/cyclin A M246Q, S247EN
Descriptor: Cyclin-A2, Cyclin-dependent kinase 2
Authors:Salamina, M, Basle, A, Massa, B, Noble, M.E.M, Endicott, J.A.
Deposit date:2019-08-02
Release date:2021-01-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation.
J.Mol.Biol., 433, 2021
6TD4
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BU of 6td4 by Molmil
IRF4 DNA-binding domain surface entropy mutant apo structure
Descriptor: CHLORIDE ION, Interferon regulatory factor 4
Authors:Tucker, J.A, Martin, M.P, Wang, L.Z, Jennings, C, Heath, R.
Deposit date:2019-11-07
Release date:2020-11-18
Last modified:2021-06-23
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Cancer-associated mutations in the IRF4 DNA-binding domain confer no disadvantage in DNA-binding affinity and may increase transcriptional activity
To Be Published
8BYA
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BU of 8bya by Molmil
Cryo-EM structure of SKP1-SKP2-CKS1-CDK2-CyclinA-p27KIP1 Complex
Descriptor: Cyclin-A2, Cyclin-dependent kinase 2, Cyclin-dependent kinase inhibitor 1B, ...
Authors:Rowland, R.J, Salamina, M, Endicott, J.A, Noble, M.E.
Deposit date:2022-12-12
Release date:2023-06-28
Last modified:2023-07-19
Method:ELECTRON MICROSCOPY (3.38 Å)
Cite:Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1.
Sci Rep, 13, 2023
8BZO
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BU of 8bzo by Molmil
Cryo-EM structure of CDK2-CyclinA in complex with p27 from the SCFSKP2 E3 ligase Complex
Descriptor: Cyclin-A2, Cyclin-dependent kinase 2, Cyclin-dependent kinase inhibitor 1B
Authors:Rowland, R.J, Salamina, M, Endicott, J.A, Noble, M.E.
Deposit date:2022-12-15
Release date:2023-06-28
Last modified:2023-07-19
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1.
Sci Rep, 13, 2023
8BYL
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BU of 8byl by Molmil
Cryo-EM structure of SKP1-SKP2-CKS1 from the SCFSKP2 E3 ligase complex
Descriptor: Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinases regulatory subunit 1, S-phase kinase-associated protein 1, ...
Authors:Rowland, R.J, Salamina, M, Endicott, J.A, Noble, M.E.M.
Deposit date:2022-12-13
Release date:2023-06-28
Last modified:2023-07-19
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM structure of SKP1-SKP2-CKS1 in complex with CDK2-cyclin A-p27KIP1.
Sci Rep, 13, 2023
7Z9U
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BU of 7z9u by Molmil
ATAD2 in complex with Acetyl-Lys
Descriptor: (2S)-2,6-diacetamido-N-methyl-hexanamide, 1,2-ETHANEDIOL, ARGININE, ...
Authors:Turberville, S, Martin, M.P, Hope, I, Noble, M.E.M.
Deposit date:2022-03-21
Release date:2022-11-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions.
J.Med.Chem., 65, 2022
7ZAQ
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BU of 7zaq by Molmil
BRD4 in complex with FragLite19
Descriptor: 4-bromo-2-methoxyphenol, GLYCEROL, Isoform C of Bromodomain-containing protein 4
Authors:Turberville, S, Martin, M.P, Hope, I, Noble, M.E.M.
Deposit date:2022-03-22
Release date:2022-11-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.11 Å)
Cite:Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions.
J.Med.Chem., 65, 2022
7Z9H
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BU of 7z9h by Molmil
ATAD2 in complex with PepLite-Asp
Descriptor: (2~{S})-2-acetamido-~{N}-(3-bromanylprop-2-ynyl)butanediamide, 1,2-ETHANEDIOL, ATPase family AAA domain-containing protein 2, ...
Authors:Turberville, S, Martin, M.P, Hope, I, Noble, M.E.M.
Deposit date:2022-03-21
Release date:2022-11-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions.
J.Med.Chem., 65, 2022
7ZFO
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BU of 7zfo by Molmil
BRD4 in complex with FragLite28
Descriptor: 4-bromo-1-(2-hydroxyethyl)pyridin-2(1H)-one, GLYCEROL, Isoform C of Bromodomain-containing protein 4
Authors:Turberville, S, Martin, M.P, Hope, I, Noble, M.E.M.
Deposit date:2022-04-01
Release date:2022-11-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions.
J.Med.Chem., 65, 2022
7ZAD
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BU of 7zad by Molmil
BRD4 in complex with FragLite12
Descriptor: 4-iodanylbenzamide, GLYCEROL, Isoform C of Bromodomain-containing protein 4
Authors:Turberville, S, Martin, M.P, Hope, I, Noble, M.E.M.
Deposit date:2022-03-22
Release date:2022-11-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.07 Å)
Cite:Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions.
J.Med.Chem., 65, 2022
7Z9O
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BU of 7z9o by Molmil
ATAD2 in complex with PepLite-Tyr
Descriptor: (2~{S})-2-acetamido-3-(4-hydroxyphenyl)-~{N}-prop-2-enyl-propanamide, 1,2-ETHANEDIOL, ATPase family AAA domain-containing protein 2, ...
Authors:Turberville, S, Martin, M.P, Hope, I, Noble, M.E.M.
Deposit date:2022-03-21
Release date:2022-11-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions.
J.Med.Chem., 65, 2022
7Z9I
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BU of 7z9i by Molmil
ATAD2 in complex with PepLite-Ala
Descriptor: (2~{S})-2-acetamido-~{N}-(3-bromanylprop-2-ynyl)propanamide, 1,2-ETHANEDIOL, ATPase family AAA domain-containing protein 2, ...
Authors:Turberville, S, Martin, M.P, Hope, I, Noble, M.E.M.
Deposit date:2022-03-21
Release date:2022-11-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions.
J.Med.Chem., 65, 2022
7ZAJ
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BU of 7zaj by Molmil
BRD4 in complex with FragLite16
Descriptor: 4-bromanyl-1,8-naphthyridine, GLYCEROL, Isoform C of Bromodomain-containing protein 4
Authors:Turberville, S, Martin, M.P, Hope, I, Noble, M.E.M.
Deposit date:2022-03-22
Release date:2022-11-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1 Å)
Cite:Mapping Ligand Interactions of Bromodomains BRD4 and ATAD2 with FragLites and PepLites─Halogenated Probes of Druglike and Peptide-like Molecular Interactions.
J.Med.Chem., 65, 2022

 

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