Author results

2MS7
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HIGH-RESOLUTION SOLID-STATE NMR STRUCTURE OF THE HELICAL SIGNAL TRANSDUCTION FILAMENT MAVS CARD
Descriptor:Mitochondrial antiviral-signaling protein
Authors:He, L., Bardiaux, B., Spehr, J., Luehrs, T., Ritter, C.
Deposit date:2014-07-25
Release date:2015-09-02
Last modified:2016-02-03
Method:SOLID-STATE NMR
Cite:Structure determination of helical filaments by solid-state NMR spectroscopy.
Proc.Natl.Acad.Sci.USA, 113, 2016
3DOY
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CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (FABZ) FROM HELICOBACTER PYLORI IN COMPLEX WITH COMPOUND 3I
Descriptor:(3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE, ...
Authors:Zhang, L., He, L., Liu, X., Liu, H., Shen, X., Jiang, H.
Deposit date:2008-07-07
Release date:2009-05-05
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination.
J.Med.Chem., 52, 2009
3DOZ
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CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (FABZ) FROM HELICOBACTER PYLORI IN COMPLEX WITH COMPOUND 3K
Descriptor:(3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE, ...
Authors:Zhang, L., He, L., Liu, X., Liu, H., Shen, X., Jiang, H.
Deposit date:2008-07-07
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination.
J.Med.Chem., 52, 2009
3DP0
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CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (FABZ) FROM HELICOBACTER PYLORI IN COMPLEX WITH COMPOUND 3M
Descriptor:(3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE, ...
Authors:Zhang, L., He, L., Liu, X., Liu, H., Shen, X., Jiang, H.
Deposit date:2008-07-07
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination.
J.Med.Chem., 52, 2009
3DP1
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CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (FABZ) FROM HELICOBACTER PYLORI IN COMPLEX WITH COMPOUND 3N
Descriptor:(3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE, ...
Authors:Zhang, L., He, L., Liu, X., Liu, H., Shen, X., Jiang, H.
Deposit date:2008-07-07
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination.
J.Med.Chem., 52, 2009
3DP2
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CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (FABZ) FROM HELICOBACTER PYLORI IN COMPLEX WITH COMPOUND 3J
Descriptor:(3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE, ...
Authors:Zhang, L., He, L., Liu, X., Liu, H., Shen, X., Jiang, H.
Deposit date:2008-07-07
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination.
J.Med.Chem., 52, 2009
3DP3
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CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (FABZ) FROM HELICOBACTER PYLORI IN COMPLEX WITH COMPOUND 3Q
Descriptor:(3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE, ...
Authors:Zhang, L., He, L., Liu, X., Liu, H., Shen, X., Jiang, H.
Deposit date:2008-07-07
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovering potent inhibitors against the beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Helicobacter pylori: structure-based design, synthesis, bioassay, and crystal structure determination.
J.Med.Chem., 52, 2009
2MS8
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SOLUTION NMR STRUCTURE OF MAVS CARD
Descriptor:Mitochondrial antiviral-signaling protein
Authors:Spehr, J., He, L., Luehrs, T., Ritter, C.
Deposit date:2014-07-25
Release date:2015-09-02
Last modified:2016-02-03
Method:SOLUTION NMR
Cite:Structure determination of helical filaments by solid-state NMR spectroscopy.
Proc.Natl.Acad.Sci.USA, 113, 2016
5WYD
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STRUCTURAL OF PSEUDOMONAS AERUGINOSA DSPI
Descriptor:Probable enoyl-CoA hydratase/isomerase, PENTANEDIAL, ISOPROPYL ALCOHOL, ...
Authors:Liu, L., Peng, C., Li, T., Li, C., He, L., Song, Y., Zhu, Y., Shen, Y., Bao, R.
Deposit date:2017-01-12
Release date:2018-01-31
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:Functional and structural characterization of Pseudomonas aeruginosa DspI verified its role in pathogenicity via the modulation of diffusible signal factor (DSF) biosynthesis
To Be Published
5YQZ
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STRUCTURE OF THE GLUCAGON RECEPTOR IN COMPLEX WITH A GLUCAGON ANALOGUE
Descriptor:Glucagon receptor,Endolysin,Glucagon receptor, Glucagon analogue, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Zhang, H., Qiao, A., Yang, L., VAN EPS, N., Frederiksen, K., Yang, D., Dai, A., Cai, X., Zhang, H., Yi, C., Can, C., He, L., Yang, H., Lau, J., Ernst, O., Hanson, M., Stevens, R., Wang, M., Seedtz-Runge, S., Jiang, H., Zhao, Q., Wu, B.
Deposit date:2017-11-08
Release date:2018-01-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of the glucagon receptor in complex with a glucagon analogue.
Nature, 553, 2018
1QES
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TANDEM GU MISMATCHES IN RNA, NMR, 30 STRUCTURES
Descriptor:RNA (5'-R(*GP*GP*AP*GP*UP*UP*CP*C)-3')
Authors:Mcdowell, J.A., He, L., Chen, X., Turner, D.H.
Deposit date:1997-03-04
Release date:1997-06-05
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Investigation of the structural basis for thermodynamic stabilities of tandem GU wobble pairs: NMR structures of (rGGAGUUCC)2 and (rGGAUGUCC)2.
Biochemistry, 36, 1997
1QET
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TANDEM GU MISMATCHES IN RNA, NMR, 30 STRUCTURES
Descriptor:RNA (5'-R(*GP*GP*AP*UP*GP*UP*CP*C)-3')
Authors:Mcdowell, J.A., He, L., Chen, X., Turner, D.H.
Deposit date:1997-03-04
Release date:1997-06-05
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Investigation of the structural basis for thermodynamic stabilities of tandem GU wobble pairs: NMR structures of (rGGAGUUCC)2 and (rGGAUGUCC)2.
Biochemistry, 36, 1997
2FET
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SYNTHESIS OF C-D-GLYCOPYRANOSYL-HYDROQUINONES AND-BENZOQUINONES. INHIBITION OF PTP1B. INHIBITION OF AND BINDING TO GLYCOGEN PHOSPHORYLASE IN THE CRYSTAL
Descriptor:Glycogen phosphorylase, muscle form, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Chrysina, E.D., Kosmopoulou, M.N., Leonidas, D.D., Oikonomakos, N.G.
Deposit date:2005-12-16
Release date:2006-12-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:In the Search of Glycogen Phosphorylase Inhibitors: Synthesis of C-D-Glycopyranosylbenzo(hydro)quinones Inhibition of and Binding to Glycogen Phosphorylase in the Crystal
Eur.J.Org.Chem., 4, 2007
2FF5
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SYNTHESIS OF C-D-GLYCOPYRANOSYL-HYDROQUINONES AND-BENZOQUINONES. INHIBITION OF PTP1B. INHIBITION OF AND BINDING TO GLYCOGEN PHOSPHORYLASE IN THE CRYSTAL
Descriptor:Glycogen phosphorylase, muscle form, PYRIDOXAL-5'-PHOSPHATE, ...
Authors:Chrysina, E.D., Kosmopoulou, M.N., Leonidas, D.D., Oikonomakos, N.G.
Deposit date:2005-12-19
Release date:2006-12-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:In the Search of Glycogen Phosphorylase Inhibitors: Synthesis of C-D-Glycopyranosylbenzo(hydro)quinones Inhibition of and Binding to Glycogen Phosphorylase in the Crystal
Eur.J.Org.Chem., 4, 2007
6CE0
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CRYSTAL STRUCTURE OF A HIV-1 CLADE B TIER-3 ISOLATE H078.14 UFO-BG ENV TRIMER IN COMPLEX WITH BROADLY NEUTRALIZING FABS PGT124 AND 35O22 AT 4.6 ANGSTROM
Descriptor:Envelope glycoprotein gp160, 35O22 Heavy chain, 35O22 Light chain, ...
Authors:Kumar, S., Sarkar, A., Wilson, I.A.
Deposit date:2018-02-09
Release date:2018-12-05
Method:X-RAY DIFFRACTION (4.602 Å)
Cite:HIV-1 vaccine design through minimizing envelope metastability.
Sci Adv, 4, 2018
5WYB
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STRUCTURE OF PSEUDOMONAS AERUGINOSA DSPI
Descriptor:Probable enoyl-CoA hydratase/isomerase, (4R)-2-METHYLPENTANE-2,4-DIOL, ACETATE ION
Authors:Liu, L., Peng, C., Li, T., Li, C., He, L., Song, Y., Zhu, Y., Shen, Y., Bao, R.
Deposit date:2017-01-12
Release date:2018-01-17
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Author Correction: Structural and functional studies on Pseudomonas aeruginosa DspI: implications for its role in DSF biosynthesis
Sci Rep, 8, 2018
5YFE
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ENZYMATIC AND STRUCTURAL CHARACTERIZATION OF THE POLY (ETHYLENE TEREPHTHALATE) HYDROLASE PETASE FROM I. SAKAIENSIS
Descriptor:Poly(ethylene terephthalate) hydrolase, SULFATE ION, GLYCEROL
Authors:Bao, R., He, L.H., Liu, B.
Deposit date:2017-09-21
Release date:2018-09-26
Last modified:2019-04-10
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Protein Crystallography and Site-Direct Mutagenesis Analysis of the Poly(ethylene terephthalate) Hydrolase PETase from Ideonella sakaiensis.
Chembiochem, 2018
3WSQ
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STRUCTURE OF HER2 WITH AN FAB
Descriptor:Receptor tyrosine-protein kinase erbB-2, Antibody Light Chain, Antibody Heavy Chain
Authors:Fu, W.Y., Wang, Y.X., Zhou, L.J.
Deposit date:2014-03-20
Release date:2015-03-25
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Insights into HER2 signaling from step-by-step optimization of anti-HER2 antibodies.
MAbs, 6, 2014
5CD3
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STRUCTURE OF IMMATURE VRC01-CLASS ANTIBODY DRVIA7
Descriptor:DRVIA7 Heavy Chain, DRVIA7 Light Chain
Authors:Kong, L., Wilson, I.A.
Deposit date:2015-07-02
Release date:2016-04-06
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor.
Immunity, 44, 2016
5CD5
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CRYSTAL STRUCTURE OF AN IMMATURE VRC01-CLASS ANTIBODY DRVIA7 FROM A CHINESE DONOR BOUND TO CLADE A/E HIV-1 GP120 CORE
Descriptor:93TH057 HIV-1 gp120 core, DRVIA7 Fab Heavy Chain, DRVIA7 Fab Light Chain, ...
Authors:Kong, L., Wilson, I.A.
Deposit date:2015-07-03
Release date:2016-04-06
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (3.396 Å)
Cite:Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor.
Immunity, 44, 2016
5JS9
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UNCLEAVED PREFUSION OPTIMIZED GP140 TRIMER WITH AN ENGINEERED 8-RESIDUE HR1 TURN BOUND TO BROADLY NEUTRALIZING ANTIBODIES 8ANC195 AND PGT128
Descriptor:broadly neutralizing antibody PGT128 heavy chain, broadly neutralizing antibody PGT128 light chain, gp120, ...
Authors:Kong, L., Wilson, I.A.
Deposit date:2016-05-07
Release date:2016-07-13
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (6.918 Å)
Cite:Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability.
Nat Commun, 7, 2016
5JSA
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UNCLEAVED PREFUSION OPTIMIZED GP140 TRIMER WITH AN ENGINEERED 10-RESIDUE HR1 TURN BOUND TO BROADLY NEUTRALIZING ANTIBODIES 8ANC195 AND PGT128
Descriptor:broadly neutralizing antibody PGT128 heavy chain, broadly neutralizing antibody PGT128 light chain, gp120, ...
Authors:Kong, L., Wilson, I.A.
Deposit date:2016-05-07
Release date:2016-07-13
Last modified:2018-03-21
Method:X-RAY DIFFRACTION (6.308 Å)
Cite:Uncleaved prefusion-optimized gp140 trimers derived from analysis of HIV-1 envelope metastability.
Nat Commun, 7, 2016
3Q8T
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CRYSTAL STRUCTURE OF THE COILED COIL DOMAIN OF BECLIN 1, AN ESSENTIAL AUTOPHAGY PROTEIN
Descriptor:Beclin-1
Authors:Li, X., Zhao, Y.
Deposit date:2011-01-07
Release date:2012-01-18
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG
Nat Commun, 3, 2012
3SJQ
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CRYSTAL STRUCTURE OF A SMALL CONDUCTANCE POTASSIUM CHANNEL SPLICE VARIANT COMPLEXED WITH CALCIUM-CALMODULIN
Descriptor:Calmodulin, Small conductance calcium-activated potassium channel protein 2, CALCIUM ION, ...
Authors:Zhang, M., Pascal, J.M., Zhang, J.-F.
Deposit date:2011-06-21
Release date:2012-05-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for calmodulin as a dynamic calcium sensor.
Structure, 20, 2012
4MD6
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CRYSTAL STRUCTURE OF PDE5 IN COMPLEX WITH INHIBITOR 5R
Descriptor:cGMP-specific 3',5'-cyclic phosphodiesterase, SULFATE ION, 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one, ...
Authors:Cui, W., Huang, M., Shao, Y., Luo, H.
Deposit date:2013-08-22
Release date:2014-07-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one as a phosphodiesterase-5 inhibitor and its complex crystal structure.
Biochem Pharmacol, 89, 2014
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