Author results

1GHE
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CRYSTAL STRUCTURE OF TABTOXIN RESISTANCE PROTEIN COMPLEXED WITH AN ACYL COENZYME A
分子名称:ACETYLTRANSFERASE, ACETYL COENZYME *A
著者He, H., Ding, Y., Bartlam, M., Sun, F., Le, Y., Qin, X., Tang, H., Zhang, R., Joachimiak, A., Liu, Y., Zhao, N., Rao, Z.
登録日2000-12-13
公開日2003-01-14
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Crystal Structure of Tabtoxin Resistance Protein Complexed with Acetyl Coenzyme A Reveals the Mechanism for beta-Lactam Acetylation
J.Mol.Biol., 325, 2003
1J4J
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CRYSTAL STRUCTURE OF TABTOXIN RESISTANCE PROTEIN (FORM II) COMPLEXED WITH AN ACYL COENZYME A
分子名称:TABTOXIN RESISTANCE PROTEIN, ACETYL COENZYME *A
著者He, H., Ding, Y., Bartlam, M., Zhang, R., Duke, N., Joachimiak, A., Shao, Y., Cao, Z., Tang, H., Liu, Y., Jiang, F., Liu, J., Zhao, N., Rao, Z.
登録日2001-10-02
公開日2003-06-03
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Crystal structure of tabtoxin resistance protein complexed with acetyl coenzyme A reveals the mechanism for beta-lactam acetylation.
J.Mol.Biol., 325, 2003
3IG3
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CRYSTAL STRUCTURE OF MOUSE PLEXIN A3 INTRACELLULAR DOMAIN
分子名称:Plxna3 protein, GLYCEROL
著者He, H., Zhang, X.
登録日2009-07-27
公開日2009-08-25
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Crystal structure of the plexin A3 intracellular region reveals an autoinhibited conformation through active site sequestration.
Proc.Natl.Acad.Sci.USA, 106, 2009
4OTM
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CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN FROM YEAST GCN2
分子名称:Serine/threonine-protein kinase GCN2
著者He, H., Georgiadis, M.M.
登録日2014-02-13
公開日2014-04-16
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal Structures of GCN2 Protein Kinase C-terminal Domains Suggest Regulatory Differences in Yeast and Mammals.
J.Biol.Chem., 289, 2014
4OTN
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CRYSTAL STRUCTURE OF THE C-TERMINAL REGULATORY DOMAIN OF MURINE GCN2
分子名称:Eukaryotic translation initiation factor 2-alpha kinase 4, SULFATE ION, 1,2-ETHANEDIOL
著者He, H., Georgiadis, M.M.
登録日2014-02-13
公開日2014-04-16
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal Structures of GCN2 Protein Kinase C-terminal Domains Suggest Regulatory Differences in Yeast and Mammals.
J.Biol.Chem., 289, 2014
4QHD
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CRYSTAL STRUCTURE OF APO HUMAN APE1
分子名称:DNA-(apurinic or apyrimidinic site) lyase, 1,2-ETHANEDIOL
著者He, H., Chen, Q., Georgiadis, M.M.
登録日2014-05-28
公開日2014-11-12
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献High-resolution crystal structures reveal plasticity in the metal binding site of apurinic/apyrimidinic endonuclease I.
Biochemistry, 53, 2014
4QHE
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CRYSTAL STRUCTURE OF MG2+ BOUND HUMAN APE1
分子名称:DNA-(apurinic or apyrimidinic site) lyase, MAGNESIUM ION, 1,2-ETHANEDIOL
著者He, H., Chen, Q., Georgiadis, M.M.
登録日2014-05-28
公開日2014-11-12
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献High-resolution crystal structures reveal plasticity in the metal binding site of apurinic/apyrimidinic endonuclease I.
Biochemistry, 53, 2014
4QH9
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CRYSTAL STRUCTURE OF MN2+ BOUND HUMAN APE1
分子名称:DNA-(apurinic or apyrimidinic site) lyase, 1,2-ETHANEDIOL, MANGANESE (II) ION
著者Chen, Q., He, H., Georgiadis, M.M.
登録日2014-05-27
公開日2014-11-12
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.175 Å)
主引用文献High-resolution crystal structures reveal plasticity in the metal binding site of apurinic/apyrimidinic endonuclease I.
Biochemistry, 53, 2014
3NWN
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CRYSTAL STRUCTURE OF THE HUMAN KIF9 MOTOR DOMAIN IN COMPLEX WITH ADP
分子名称:Kinesin-like protein KIF9, MAGNESIUM ION, CHLORIDE ION, ...
著者Zhu, H., Tempel, W., He, H., Shen, Y., Wang, J., Brothers, G., Landry, R., Arrowsmith, C.H., Edwards, A.M., Sundstrom, M., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
登録日2010-07-09
公開日2010-07-21
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of the human KIF9 motor domain in complex with ADP
To be Published
4HC4
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HUMAN HMT1 HNRNP METHYLTRANSFERASE-LIKE PROTEIN 6 (S. CEREVISIAE)
分子名称:Protein arginine N-methyltransferase 6, S-ADENOSYL-L-HOMOCYSTEINE, 1,2-ETHANEDIOL, ...
著者Dong, A., Zeng, H., He, H., El Bakkouri, M., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Wu, H., Structural Genomics Consortium (SGC)
登録日2012-09-28
公開日2012-10-17
最終更新日2018-05-16
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Structural basis of arginine asymmetrical dimethylation by PRMT6.
Biochem. J., 473, 2016
4MI0
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HUMAN ENHANCER OF ZESTE (DROSOPHILA) HOMOLOG 2(EZH2)
分子名称:Histone-lysine N-methyltransferase EZH2, ZINC ION, UNKNOWN ATOM OR ION
著者Dong, A., Zeng, H., He, H., Wernimont, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Wu, H., Structural Genomics Consortium (SGC)
登録日2013-08-30
公開日2013-09-25
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations.
Plos One, 8, 2013
4QPP
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THE CRYSTAL STRUCTURE OF HUMAN HMT1 HNRNP METHYLTRANSFERASE-LIKE PROTEIN 6 IN COMPLEX WITH COMPOUND DS-421 (2-{4-[3-CHLORO-2-(2-METHOXYPHENYL)-1H-INDOL-5-YL]PIPERIDIN-1-YL}-N-METHYLETHANAMINE
分子名称:Protein arginine N-methyltransferase 6, POLY-UNK, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Dong, A., Zeng, H., Smil, D., Walker, J.R., He, H., Eram, M., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Vedadi, M., Brown, P.J., Wu, H., Structural Genomics Consortium (SGC)
登録日2014-06-24
公開日2014-08-20
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.52 Å)
主引用文献The Crystal Structure of Human HMT1 hnRNP methyltransferase-like protein 6 in complex with compound DS-421
To be Published
4QQK
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HUMAN HMT1 HNRNP METHYLTRANSFERASE-LIKE PROTEIN 6 (S. CEREVISIAE) WITH GMS
分子名称:Protein arginine N-methyltransferase 6, (5S)-5-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}-N~6~-carbamimidoyl-L-lysine, GLYCEROL, ...
著者Dong, A., Zeng, H., He, H., Wernimont, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Min, J., Luo, M., Wu, H., Structural Genomics Consortium (SGC)
登録日2014-06-27
公開日2014-07-16
最終更新日2018-05-16
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Structural basis of arginine asymmetrical dimethylation by PRMT6.
Biochem. J., 473, 2016
4YVD
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CRYTSAL STRUCTURE OF HUMAN PLEIOTROPIC REGULATOR 1 (PRL1)
分子名称:Pleiotropic regulator 1, SODIUM ION, CHLORIDE ION, ...
著者Dong, A., Zeng, H., Xu, C., Tempel, W., Li, Y., He, H., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Min, J., Wu, H., Structural Genomics Consortium (SGC)
登録日2015-03-19
公開日2015-04-15
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crytsal structure of human Pleiotropic Regulator 1 (PRL1).
to be published
4IKP
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CRYSTAL STRUCTURE OF COACTIVATOR-ASSOCIATED ARGININE METHYLTRANSFERASE 1 WITH METHYLENESINEFUNGIN
分子名称:Histone-arginine methyltransferase CARM1, (2S,5S)-2,6-diamino-5-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}hexanoic acid, GLYCEROL, ...
著者Dong, A., Dombrovski, L., He, H., Ibanez, G., Wernimont, A., Zheng, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Brown, P.J., Min, J., Luo, M., Wu, H., Structural Genomics Consortium (SGC)
登録日2012-12-27
公開日2013-02-13
最終更新日2018-04-18
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of coactivator-associated arginine methyltransferase 1 with methylenesinefungin
TO BE PUBLISHED
3HM6
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CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF HUMAN PLEXIN B1
分子名称:Plexin-B1, Unknown peptide, UNKNOWN ATOM OR ION
著者Tong, Y., He, H., Shen, L., Tempel, W., MacKenzie, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Bochkarev, A., Park, H., Structural Genomics Consortium (SGC)
登録日2009-05-28
公開日2009-06-09
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.402 Å)
主引用文献Structure and function of the intracellular region of the plexin-b1 transmembrane receptor.
J.Biol.Chem., 284, 2009
4LG8
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CRYSTAL STRUCTURE OF PRPF19 WD40 REPEATS
分子名称:Pre-mRNA-processing factor 19, SODIUM ION, UNKNOWN ATOM OR ION
著者Xu, C., Tempel, W., He, H., Dobrovetsky, E., Seitova, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2013-06-27
公開日2013-08-07
最終更新日2018-01-03
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Crystal structure of the WD40 domain of human PRPF19.
Biochem. Biophys. Res. Commun., 493, 2017
4OA7
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CRYSTAL STRUCTURE OF TANKYRASE1 IN COMPLEX WITH IWR1
分子名称:Tankyrase-1, ZINC ION, 4-[(3aR,4R,7S,7aS)-1,3-dioxo-1,3,3a,4,7,7a-hexahydro-2H-4,7-methanoisoindol-2-yl]-N-(quinolin-8-yl)benzamide
著者Zhang, X., He, H.
登録日2014-01-03
公開日2015-01-07
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.301 Å)
主引用文献Disruption of Wnt/ beta-Catenin Signaling and Telomeric Shortening Are Inextricable Consequences of Tankyrase Inhibition in Human Cells.
Mol.Cell.Biol., 35, 2015
5GXH
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THE STRUCTURE OF THE GEMIN5 WD40 DOMAIN WITH AAUUUUUG
分子名称:Gem-associated protein 5, RNA (5'-R(*A*AP*UP*UP*UP*UP*UP*G)-3'), UNKNOWN ATOM OR ION, ...
著者Xu, C., He, H., Li, Y., Dong, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2016-09-17
公開日2016-10-26
最終更新日2018-10-17
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly
Genes Dev., 30, 2016
5GXI
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STRUCUTRE OF THE GEMIN5 WD40 DOMAIN IN COMPLEX WITH AAUUUUUGAG
分子名称:Gem-associated protein 5, RNA (5'-R(*A*AP*UP*UP*UP*UP*UP*GP*AP*G)-3'), UNKNOWN ATOM OR ION
著者Xu, C., He, H., Li, Y., Dong, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2016-09-18
公開日2016-10-26
最終更新日2018-10-17
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly
Genes Dev., 30, 2016
5TEE
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CRYSTAL STRUCTURE OF GEMIN5 WD40 REPEATS IN APO FORM
分子名称:Gem-associated protein 5, GLYCEROL, UNKNOWN ATOM OR ION, ...
著者Chao, X., Tempel, W., Bian, C., Cerovina, T., He, H., Walker, J.R., Seitova, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2016-09-21
公開日2016-10-19
最終更新日2017-05-10
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly.
Genes Dev., 30, 2016
5TEF
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CRYSTAL STRUCTURE OF GEMIN5 WD40 REPEATS IN COMPLEX WITH M7GPPPG
分子名称:Gem-associated protein 5, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, GLYCEROL, ...
著者Chao, X., Tempel, W., Bian, C., He, H., Cerovina, T., Seitova, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2016-09-21
公開日2016-10-19
最終更新日2017-05-10
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly.
Genes Dev., 30, 2016
5THA
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GEMIN5 WD40 REPEATS IN COMPLEX WITH A GUANOSYL MOIETY
分子名称:Gem-associated protein 5, UNKNOWN ATOM OR ION, DIGUANOSINE-5'-TRIPHOSPHATE
著者Chao, X., Tempel, W., Bian, C., Cerovina, T., He, H., Seitova, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2016-09-29
公開日2016-10-19
最終更新日2017-05-10
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural insights into Gemin5-guided selection of pre-snRNAs for snRNP assembly.
Genes Dev., 30, 2016
1X70
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HUMAN DIPEPTIDYL PEPTIDASE IV IN COMPLEX WITH A BETA AMINO ACID INHIBITOR
分子名称:Dipeptidyl peptidase IV, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
著者Kim, D., Wang, L., Beconi, M., Eiermann, G.J., Fisher, M.H., He, H., Hickey, G.J., Leiting, B., Lyons, K.
登録日2004-08-12
公開日2005-01-18
最終更新日2012-06-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献(2R)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin- 7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes
J.Med.Chem., 48, 2005
3DLJ
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CRYSTAL STRUCTURE OF HUMAN CARNOSINE DIPEPTIDASE 1
分子名称:Beta-Ala-His dipeptidase, ZINC ION, UNKNOWN ATOM OR ION, ...
著者Dong, A., Dobrovetsky, E., Seitova, A., He, H., Tempel, W., Kozieradzki, I., Arrowsmith, C.H., Weigelt, J., Bountra, C., Edwards, A.M., Bochkarev, A., Cossar, D., Structural Genomics Consortium (SGC)
登録日2008-06-27
公開日2008-08-19
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Crystal structure of human carnosine dipeptidase 1.
To be Published